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    US Patient Derived Xenograft Model Market

    ID: MRFR/HC/15216-HCR
    100 Pages
    Garvit Vyas
    September 2025

    US Patient-Derived Xenograft Model Market Research Report By Tumor Type (Lung Cancer, Pancreatic Cancer, Prostate Cancer, Breast Cancer, Other Cancer), By Model Type (Mice, Rats) and By End-User (Pharmaceutical, Biopharmaceutical Companies, Academic & Research Institutes, CROs, CDMOs) - Forecast to 2035

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    US Patient Derived Xenograft Model Market Infographic
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    US Patient Derived Xenograft Model Market Summary

    The US Patient-Derived Xenograft Model market is projected to experience substantial growth from 89.6 million USD in 2024 to 349.0 million USD by 2035.

    Key Market Trends & Highlights

    US Patient-Derived Xenograft Model Key Trends and Highlights

    • The market valuation is expected to rise from 89.6 million USD in 2024 to 349.0 million USD by 2035.
    • A compound annual growth rate (CAGR) of 13.16 percent is anticipated for the period from 2025 to 2035.
    • The increasing demand for personalized medicine is likely to drive the growth of the Patient-Derived Xenograft Model market.
    • Growing adoption of advanced cancer research technologies due to the rising prevalence of cancer is a major market driver.

    Market Size & Forecast

    2024 Market Size 89.6 (USD Million)
    2035 Market Size 349.0 (USD Million)
    CAGR (2025-2035) 13.16%

    Major Players

    The Jackson Laboratory, Genentech, AstraZeneca, Xenotech, National Cancer Institute, MediSapiens, Crown Bioscience, Inovio Pharmaceuticals, Bristol Myers Squibb, Horizon Discovery, Pfizer, Everest Medicines, Champions Oncology, OncoOne, Charles River Laboratories

    US Patient Derived Xenograft Model Market Trends

    The US Patient-Derived Xenograft (PDX) Model market is witnessing significant growth driven by several key market drivers. Increased investment in personalized medicine is one of the primary factors, as researchers and biotechnology firms look to develop tailored therapies that cater to individual patient needs.

    Advances in technology, particularly with regard to genomic sequencing and biobanking, have enabled the successful establishment of PDX models, allowing for better understanding of tumor biology and drug responses. Moreover, there is a heightened focus on cancer research within federal agencies and significant funding from initiatives designed to enhance cancer research capabilities in the US, contributing to the demand for PDX models.

    Opportunities to be explored in this market include collaborations between academic institutions and private sector companies. Such partnerships can lead to significant advancements in understanding tumor heterogeneity and improving treatment methodologies. Furthermore, there is a growing trend of utilizing PDX models in drug efficacy testing, which opens up avenues for pharmaceutical companies to refine their pipelines and enhance drug development processes.

    The ability to closely mimic human tumors makes PDX models invaluable in the clinical setting, further driving their adoption. Trends in recent times also indicate a shift towards integrating PDX models with artificial intelligence and machine learning to predict treatment outcomes more accurately.

    This complements the traditional experimental approaches, allowing researchers to derive more robust insights from PDX studies. As more users begin to realize the limitations of traditional cancer models, the shift towards using PDX models is poised to accelerate, creating new pathways for research and development in oncology within the US.

    Overall, the dynamic evolution of the PDX model market underscores its essential role in contemporary cancer research and personalized therapeutics in the US.

    Market Segment Insights

    Patient-Derived Xenograft Model Market Tumor Type Insights

    The US Patient-Derived Xenograft Model Market, particularly in the context of Tumor Type, presents a diverse landscape characterized by various cancer types, each holding significant relevance in research and therapeutic applications. Lung cancer remains a prominent focus within this market segment due to its high incidence and mortality rates in the United States, driving demand for innovative treatment models to better understand tumorigenesis and test new drug candidates.

    Pancreatic cancer, while less common, has garnered increasing attention due to its aggressive nature and poor prognoses, necessitating advanced research models that can mimic patient responses. Prostate cancer, being one of the most frequently diagnosed cancers among men, influences the US Patient-Derived Xenograft Model Market by creating a need for reliable preclinical models that assist in the development of targeted therapies and understand biochemical pathways.

    Breast cancer, meanwhile, represents a large patient population and benefits from extensive research efforts aimed at personalizing treatment approaches, thus contributing to the overall demand for patient-derived xenograft models. Other cancer types also play a crucial role in this segmented market, as they encompass diverse pathologies requiring unique models to explore effective treatment strategies.

    The advent of personalized medicine and increasing funding directed towards cancer research serve as growth drivers, while challenges such as model standardization and high operational costs may inhibit broader adoption. Collectively, the Tumor Type segment within the US Patient-Derived Xenograft Model Market highlights the critical need for specialized research tools that can deal with the complexities of cancer biology and improve therapeutic outcomes.

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Patient-Derived Xenograft Model Market Model Type Insights

    The US Patient-Derived Xenograft Model Market is characterized by distinct models, primarily including Mice and Rats, both of which play crucial roles in preclinical research, specifically in cancer therapy and drug development. Mice have been widely recognized for their genetic similarity to humans, allowing researchers to study human diseases effectively.

    This model type is preferred for its ability to facilitate high-throughput screening and analyze therapeutic responses. Rats, on the other hand, offer advantages in pharmacokinetics and behavioral studies due to their larger size, which makes them suitable for some surgical interventions and monitoring complex behaviors.

    The combination of these model types in the US market exemplifies the trend towards personalized medicine, with increasing demand for advanced models that assist in tailored treatment approaches. The robust growth of Research and Development efforts in biotechnology and pharmaceutical sectors drives the need for effective xenograft models, as they provide critical insights into tumor biology and treatment efficacy.

    Both Mice and Rats are essential for addressing the challenges posed by human variability, maximizing the success rates in translational research, and ultimately enhancing patient outcomes in oncology treatments.

    Patient-Derived Xenograft Model Market End-User Insights

    The End-User segment of the US Patient-Derived Xenograft Model Market encompasses a diverse range of applications across various industries. Pharmaceutical and Biopharmaceutical Companies are key drivers in utilizing these models for drug discovery and development, enabling more targeted therapies and reducing the time to market.

    Academic and Research Institutes leverage patient-derived xenografts for translational research, contributing significantly to advancements in personalized medicine. Contract Research Organizations (CROs) play a crucial role in facilitating studies using these models, catering to the growing demand for outsourced research services.

    Furthermore, Contract Development and Manufacturing Organizations (CDMOs) utilize these models to enhance their drug development processes, thus supporting biopharmaceutical product pipelines. The increasing prevalence of complex diseases and the growing focus on tailored therapies are among the main growth drivers in this segment.

    Challenges such as regulatory compliance and model standardization remain, yet the opportunities for innovation and collaboration within this sector continue to expand as the demand for effective and patient-centered medical solutions rises. In this competitive landscape, each End-User type navigates its unique challenges and advantages, collectively shaping the trajectory of the US Patient-Derived Xenograft Model Market.

    Get more detailed insights about US Patient Derived Xenograft Model Market

    Key Players and Competitive Insights

    The US Patient-Derived Xenograft Model Market has emerged as a crucial component in the landscape of biomedical research and drug development, focusing on providing models that accurately replicate human cancers for preclinical studies. This market is characterized by a complex interplay of biotechnology firms, research institutions, and pharmaceutical companies that continuously innovate to improve PDX models.

    The competitive insights in this landscape are shaped by factors such as technological advancements, regulatory frameworks, and the relentless pursuit of personalized medicine. Companies are increasingly leveraging collaborations and strategic alliances to enhance their capabilities and expand their market reach, leading to a dynamic environment where competition drives better patient outcomes and accelerates the path to novel therapies.

    The Jackson Laboratory stands out in the US Patient-Derived Xenograft Model Market due to its robust commitment to genetics and cancer research. With a rich history of facilitating innovative experiments, The Jackson Laboratory is recognized for its unparalleled quality in developing and providing patient-derived xenograft models that serve as reliable platforms for drug testing and therapeutic validation.

    Their strengths lie in their expert workforce, comprehensive resources, and substantial investment in research and development, which collectively empower them to deliver advanced models tailored to meet specific research needs. The Jackson Laboratory's established reputation and academic partnerships further bolster its presence in the market, providing researchers with valuable resources and support, thereby enhancing its competitive edge.

    Genentech holds a formidable position within the US Patient-Derived Xenograft Model Market, leveraging its extensive expertise in biotechnology to create therapies that address unmet medical needs. The company is known for its innovative solutions in cancer treatment, drawing upon its robust pipeline that includes therapies extensively validated through PDX models.

    Genentech’s strengths include a strong focus on research collaborations with academic institutions and biopharmaceutical entities, which facilitates access to the latest findings and technologies. Its strategic approach to mergers and acquisitions has further solidified its market presence, allowing for expanded capabilities and diversification of product offerings.

    This proactive stance not only enhances Genentech's portfolio but also drives advancements in personalized medicine, solidifying its role as a leader in the US Patient-Derived Xenograft Model Market.

    Key Companies in the US Patient Derived Xenograft Model Market market include

    Industry Developments

    The US Patient-Derived Xenograft Model Market has seen significant developments recently, particularly in the context of advancements in cancer research. The Jackson Laboratory continues to drive innovation with their expanding portfolio of mouse models tailored for precision medicine.

    Inovia Pharmaceuticals and Bristol Myers Squibb are leveraging patient-derived xenografts to enhance their drug development pipelines, showing a growing recognition of these models in oncology. In September 2023, Crown Bioscience announced an expansion of their services, significantly increasing capabilities in PDX models for a variety of cancer types.

    Mergers and acquisitions have also been a notable trend, with Inovio Pharmaceuticals acquiring a smaller biotech firm to bolster their Research and Development in this area, announced in August 2023. This trend is complemented by AstraZeneca and Genentech increasing investments in partnerships for improved access to patient-derived models, reflecting a robust growth trajectory in the market valuation of these companies.

    The focus on patient-centered approaches in drug development and the utilization of cutting-edge technologies are shaping the landscape of the US Patient-Derived Xenograft Model Market, marked by key happenings over the last two to three years that demonstrate significant market potential.

    Market Segmentation

    Patient-Derived Xenograft Model Market End-User Outlook

    • Pharmaceutical
    • Biopharmaceutical Companies
    • Academic & Research Institutes
    • CROs
    • CDMOs

    Patient-Derived Xenograft Model Market Model Type Outlook

    • Mice
    • Rats

    Patient-Derived Xenograft Model Market Tumor Type Outlook

    • Lung Cancer
    • Pancreatic Cancer
    • Prostate Cancer
    • Breast Cancer
    • Other Cancer

    Report Scope

    Report Attribute/Metric Source: Details
    MARKET SIZE 2018 79.08(USD Million)
    MARKET SIZE 2024 89.6(USD Million)
    MARKET SIZE 2035 348.96(USD Million)
    COMPOUND ANNUAL GROWTH RATE (CAGR) 13.156% (2025 - 2035)
    REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR 2024
    MARKET FORECAST PERIOD 2025 - 2035
    HISTORICAL DATA 2019 - 2024
    MARKET FORECAST UNITS USD Million
    KEY COMPANIES PROFILED The Jackson Laboratory, Genentech, AstraZeneca, Xenotech, National Cancer Institute, MediSapiens, Crown Bioscience, Inovio Pharmaceuticals, BristolMyers Squibb, Horizon Discovery, Pfizer, Everest Medicines, Champions Oncology, OncoOne, Charles River Laboratories
    SEGMENTS COVERED Tumor Type, Model Type, End-User
    KEY MARKET OPPORTUNITIES Increased demand for personalized medicine, Rising cancer research funding, Growth in biopharmaceutical development, Advancements in genetic engineering, Rising adoption in drug testing
    KEY MARKET DYNAMICS increasing cancer research funding, growing demand for personalized medicine, advancements in PDX technology, rise in preclinical testing needs, collaborations between researchers and pharmaceutical companies
    COUNTRIES COVERED US

    FAQs

    What is the current market size of the US Patient-Derived Xenograft Model Market?

    In 2024, the US Patient-Derived Xenograft Model Market is expected to be valued at approximately 89.6 million USD.

    What is the projected market size of the US Patient-Derived Xenograft Model Market by 2035?

    By 2035, it is projected that the market will reach approximately 348.96 million USD.

    What is the expected compound annual growth rate (CAGR) for the US Patient-Derived Xenograft Model Market from 2025 to 2035?

    The market is expected to grow at a CAGR of 13.156% during the forecast period from 2025 to 2035.

    Which tumor type has the largest market share in the US Patient-Derived Xenograft Model Market in 2024?

    Breast Cancer is expected to have the largest market share valued at 25.0 million USD in 2024.

    What are the anticipated market values for Lung Cancer and Breast Cancer in 2035?

    In 2035, Lung Cancer is projected to be valued at 75.6 million USD, while Breast Cancer is expected to reach 100.0 million USD.

    What are the prominent players in the US Patient-Derived Xenograft Model Market?

    Key players in the market include The Jackson Laboratory, Genentech, AstraZeneca, and Bristol-Myers Squibb.

    How does the market for Pancreatic Cancer look in 2024?

    The market for Pancreatic Cancer is expected to be valued at approximately 18.5 million USD in 2024.

    What is the projected market value for Prostate Cancer in 2035?

    By 2035, the market for Prostate Cancer is projected to be valued at around 55.0 million USD.

    What challenges or trends are currently affecting the US Patient-Derived Xenograft Model Market?

    Key trends include advancements in cancer research and increasing demand for personalized medicine, posing challenges in regulatory approvals.

    What market growth is expected for other cancer types by 2035?

    By 2035, the market for other cancer types is anticipated to reach approximately 48.3 million USD.

    Report Infographic
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