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    Antisense and RNAi Therapeutics Market

    ID: MRFR/HC/41284-HCR
    200 Pages
    Garvit Vyas
    October 2025

    Antisense and RNAi Therapeutics Market Research Report By Therapeutic Application (Cancer, Cardiovascular Diseases, Genetic Disorders, Viral Infections, Neurological Disorders), By Technology Type (Antisense Oligonucleotides, Small Interfering RNAs, MicroRNAs, Long Non-Coding RNAs), By Route of Administration (Intravenous, Subcutaneous, Intramuscular, Oral), By End User (Pharmaceutical Companies, Research Institutions, Contract Research Organizations) and By Regional - Forecast to 2035

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    Antisense and RNAi Therapeutics Market Infographic
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    Antisense and RNAi Therapeutics Market Summary

    The Global Antisense and RNAi Therapeutics Market is projected to grow from 5.21 USD Billion in 2024 to 12.5 USD Billion by 2035.

    Key Market Trends & Highlights

    Antisense and RNAi Therapeutics Key Trends and Highlights

    • The market is expected to experience a compound annual growth rate (CAGR) of 8.28% from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 12.5 USD Billion, indicating robust growth potential.
    • In 2024, the market is valued at 5.21 USD Billion, reflecting the increasing interest in innovative therapeutic approaches.
    • Growing adoption of RNAi therapeutics due to advancements in gene silencing technologies is a major market driver.

    Market Size & Forecast

    2024 Market Size 5.21 (USD Billion)
    2035 Market Size 12.5 (USD Billion)
    CAGR (2025-2035) 8.28%

    Major Players

    Ionis Pharmaceuticals, Alnylam Pharmaceuticals, Dicerna Pharmaceuticals, Merck, Pfizer, Silence Therapeutics, Vertex Pharmaceuticals, Prothena Corporation, Novartis, Bayer, Sanofi, Roche, AstraZeneca, Regeneron Pharmaceuticals, Hoffmann la Roche

    Antisense and RNAi Therapeutics Market Trends

    Because chronic diseases and genetic disorders are becoming more common, the market for antisense and RNAi therapeutics has grown significantly. One important element is the growing acceptability of customized medicine since these therapies provide patients with individualized treatment alternatives. Additionally, the creation of novel medicines is being fueled by advances in biotechnology and a deeper comprehension of RNA biology. The growth of this industry is also aided by increased governmental and private sector investment in research and development.

    The growing patient base and improved regulatory approvals for novel treatments both support the generally favorable market conditions.

    Emerging opportunities in this market are noteworthy. The potential for novel drug candidates targeting a range of diseases, including cancer, cardiovascular disorders, and neurodegenerative diseases, remains significant. Expansion into emerging markets offers an avenue for growth, as these regions are increasingly recognizing the benefits of advanced therapies.

    Collaborations between pharmaceutical companies and academic institutions are fostering innovation and the development of new treatment modalities. Furthermore, the integration of RNAi therapeutics into existing therapeutic frameworks can enhance treatment effectiveness, providing opportunities for combination therapies that improve patient outcomes.

    In recent times, trends indicate a shift towards the use of technologies such as CRISPR and other gene editing tools, which complement antisense and RNAi approaches. The focus on developing more effective delivery systems to ensure that therapeutic molecules reach their target cells is gaining traction.

    Additionally, the use of artificial intelligence and machine learning in drug discovery is transforming the landscape by increasing the efficiency of identifying potential therapeutic candidates.

    As patient-centric approaches gain momentum, the market is expected to witness an influx of therapies aimed at specific genetic profiles, catering to the growing demand for customized healthcare solutions.

    The ongoing advancements in antisense and RNAi therapeutics suggest a transformative potential in the treatment of genetic disorders, highlighting the necessity for continued research and development in this innovative field.

    National Institutes of Health (NIH)

    Antisense and RNAi Therapeutics Market Drivers

    Increasing Prevalence of Genetic Disorders

    The rising incidence of genetic disorders globally drives the demand for innovative therapies, particularly in the Global Antisense and RNAi Therapeutics Market Industry. Conditions such as Duchenne muscular dystrophy and spinal muscular atrophy highlight the urgent need for targeted treatments. As of 2024, the market is valued at approximately 5.21 USD Billion, reflecting a growing recognition of the potential of antisense and RNAi technologies. The increasing focus on precision medicine further emphasizes the necessity for tailored therapeutic approaches, which are expected to gain traction in the coming years, potentially leading to a market expansion to 12.5 USD Billion by 2035.

    Market Segment Insights

    Antisense and RNAi Therapeutics Market Therapeutic Application Insights

    The Antisense and RNAi Therapeutics Market focused on Therapeutic Application witnessed notable growth, with significant advancements shaping its trajectory.

    Notably, the segment catering to Cancer was one of the most substantial contributors, valued at 1.4 USD Billion in 2024, reflecting the increasing urgency to innovate therapies for a disease that remains a major healthcare burden globally.

    Following closely, the cardiovascular diseases sector garnered 1.05 USD Billion in the same year, highlighting the importance of developing targeted therapeutics for prevalent cardiac conditions.

    The Genetic Disorders segment also became increasingly significant, expected to generate revenue of 1.0 USD Billion in 2024, as advancements in gene therapy and tailored treatments for hereditary diseases gain traction.

    In addition, the Viral Infections market held a value of 1.0 USD Billion, indicating a strong need for effective antiviral therapies, especially in the wake of recent health crises.

    Antisense and RNAi Therapeutics Market Technology Type Insights

    The market segment revolves around several key technology types, each contributing to its expansion in unique ways. Antisense Oligonucleotides, recognized for their capacity to inhibit specific gene expression, are fundamental in combating various genetic disorders.

    Small Interfering RNAs (siRNAs) also play a crucial role in gene silencing and are a driving force behind many therapeutic advancements. Meanwhile, microRNAs are increasingly acknowledged for their regulatory capabilities in cellular processes, showcasing their importance in disease mechanisms.

    Long non-coding RNAs are emerging as vital components in gene regulation and have shown promise in several therapeutic applications. This diverse segmentation within the Antisense and RNAi Therapeutics Market indicates various growth opportunities as innovative therapies continue to emerge, promising to address unmet medical needs across a broad spectrum of conditions.

    With a collective market growth trend observed, the future looks optimistic for continued investment and research within this dynamic field.

    Antisense and RNAi Therapeutics Market Route of Administration Insights

    The market segmentation reveals that different routes, including Intravenous, Subcutaneous, Intramuscular, and Oral, cater to distinct patient needs and therapeutic requirements.

    Intravenous administration is pertinent for its rapid delivery and is often preferred in settings requiring immediate action, while the Subcutaneous route offers a more convenient option, becoming increasingly popular due to its ease of self-administration.

    Intramuscular administration serves as a viable intermediary, providing a balance between effectiveness and patient comfort. In contrast, Oral administration, although more challenging for RNA-based therapies, holds significant potential for expanding patient compliance due to its non-invasive nature.

    Overall, the diversity in routing illustrates the market’s adaptability and highlights the opportunities and challenges presented by each method, contributing to the anticipated growth in the Antisense and RNAi Therapeutics Market revenue in the coming years.

    The integration of innovations along these routes will continue to drive the evolution within the Antisense and RNAi Therapeutics Market, enhancing treatment accessibility and effectiveness.

    Antisense and RNAi Therapeutics Market End User Insights

    The End User segment of the Antisense and RNAi Therapeutics Market is crucial for the overall market dynamics, reflecting robust growth and diversity. Research institutions also contribute significantly, as they are essential for advancing scientific knowledge and experimentation necessary for drug discovery in this field.

    Furthermore, Contract Research Organizations (CROs) have become integral in providing outsourced research services, helping streamline development processes efficiently. The collaboration among these entities fosters an environment ripe for innovation while also navigating challenges such as regulatory hurdles and funding limitations.

    With engaging opportunities emerging from advancements in technology and a rising demand for targeted therapies, the segmentation within the Antisense and RNAi Therapeutics Market is indicative of a growing, sophisticated landscape that is increasingly adept at addressing complex health issues.

    Get more detailed insights about Antisense and RNAi Therapeutics Market

    Regional Insights

    The Antisense and RNAi Therapeutics Market revenue was prominently shaped by regional dynamics, with North America holding a majority share, valued at 2.1 USD Billion in 2024 and expected to rise to 5.2 USD Billion by 2035. This region's advanced healthcare infrastructure and robust investment in biotech research significantly contribute to its dominance.

    Europe followed, with a market valuation of 1.3 USD Billion in 2024 and projected to grow to 3.2 USD Billion by 2035, supported by increasing government initiatives for genetic research. The APAC region showed substantial growth potential, valued at 1.2 USD Billion in 2024 and forecasted to reach 2.9 USD Billion by 2035, driven by rising healthcare expenditure and growing awareness of RNA-based therapies.

    South America and MEA represented smaller market shares, with valuations of 0.3 USD Billion and 0.31 USD Billion in 2024, respectively, anticipated to reach 0.8 USD Billion and 0.55 USD Billion by 2035. These regions, while lesser contributors, indicated expanding opportunities, particularly as healthcare systems evolve and investment in biopharmaceuticals grows.

    The Antisense and RNAi Therapeutics Market statistics reflected a regionally diverse landscape that witnessed gradual maturation alongside increasing adoption of innovative therapies.

    Antisense and RNAi Therapeutics Market Regional

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Key Players and Competitive Insights

    The competitive insights of the Antisense and RNAi Therapeutics Market reveal a dynamic landscape marked by innovation and strategic collaborations. This market has gained traction due to the promising applications of these therapies in treating various genetic disorders and chronic diseases.

    Key players are investing in research and development to enhance the efficacy of their products while navigating regulatory challenges to ensure compliance and accelerated approvals. The growing prevalence of genetic diseases, coupled with advancements in genomics, is propelling interest among stakeholders.

    Additionally, strategic partnerships and collaborations between biotech companies and research institutions are fostering a conducive environment for innovation, allowing for the exploration of new therapeutic targets.

    Ionis Pharmaceuticals holds a strong position in the Antisense and RNAi Therapeutics Market, leveraging its proprietary antisense technology platform to develop treatments for a range of diseases, including neurological disorders and cancer. The company boasts a robust pipeline of drug candidates that have demonstrated efficacy in clinical trials, establishing it as a leader in this sector.

    Ionis Pharmaceuticals is recognized for its commitment to precision medicine, focusing on personalized approaches that cater to individual patient needs. Moreover, its strong intellectual property portfolio protects its innovative discoveries while enabling collaborations with larger pharmaceutical companies, giving it a competitive edge in securing market share.

    The company's experience in navigating the regulatory landscape further strengthens its market presence, making it a formidable player in the field of antisense and RNAi therapeutics.

    Alnylam Pharmaceuticals is another key contender in the Antisense and RNAi Therapeutics Market, renowned for its pioneering work in RNA interference technology. The company focuses on developing transformative therapies that address rare diseases caused by genetic mutations, positioning itself as a leader in this niche market segment.

    Alnylam Pharmaceuticals has achieved significant milestones, including the successful commercialization of its products, which have shown promising clinical outcomes. The company's commitment to advancing its RNAi platform enables continuous research into innovative therapeutic solutions.

    Through strategic alliances and collaborations with other industry players, Alnylam Pharmaceuticals enhances its footprint and expands its product offerings. The ability to rapidly bring novel therapies to market due to efficient development processes underscores its competitive advantage in the evolving landscape of antisense and RNAi therapeutics.

    Key Companies in the Antisense and RNAi Therapeutics Market market include

    Industry Developments

    • Q2 2024: Alnylam Pharmaceuticals Announces FDA Approval of AMVUTTRA (vutrisiran) for the Treatment of Hereditary Transthyretin-Mediated Amyloidosis Alnylam Pharmaceuticals received FDA approval for AMVUTTRA (vutrisiran), an RNAi therapeutic for hereditary transthyretin-mediated amyloidosis, marking a significant regulatory milestone in the RNAi therapeutics sector.
    • Q2 2024: Ionis Pharmaceuticals Announces FDA Approval of WAINUA™ (eplontersen) for the Treatment of Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis Ionis Pharmaceuticals, in partnership with AstraZeneca, announced FDA approval of WAINUA™ (eplontersen), an antisense oligonucleotide therapy for polyneuropathy of hereditary transthyretin-mediated amyloidosis.
    • Q1 2024: Silence Therapeutics Announces Strategic Collaboration with Hansoh Pharma to Develop and Commercialize RNAi Therapeutics in China Silence Therapeutics entered a strategic partnership with Hansoh Pharma to co-develop and commercialize RNAi therapeutics targeting cardiovascular, metabolic, and other diseases in China.
    • Q2 2024: Arrowhead Pharmaceuticals Announces $120 Million Public Offering of Common Stock Arrowhead Pharmaceuticals completed a $120 million public offering to support the advancement of its RNAi-based therapeutic pipeline.
    • Q1 2024: Dicerna Pharmaceuticals Announces Research Collaboration and Licensing Agreement with Novo Nordisk to Discover and Develop RNAi Therapies for Cardiometabolic Diseases Dicerna Pharmaceuticals entered a research and licensing agreement with Novo Nordisk to develop RNAi therapies for cardiometabolic diseases, expanding its partnership portfolio.
    • Q2 2024: Wave Life Sciences Raises $100M in Public Offering to Advance RNA Medicines Wave Life Sciences raised $100 million through a public offering to accelerate the development of its RNA-targeting therapeutics, including antisense and RNAi candidates.
    • Q2 2024: Alnylam Pharmaceuticals and Regeneron Announce Expansion of RNAi Therapeutics Collaboration Alnylam Pharmaceuticals and Regeneron expanded their collaboration to discover, develop, and commercialize RNAi therapeutics for nonalcoholic steatohepatitis (NASH) and other diseases.
    • Q1 2024: Sarepta Therapeutics Appoints Dr. Louise Rodino-Klapac as Chief Scientific Officer Sarepta Therapeutics announced the appointment of Dr. Louise Rodino-Klapac as Chief Scientific Officer to lead its RNA-targeted therapeutics research and development.
    • Q2 2024: Ionis Pharmaceuticals Announces Opening of New Manufacturing Facility for Antisense Oligonucleotide Production Ionis Pharmaceuticals opened a new manufacturing facility dedicated to the production of antisense oligonucleotides, increasing its capacity to support commercial and clinical programs.
    • Q1 2024: Silence Therapeutics Announces $45 Million Private Placement Financing Silence Therapeutics secured $45 million in private placement financing to advance its pipeline of RNAi therapeutics.
    • Q2 2024: Alnylam Pharmaceuticals and Roche Enter Strategic Partnership to Develop and Commercialize RNAi Therapeutics for Hypertension Alnylam Pharmaceuticals and Roche entered a strategic partnership to co-develop and commercialize RNAi therapeutics targeting hypertension.
    • Q1 2024: Arrowhead Pharmaceuticals Announces FDA Clearance of Investigational New Drug Application for ARO-ANG3 Arrowhead Pharmaceuticals received FDA clearance for its investigational new drug application for ARO-ANG3, an RNAi therapeutic candidate targeting ANGPTL3 for the treatment of dyslipidemia.

    Future Outlook

    Antisense and RNAi Therapeutics Market Future Outlook

    The Antisense and RNAi Therapeutics Market is projected to grow at 8.28% CAGR from 2024 to 2035, driven by advancements in gene editing and increasing prevalence of genetic disorders.

    New opportunities lie in:

    • Develop targeted delivery systems to enhance therapeutic efficacy.
    • Invest in partnerships with biotech firms for innovative RNAi applications.
    • Expand into emerging markets with tailored therapeutic solutions.

    By 2035, the market is expected to achieve substantial growth, positioning itself as a leader in innovative therapeutic solutions.

    Market Segmentation

    Antisense and RNAi Therapeutics Market End User Outlook

    • Pharmaceutical Companies
    • Research Institutions
    • Contract Research Organizations

    Antisense and RNAi Therapeutics Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Antisense and RNAi Therapeutics Market Technology Type Outlook

    • Antisense Oligonucleotides
    • Small Interfering RNAs
    • MicroRNAs
    • Long Non-Coding RNAs

    Antisense and RNAi Therapeutics Market Route of Administration Outlook

    • Intravenous
    • Subcutaneous
    • Intramuscular
    • Oral

    Antisense and RNAi Therapeutics Market Therapeutic Application Outlook

    • Cancer
    • Cardiovascular Diseases
    • Genetic Disorders
    • Viral Infections
    • Neurological Disorders

    Report Scope

    Scope:
    Attribute/Metric Source: Details
    MARKET SIZE 2023 4.81(USD Billion)
    MARKET SIZE 2024 5.21(USD Billion)
    MARKET SIZE 2035 12.5(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR) 8.28% (2025 - 2035)
    REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR 2024
    MARKET FORECAST PERIOD 2025 - 2035
    HISTORICAL DATA 2019 - 2023
    MARKET FORECAST UNITS USD Billion
    KEY COMPANIES PROFILED Ionis Pharmaceuticals, Alnylam Pharmaceuticals, Dicerna Pharmaceuticals, Merck, Pfizer, Silence Therapeutics, Vertex Pharmaceuticals, Prothena Corporation, Novartis, Bayer, Sanofi, Roche, AstraZeneca, Regeneron Pharmaceuticals, HoffmannLa Roche
    SEGMENTS COVERED Therapeutic Application, Technology Type, Route of Administration, End User, Regional
    KEY MARKET OPPORTUNITIES Personalized medicine development, Expanding pipeline of therapies, Increased funding for research, Advancements in delivery mechanisms, Rising prevalence of genetic disorders
    KEY MARKET DYNAMICS Increasing investment in research, Growing incidence of genetic disorders, Advancements in drug delivery systems, Rising demand for personalized medicine, Expanding pipeline of RNAi therapies
    COUNTRIES COVERED North America, Europe, APAC, South America, MEA

    FAQs

    What is the expected market size of the Global Antisense and RNAi Therapeutics Market in 2024?

    The market is expected to be valued at 5.21 USD Billion in 2024.

    What will be the market value of the Global Antisense and RNAi Therapeutics Market by 2035?

    By 2035, the market is projected to reach a value of 12.5 USD Billion.

    What is the expected compound annual growth rate (CAGR) for the Global Antisense and RNAi Therapeutics Market from 2025 to 2035?

    The expected CAGR for the market during this period is 8.28%.

    Which region is projected to hold the largest market share of the Global Antisense and RNAi Therapeutics Market in 2024?

    North America is projected to dominate the market with a value of 2.1 USD Billion in 2024.

    How much is the European market for Antisense and RNAi Therapeutics expected to be valued at in 2035?

    The European market is expected to be valued at 3.2 USD Billion in 2035.

    What are the anticipated market sizes for Cancer therapeutics in 2024 and 2035 within the Global Antisense and RNAi Therapeutics Market?

    The Cancer therapeutics market is valued at 1.4 USD Billion in 2024 and expected to reach 3.4 USD Billion in 2035.

    Which major players are key competitors in the Global Antisense and RNAi Therapeutics Market?

    Major players include Ionis Pharmaceuticals, Alnylam Pharmaceuticals, and Merck, among others.

    What is the projected market size for Cardiovascular Diseases therapeutics in 2024?

    The market for Cardiovascular Diseases therapeutics is projected to be valued at 1.05 USD Billion in 2024.

    How much is the Global Antisense and RNAi Therapeutics Market expected to grow in the Asia-Pacific region by 2035?

    By 2035, the Asia-Pacific region is projected to have a market size of 2.9 USD Billion.

    What is the expected market size for Genetic Disorders therapeutics by 2035?

    The market for Genetic Disorders therapeutics is expected to reach 2.5 USD Billion by 2035.

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