Vepdegestrant (ARV-471) monotherapy has been granted fast track designation by the FDA as a treatment for adult patients with estrogen receptor (ER)–positive, HER2-negative locally advanced or metastatic breast cancer who have received prior treatment with endocrine-based therapy. This designation was granted in February 2024. Vepdegestrant was found to have ER degradation rates of up to 97% in tumor cells, as indicated by preclinical studies. Furthermore, the agent exhibited enhanced anti-tumor activity in comparison to fulvestrant (Faslodex) when administered as monotherapy or in combination with a CDK4/6 inhibitor, as well as tumor shrinkage in ER-driven xenograft models. They are committed to addressing the persistent unmet requirements of individuals with ER-positive, HER2-negative breast cancer and are making every effort to accelerate the development of vepdegestrant as a novel, oral ER-targeted potential therapy for this patient population. They are delighted that the FDA has granted fast track designation for vepdegestrant, and we remain convinced that this investigational medication has the potential to utilize the body's natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.
In October 2023, the FDA approved Entrectinib (Rozlytrek) as a treatment for pediatric patients with solid tumors that contain an NTRK gene fusion. In order to qualify, patients must be at least one month of age, have metastatic disease, have no known acquired resistance mutation, and have no standard or satisfactory standard therapy options. Additionally, a novel oral pellet formulation was authorized by the regulatory agency. The decision was substantiated by the results of 33 pediatric patients who were enrolled in one of two multicenter, single-arm clinical trials: the phase 1/2 STARTRK-NG trial (NCT02650401) or the phase 2 TAPISTRY trial (NCT04589845). Patients were administered entrectinib orally or through an enteral feeding tube in 4-week cycles, with once-daily doses ranging from 20 mg to 600 mg, based on their body surface area. The open-label, multicenter trials included pediatric patients with unresectable or metastatic solid tumors that contained an NTRK gene fusion. The patients had measurable or evaluable disease at baseline and had not previously been exposed to a TRK inhibitor. In order to be included in the analysis, participants were required to have received a minimum of one dose of entrectinib and have a minimum of six months of follow-up.
Segmentation
The spindle cell sarcoma treatment market has been segmented on the basis of types of treatment and end-user.
On the basis of types of treatment, the spindle cell sarcoma treatment market is segmented into surgical removal, cryotherapy, radiotherapy, hormone therapy, and Chemotherapy. Surgical therapy is further sub-segmented into conservative surgical removal type and wide surgical removal type.
On the basis of end-user, the spindle cell sarcoma treatment market is segmented into hospital, clinics, and others.
Key players
Key players for the spindle cell sarcoma treatment market are PharmaEngine, Inc, Morphotek Inc, Threshold Pharmaceutical, Merck KGaA, NantCell Inc, NanoCarrier Co., Ltd, Athenex, Inc.
Regional Market Summary
On a regional basis, the market is segmented into the Americas, Europe, Asia-Pacific, and the Middle East and Africa.
Americas is likely to dominate the spindle cell sarcoma treatment market owing to the remarkable use of chemotherapy for the prevention of disease and favorable conditions for research and development.
According to a scientific report, of Surveillance, Epidemiology and End Results (SEER) database white people account for 79.1 % with spindle cell sarcoma cancer within the median age of 57 years.
Europe is the second largest market for the spindle cell sarcoma treatment followed by Asia-Pacific. Due to the availability of fund for research and development activity and growing emphasis on treating disease. Asia-Pacific shows the fastest growth in the market due to an increase in the prevalence of communicable disease. India and China are expected to be the fastest growing market for spindle cell sarcoma treatment.
The Middle East and Africa has the lowest market for spindle cell sarcoma treatment due to poor medical facilities and lack of technology.
Spindle Cell Sarcoma Treatment Market, by Types of Treatment
Spindle Cell Sarcoma Treatment Market, by End-User
Spindle Cell Sarcoma Treatment Market, by Region
Spindle Cell Sarcoma Treatment Market, by Key Players
Recent Developmet
Intended Audience
| Report Attribute/Metric | Details |
| Market Size | 2032: Significant Value USD 2.81 Billion |
| CAGR | 6.3% |
| Base Year | 2021 |
| Forecast Period | 2023-2032 |
| Historical Data | 2020 |
| Forecast Units | Value (USD Million) |
| Report Coverage | Revenue Forecast, Competitive Landscape, Growth Factors, and Trends |
| Segments Covered | Types of treatment and End-user |
| Geographies Covered | North America, Europe, Asia-Pacific, and Rest of the World (RoW) |
| Key Vendors | PharmaEngine, Inc, Morphotek Inc, Threshold Pharmaceutical, Merck KGaA, NantCell Inc, NanoCarrier Co., Ltd, Athenex, Inc. |
| Key Market Opportunities | key players in the market are engaged in new launches of chemotherapy drugs and strategic collaborations |
| Key Market Drivers | · Increase in aging population · Rising use of various treatment options to cure spindle cell sarcoma tumor · Increasing investment in research and development by government and non-government organization |
Spindle Cell Sarcoma Treatment Market Highlights:
Frequently Asked Questions (FAQ) :
Spindle cell sarcoma treatment market CAGR would be 6.3% during the forecast period.
Spindle cell sarcoma treatment market hurdles would be failure to follow distraction protocols and its adverse impact on the nerves.
Spindle cell sarcoma treatment market has segments like hormone therapy, cryotherapy, surgical removal, radiotherapy, and chemotherapy.
The end users are hospitals, clinics, and others.
The Americas would ensure maximum growth for the spindle cell sarcoma treatment market.
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Assistant Manager He holds an experience of about 7+ years in market research and business consulting, working under the spectrum of life sciences and healthcare domains. rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. his expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. in addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives
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