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US Submucosal Injections Market Research Report: By Type of Agent (Eleview and ORISE Gel, Normal Saline, Sextrose Water, Hydroxyethyl Starch, Hydroxypropyl Methylcellulose, Succinylated Gelatin, Hyaluronic Acid, Fibrinogen Mixture), By Application (Colorectal Cancer, Gastic Cancer, Esophageal Cancer) and By End User (Hospitals, Surgical Centers, Others) - Forecast to 2035


ID: MRFR/Pharma/11998-HCR | 100 Pages | Author: Garvit Vyas| December 2023

Key Highlights and Growth Projections


As per MRFR analysis, the US Submucosal Injections Market Size was estimated at 283.73 (USD Million) in 2023. The US Submucosal Injections Market Industry is expected to grow from 301.35(USD Million) in 2024 to 585 (USD Million) by 2035. The US Submucosal Injections Market CAGR (growth rate) is expected to be around 6.216% during the forecast period (2025 - 2035).


Significant Market Trends


The US Submucosal Injections Market is currently witnessing significant trends driven by advancements in medical technology and increasing patient demand for minimally invasive procedures. The rising prevalence of chronic diseases, such as diabetes and obesity, is a key market driver, as submucosal injections are becoming a preferred choice for effective drug delivery and therapeutic interventions. Innovations in drug formulation and delivery systems are enhancing the efficacy and safety profiles of these injections, making them more appealing to healthcare providers and patients alike.


Moreover, the expanding application of submucosal injections beyond traditional uses, such as in the treatment of gastrointestinal disorders and aesthetic procedures, is creating opportunities to be explored. The implementation of these techniques in outpatient settings is also encouraging higher patient turnover, thereby capturing a larger share of the healthcare market. Recent trends reflect a growing emphasis on personalized medicine, leading to the development of customized injections tailored to individual patient needs, which is a promising avenue for market growth.


Additionally, the US healthcare infrastructure continues to evolve with regulatory support for new drug delivery technologies and increased funding for research and development. This environment propels the exploration of new indications for submucosal injections, further broadening their use in various medical fields. Overall, the combination of these factors points toward a dynamic future for the US Submucosal Injections Market, with continued innovation and expansion in application driving its progress.


US Submucosal Injections Market size

Source: Primary Research, Secondary Research, MRFR Database and Analyst Review


US Submucosal Injections Market Drivers


Increasing Prevalence of Chronic Diseases


The rise in chronic diseases in the United States significantly drives the US Submucosal Injections Market Industry. According to the Centers for Disease Control and Prevention (CDC), approximately 60% of adults have at least one chronic condition, and 40% have two or more chronic conditions. This trend is expected to continue, leading to a greater demand for various therapeutic interventions, including submucosal injections.


Organizations such as the American Diabetes Association and the American Heart Association are actively involved in highlighting these statistics, emphasizing the need for improved and accessible treatment options. The initiative aims at both prevention and management of these conditions, which will likely bolster the market for submucosal injections in the coming years.


Advancements in Injection Technologies


The technological advancements in injection methodologies are poised to accelerate the growth of the US Submucosal Injections Market Industry. Innovations in needle design and drug delivery systems have improved the efficacy and patient compliance associated with these injections. The U.S. Food and Drug Administration (FDA) has approved several new technologies that enhance patient comfort and reduce the risk of complications.


For example, the proliferation of pre-filled syringes and auto-injectors reflects a significant shift towards easier and safer administration of medications. With the increasing push from established firms such as Medtronic and BD (Becton, Dickinson and Company) to develop cutting-edge products, this trend is expected to drive higher adoption rates of submucosal injections.


Rising Geriatric Population


The growing geriatric population in the United States presents a noteworthy driver for the US Submucosal Injections Market Industry. The U.S. Census Bureau indicates that individuals aged 65 and older are projected to outnumber children for the first time in U.S. history by the year 2034. This demographic shift is accompanied by an increase in age-related health issues, which in turn is expected to lead to a higher demand for effective treatment modalities, including submucosal injections, to manage these conditions.


Industry leaders like Johnson & Johnson and Pfizer have recognized this trend, thus investing heavily in developing treatments suitable for older adults, promoting growth in this specific market segment.


US Submucosal Injections Market Segment Insights


Submucosal Injections Market Type of Agent Insights


In the US Submucosal Injections Market, the Type of Agent segment plays a crucial role in the effective delivery of therapeutic solutions for various medical conditions. With several agents available, including Eleview and ORISE Gel, Normal Saline, Sextrose Water, Hydroxyethyl Starch, Hydroxypropyl Methylcellulose, Succinylated Gelatin, Hyaluronic Acid, and Fibrinogen Mixture, the diversity within this segment caters to a range of specific clinical needs.


Among these, agents like Eleview and ORISE Gel are particularly significant due to their effectiveness in aiding endoscopic procedures by providing optimal visibility and stability during various surgical interventions. Normal Saline serves as a fundamental agent used for hydration and as a diluent, while Hydroxyethyl Starch is utilized for its volume expansion properties, making it a preferred choice in critical care settings.


Hydroxypropyl Methylcellulose provides a viscous medium that enhances the stability of the injected substance, lending to its importance in procedures requiring extended durations. Succinylated Gelatin offers an alternative to traditional volume expanders by providing an injectable that is well-tolerated and has good safety profiles. Hyaluronic Acid is gaining traction in aesthetic procedures due to its favorable rheological properties and biocompatibility.


Moreover, Fibrinogen Mixture demonstrates its importance in wound healing and tissue repair applications, highlighting the growing trend towards regenerative medicine. As clinicians increasingly seek tailored solutions, the agents selected for submucosal injections are pivotal in enhancing patient outcomes, showcasing the dynamic landscape of the US Submucosal Injections Market. This segment reflects ongoing innovations and growing demands in healthcare, thereby driving the evolution and expansion of this market.


The effectiveness and versatility of these agents position them as essential components in modern medical practice, creating opportunities for further research and development.


US Submucosal Injections Market segment

Source: Primary Research, Secondary Research, MRFR Database and Analyst Review


Submucosal Injections Market Application Insights


The Application segment of the US Submucosal Injections Market reflects a significant focus on advancing treatment options for various cancers, notably Colorectal Cancer, Gastric Cancer, and Esophageal Cancer. Colorectal Cancer remains one of the leading causes of cancer-related mortality in the United States, driving a demand for innovative therapies such as submucosal injections that offer targeted treatment with minimal invasiveness.


Gastric Cancer, although less prevalent, has seen rising rates in specific demographics, prompting an urgent need for effective treatment alternatives to improve patient outcomes. Esophageal Cancer, characterized by its aggressive nature, necessitates advanced therapeutic strategies to enhance survival rates. These applications highlight the critical role of submucosal injections in modern oncology, addressing the limitations of traditional therapies and responding to growing patient needs.


Overall, the US Submucosal Injections Market segmentation demonstrates a concerted effort to leverage innovative injection techniques in oncology, aiming to enhance therapeutic efficacy and cater to an increasing patient population grappling with these severe conditions.


Submucosal Injections Market End User Insights


The US Submucosal Injections Market is characterized by its diverse End User segment, essential for understanding market dynamics and growth potential. Among this sector, Hospitals play a crucial role, as they are often the primary providers of advanced healthcare services, including submucosal injections for various therapeutic applications. Surgical Centers represent another significant portion, facilitating outpatient procedures that require efficient and effective care, thus driving the demand for these injections.


The presence of specialized Clinics and Other facilities further diversifies the market landscape, catering to specific patient needs while enhancing accessibility to submucosal treatments. The trend towards minimally invasive procedures has propelled the importance of these facilities in the healthcare ecosystem. In addition, the increasing prevalence of chronic diseases that require targeted injections is a substantial growth driver for this segment.


Overall, the End User category in the US Submucosal Injections Market reflects both an immediate response to healthcare demands and a long-term shift towards enhanced, patient-centric treatment options.


US Submucosal Injections Market Key Players and Competitive Insights


The US Submucosal Injections Market is experiencing a notable expansion, drawing attention from both healthcare professionals and investors. This market segment primarily focuses on minimally invasive procedures that deliver therapeutic agents directly into the submucosal layer of tissues, enhancing the efficacy of treatments for various medical conditions. As the demand for advanced aesthetic procedures and effective therapeutic interventions continues to grow, competition within this market is intensifying.


With a diverse range of products, technological advancements, and a focus on patient-centric solutions, companies are actively vying for market share, positioning themselves through innovative techniques and strategic partnerships to capitalize on the evolving needs of the healthcare industry.


Medytox's Strategic Positioning


Medytox stands out in the US Submucosal Injections Market due to its robust research and development capabilities, which have led to a series of innovative products tailored for specific medical needs. The company has established a strong presence through its commitment to quality, ensuring that its submucosal injection formulations meet the highest industry standards. Medytox leverages its extensive experience and knowledge in biotechnology to develop next-generation products, focusing on safety, efficacy, and patient satisfaction.


This strategic positioning enhances Medytox's competitiveness, allowing the company to cultivate strong relationships with healthcare providers and stakeholders while maintaining a focus on addressing market demands effectively.


Revance's Advancements in the Market


Revance has also made significant strides within the US Submucosal Injections Market by offering cutting-edge solutions aimed at improving patients' overall quality of life through aesthetic and therapeutic applications. The company is well-known for its innovative DaxibotulinumtoxinA injection, which is pivotal in various aesthetic treatments and demonstrates Revance's commitment to leveraging advanced technology for enhanced patient outcomes.


Revance's market presence is bolstered by its strategic partnerships and collaborations, aimed at expanding its product portfolio and distribution channels. Additionally, the company has participated in mergers and acquisitions that have effectively integrated new technologies and expertise, further diversifying its offerings in the US market. Revance's strengths lie in its ability to deliver high-quality, targeted solutions that cater to both healthcare providers and patients, reinforcing its competitive stance in this dynamic market.


Key Companies in the US Submucosal Injections Market Include


Leading Market Participants



  • Medytox

  • Revance

  • Revance Therapeutics

  • Medytox USA

  • Sientra

  • Evolus

  • Hugel

  • Ipsen

  • Allergan

  • Galderma

  • AptarGroup


US Submucosal Injections Market Industry Developments


Recent developments in the US Submucosal Injections Market have seen significant activity among key players including Medytox, Revance, Evolus, and Allergan. As of September 2023, Revance has been expanding its portfolio with the recent FDA approval of its DaxibotulinumtoxinA injection for the treatment of glabellar lines, highlighting the increasing importance of neurotoxins in aesthetic applications. Similarly, Allergan has been pushing forward with its products used for cosmetic procedures, as demand continues to rise post-pandemic.


In terms of current affairs, robust growth projections for the market have been discussed, supported by a 15% increase in procedures utilizing submucosal injections from early 2022 to mid-2023. Furthermore, Medytox USA announced in August 2023 its intention to enhance production capabilities in the U.S., anticipating a growth in market share and consumer demand.


Notably, no recent mergers or acquisitions have been reported among the specified companies in this particular market segment, indicating a stable competitive landscape for the foreseeable future. The overall valuation of submucosal injection products in the U.S. is projected to elevate as more innovations and clinical applications are unveiled, ushering in a new era for the industry.


US Submucosal Injections Market Segmentation Insights


Submucosal Injections Market Type of Agent Outlook



  • Eleview and ORISE Gel

  • Normal Saline

  • Sextrose Water

  • Hydroxyethyl Starch

  • Hydroxypropyl Methylcellulose

  • Succinylated Gelatin

  • Hyaluronic Acid

  • Fibrinogen Mixture


Submucosal Injections Market Application Outlook



  • Colorectal Cancer

  • Gastic Cancer

  • Esophageal Cancer


Submucosal Injections Market End User Outlook



  • Hospitals

  • Surgical Centers

  • Others

Report Scope:
Report Attribute/Metric Source: Details
MARKET SIZE 2018 283.73(USD Million)
MARKET SIZE 2024 301.35(USD Million)
MARKET SIZE 2035 585.0(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 6.216% (2025 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
MARKET FORECAST PERIOD 2025 - 2035
HISTORICAL DATA 2019 - 2024
MARKET FORECAST UNITS USD Million
KEY COMPANIES PROFILED Medytox, Revance, Revance Therapeutics, Medytox USA, Sientra, Evolus, Hugel, Ipsen, Allergan, Galderma, AptarGroup
SEGMENTS COVERED Type of Agent, Application, End User
KEY MARKET OPPORTUNITIES Increasing prevalence of chronic diseases, Growing demand for minimally invasive procedures, Advancements in needle technology, Rising geriatric population, Expanding applications in aesthetic treatments
KEY MARKET DYNAMICS growing demand for aesthetic procedures, increasing prevalence of chronic diseases, advancements in injection technology, rising geriatric population, expansion of healthcare infrastructure
COUNTRIES COVERED US


Frequently Asked Questions (FAQ) :

The expected market size of the US Submucosal Injections Market in 2024 is valued at 301.35 million USD.

By 2035, the projected market value of the US Submucosal Injections Market is expected to reach 585.0 million USD.

The expected CAGR for the US Submucosal Injections Market from 2025 to 2035 is 6.216 percent.

Eleview and ORISE Gel is expected to dominate the US Submucosal Injections Market by reaching a value of 175.0 million USD by 2035.

Normal Saline is projected to have a market value of 130.0 million USD in the US Submucosal Injections Market by 2035.

Major players in the US Submucosal Injections Market include Medytox, Revance, Sientra, Evolus, and Allergan.

Sextrose Water is expected to have a market size of 50.0 million USD in 2024.

Factors such as increasing demand for minimally invasive procedures and advancements in injection technologies are driving growth in the US Submucosal Injections Market.

Challenges include regulatory hurdles and the need for continuous innovation to meet patient safety standards in the US Submucosal Injections Market.

The US Submucosal Injections Market is expected to grow from 301.35 million USD in 2024 to 585.0 million USD in 2035, showcasing significant growth.

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