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    Knee Hyaluronic Acid Injections Market

    ID: MRFR/CnM/20859-HCR
    100 Pages
    Priya Nagrale
    September 2025

    Knee Hyaluronic Acid Injections Market Research Report By Indication (Osteoarthritis, Rheumatoid Arthritis, Other Indications), By Route of Administration (Intra-articular Injection, Other Routes), By Product Type (Biopharmaceuticals, Generic Medications), By Molecular Weight (Low Molecular Weight, Medium Molecular Weight, High Molecular Weight), By Product Form (Viscosupplementation Injections, Combinational Products) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Forecast to 2034

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    Knee Hyaluronic Acid Injections Market Research Report — Global Forecast till 2034 Infographic
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    Knee Hyaluronic Acid Injections Market Summary

    The Global Knee Hyaluronic Acid Injections Market is projected to grow from 3.5 USD Billion in 2024 to 7.2 USD Billion by 2035.

    Key Market Trends & Highlights

    Knee Hyaluronic Acid Injections Key Trends and Highlights

    • The market is expected to experience a compound annual growth rate (CAGR) of 6.78% from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 7.2 USD Billion, indicating robust growth potential.
    • In 2024, the market is valued at 3.5 USD Billion, reflecting a solid foundation for future expansion.
    • Growing adoption of knee hyaluronic acid injections due to increasing prevalence of osteoarthritis is a major market driver.

    Market Size & Forecast

    2024 Market Size 3.5 (USD Billion)
    2035 Market Size 7.2 (USD Billion)
    CAGR (2025 - 2035) 6.78%

    Major Players

    Apple Inc (US), Microsoft Corp (US), Amazon.com Inc (US), Alphabet Inc (US), Berkshire Hathaway Inc (US), Tesla Inc (US), Meta Platforms Inc (US), Johnson & Johnson (US), Visa Inc (US), Procter & Gamble Co (US)

    Knee Hyaluronic Acid Injections Market Trends

    The Knee Hyaluronic Acid Injections Market is witnessing significant growth due to an aging population, rising prevalence of osteoarthritis, and increasing awareness of the benefits of hyaluronic acid injections. The market is expected to continue expanding as more patients seek alternative treatments for knee pain and discomfort.Key market drivers include the growing geriatric population, increasing adoption of minimally invasive procedures, and rising healthcare expenditure. Moreover, technological advancements in hyaluronic acid formulations and delivery devices are creating new opportunities for market expansion.

    Trends in recent times include the development of viscosupplementation therapies, advancements in injection techniques, and the use of hyaluronic acid in combination with other treatments.

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    The increasing prevalence of osteoarthritis and the growing demand for non-surgical treatment options are driving the expansion of the knee hyaluronic acid injections market, reflecting a shift towards more conservative management of joint pain.

    U.S. National Library of Medicine

    Knee Hyaluronic Acid Injections Market Drivers

    Market Growth Projections

    The Global Knee Hyaluronic Acid Injections Market Industry is projected to experience substantial growth over the next decade. With an estimated market value of 3.5 USD Billion in 2024, it is expected to reach 7.2 USD Billion by 2035. This growth represents a CAGR of 6.78% from 2025 to 2035, indicating a strong upward trend. Factors contributing to this growth include rising awareness of treatment options, advancements in injection techniques, and increasing prevalence of knee-related disorders. The market's trajectory suggests a promising future for hyaluronic acid injections as a preferred treatment modality.

    Increase in Sports Injuries

    The rise in sports-related injuries is another significant factor driving the Global Knee Hyaluronic Acid Injections Market Industry. As more individuals engage in physical activities and sports, the incidence of knee injuries has increased. Hyaluronic acid injections are becoming a popular choice for athletes seeking to recover quickly and maintain performance levels. This trend is expected to contribute to the market's growth, as athletes and active individuals turn to these injections for effective pain management and recovery. The demand for such treatments is likely to escalate, further solidifying the market's position.

    Rising Prevalence of Osteoarthritis

    The increasing incidence of osteoarthritis globally is a primary driver for the Global Knee Hyaluronic Acid Injections Market Industry. As populations age, the prevalence of joint disorders, particularly osteoarthritis, is expected to rise significantly. In 2024, the market is projected to reach 3.5 USD Billion, reflecting the growing demand for effective treatment options. Hyaluronic acid injections serve as a viable alternative to surgical interventions, offering pain relief and improved mobility for patients. This trend is likely to continue, with the market anticipated to expand further as awareness of non-surgical treatments increases.

    Advancements in Injection Techniques

    Innovations in injection techniques and formulations are contributing to the growth of the Global Knee Hyaluronic Acid Injections Market Industry. Enhanced delivery methods, such as ultrasound-guided injections, improve accuracy and patient outcomes. These advancements not only increase the efficacy of hyaluronic acid treatments but also reduce the risk of complications. As healthcare providers adopt these new techniques, patient satisfaction is likely to improve, driving further demand. The market is expected to grow at a CAGR of 6.78% from 2025 to 2035, indicating a robust future for these advanced treatment options.

    Growing Awareness of Non-Surgical Treatments

    There is a notable increase in awareness regarding non-surgical treatment options for knee pain, which is propelling the Global Knee Hyaluronic Acid Injections Market Industry. Patients are increasingly seeking alternatives to invasive surgeries, leading to a rise in the adoption of hyaluronic acid injections. Educational campaigns and healthcare provider recommendations play a crucial role in this shift. As a result, the market is projected to reach 7.2 USD Billion by 2035, reflecting a significant shift in treatment paradigms. This growing awareness is likely to continue influencing patient choices in the coming years.

    Regulatory Support for Hyaluronic Acid Products

    Regulatory bodies are increasingly supporting the use of hyaluronic acid products for knee treatments, which is positively impacting the Global Knee Hyaluronic Acid Injections Market Industry. Approvals and endorsements from health authorities enhance the credibility of these treatments, encouraging healthcare providers to adopt them. This regulatory support not only boosts patient confidence but also facilitates market expansion. As more products gain approval, the market is likely to experience accelerated growth, with projections indicating a robust trajectory leading into the next decade.

    Market Segment Insights

    Knee Hyaluronic Acid Injections Market Indication Insights

    The Knee Hyaluronic Acid Injections Market is segmented by Indication into Osteoarthritis, Rheumatoid Arthritis, and Other Indications. Osteoarthritis held the largest market share in 2023 and will maintain its leading position during the forecast period. The segment growth can be explained by the high incidence of osteoarthritis, growing geriatric population, and increasing demand for minimally invasive surgeries. Sale of hyaluronic acid injections which can help relief knee osteoarthritis is a powerful booster of the Osteoarthritis segment.Rheumatoid Arthritis is another major indication for knee hyaluronic acid injections. It affects synovial joints including knees.

    Hyaluronic acid injections can be used to relieve pain from and reduce inflammation of these joints. The Other Indications segment includes such conditions as post-operative pain, cartilage defects, and meniscus tears. This growth rate will be promoted be the rising incidence of OSS in the knee, the increasing popularity of minimally invasive procedure, and the adoption of hyaluronic injections as a safe and effective method of treating conditions contributing to knee pain.

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Knee Hyaluronic Acid Injections Market Route of Administration Insights

    The `Knee Hyaluronic Acid Injections Market segmentation by Route of Administration into Intra-articular Injection and Other Routes provides useful information about market dynamics. Intra-articular Injection dominates the market and will generate $4.2 billion in revenue in 2024 having a CAGR of 5.6%. Other Routes, which include oral and topical administration, is a smaller market segment. However, non-invasive methods are rapidly developing, and Other Routes’ market share is expected to increase in the medium term.

    Knee Hyaluronic Acid Injections Market Product Type Insights

    The Knee Hyaluronic Acid Injections Market is segmented based on product type into biopharmaceuticals and generic medications. Biopharmaceuticals held a larger market share in 2023 and are expected to continue to dominate the market through 2032. The growth of the biopharmaceuticals segment can be attributed to the increasing prevalence of osteoarthritis and the rising demand for minimally invasive treatments. Generic medications are expected to grow at a faster CAGR during the forecast period due to the increasing adoption of cost-effective treatment options.

    Knee Hyaluronic Acid Injections Market Molecular Weight Insights

    Low, medium, and high molecular weight hyaluronic acid (HA) injections are used to treat knee osteoarthritis. The molecular weight of HA refers to the size of the HA molecule, which can affect its viscosity and effectiveness. Low molecular weight HA injections have a smaller molecular size and are less viscous than medium or high molecular weight HA. They are typically used to treat early-stage knee osteoarthritis, as they can penetrate the cartilage more easily.

    Medium molecular weight HA injections have a larger molecular size and are more viscous than low molecular weight HA.They are typically used to treat moderate-stage knee osteoarthritis, as they can provide longer-lasting pain relief. High molecular weight HA injections have the largest molecular size and are the most viscous of all three types of HA injections. The growth of the market can be attributed to the increasing prevalence of knee osteoarthritis, the rising demand for minimally invasive treatments, and the growing awareness of the benefits of HA injections.

    In terms of market segmentation, the molecular weight of HA is a key factor that influences the choice of injection type.Low molecular weight HA injections are expected to hold a dominant share of the market in 2023, owing to their widespread use in early-stage knee osteoarthritis. However, medium, and high molecular weight HA injections are expected to gain traction during the forecast period, due to their superior efficacy in treating moderate and severe-stage knee osteoarthritis.

    Knee Hyaluronic Acid Injections Market Product Form Insights

    The Knee Hyaluronic Acid Injections Market is segmented into product form, which includes Viscosupplementation Injections and Combinational Products. Viscosupplementation injections, which are the more traditional form of knee hyaluronic acid injections, are expected to account for a larger share of the market in 2023, valued at approximately USD 2.2 billion.

    Combinational products, which combine hyaluronic acid with other active ingredients such as corticosteroids or pain relievers, are expected to experience significant growth over the forecast period, reaching a projected valuation of USD 1.1 billion by 2032.This growth is attributed to the increasing adoption of combination therapies for the treatment of knee pain and osteoarthritis.

    Get more detailed insights about Knee Hyaluronic Acid Injections Market Research Report — Global Forecast till 2034

    Regional Insights

    The Knee Hyaluronic Acid Injections Market is segmented into North America, Europe, APAC, South America, and MEA. North America and Europe dominate the market, collectively accounting for over 60% of the Knee Hyaluronic Acid Injections Market revenue in 2023. The market in APAC is expected to grow at the highest CAGR during the forecast period, driven by increasing healthcare expenditure and rising prevalence of osteoarthritis. The market in South America and MEA is expected to witness moderate growth, due to limited access to healthcare infrastructure and low awareness about the benefits of knee hyaluronic acid injections.

    Knee Hyaluronic Acid Injections Market Regional Insights

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Key Players and Competitive Insights

    Big players in the Knee Hyaluronic Acid Injections Market, such as Horizon Pharma Plc, and Sanofi play a significant role in the industry. They are highly active in research and development in creating new products and introducing new technologies in the industry. Nevertheless, alongside developing their own products, these leading players also tend to strive for new partnerships that could help them to expand the existing market boundaries. The Knee Hyaluronic Acid Injections Market should be characterized as competitive, involving numerous significant players.

    Thus, these players engage in massive investment in the research of new product types and technologies as well as in the expansion of their distribution technologies and the development of new brand names. The development of these companies should be considered highly dynamic, involving the emergence of new important players offering an expanded product range.Arthrex, Inc. is a leader in researching and developing, manufacturing, and distributing orthopedic surgical devices. One of their central products includes knee hyaluronic acid injections. They operate in the United States and Europe and study the possibility to enter other industrial markets.

    Arthrex is critically focused on providing its clients with high-quality products that cannot be distinguished from the customer service.DePuy Synthes is a worldwide leader in the production and the distribution of a wide range of orthopedic surgical devices and implants. Additionally, one of the main operations of the organizations includes knee hyaluronic acid injections. Operating in the United States and Europe, the company has recently begun operations to enter other global markets. DePuy Synthes is constantly striving to provide its customers with high-quality products that can hardly be contrasted with customer service.

    Key Companies in the Knee Hyaluronic Acid Injections Market market include

    Industry Developments

    The Knee Hyaluronic Acid Injections Market is expected to reach a value of USD 6.05 billion by 2034, exhibiting a CAGR of 5.17% during the forecast period (2025-2034). The market growth is attributed to the rising prevalence of knee osteoarthritis, increasing adoption of minimally invasive procedures, and growing awareness about the benefits of hyaluronic acid injections. Recent advancements in hyaluronic acid formulations, such as cross-linked and viscosupplemented injections, are further driving market expansion. Key players in the market include Anika Therapeutics, Sanofi, Zimmer Biomet, and Ferring Pharmaceuticals. Strategic collaborations and product launches are among the notable developments in the industry.

    For instance, in 2023, Anika Therapeutics announced a partnership with Arthrex to distribute its hyaluronic acid-based viscosupplementation product, Orthovita, in the United States.

    Future Outlook

    Knee Hyaluronic Acid Injections Market Future Outlook

    The Knee Hyaluronic Acid Injections Market is projected to grow at a 6.78% CAGR from 2024 to 2035, driven by increasing aging populations and rising prevalence of osteoarthritis.

    New opportunities lie in:

    • Develop innovative combination therapies integrating hyaluronic acid with other treatments.
    • Expand distribution networks in emerging markets to capture new customer segments.
    • Invest in R&D for enhanced formulations with improved efficacy and patient compliance.

    By 2035, the market is expected to demonstrate robust growth, reflecting evolving consumer needs and advancements in treatment options.

    Market Segmentation

    Knee Hyaluronic Acid Injections Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Knee Hyaluronic Acid Injections Market Indication Outlook

    • Intra-articular Injection
    • Other Routes

    Knee Hyaluronic Acid Injections Market Product Form Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Knee Hyaluronic Acid Injections Market Product Type Outlook

    • Low Molecular Weight
    • Medium Molecular Weight
    • High Molecular Weight

    Knee Hyaluronic Acid Injections Market Molecular Weight Outlook

    • Viscosupplementation Injections
    • Combinational Products

    Knee Hyaluronic Acid Injections Market Route of Administration Outlook

    • Biopharmaceuticals
    • Generic Medications

    Report Scope

    Report Attribute/Metric Details
    Market Size 2024 3.65 (USD Billion)
    Market Size 2025 3.84 (USD Billion)
    Market Size 2034 6.05 (USD Billion)
    Compound Annual Growth Rate (CAGR) 5.17% (2025 - 2034)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2024
    Market Forecast Period 2025 - 2034
    Historical Data 2020 - 2024
    Market Forecast Units USD Billion
    Key Companies Profiled Geistlich Biomaterials, Hyalgan, Marker Therapeutics, Johnson Johnson, Fidia Farmaceutici, Orthogenix, DePuy Synthes, OssDsign, Stryker, Arthrex, Medtronic, Sanofi Aventis, Zimmer Biomet, Bioventus
    Segments Covered Indication, Route of Administration, Product Type, Molecular Weight, Product Form, Regional
    Key Market Opportunities Increasing prevalence of knee osteoarthritis Growing geriatric population Technological advancements in hyaluronic acid formulations Development of costeffective hyaluronic acid injections Rising demand for minimally invasive treatments
    Key Market Dynamics Rising geriatric population Increasing prevalence of knee osteoarthritis Growing awareness of hyaluronic acid injections Technological advancements in injection techniques Expanding healthcare coverage
    Countries Covered North America, Europe, APAC, South America, MEA

    FAQs

    What is the market size of the Knee Hyaluronic Acid Injections Market?

    The Knee Hyaluronic Acid Injections Market was valued at USD 3.65 billion in 2024 and is expected to reach a value of USD 6.05 billion by 2034, with a CAGR of 5.17% over the forecast period.

    What are the key regions in the Knee Hyaluronic Acid Injections Market?

    The key regions in the Knee Hyaluronic Acid Injections Market are North America, Europe, Asia Pacific, and the Rest of the World. North America is expected to hold the largest market share during the forecast period, followed by Europe and Asia Pacific.

    What are the key applications of Knee Hyaluronic Acid Injections?

    The key applications of Knee Hyaluronic Acid Injections are the treatment of osteoarthritis, rheumatoid arthritis, and other knee conditions. Osteoarthritis is the most common type of arthritis, and it is characterized by the breakdown of cartilage in the knee joint. Hyaluronic acid injections can help to lubricate the knee joint and reduce pain and stiffness.

    Who are the key competitors in the Knee Hyaluronic Acid Injections Market?

    The key competitors in the Knee Hyaluronic Acid Injections Market include Anika Therapeutics, Inc., Arthrex, Inc., Bioventus LLC, Fidia Farmaceutici S.p.A., and Zimmer Biomet Holdings, Inc.

    What are the key factors driving the growth of the Knee Hyaluronic Acid Injections Market?

    The key factors driving the growth of the Knee Hyaluronic Acid Injections Market include the increasing prevalence of osteoarthritis, the rising number of knee injuries, and the growing awareness of the benefits of hyaluronic acid injections.

    What are the challenges faced by the Knee Hyaluronic Acid Injections Market?

    The challenges faced by the Knee Hyaluronic Acid Injections Market include the high cost of treatment, the need for multiple injections, and the potential for side effects.

    What are the opportunities for the Knee Hyaluronic Acid Injections Market?

    The opportunities for the Knee Hyaluronic Acid Injections Market include the development of new and more effective products, the expansion of the market into new regions, and the growing awareness of the benefits of hyaluronic acid injections.

    What are the key trends in the Knee Hyaluronic Acid Injections Market?

    The key trends in the Knee Hyaluronic Acid Injections Market include the development of new and more effective products, the expansion of the market into new regions, and the growing awareness of the benefits of hyaluronic acid injections.

    What is the forecast for the Knee Hyaluronic Acid Injections Market?

    The Knee Hyaluronic Acid Injections Market is expected to grow at a CAGR of 5.17% over the forecast period.

    What are the key drivers of the Knee Hyaluronic Acid Injections Market?

    The key drivers of the Knee Hyaluronic Acid Injections Market include the increasing prevalence of osteoarthritis, the rising number of knee injuries, and the growing awareness of the benefits of hyaluronic acid injections.

    Knee Hyaluronic Acid Injections Market Research Report — Global Forecast till 2034 Infographic
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