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    Knock Out Mice Model Market

    ID: MRFR/HC/30879-HCR
    128 Pages
    Rahul Gotadki
    September 2025

    Knockout Mice Model Market Research Report By Application (Oncology Research, Genetic Research, Pharmaceutical Research, Immunology Research), By Type (Constitutive Knockout Mice, Conditional Knockout Mice, Transgenic Mice), By Key End User (Academic Institutions, Biotechnology Companies, Pharmaceutical Companies, Contract Research Organizations), By Technology (CRISPR-Cas9, Homologous Recombination, Gene Targeting) and By Regional (North America, Europe, South America, Asia-Pacific, Middle East and Africa) - Forecast to 2034

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    Knock Out Mice Model Market Summary

    The Global Knockout Mice Model Market is projected to grow from 2.74 USD Billion in 2024 to 5.97 USD Billion by 2035, reflecting a robust growth trajectory.

    Key Market Trends & Highlights

    Knockout Mice Model Key Trends and Highlights

    • The market is expected to achieve a compound annual growth rate (CAGR) of 7.33 percent from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 5.97 USD Billion, indicating substantial growth potential.
    • In 2024, the market is valued at 2.74 USD Billion, laying a solid foundation for future expansion.
    • Growing adoption of genetic research technologies due to increased funding for biomedical research is a major market driver.

    Market Size & Forecast

    2024 Market Size 2.74 (USD Billion)
    2035 Market Size 5.97 (USD Billion)
    CAGR (2025-2035) 7.33%

    Major Players

    genOway, Charles River Laboratories, Horizon Discovery, The Jackson Laboratory, Envigo, Biocytogen, Cure Genetics, Thermo Fisher Scientific, Crown Bioscience, Integrative Biology, Celerion, OncoOne, Taconic Biosciences, PharmaCyte Biotech

    Knock Out Mice Model Market Trends

    The Global Knockout Mice Model Market is witnessing significant growth due to several key market drivers. Increased investment in biomedical research, driven by the demand for advanced therapeutic solutions, is propelling the use of knockout mice in studies related to genetic disorders, cancer, and cardiovascular diseases. The rise of personalized medicine is also fueling the need for precise animal models that can closely mimic human genetic conditions. Additionally, supportive government initiatives and funding for research and development activities further stimulate market growth.

    There are abundant opportunities to be explored in the knockout mice model market, primarily in areas that focus on innovation in genetic engineering technologies. As CRISPR and other gene-editing tools become more accessible, researchers are likely to adopt these advanced techniques to create custom models tailored to specific research needs, thus enhancing the scope of studies conducted. Collaboration between academia and industry can also lead to the development of novel knockout mouse models that address unmet medical needs, expanding their application in drug discovery and toxicology studies.

    Recent trends indicate a shift toward the use of high-throughput screening techniques and more sophisticated genetic manipulations that offer researchers greater efficiency and accuracy. The increasing integration of artificial intelligence and machine learning in research, including the analysis of knockout mice data, is also transforming the landscape.

    This convergence allows for an enhanced understanding of biological pathways, paving the way for new therapeutic discoveries. As the market evolves, ethical considerations and animal welfare regulations are becoming integral, driving the need for more comprehensive and humane research practices. Overall, the knockout mice model market is positioned for continued expansion, driven by technological advancements, heightened research initiatives, and an ever-growing focus on precision medicine.

    The increasing prevalence of genetic disorders and the growing demand for personalized medicine are driving advancements in the development and application of knockout mice models, which are pivotal for understanding gene function and disease mechanisms.

    National Institutes of Health (NIH)

    Knock Out Mice Model Market Drivers

    Market Growth Projections

    The Global Knockout Mice Model Market Industry is projected to experience substantial growth in the coming years. With a market value of 2.74 USD Billion in 2024, it is anticipated to reach 5.97 USD Billion by 2035, reflecting a CAGR of 7.33% from 2025 to 2035. This growth trajectory suggests a robust demand for knockout mice models across various research sectors, including pharmaceuticals and academia. As the understanding of genetic functions deepens and the applications of knockout models expand, the market is likely to flourish, driven by ongoing advancements in technology and research funding.

    Advancements in Biotechnology

    Technological advancements in biotechnology significantly influence the Global Knockout Mice Model Market Industry. Innovations in gene editing techniques, such as CRISPR-Cas9, facilitate the creation of more precise knockout models, enhancing their utility in research. These advancements not only improve the efficiency of generating knockout mice but also expand their applications in studying complex diseases. As a result, the market is expected to grow at a CAGR of 7.33% from 2025 to 2035, potentially reaching 5.97 USD Billion by 2035. This growth underscores the importance of integrating cutting-edge technologies in the development of knockout models.

    Rising Demand for Genetic Research

    The Global Knockout Mice Model Market Industry experiences a surge in demand driven by the increasing focus on genetic research. As researchers aim to understand gene functions and their implications in various diseases, knockout mice serve as essential tools for elucidating genetic pathways. The market is projected to reach 2.74 USD Billion in 2024, reflecting the growing investment in genetic studies. Institutions and pharmaceutical companies are increasingly utilizing these models to develop targeted therapies, thereby enhancing the overall research landscape. This trend indicates a robust future for the knockout mice model, as genetic research continues to expand.

    Regulatory Support for Animal Models

    Regulatory bodies worldwide are increasingly recognizing the importance of animal models, including knockout mice, in biomedical research. The Global Knockout Mice Model Market Industry benefits from supportive regulations that facilitate the use of these models in preclinical studies. Such regulations ensure that research adheres to ethical standards while promoting scientific advancement. As regulatory frameworks evolve to accommodate innovative research methodologies, the demand for knockout mice models is likely to increase. This supportive environment fosters growth in the market, as researchers seek to comply with regulations while advancing their studies.

    Growing Prevalence of Genetic Disorders

    The rising prevalence of genetic disorders globally drives the demand for the Global Knockout Mice Model Market Industry. As the incidence of conditions such as cancer, diabetes, and rare genetic diseases increases, researchers are turning to knockout mice to explore the underlying genetic mechanisms. These models provide invaluable insights into disease pathology and potential therapeutic targets. Consequently, the market is poised for growth, as the need for effective treatments for genetic disorders becomes more urgent. This trend highlights the critical role of knockout mice in advancing medical research.

    Increased Funding for Biomedical Research

    The Global Knockout Mice Model Market Industry benefits from increased funding allocated to biomedical research. Governments and private organizations are investing heavily in research initiatives aimed at understanding diseases and developing new therapies. This influx of funding supports the creation and utilization of knockout mice models, which are pivotal in preclinical studies. As research institutions receive more financial resources, the demand for knockout models is likely to rise, further propelling market growth. The commitment to advancing biomedical research indicates a promising trajectory for the knockout mice model market.

    Market Segment Insights

    Knockout Mice Model Market Application Insights

    The Application segment within the Global Knockout Mice Model Market is a pivotal aspect that highlights the diverse areas of research leveraging these models. As of 2023, the overall market is valued at 2.39 USD Billion, reflecting the growing reliance on knockout mice for biomedical research. The segment includes key applications such as Oncology Research, Genetic Research, Pharmaceutical Research, and Immunology Research, each playing a crucial role in advancing scientific knowledge and therapeutic developments.

    Oncology Research holds the largest share, valued at 0.95 USD Billion in 2023, and is projected to grow to 1.8 USD Billion by 2032, underscoring its significance in cancer research. The extensive use of knockout mice in this area aids in understanding tumor biology and developing targeted therapies.

    Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

    Genetic Research, valued at 0.65 USD Billion in 2023, is another significant area, expected to reach 1.2 USD Billion by the end of the forecast period. This application is critical for insights into genetic diseases and gene function, making it foundational for the development of gene editing technologies and personalized medicine.

    Pharmaceutical Research, at 0.59 USD Billion in 2023, is projected to grow to 1.1 USD Billion by 2032, highlighting its role in drug discovery and efficacy testing, where knockout models help in elucidating drug mechanisms and potential downstream effects. Lastly, Immunology Research, although the smallest segment valued at 0.2 USD Billion in 2023, is expected to double to 0.4 USD Billion by 2032.

    This application enables researchers to study immune responses and develop vaccines, making it essential for public health initiatives. The evident dominance of Oncology Research within the Global Knockout Mice Model Market reflects its critical importance in addressing one of the most challenging health issues worldwide, while Genetics and Pharmaceutical Research also play crucial roles in revolutionizing modern medicine.

    Various market trends indicate a growing investment in these areas, driven by advancements in technology and a greater focus on personalized treatments. Therefore, the Global Knockout Mice Model Market data reveals a dynamic landscape marked by significant growth opportunities and challenges, particularly in expanding the application of these models to further enhance research capabilities across multiple disciplines.

    Knockout Mice Model Market Type Insights

    In 2023, the Global Knockout Mice Model Market was valued at 2.39 billion USD, reflecting a robust market focused on various types of knockout mice, including Constitutive, Conditional, and Transgenic Mice. Constitutive Knockout Mice, which have gene deletions that occur in all cells, often play a critical role in studying gene function across different tissues, aiding biomedical research substantially.

    Conditional Knockout Mice provide an advantage by allowing researchers to control when and where genes are inactivated, leading to more targeted studies, which have gained traction due to their precise applications in disease modeling. Transgenic Mice, designed to carry extra genes, significantly contribute to understanding gene expression and function, hence occupying a significant portion of the market share.

    These mouse types are increasingly used due to their essential roles in drug development, genetic research, and studying various diseases. The market growth is propelled by advancements in genetic engineering technologies and an increasing focus on personalized medicine, although challenges like ethical concerns and high production costs continue to impact accessibility. As the landscape for research methodologies evolves, the need for innovative knockout models will drive the Global Knockout Mice Model Market revenue further upwards.

    Knockout Mice Model Market Key End User Insights

    In 2023, the Global Knockout Mice Model Market was valued at approximately 2.39 billion USD and is experiencing significant traction due to its application across various key end users. Academic institutions are crucial players, utilizing knockout mice models extensively for genetic research and educational purposes. Biotechnology companies also contribute notably to the market, focusing on innovative therapies and drug development, which rely heavily on these models to understand gene functions.

    Pharmaceutical companies dominate this space, as they leverage knockout mice for preclinical studies to test drug efficacy and safety. Furthermore, contract research organizations play a vital role in offering services that streamline the research process for biotech and pharmaceutical companies. The increasing demand for personalized medicine and advancements in genetic engineering are driving the growth of these end-user segments, contributing to a robust market landscape.

    Challenges such as ethical considerations and regulatory hurdles persist, but the opportunities for innovation and research advancement remain promising, positioning the Global Knockout Mice Model Market for continued growth and engagement across key sectors.

    Knockout Mice Model Market Technology Insights

    The Technology segment of the Global Knockout Mice Model Market reflects substantial growth, with the overall market valued at 2.39 USD Billion in 2023. As science progresses, techniques such as CRISPR-Cas9 have gained prominence due to their efficiency and precision in gene editing, making them crucial for advancing genetic research.

    Homologous recombination also plays a significant role, providing established methodologies for targeted gene alteration in mice. Gene targeting remains foundational as it helps create specific mutations for studying various diseases, thus enabling significant discoveries in biomedical research.

    Together, these methodologies demonstrate the dynamic landscape of the Global Knockout Mice Model Market, showcasing the integration of innovative technologies that drive research and therapeutic developments. The market, driven by increasing demand for personalized medicine and genetic studies, faces challenges such as ethical considerations and regulatory hurdles, but opportunities in novel applications continue to emerge, fostering robust market growth. The importance of these technologies is underscored by their ability to enhance understanding of genetic functions and promote the development of advanced treatment strategies.

    Get more detailed insights about Knock Out Mice Model Market Research Report-Forecast till 2034

    Regional Insights

    The Global Knockout Mice Model Market revenue is witnessing consistent growth across various regions, with North America taking a significant lead in market valuation. In 2023, North America was valued at 1.05 USD Billion and is projected to reach 2.1 USD Billion by 2032, demonstrating its majority holding in the market. Europe follows as another key player, registering a market value of 0.8 USD Billion in 2023 and advancing to 1.4 USD Billion by 2032, highlighting its important role in research and development.

    The APAC region, valued at 0.41 USD Billion in 2023, shows potential for growth, reaching 0.9 USD Billion by 2032, driven by increasing investments in biotechnology.

    South America and MEA represent smaller yet developing segments, with valuations of 0.07 USD Billion and 0.06 USD Billion in 2023, respectively, expected to grow modestly to 0.15 USD Billion each by 2032. The market faces challenges such as stringent regulations and high costs, but opportunities arise from improved research capabilities and technological advancements, enhancing overall market growth and Global Knockout Mice Model Market statistics.

    Knockout Mice Model Market Regional

    Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

    Key Players and Competitive Insights

    The competitive landscape of the Global Knockout Mice Model Market is characterized by a diverse array of players, each contributing to the advancement of genetic research and pharmaceutical development through innovative approaches. This market has seen significant growth due to the increasing demand for personalized medicine and the rising prevalence of genetic disorders.

    As research institutions and pharmaceutical companies strive to overcome challenges in drug development and understanding complex diseases, the need for precise and reliable animal models becomes paramount. Knockout mice, which are genetically modified to lack specific genes, serve as critical tools in this endeavor. Thus, companies involved in the production and development of knockout mice are continuously enhancing their technologies, methodologies, and service offerings, creating a dynamic competitive environment that drives innovation and collaboration across the industry.

    genOway stands out in the Global Knockout Mice Model Market due to its strong focus on customized genetic models and its commitment to high-quality service. The company leverages advanced genetic engineering techniques to develop tailored knockout models that meet specific client requirements, thereby addressing unique research questions. This adaptability gives genOway a competitive advantage, as researchers are increasingly seeking models that closely mimic human diseases for more effective drug testing and therapeutic development.

    With a robust portfolio of knockout mice that are effectively validated for various applications, genOway enjoys a solid reputation among academic and biotech organizations. The company's emphasis on customer support, scientific expertise, and reliability further solidifies its market presence, allowing it to build long-term partnerships with clients in need of sophisticated genetic models.

    Charles River Laboratories holds a prominent position in the Global Knockout Mice Model Market, recognized for its comprehensive portfolio of research models and in-depth expertise in genetic engineering. The company has established a reputation for delivering high-quality knockout models that accelerate drug discovery and preclinical development.

    Charles River Laboratories distinguishes itself through its extensive breeding and production capabilities, ensuring a consistent supply of genetically modified mice that meet stringent quality standards. Furthermore, the company emphasizes innovation through ongoing investment in cutting-edge technology and research collaborations, enabling it to stay at the forefront of genetic research. The combination of a wide-ranging product offering and a focus on advancing genetic models makes Charles River Laboratories a key player in the knockout mice market, catering to diverse needs across the pharmaceutical and academic sectors.

    Key Companies in the Knock Out Mice Model Market market include

    Industry Developments

    In the Global Knockout Mice Model Market, significant recent developments have been noted, particularly among leading companies like genOway, Charles River Laboratories, and Horizon Discovery. These organizations have been increasingly focusing on expanding their product portfolios and enhancing their technological capabilities to meet growing research demands.

    The Jackson Laboratory and Envigo have also made strides in improving the genetic engineering techniques used for creating knockout mice, which contribute to advancements in biomedical research. Additionally, Biocytogen has gained attention for its innovative models catering to specific therapeutic areas.

    On the merger and acquisition front, notable transactions have involved key players such as Thermo Fisher Scientific and Crown Bioscience, with activities aimed at consolidating capabilities and expanding market reach.

    The financial health of companies involved in this market has been bolstered by a rising demand for genetic disease modeling, significantly impacting overall market growth. This evolution reflects a dynamic landscape where collaboration, technological innovation, and strategic partnerships are paramount for driving the success of knockout mice models in various research applications.

    Future Outlook

    Knock Out Mice Model Market Future Outlook

    The Global Knockout Mice Model Market is projected to grow at a 7.33% CAGR from 2024 to 2035, driven by advancements in genetic research and increasing demand for personalized medicine.

    New opportunities lie in:

    • Develop innovative gene-editing technologies to enhance model accuracy and efficiency.
    • Expand partnerships with pharmaceutical companies for tailored drug development solutions.
    • Invest in AI-driven data analysis tools to optimize research outcomes and reduce time-to-market.

    By 2035, the market is expected to exhibit robust growth, positioning itself as a cornerstone in biomedical research.

    Market Segmentation

    Knockout Mice Model Market Type Outlook

    • Constitutive Knockout Mice
    • Conditional Knockout Mice
    • Transgenic Mice

    Knockout Mice Model Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia-Pacific
    • Middle East and Africa

    Knockout Mice Model Market Technology Outlook

    • CRISPR-Cas9
    • Homologous Recombination
    • Gene Targeting

    Knockout Mice Model Market Application Outlook

    • Oncology Research
    • Genetic Research
    • Pharmaceutical Research
    • Immunology Research

    Knockout Mice Model Market Key End User Outlook

    • Academic Institutions
    • Biotechnology Companies
    • Pharmaceutical Companies
    • Contract Research Organizations

    Report Scope

    Report Attribute/Metric Details
    Market Size 2024    2.74 (USD Billion)
    Market Size 2025    2.94 (USD Billion)
    Market Size 2034    5.56 (USD Billion)
    Compound Annual Growth Rate (CAGR)    7.32 % (2025 - 2034)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2024
    Market Forecast Period 2025 - 2034
    Historical Data 2020 - 2024
    Market Forecast Units USD Billion
    Key Companies Profiled genOway, Charles River Laboratories, Horizon Discovery, The Jackson Laboratory, Envigo, Biocytogen, Cure Genetics, Thermo Fisher Scientific, Crown Bioscience, Integrative Biology, Celerion, OncoOne, Jackson Laboratory, Taconic Biosciences, PharmaCyte Biotech
    Segments Covered Application, Type, Key End User, Technology, Regional
    Key Market Opportunities Increased genetic research funding, Rise in personalized medicine demand, Growth in pharmaceutical R investment, Advancements in gene editing technologies, Expansion of academic research institutions
    Key Market Dynamics Increasing R in biotechnology, Growing demand for personalized medicine, Advancements in genetic engineering, Rising funding for genetic research, Expanding applications in drug development
    Countries Covered North America, Europe, APAC, South America, MEA

    FAQs

    What is the projected market size of the Global Knockout Mice Model Market by 2034?

    The projected market size of the Global Knockout Mice Model Market by 2034 is expected to reach approximately 5.56 USD Billion.

    What is the expected CAGR for the Global Knockout Mice Model Market from 2025 to 2034?

    The expected CAGR for the Global Knockout Mice Model Market from 2025 to 2034 is 7.32%.

    Which region held the largest market share in the Global Knockout Mice Model Market in 2023?

    North America held the largest market share in the Global Knockout Mice Model Market, valued at 1.05 USD Billion in 2023.

    How much is the Oncology Research application segment valued in 2032?

    The Oncology Research application segment is expected to be valued at 1.8 USD Billion in 2032.

    What are the projected values for the Genetic Research application segment by 2032?

    The Genetic Research application segment is projected to be valued at 1.2 USD Billion by 2032.

    What is the expected market value of the Pharmaceutical Research application segment in 2032?

    The Pharmaceutical Research application segment is expected to be valued at 1.1 USD Billion in 2032.

    Which emerging players are key competitors in the Global Knockout Mice Model Market?

    Key competitors in the Global Knockout Mice Model Market include genOway, Charles River Laboratories, and Horizon Discovery.

    How much is the APAC region expected to be valued in the Global Knockout Mice Model Market by 2032?

    The APAC region is expected to be valued at approximately 0.9 USD Billion in the Global Knockout Mice Model Market by 2032.

    What is the market value of the Immunology Research application segment in 2032?

    The Immunology Research application segment is projected to reach a value of 0.4 USD Billion in 2032.

    What is the market outlook for the South American region in the Global Knockout Mice Model Market by 2032?

    The South American region is projected to have a market value of around 0.15 USD Billion by 2032.

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