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    Bradykinin Mediated Angioedema Market

    ID: MRFR/HC/34260-HCR
    128 Pages
    Rahul Gotadki
    September 2025

    Bradykinin Mediated Angioedema Market Research Report By Type (Hereditary Angioedema, Acquired Angioedema, Idiopathic Angioedema), By Treatment Options (C1-Inhibitor Replacement Therapy, Bradykinin B2 Receptor Antagonists, Kalinate Therapy, Antifibrinolytic Agents), By Route of Administration (Subcutaneous, Intravenous, Oral), By Patient Demographics (Pediatric Patients, Adult Patients, Geriatric Patients) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Forecast to 2034

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    Bradykinin Mediated Angioedema Market Research Report — Global Forecast till 2034 Infographic
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    Bradykinin Mediated Angioedema Market Summary

    The Global Bradykinin Mediated Angioedema Market is projected to grow significantly from 1.15 USD Billion in 2024 to 3.87 USD Billion by 2035.

    Key Market Trends & Highlights

    Bradykinin Mediated Angioedema Key Trends and Highlights

    • The market is expected to experience a compound annual growth rate (CAGR) of 11.67% from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 3.87 USD Billion, indicating robust growth potential.
    • In 2024, the market is valued at 1.15 USD Billion, reflecting the current demand for treatment options.
    • Growing adoption of innovative therapies due to increasing awareness of Bradykinin Mediated Angioedema is a major market driver.

    Market Size & Forecast

    2024 Market Size 1.15 (USD Billion)
    2035 Market Size 3.87 (USD Billion)
    CAGR (2025-2035) 11.67%

    Major Players

    Takeda Pharmaceutical Company, Novo Nordisk, Biocryst Pharmaceuticals, GSK, Bayer AG, Pfizer Inc, CSL Limited, Amgen Inc, Regeneron Pharmaceuticals, Roche Holding AG, Eli Lilly and Company, Merck and Co, Sanofi, AstraZeneca, Shire plc

    Bradykinin Mediated Angioedema Market Trends

    The Bradykinin Mediated Angioedema Market is significantly influenced by several key market drivers. An increasing awareness of the disorder has led to a rise in early diagnosis and treatment options. Enhancements in medical research have improved the understanding of angioedema, promoting the development of targeted therapies. Additionally, the growing prevalence of underlying conditions such as hereditary angioedema and increased access to healthcare services are facilitating market expansion. Pharmaceutical advancements are also pushing the boundaries of treatment modalities, further driving the market. Opportunities in this market are abundant, particularly in the development of innovative therapies and products targeting various patient demographics.

    The rise of personalized medicine opens new avenues for customized treatment solutions. Collaborations between pharmaceutical companies and research institutions can accelerate drug discovery processes. Expanding geographical presence in emerging markets represents another significant opportunity, as these regions often have unmet medical needs and a growing patient population. The establishment of educational programs focused on angioedema can help in raising awareness, leading to better patient outcomes and market growth. In recent times, there has been a noticeable trend towards the development of biologic drugs, which are showing promise in effectively managing symptoms of bradykinin-mediated angioedema.

    Advancements in biotechnology are contributing to this trend, along with a shift toward chronic disease management models. Digital health solutions, including telemedicine and mobile applications for monitoring symptoms, are gaining traction. These trends indicate a shift in how healthcare is delivered, making it more accessible and patient-centered. As the market evolves, these dynamics will likely shape its future direction, offering new potential pathways for growth and innovation.

    The increasing recognition of bradykinin-mediated angioedema as a distinct clinical entity is likely to drive advancements in therapeutic options and improve patient outcomes.

    National Institutes of Health (NIH)

    Bradykinin Mediated Angioedema Market Drivers

    Market Growth Projections

    The Global Bradykinin Mediated Angioedema Market Industry is projected to experience substantial growth over the coming years. With a market value of 1.15 USD Billion in 2024, it is anticipated to reach 3.87 USD Billion by 2035, reflecting a compound annual growth rate of 11.67% from 2025 to 2035. This growth trajectory is indicative of the increasing demand for effective treatment options and the ongoing advancements in medical research. As the market evolves, it will likely attract further investment and innovation, positioning it as a key area of focus within the broader healthcare landscape.

    Rising Incidence of Angioedema

    The Global Bradykinin Mediated Angioedema Market Industry is witnessing a notable increase in the incidence of angioedema cases, driven by genetic factors and environmental triggers. Current estimates suggest that hereditary angioedema affects approximately 1 in 50,000 individuals globally. This rising prevalence is prompting healthcare systems to allocate more resources towards diagnosis and treatment, thereby expanding the market. As awareness grows, the demand for effective therapies is expected to surge, contributing to the market's projected growth from 1.15 USD Billion in 2024 to an estimated 3.87 USD Billion by 2035, reflecting a compound annual growth rate of 11.67% from 2025 to 2035.

    Growing Awareness and Education

    There is an increasing emphasis on awareness and education regarding bradykinin mediated angioedema within the Global Bradykinin Mediated Angioedema Market Industry. Healthcare providers and patient advocacy groups are actively working to disseminate information about the condition, its symptoms, and available treatments. This heightened awareness is crucial in facilitating early diagnosis and intervention, which can significantly improve patient quality of life. As more individuals become informed about angioedema, the demand for specialized care and treatment options is expected to rise, further propelling market growth.

    Increased Healthcare Expenditure

    The Global Bradykinin Mediated Angioedema Market Industry is benefiting from rising healthcare expenditure across various regions. Governments and private sectors are increasingly investing in healthcare infrastructure, which includes the development of specialized treatment centers for conditions like angioedema. This investment not only enhances access to care but also promotes research initiatives aimed at understanding and treating the condition. As healthcare spending continues to rise, it is expected to positively impact the market, facilitating the introduction of advanced therapies and improving patient outcomes.

    Regulatory Support and Approvals

    Regulatory bodies are playing a pivotal role in shaping the Global Bradykinin Mediated Angioedema Market Industry through streamlined approval processes for new therapies. Recent initiatives aimed at expediting the review of orphan drugs have led to quicker access to innovative treatments for patients suffering from angioedema. This supportive regulatory environment encourages pharmaceutical companies to invest in research and development, thereby fostering innovation. As a result, the market is likely to experience accelerated growth, driven by the introduction of new therapies that meet the needs of patients and healthcare providers alike.

    Advancements in Treatment Options

    Innovations in treatment modalities are significantly influencing the Global Bradykinin Mediated Angioedema Market Industry. The development of targeted therapies, such as C1-inhibitor replacement therapies and bradykinin receptor antagonists, has transformed the management of angioedema. These advancements not only enhance patient outcomes but also foster a competitive landscape among pharmaceutical companies. As new therapies emerge, they are likely to capture a larger market share, thereby driving revenue growth. The anticipated increase in treatment options aligns with the overall market expansion, as patients seek more effective and personalized solutions.

    Market Segment Insights

    Bradykinin Mediated Angioedema Market Type Insights

    The Bradykinin Mediated Angioedema Market is witnessing significant growth, with a market valuation of 0.93 USD Billion in 2023 and expected to reach 2.5 USD Billion by 2032, driven by rising awareness and improved diagnostics. The market segmentation around Type prominently features Hereditary Angioedema, Acquired Angioedema, and Idiopathic Angioedema. Among these, Hereditary Angioedema holds a majority market share, valued at 0.4 USD Billion in 2023, and is projected to grow substantially to 1.05 USD Billion by 2032, highlighting its dominance due to genetic predispositions and increasing patient identification.

    This sub-segment is particularly significant as it emphasizes the need for targeted therapies and ongoing patient management strategies. Acquired Angioedema, while smaller in comparison, reflects a substantial market presence, with a valuation of 0.3 USD Billion in 2023 and expected growth to 0.8 USD Billion by 2032. The challenges surrounding the identification of triggers and underlying conditions contribute to its relevance in the market, making the development of therapeutic options increasingly important. Lastly, Idiopathic Angioedema, which accounted for 0.23 USD Billion in 2023 and aims for a future valuation of 0.65 USD Billion, is the least dominant type.

    However, it presents unique challenges due to its unpredictable nature, leading to a notable opportunity for pharmaceutical advancements and improved treatment strategies. The Bradykinin Mediated Angioedema Market data reflects a balanced yet complex interplay of these segments, with varying growth drivers, including heightened research initiatives and patient advocacy groups fostering a conducive environment for market expansion. Understanding this market segmentation allows stakeholders to tailor their approaches to meet the varying needs of each type effectively while capitalizing on the growth potential and complexities inherent in the treatment landscape.

    As such, the industry faces opportunities and challenges that influence the development of effective therapies tailored for specific Angioedema types, ensuring that patient outcomes continue to improve as the market evolves.

    Source Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Bradykinin Mediated Angioedema Market Treatment Options Insights

    The Bradykinin Mediated Angioedema Market, focusing on Treatment Options, shows a robust growth trajectory, with the market valued at 0.93 billion USD in 2023. By 2032, this market is expected to grow significantly. The Treatment Options segment is driven by an increasing prevalence of Bradykinin Mediated Angioedema, with key therapies such as C1-Inhibitor Replacement Therapy playing a pivotal role owing to its effectiveness in managing acute attacks. Bradykinin B2 Receptor Antagonists are also essential, showcasing a significant demand due to their targeted action in slowing down symptoms related to angioedema.

    Additionally, Kalinate Therapy is garnering attention as it presents opportunities for enhanced patient outcomes. Antifibrinolytic Agents remain crucial within this market, offering therapeutic benefits that complement other treatment modalities. Overall, the Bradykinin Mediated Angioedema Market revenue illustrates a clear alignment between growing treatment needs and innovative drug development strategies, emphasizing the importance of each therapy in providing effective management of the disorder amidst evolving patient care standards.

    Bradykinin Mediated Angioedema Market Route of Administration Insights

    The Bradykinin Mediated Angioedema Market is experiencing significant growth, particularly in the Route of Administration segment, which plays a critical role in treatment efficacy and patient compliance. In 2023, the market was valued at 0.93 billion USD and is projected to expand substantially in the coming years. The market sees a strong emphasis on various methods of administration, including Subcutaneous, Intravenous, and Oral, each catering to different patient needs. Subcutaneous administration is noted for its ease of use and ability to improve patient adherence, making it a preferred choice among healthcare providers.

    Intravenous administration, albeit less common, offers rapid action for acute cases and is vital in clinical settings. The Oral route, with its convenience and patient-friendly nature, continues to gain traction, appealing particularly to home care settings. These various routes contribute to the segmentation of the Bradykinin Mediated Angioedema Market, which is crucial for targeted therapies tailored to individual patient profiles. The growth in this segment is driven by an increasing prevalence of bradykinin-mediated conditions, evolving treatment paradigms, and ongoing research into improving administration methods while enhancing patient experience and outcomes.

    The Bradykinin Mediated Angioedema Market data reveals promising trends around these administration routes, highlighting their potential to meet diverse healthcare needs.

    Bradykinin Mediated Angioedema Market Patient Demographics Insights

    The Bradykinin Mediated Angioedema Market, valued at 0.93 billion USD in 2023, showcases a diverse Patient Demographics segment that includes Pediatric, Adult, and Geriatric Patients. Each group presents unique needs and characteristics, playing a crucial role in shaping the overall market dynamics. Pediatric Patients often face challenges with diagnosis and treatment adherence, making this demographic vital for future treatment innovations. Meanwhile, Adult Patients typically dominate the market due to the higher prevalence of bradykinin-mediated conditions within this age group, driven by lifestyle factors and genetic predispositions.

    The Geriatric Patients segment is also significant as it is increasingly impacted by this condition alongside age-related health issues, creating a demand for tailored therapeutic solutions. These demographics collectively contribute to the Bradykinin Mediated Angioedema Market growth as the industry responds to their specific treatment requirements and associated healthcare trends. Overall, the market exhibits a steady increase in interest and investment, emphasizing the importance of understanding these patient segments for future strategies and developments in the industry.With an expected continued expansion, the market is poised to address escalating healthcare needs responsibly and effectively.

    Get more detailed insights about Bradykinin Mediated Angioedema Market Research Report — Global Forecast till 2034

    Regional Insights

    The Bradykinin Mediated Angioedema Market revenue is witnessing substantial growth across different regions, with North America holding a significant market share of 0.42 USD Billion in 2023, projected to increase to 1.05 USD Billion by 2032. This dominance can be attributed to advanced healthcare infrastructure and a high prevalence of angioedema cases. Europe follows as another key region, with market values of 0.25 USD Billion in 2023 and 0.65 USD Billion in 2032, benefiting from a strong regulatory framework and research initiatives.

    The APAC region, though smaller, shows promising growth potential, escalating from 0.15 USD Billion in 2023 to 0.45 USD Billion by 2032, driven by rising healthcare awareness and investments in treatment options.

    South America and MEA represent the emerging markets in the Bradykinin Mediated Angioedema Market industry, with values of 0.06 USD Billion and 0.05 USD Billion in 2023, respectively, reflecting a growth trajectory as healthcare access improves. These regions present significant opportunities to tap into increasing demand for effective treatments as more awareness of this condition grows. Bradykinin Mediated Angioedema Market statistics indicate a clear trend toward increased investments, highlighting the importance of continuously expanding healthcare access and innovation across these diverse regions.

    Bradykinin Mediated Angioedema Market By North America

    Source Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Key Players and Competitive Insights

    The Bradykinin Mediated Angioedema Market is characterized by a dynamic competitive landscape, driven by the increasing prevalence of angioedema conditions and the growing understanding of bradykinin's role in these diseases. As research advances, companies are focusing on the development of innovative therapeutic options that cater to the specific needs of patients suffering from angioedema. 

    The market includes a variety of stakeholders ranging from pharmaceutical giants to specialized biotechnology firms, all vying for a significant share. Companies are employing strategies such as collaborations, mergers, and acquisitions to enhance their product portfolios and extend their market reach. The landscape is also marked by intense competition where product differentiation and effective marketing strategies play crucial roles in capturing consumer attention.

    Takeda Pharmaceutical Company holds a prominent position in the Bradykinin Mediated Angioedema Market, showcasing its strengths through a robust pipeline of products and research initiatives targeted specifically at treating angioedema. The company is recognized for its commitment to patient-centric solutions, which is reflected in its innovative approaches to treatment development. Takeda's strategy emphasizes the importance of addressing patient needs and improving health outcomes, enabling it to maintain a competitive edge in the market. 

    Additionally, its extensive network and experience in managing complex therapeutic areas bolster its operational capabilities and market presence. By investing in research and development, Takeda continually seeks to enhance its therapeutic offerings, solidifying its reputation in the bradykinin-mediated angioedema segment.

    Novo Nordisk has also established itself as a key player in the Bradykinin Mediated Angioedema Market, bringing valuable expertise and resources to the table. The company is known for its strong focus on innovation, particularly in developing effective therapies that manage rare and chronic conditions like bradykinin-mediated angioedema. Novo Nordisk adopts a holistic approach to treatment by incorporating advancements in biotechnology and leveraging its extensive knowledge of patient care. Its commitment to research allows for the continuous evolution of its product offerings, positioning the company effectively against its competitors. 

    Furthermore, Novo Nordisk's strategic partnerships and collaborations enhance its ability to introduce novel solutions to the market, ensuring it meets the demands and needs of patients suffering from angioedema in an increasingly competitive environment.

    Key Companies in the Bradykinin Mediated Angioedema Market market include

    Industry Developments

    • Q2 2025: Pharvaris Presents Promising Data on Deucrictibant for Bradykinin-Mediated Angioedema at EAACI Congress 2025 Pharvaris presented new clinical data on deucrictibant, an oral bradykinin B2 receptor antagonist, at the EAACI Congress 2025, showing significant attack reduction and improved quality of life for hereditary angioedema patients. The company also announced advancement into Phase 3 trials for both prophylactic and on-demand treatment indications.
    • Q2 2025: Pharvaris AGM 2025: A Pivotal Moment for Braking into the Angioedema Market Pharvaris N.V. announced that its lead drug candidate, deucrictibant, is approaching pivotal clinical readouts and regulatory milestones, with the company preparing for its June 27, 2025 Annual General Meeting. The oral therapy targets both hereditary and acquired bradykinin-mediated angioedema, with Phase 3 trials underway.
    • Q1 2025: Pharvaris Outlines 2025 Strategic Priorities Pharvaris announced the initiation of CHAPTER-3, a pivotal Phase 3 study of deucrictibant for prophylaxis against hereditary angioedema attacks, and confirmed ongoing preparations for regulatory submission and commercialization pending trial results.

    Future Outlook

    Bradykinin Mediated Angioedema Market Future Outlook

    The Bradykinin Mediated Angioedema Market is projected to grow at an 11.67% CAGR from 2024 to 2035, driven by increasing awareness, innovative therapies, and enhanced diagnostic techniques.

    New opportunities lie in:

    • Develop targeted therapies focusing on genetic mutations associated with angioedema.
    • Invest in telemedicine solutions for remote patient monitoring and management.
    • Explore partnerships with diagnostic companies to enhance early detection capabilities.

    By 2035, the market is expected to achieve substantial growth, positioning itself as a leader in innovative therapeutic solutions.

    Market Segmentation

    Bradykinin Mediated Angioedema Market Type Outlook

    • Hereditary Angioedema
    • Acquired Angioedema
    • Idiopathic Angioedema

    Bradykinin Mediated Angioedema Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Bradykinin Mediated Angioedema Market Treatment Options Outlook

    • C1-Inhibitor Replacement Therapy
    • Bradykinin B2 Receptor Antagonists
    • Kalinate Therapy
    • Antifibrinolytic Agents

    Bradykinin Mediated Angioedema Market Patient Demographics Outlook

    • Pediatric Patients
    • Adult Patients
    • Geriatric Patients

    Bradykinin Mediated Angioedema Market Route of Administration Outlook

    • Subcutaneous
    • Intravenous
    • Oral

    Report Scope

    Bradykinin Mediated Angioedema Market Report Scope

    Report Attribute/Metric Details
    Market Size 2024    1.15 (USD Billion)
    Market Size 2025    1.29 (USD Billion)
    Market Size 2034    3.47 (USD Billion)
    Compound Annual Growth Rate (CAGR)   11.62 % (2025 - 2034)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2024
    Market Forecast Period 2025 - 2034
    Historical Data 2020 - 2024
    Market Forecast Units USD Billion
    Key Companies Profiled Takeda Pharmaceutical Company, Novo Nordisk, Biocryst Pharmaceuticals, GSK, Bayer AG, Pfizer Inc, CSL Limited, Amgen Inc, Regeneron Pharmaceuticals, Roche Holding AG, Eli Lilly and Company, Merck and Co, Sanofi, AstraZeneca, Shire plc
    Segments Covered Type, Treatment Options, Route of Administration, Patient Demographics, Regional
    Key Market Opportunities Increased awareness and diagnosis, Advancements in targeted therapies, Growing prevalence of hereditary angioedema, Investment in research and development, Expanding healthcare access
    Key Market Dynamics Increasing prevalence of angioedema, Growing demand for effective therapies, Advances in biologics development, Rising awareness and diagnosis, Strong investment in research
    Countries Covered North America, Europe, APAC, South America, MEA

    FAQs

    What is the expected market size of the Bradykinin Mediated Angioedema Market by 2034?

    The Bradykinin Mediated Angioedema Market is expected to be valued at 3.47 USD Billion by 2034.

    What is the Compound Annual Growth Rate (CAGR) of the Bradykinin Mediated Angioedema Market from 2025 to 2034?

    The market is projected to grow at a CAGR of 11.6% from 2025 to 2034.

    Which region dominates the Bradykinin Mediated Angioedema Market in 2023?

    North America holds the largest share of the market, valued at 0.42 USD Billion in 2023.

    What is the market size of the Hereditary Angioedema segment in 2032?

    The Hereditary Angioedema segment is expected to be valued at 1.05 USD Billion in 2032.

    Who are the key players in the Bradykinin Mediated Angioedema Market?

    Key players include Takeda Pharmaceutical Company, Novo Nordisk, Biocryst Pharmaceuticals, GSK, and Bayer AG.

    What is the market size for the Acquired Angioedema segment by 2032?

    The Acquired Angioedema segment is anticipated to reach 0.8 USD Billion by 2032.

    How much is the APAC region expected to contribute to the market by 2032?

    The APAC region is projected to contribute 0.45 USD Billion to the market by 2032.

    What is the forecasted market size for the Idiopathic Angioedema segment in 2032?

    The Idiopathic Angioedema segment is expected to be valued at 0.65 USD Billion in 2032.

    What are the challenges expected to impact the growth of the Bradykinin Mediated Angioedema Market?

    Challenges include regulatory hurdles and varying healthcare infrastructure across regions.

    What is the projected market size for South America in 2032?

    The South America segment is expected to be valued at 0.15 USD Billion by 2032.

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