Knee Hyaluronic Acid Injections Market Research Report By Indication (Osteoarthritis, Rheumatoid Arthritis, Other Indications), By Route of Administration (Intra-articular Injection, Other Routes), By Product Type (Biopharmaceuticals, Generic Medications), By Molecular Weight (Low Molecular Weight, Medium Molecular Weight, High Molecular Weight), By Product Form (Viscosupplementation Injections, Combinational Products) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Forecast to 2032

Global Knee Hyaluronic Acid Injections Market Overview

The Knee Hyaluronic Acid Injections Market Size was estimated at USD 3.14 Billion in 2022. The Knee Hyaluronic Acid Injections Industry is expected to grow from USD 3.3 Billion in 2023 to USD 5.2 Billion by 2032. exhibiting a compound annual growth rate (CAGR) of 5.17% during the forecast period (2024 - 2032).

Key Knee Hyaluronic Acid Injections Market Trends Highlighted

The Knee Hyaluronic Acid Injections Market is witnessing significant growth due to an aging population, rising prevalence of osteoarthritis, and increasing awareness of the benefits of hyaluronic acid injections. The market is expected to continue expanding as more patients seek alternative treatments for knee pain and discomfort.Key market drivers include the growing geriatric population, increasing adoption of minimally invasive procedures, and rising healthcare expenditure. Moreover, technological advancements in hyaluronic acid formulations and delivery devices are creating new opportunities for market expansion. Trends in recent times include the development of viscosupplementation therapies, advancements in injection techniques, and the use of hyaluronic acid in combination with other treatments.

Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

Knee Hyaluronic Acid Injections Market Drivers

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  Rising Prevalence of Knee Osteoarthritis

  
  

Osteoarthritis is an arthritic condition that is characterized by the destruction of the cartilage in the joints. It is the most common type of arthritis, and millions of people. There are different types of osteoarthritis with knee osteoarthritis being the case. The condition can result in the development of severe pain, stiffness, and limitation of movement of the knees. The increasing incidences of knee osteoarthritis is one key driver of growth in the Knee Hyaluronic Acid Injections Market.As the population continues to become older, the number of people with knee osteoarthritis will increase. This is because osteoarthritis is most common in the elderly. Another factor that will increase the prevalence of the condition is the increasing number of people with obesity. Obese people are at a higher risk of developing knee osteoarthritis than those with healthy weights. This is because the weight exerted on the joints increases the chances of developing osteoarthritis.The increasing cases of knee osteoarthritis create a need for better treatments. Knee hyaluronic acid injections are safe and effective treatments for the condition. The product can reduce pain, stiffness, and disability. The increasing need for effective treatments creates a lot of potential for growth of the market.

Technological Advancements in Hyaluronic Acid Injections

 Introduction In the early days, knee hyaluronic acid injections were finally halted on April 8, 2016. Later the demand for orthopedic devices was estimated to be at USD 39.0 billion in 2021, with a compound annual growth rate (CAGR) of 5.3% from 2016 to 2021. It was known that around 16.4% of the revenue was generated from joint replacement and reconstruction activities. The natural history of knee osteoarthritis indicates that it is a degenerative and progressive condition that worsens over time.The Knee Hyaluronic Acid Injections Market Industry is witnessing significant technological advancements that are improving the efficacy and safety of these injections. These advancements include the development of new formulations of hyaluronic acid, as well as new injection techniques. New formulations of hyaluronic acid are being developed that have longer-lasting effects. This is important because it means that patients can receive fewer injections over time.Additionally, new injection techniques are being developed that are less painful and more precise. This is important because it makes the procedure more comfortable for patients. The technological advancements in hyaluronic acid injections are making them a more attractive treatment option for patients with knee osteoarthritis. As a result, the demand for knee hyaluronic acid injections is expected to continue to grow in the coming years.

Increasing Awareness of Hyaluronic Acid Injections

One of the other main driving factors of the increasing growth of the global knee hyaluronic acid injections is rising awareness. Due to a lack of knowledge, many patients did not understand the existence of this treatment in the past. However, the growing amount of information available to patients, and the increasing number of doctors prescribing hylasic value increase, are raising patient awareness of knee hyaluronic acid injection. HCPs play an essential role in patients’ awareness of such injections.They educate their patients about the demand and efficiency of hyaluronic acid injections. In addition to HCPs, the media plays a significant role in patient awareness, due to some articles or news present on Google. As the awareness of the patients is increasing, the demand for this treatment is also growing simultaneously. Thus, we can state one of the main driving forces leading to the growth of the global market for knee hyaluronic acid injections in increasing awareness.

Knee Hyaluronic Acid Injections Market Segment Insights:

Knee Hyaluronic Acid Injections Market Indication Insights

The Knee Hyaluronic Acid Injections Market is segmented by Indication into Osteoarthritis, Rheumatoid Arthritis, and Other Indications. Osteoarthritis held the largest market share in 2023 and will maintain its leading position during the forecast period. The segment growth can be explained by the high incidence of osteoarthritis, growing geriatric population, and increasing demand for minimally invasive surgeries. Sale of hyaluronic acid injections which can help relief knee osteoarthritis is a powerful booster of the Osteoarthritis segment.Rheumatoid Arthritis is another major indication for knee hyaluronic acid injections. It affects synovial joints including knees. Hyaluronic acid injections can be used to relieve pain from and reduce inflammation of these joints. The Other Indications segment includes such conditions as post-operative pain, cartilage defects, and meniscus tears. This growth rate will be promoted be the rising incidence of OSS in the knee, the increasing popularity of minimally invasive procedure, and the adoption of hyaluronic injections as a safe and effective method of treating conditions contributing to knee pain.

Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

Knee Hyaluronic Acid Injections Market Route of Administration Insights

The `Knee Hyaluronic Acid Injections Market segmentation by Route of Administration into Intra-articular Injection and Other Routes provides useful information about market dynamics. Intra-articular Injection dominates the market and will generate $4.2 billion in revenue in 2024 having a CAGR of 5.6%. Other Routes, which include oral and topical administration, is a smaller market segment. However, non-invasive methods are rapidly developing, and Other Routes’ market share is expected to increase in the medium term.

Knee Hyaluronic Acid Injections Market Product Type Insights

The Knee Hyaluronic Acid Injections Market is segmented based on product type into biopharmaceuticals and generic medications. Biopharmaceuticals held a larger market share in 2023 and are expected to continue to dominate the market through 2032. The growth of the biopharmaceuticals segment can be attributed to the increasing prevalence of osteoarthritis and the rising demand for minimally invasive treatments. Generic medications are expected to grow at a faster CAGR during the forecast period due to the increasing adoption of cost-effective treatment options.

Knee Hyaluronic Acid Injections Market Molecular Weight Insights

Low, medium, and high molecular weight hyaluronic acid (HA) injections are used to treat knee osteoarthritis. The molecular weight of HA refers to the size of the HA molecule, which can affect its viscosity and effectiveness. Low molecular weight HA injections have a smaller molecular size and are less viscous than medium or high molecular weight HA. They are typically used to treat early-stage knee osteoarthritis, as they can penetrate the cartilage more easily. Medium molecular weight HA injections have a larger molecular size and are more viscous than low molecular weight HA.They are typically used to treat moderate-stage knee osteoarthritis, as they can provide longer-lasting pain relief. High molecular weight HA injections have the largest molecular size and are the most viscous of all three types of HA injections. The growth of the market can be attributed to the increasing prevalence of knee osteoarthritis, the rising demand for minimally invasive treatments, and the growing awareness of the benefits of HA injections. In terms of market segmentation, the molecular weight of HA is a key factor that influences the choice of injection type.Low molecular weight HA injections are expected to hold a dominant share of the market in 2023, owing to their widespread use in early-stage knee osteoarthritis. However, medium, and high molecular weight HA injections are expected to gain traction during the forecast period, due to their superior efficacy in treating moderate and severe-stage knee osteoarthritis.

Knee Hyaluronic Acid Injections Market Product Form Insights

The Knee Hyaluronic Acid Injections Market is segmented into product form, which includes Viscosupplementation Injections and Combinational Products. Viscosupplementation injections, which are the more traditional form of knee hyaluronic acid injections, are expected to account for a larger share of the market in 2023, valued at approximately USD 2.2 billion. Combinational products, which combine hyaluronic acid with other active ingredients such as corticosteroids or pain relievers, are expected to experience significant growth over the forecast period, reaching a projected valuation of USD 1.1 billion by 2032.This growth is attributed to the increasing adoption of combination therapies for the treatment of knee pain and osteoarthritis.

Knee Hyaluronic Acid Injections Market Regional Insights

The Knee Hyaluronic Acid Injections Market is segmented into North America, Europe, APAC, South America, and MEA. North America and Europe dominate the market, collectively accounting for over 60% of the Knee Hyaluronic Acid Injections Market revenue in 2023. The market in APAC is expected to grow at the highest CAGR during the forecast period, driven by increasing healthcare expenditure and rising prevalence of osteoarthritis. The market in South America and MEA is expected to witness moderate growth, due to limited access to healthcare infrastructure and low awareness about the benefits of knee hyaluronic acid injections.

Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

Knee Hyaluronic Acid Injections Market Key Players and Competitive Insights:

Big players in the Knee Hyaluronic Acid Injections Market, such as Horizon Pharma Plc, and Sanofi play a significant role in the industry. They are highly active in research and development in creating new products and introducing new technologies in the industry. Nevertheless, alongside developing their own products, these leading players also tend to strive for new partnerships that could help them to expand the existing market boundaries. The Knee Hyaluronic Acid Injections Market should be characterized as competitive, involving numerous significant players. Thus, these players engage in massive investment in the research of new product types and technologies as well as in the expansion of their distribution technologies and the development of new brand names. The development of these companies should be considered highly dynamic, involving the emergence of new important players offering an expanded product range.Arthrex, Inc. is a leader in researching and developing, manufacturing, and distributing orthopedic surgical devices. One of their central products includes knee hyaluronic acid injections. They operate in the United States and Europe and study the possibility to enter other industrial markets. Arthrex is critically focused on providing its clients with high-quality products that cannot be distinguished from the customer service.DePuy Synthes is a worldwide leader in the production and the distribution of a wide range of orthopedic surgical devices and implants. Additionally, one of the main operations of the organizations includes knee hyaluronic acid injections. Operating in the United States and Europe, the company has recently begun operations to enter other global markets. DePuy Synthes is constantly striving to provide its customers with high-quality products that can hardly be contrasted with customer service.

Key Companies in the Knee Hyaluronic Acid Injections Market Include:

• Geistlich Biomaterials


• Hyalgan


• Marker Therapeutics


• Johnson Johnson


• Fidia Farmaceutici


• Orthogenix


• DePuy Synthes


• OssDsign


• Stryker


• Arthrex


• Medtronic


• Sanofi Aventis


• Zimmer Biomet


• Bioventus

Knee Hyaluronic Acid Injections Market Industry Developments

The Knee Hyaluronic Acid Injections Market is expected to reach a value of USD 5.2 billion by 2032, exhibiting a CAGR of 5.17% during the forecast period (2024-2032). The market growth is attributed to the rising prevalence of knee osteoarthritis, increasing adoption of minimally invasive procedures, and growing awareness about the benefits of hyaluronic acid injections. Recent advancements in hyaluronic acid formulations, such as cross-linked and viscosupplemented injections, are further driving market expansion. Key players in the market include Anika Therapeutics, Sanofi, Zimmer Biomet, and Ferring Pharmaceuticals. Strategic collaborations and product launches are among the notable developments in the industry. For instance, in 2023, Anika Therapeutics announced a partnership with Arthrex to distribute its hyaluronic acid-based viscosupplementation product, Orthovita, in the United States.

Knee Hyaluronic Acid Injections Market Segmentation Insights

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  Knee Hyaluronic Acid Injections Market Indication Outlook

  
  
  
  
  • Osteoarthritis
  
  
  • Rheumatoid Arthritis
  
  
  • Other Indications
  
  
  
  

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  Knee Hyaluronic Acid Injections Market Route of Administration Outlook

  
  
  
  
  • Intra-articular Injection
  
  
  • Other Routes
  
  
  
  

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  Knee Hyaluronic Acid Injections Market Product Type Outlook

  
  
  
  
  • Biopharmaceuticals
  
  
  • Generic Medications
  
  
  
  

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  Knee Hyaluronic Acid Injections Market Molecular Weight Outlook

  
  
  
  
  • Low Molecular Weight
  
  
  • Medium Molecular Weight
  
  
  • High Molecular Weight
  
  
  
  

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  Knee Hyaluronic Acid Injections Market Product Form Outlook

  
  
  
  
  • Viscosupplementation Injections
  
  
  • Combinational Products
  
  
  
  

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  Knee Hyaluronic Acid Injections Market Regional Outlook

  
  
  
  
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    North America

    
    
  
  
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    Europe

    
    
  
  
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    South America

    
    
  
  
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    Asia Pacific

    
    
  
  
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    Middle East and Africa