• Cat-intel
  • MedIntelliX
  • Resources
  • About Us
  • Request Free Sample ×

    Kindly complete the form below to receive a free sample of this Report

    Leading companies partner with us for data-driven Insights

    clients tt-cursor
    Hero Background

    RNAi Drug Delivery Market

    ID: MRFR/Pharma/39145-HCR
    128 Pages
    Kinjoll Dey
    October 2025

    RNAi Drug Delivery Market Research Report By Delivery Route (Systemic, Local), By Technology (siRNA, miRNA, shRNA, Others), By Target Disease (Cancer, Viral Infections, Genetic Disorders, Metabolic Diseases, Others), By Delivery System (Liposomes, Polymeric Nanoparticles, Viral Vectors, Lipid Nanoparticles, Others), By Targeted Tissue (Liver, Lungs, Brain, Heart, Others) and By Regional (North America, Europe, South America, Asia-Pacific, Middle East and Africa) - Forecast to 2035

    Share:
    Download PDF ×

    We do not share your information with anyone. However, we may send you emails based on your report interest from time to time. You may contact us at any time to opt-out.

    RNAi Drug Delivery Market Infographic
    Purchase Options

    RNAi Drug Delivery Market Summary

    The Global RNAi Drug Delivery Market is projected to experience substantial growth from 4.53 USD Billion in 2024 to 24.8 USD Billion by 2035.

    Key Market Trends & Highlights

    RNAi Drug Delivery Key Trends and Highlights

    • The market is expected to grow at a compound annual growth rate (CAGR) of 16.71% from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 24.8 USD Billion, indicating robust expansion.
    • In 2024, the market is valued at 4.53 USD Billion, reflecting a strong foundation for future growth.
    • Growing adoption of RNA interference technology due to its potential in targeted therapies is a major market driver.

    Market Size & Forecast

    2024 Market Size 4.53 (USD Billion)
    2035 Market Size 24.8 (USD Billion)
    CAGR (2025-2035) 16.71%

    Major Players

    Alnylam Pharmaceuticals, Inc., Bayer AG, Arrowhead Pharmaceuticals, Inc., Pfizer Inc., Roche Holding Ltd., Arcturus Therapeutics Holdings Ltd., Regeneron Pharmaceuticals, Inc., Ionis Pharmaceuticals, Inc., Sanofi S.A., Viridian Therapeutics, Inc., Takeda Pharmaceutical Company Limited, Moderna Therapeutics, Inc., BioNTech SE, Dicerna Pharmaceuticals, Inc., Novartis AG

    RNAi Drug Delivery Market Trends

    The RNAi Drug Delivery Market is driven by several factors, such as the growing prevalence of chronic illness, the increasing number of RNAi research funding from governments, and the development of technology related to RNAi. The demand for effective therapies that are well-targeted is high, and hence, the competition to provide therapies based on RNAi is growing.

    The entry of new players and new biotechnological advancements are potential opportunities for the growth of the delivery of RNAi drugs market. The use of novel delivery techniques, such as lipid nanoparticles and viral vectors, is expected to enhance the targeting and transportation of RNA therapeutics. With the added possibility of inhibiting several genes at once, as well as the incorporation of multi-drug dosage forms, this increases the scope for market expansion.

    The combining needs for RNAi with other therapeutic options, the increasing number of gene editing technologies, and the increasing number of biopharmaceuticals focusing on anthracycline-free therapies would each fit into the trend for the RNAi drug delivery market. Treatments based on RNAi are becoming more effective and less damaging as these approaches can be modified to meet the specific needs of patients. Therapies aimed at increasing cutting-edge technologies like CRISPR-Cas9 would add to changing the future of RNAi therapeutics targeting and drug delivery.

    The increasing focus on precision medicine and the growing understanding of RNA interference mechanisms are driving advancements in RNAi drug delivery systems, which may revolutionize therapeutic approaches for various diseases.

    National Institutes of Health (NIH)

    RNAi Drug Delivery Market Drivers

    Market Growth Projections

    The Global RNAi Drug Delivery Market Industry is poised for remarkable growth, with projections indicating a market value of 4.53 USD Billion in 2024 and an anticipated increase to 24.8 USD Billion by 2035. This growth trajectory reflects a compound annual growth rate (CAGR) of 16.71% from 2025 to 2035. Such projections underscore the increasing interest in RNAi technology and its potential to revolutionize therapeutic approaches across various medical fields. The market's expansion is likely to be driven by advancements in delivery mechanisms, rising investments in biotechnology, and the growing demand for personalized medicine.

    Advancements in RNAi Technology

    Technological advancements in RNAi delivery systems significantly enhance the efficacy and safety of RNAi therapeutics. Innovations such as lipid nanoparticles and polymer-based carriers improve the stability and bioavailability of RNAi molecules, facilitating their delivery to target cells. These advancements not only increase the therapeutic potential of RNAi but also expand its application across various diseases, including cancer and viral infections. As the Global RNAi Drug Delivery Market Industry evolves, the integration of cutting-edge technologies is likely to attract investments and foster collaborations, further propelling market growth. The anticipated CAGR of 16.71% from 2025 to 2035 underscores the potential of these advancements.

    Growing Investment in Biotechnology

    The surge in investment within the biotechnology sector plays a crucial role in the expansion of the Global RNAi Drug Delivery Market Industry. Governments and private entities are increasingly funding research and development initiatives aimed at harnessing RNAi technology for therapeutic applications. This financial support facilitates the exploration of novel drug delivery mechanisms and the development of RNAi-based therapeutics. For example, initiatives by various governments to promote biotechnology innovation create a conducive environment for breakthroughs in RNAi drug delivery. As a result, the market is poised for substantial growth, with projections indicating a market value of 4.53 USD Billion in 2024.

    Rising Demand for Personalized Medicine

    The shift towards personalized medicine significantly influences the Global RNAi Drug Delivery Market Industry. Patients increasingly seek treatments tailored to their genetic profiles, and RNAi technology aligns well with this trend by enabling targeted gene silencing. This approach not only enhances therapeutic efficacy but also minimizes adverse effects associated with traditional treatments. The growing emphasis on precision medicine encourages pharmaceutical companies to invest in RNAi-based therapies, thereby expanding the market. As the industry adapts to these changing demands, the market is expected to experience robust growth, with a projected value of 24.8 USD Billion by 2035.

    Regulatory Support for RNAi Therapeutics

    Regulatory bodies worldwide are increasingly recognizing the potential of RNAi therapeutics, providing a favorable environment for the Global RNAi Drug Delivery Market Industry. Streamlined approval processes and guidelines for RNAi-based products encourage pharmaceutical companies to invest in research and development. This regulatory support not only accelerates the introduction of innovative therapies but also enhances public confidence in RNAi treatments. As more RNAi therapeutics receive regulatory approval, the market is likely to witness significant growth, driven by the increasing availability of effective treatment options for various diseases.

    Increasing Prevalence of Genetic Disorders

    The rising incidence of genetic disorders globally drives the Global RNAi Drug Delivery Market Industry. As genetic diseases become more prevalent, the demand for innovative therapeutic solutions intensifies. RNA interference (RNAi) technology offers a promising approach to target and silence specific genes responsible for these disorders. For instance, conditions such as Huntington's disease and certain types of muscular dystrophy highlight the urgent need for effective treatments. This growing awareness and need for targeted therapies contribute to the projected market growth, with the industry expected to reach 4.53 USD Billion in 2024 and 24.8 USD Billion by 2035.

    Market Segment Insights

    RNAi Drug Delivery Market Delivery Route Insights

    The RNAi Drug Delivery Market segmentation by Delivery Route into Systemic and Local provides valuable insights into the market dynamics and growth opportunities. The Systemic delivery route held a significant share of the RNAi Drug Delivery Market revenue in 2023, owing to the ease of administration and broader distribution of RNAi therapeutics throughout the body. Systemic delivery can be achieved through various methods, including intravenous, subcutaneous, and intramuscular injections.

    The Local delivery route, on the other hand, is gaining traction due to its targeted approach and reduced systemic side effects.Local delivery involves administering RNAi therapeutics directly to the affected tissues or organs, bypassing the systemic circulation. This route is particularly beneficial for treating localized diseases, such as cancer, eye disorders, and skin conditions. Advancements in nanotechnology and drug delivery systems have enabled the development of novel approaches for local delivery, such as nanoparticles, micelles, and liposomes.

    The RNAi Drug Delivery Market growth for both Systemic and Local delivery routes is driven by factors such as the rising prevalence of chronic diseases, the increasing demand for personalized medicine, and the development of innovative RNAi-based therapies.The market is expected to witness significant growth in the coming years, with the Systemic delivery route continuing to dominate the market share but the Local delivery route gaining momentum due to its targeted and effective approach.

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    RNAi Drug Delivery Market Technology Insights

    The technology segment of the RNAi Drug Delivery Market is divided into siRNA, miRNA, shRNA, and Others. The siRNA segment dominated the market in 2023 and is expected to continue its dominance during the forecast period. The growth of this segment can be attributed to the high adoption of siRNA-based therapies for the treatment of various diseases such as cancer, viral infections, and genetic disorders.

    The miRNA segment is also witnessing significant growth as the understanding of the role of miRNAs in regulating gene expression is increasing, and they are also considered potential therapeutic targets.The shRNA segment is expected to grow at a steady rate during the forecast period due to the advantages of long-lasting gene silencing effects. The Others segment includes technologies such as DNAzymes and aptamers, which are gaining traction in the research and development of novel RNAi-based therapeutics.

    RNAi Drug Delivery Market Target Disease Insights

    The RNAi Drug Delivery Market is segmented by target disease into cancer, viral infections, genetic disorders, metabolic diseases, and others. Among these segments, cancer is expected to hold the largest market share in 2023, owing to the high prevalence of cancer and the increasing demand for targeted therapies. The viral infections segment is also expected to witness significant growth, driven by the rising incidence of viral diseases such as HIV, hepatitis, and influenza.

    Genetic disorders and metabolic diseases are other key segments that are expected to contribute to the growth of the RNAi Drug Delivery Market.The "others" segment includes diseases such as cardiovascular diseases, respiratory diseases, and neurological disorders.

    RNAi Drug Delivery Market Delivery System Insights

    The Delivery System segment is a crucial component of the RNAi Drug Delivery Market, accounting for a significant share of the market revenue. Liposomes, polymeric nanoparticles, viral vectors, lipid nanoparticles, and others are the key delivery systems used in the Rnai Drug Delivery Market. Liposomes, with their ability to encapsulate and deliver therapeutic molecules, have been widely adopted and hold a substantial market share. Polymeric nanoparticles offer advantages such as stability, controlled release, and targeted delivery, driving their growth in the market.Viral vectors, despite their high efficiency, face challenges related to immunogenicity and safety concerns, which limit their widespread use.

    Lipid nanoparticles have gained prominence due to their ability to deliver RNAi therapeutics across various barriers, including the blood-brain barrier. The "Others" category encompasses emerging delivery systems such as exosomes and cell-penetrating peptides, which are being explored for their potential in RNAi Drug Delivery. As the RNAi Drug Delivery Market continues to expand, advancements in delivery systems will play a pivotal role in enhancing the efficacy and safety of RNAi therapeutics.

    RNAi Drug Delivery Market Targeted Tissue Insights

    The RNAi Drug Delivery Market is segmented based on targeted tissue into the Liver, Lungs, Brain, Heart, and Others. Among these segments, the Liver segment is expected to hold the largest market share in 2024 and is estimated to reach a market valuation of USD 4.2 billion by 2032, exhibiting a CAGR of 16.8% during the forecast period. The growth of this segment can be attributed to the increasing prevalence of liver diseases such as Hepatitis B and C and the rising demand for effective treatments for these diseases.

    Furthermore, the increasing research and development activities in the field of RNAi-based therapeutics are expected to drive the growth of this segment in the coming years.

    Get more detailed insights about RNAi Drug Delivery Market

    Regional Insights

    The RNAi Drug Delivery Market is segmented into North America, Europe, APAC, South America, and MEA. North America is expected to hold the largest share of the market in 2023 and is projected to continue to dominate the market throughout the forecast period. The growth of the North American market is attributed to the presence of a large number of pharmaceutical and biotechnology companies, as well as the increasing adoption of RNAi therapeutics.

    Europe is expected to be the second-largest market for RNAi drug delivery, followed by APAC.The APAC market is expected to grow at the highest CAGR during the forecast period due to the increasing demand for RNAi therapeutics in the region. South America and MEA are expected to account for a relatively small share of the market.

    RNAi Drug Delivery Market Regional Insights

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Key Players and Competitive Insights

    Major players in the RNAi Drug Delivery Market industry are continuously striving to stay ahead of the competition by investing in research and development, expanding their product portfolios, and forming strategic alliances. Leading RNAi Drug Delivery Market players are actively involved in mergers and acquisitions to consolidate their market position and gain access to new technologies and markets. The RNAi Drug Delivery Market development landscape is characterized by the emergence of innovative technologies, such as lipid nanoparticles and polymeric micelles, which offer improved delivery efficiency and reduced side effects.

    These advancements are expected to drive the growth of the market in the coming years.Alnylam Pharmaceuticals, Inc., a leading player in the Rnai Drug Delivery Market, has a strong focus on developing and commercializing RNAi therapeutics for a range of genetic diseases. The company has a pipeline of multiple RNAi drug candidates in various stages of clinical development, targeting diseases such as amyloidosis, hemophilia, and cancer. Alnylam's commitment to innovation and clinical research has positioned it as a pioneer in the field of RNAi therapeutics.A competitor of Alnylam Pharmaceuticals, Inc. in the RNAi Drug Delivery Market is Arrowhead Pharmaceuticals, Inc.

    The company has a diverse portfolio of RNAi therapeutics, including candidates for treating hepatitis B virus infection, cardiovascular diseases, and cancer. Arrowhead's proprietary delivery platform, TRiM, enables the targeted delivery of RNAi therapeutics to specific organs and tissues. The company's pipeline of RNAi drug candidates is supported by a strong intellectual property position, including multiple patents covering its delivery technology and RNAi therapeutics.

    Key Companies in the RNAi Drug Delivery Market market include

    Industry Developments

    The RNAi Drug Delivery Market is anticipated to witness steady growth over the forecast period, driven by factors such as the rising prevalence of chronic diseases, increasing government funding for RNAi research, and growing adoption of RNAi therapeutics. Key market players are focusing on developing novel RNAi delivery systems to improve the efficacy and specificity of RNAi therapies. Recent advancements in nanotechnology have led to the development of innovative delivery systems, such as lipid nanoparticles and polymer-based nanoparticles, which offer enhanced tumor targeting and reduced off-target effects.

    Additionally, strategic collaborations and partnerships between pharmaceutical companies and research institutions are expected to accelerate the development and commercialization of RNAi therapeutics, further propelling market growth.

    Future Outlook

    RNAi Drug Delivery Market Future Outlook

    The RNAi Drug Delivery Market is poised for robust growth at 16.71% CAGR from 2024 to 2035, driven by advancements in nanotechnology, increased R&D investments, and rising demand for targeted therapies.

    New opportunities lie in:

    • Develop novel delivery systems utilizing lipid nanoparticles for enhanced RNAi efficacy.
    • Invest in partnerships with biotech firms to accelerate RNAi therapeutic development.
    • Explore personalized medicine approaches to tailor RNAi treatments for specific patient populations.

    By 2035, the RNAi Drug Delivery Market is expected to achieve substantial growth, reflecting its critical role in modern therapeutics.

    Market Segmentation

    RNAi Drug Delivery Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia-Pacific
    • Middle East and Africa

    RNAi Drug Delivery Market Technology Outlook

    • siRNA
    • miRNA
    • shRNA
    • Others

    RNAi Drug Delivery Market Delivery Route Outlook

    • Systemic
    • Local

    RNAi Drug Delivery Market Target Disease Outlook

    • Cancer
    • Viral Infections
    • Genetic Disorders
    • Metabolic Diseases
    • Others

    RNAi Drug Delivery Market Delivery System Outlook

    • Liposomes
    • Polymeric Nanoparticles
    • Viral Vectors
    • Lipid Nanoparticles
    • Others

    RNAi Drug Delivery Market Targeted Tissue Outlook

    • Liver
    • Lungs
    • Brain
    • Heart
    • Others

    Report Scope

    Report Attribute/Metric Details
    Market Size 2022 3.34(USD Billion)
    Market Size 2023 3.89(USD Billion)
    Market Size 2032 15.6(USD Billion)
    Compound Annual Growth Rate (CAGR) 16.68% (2024 - 2032)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2023
    Market Forecast Period 2024 - 2032
    Historical Data 2019 - 2023
    Market Forecast Units USD Billion
    Key Companies Profiled Alnylam Pharmaceuticals, Inc., Bayer AG, Arrowhead Pharmaceuticals, Inc., Pfizer Inc., Roche Holding Ltd., Arcturus Therapeutics Holdings Ltd., Regeneron Pharmaceuticals, Inc., Ionis Pharmaceuticals, Inc., Sanofi S.A., Viridian Therapeutics, Inc., Takeda Pharmaceutical Company Limited, Moderna Therapeutics, Inc., BioNTech SE, Dicerna Pharmaceuticals, Inc., Novartis AG
    Segments Covered Delivery Route, Technology, Target Disease, Delivery System, Targeted Tissue, Regional
    Key Market Opportunities Targeted drug delivery siRNA-based therapeutics personalized medicine Nanotechnology advancements Gene silencing
    Key Market Dynamics RNA-based therapy advancements increasing the prevalence of chronic diseases, patent expiries of existing therapies, collaborations and partnerships government support for research and development
    Countries Covered North America, Europe, APAC, South America, MEA

    FAQs

    What is the projected CAGR of the RNAi Drug Delivery Market from 2024 to 2032?

    The RNAi Drug Delivery Market is projected to register a CAGR of 16.68% from 2024 to 2032

    Who are some of the key competitors in the RNAi Drug Delivery Market?

    Some of the key competitors in the RNAi Drug Delivery Market include Alnylam Pharmaceuticals, Arrowhead Pharmaceuticals, and Dicerna Pharmaceuticals

    What are the major factors driving the growth of the RNAi Drug Delivery Market?

    The major factors driving the growth of the RNAi Drug Delivery Market include the rising prevalence of chronic diseases, the increasing demand for targeted therapies, and the technological advancements in RNAi-based therapeutics.

    What are the challenges faced by the RNAi Drug Delivery Market?

    The challenges faced by the RNAi Drug Delivery Market include the high cost of development, the limited number of approved drugs, and the safety concerns associated with RNAi-based therapies.

    What are the opportunities for growth in the Rnai Drug Delivery Market?

    The opportunities for growth in the RNAi Drug Delivery Market include the development of new RNAi-based therapies, the expansion into new markets, and the increasing demand for personalized medicine.

    What are the key trends in the RNAi Drug Delivery Market?

    The key trends in the RNAi Drug Delivery Market include the development of combination therapies, the use of nanotechnology to improve drug delivery, and the increasing focus on patient-centric care.

    What is the expected market size of the RNAi Drug Delivery Market in 2032?

    The RNAi Drug Delivery Market is expected to reach USD 15.6 billion by 2032.

    Download Free Sample

    Kindly complete the form below to receive a free sample of this Report

    Case Study
    Chemicals and Materials