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    Bradykinin Mediated Angioedema Market

    ID: MRFR/HC/34260-HCR
    128 Pages
    Rahul Gotadki
    October 2025

    Bradykinin Mediated Angioedema Market Research Report By Type (Hereditary Angioedema, Acquired Angioedema, Idiopathic Angioedema), By Treatment Options (C1-Inhibitor Replacement Therapy, Bradykinin B2 Receptor Antagonists, Kalinate Therapy, Antifibrinolytic Agents), By Route of Administration (Subcutaneous, Intravenous, Oral), By Patient Demographics (Pediatric Patients, Adult Patients, Geriatric Patients) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Forecast to 2035

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    Bradykinin Mediated Angioedema Market Summary

    As per MRFR analysis, the Bradykinin Mediated Angioedema Market Size was estimated at 1.154 USD Billion in 2024. The Bradykinin Mediated Angioedema industry is projected to grow from 1.288 in 2025 to 3.868 by 2035, exhibiting a compound annual growth rate (CAGR) of 11.62 during the forecast period 2025 - 2035.

    Key Market Trends & Highlights

    The Bradykinin Mediated Angioedema Market is poised for substantial growth driven by innovative therapies and increasing awareness.

    • The emergence of targeted therapies is reshaping treatment paradigms in the Bradykinin Mediated Angioedema Market.
    • North America remains the largest market, while Asia-Pacific is recognized as the fastest-growing region for angioedema treatments.
    • Hereditary Angioedema continues to dominate the market, whereas Acquired Angioedema is experiencing rapid growth.
    • Rising incidence of angioedema and advancements in therapeutic options are key drivers propelling market expansion.

    Market Size & Forecast

    2024 Market Size 1.154 (USD Billion)
    2035 Market Size 3.868 (USD Billion)
    CAGR (2025 - 2035) 11.62%

    Major Players

    Takeda Pharmaceutical Company Limited (JP), CSL Behring LLC (US), Pharming Group N.V. (NL), Sobi AB (SE), BioCryst Pharmaceuticals, Inc. (US), Eisai Co., Ltd. (JP), Grifols S.A. (ES), Amgen Inc. (US)

    Bradykinin Mediated Angioedema Market Trends

    The Bradykinin Mediated Angioedema Market is currently experiencing notable developments, driven by an increasing awareness of the condition and advancements in treatment options. This market encompasses a range of therapies aimed at managing the symptoms associated with angioedema, which is characterized by swelling due to the accumulation of fluid in tissues. The growing understanding of the underlying mechanisms of bradykinin-mediated angioedema has led to the exploration of novel therapeutic agents, which may offer improved efficacy and safety profiles. As healthcare providers become more informed about this condition, the demand for effective treatments is likely to rise, potentially influencing market dynamics. Moreover, the regulatory landscape appears to be evolving, with an emphasis on expediting the approval processes for innovative therapies. This shift may facilitate quicker access to new treatment options for patients suffering from bradykinin-mediated angioedema. Additionally, the increasing prevalence of this condition, coupled with a heightened focus on patient-centered care, suggests that stakeholders in the Bradykinin Mediated Angioedema Market must adapt to changing patient needs and preferences. Overall, the market seems poised for growth, driven by a combination of scientific advancements and a commitment to improving patient outcomes.

    Emergence of Targeted Therapies

    The Bradykinin Mediated Angioedema Market is witnessing a shift towards targeted therapies that specifically address the underlying mechanisms of the condition. These therapies aim to inhibit the action of bradykinin, potentially leading to more effective management of symptoms. As research progresses, the introduction of such treatments may reshape the therapeutic landscape.

    Increased Patient Awareness

    There is a growing awareness among patients regarding bradykinin-mediated angioedema, which is likely to drive demand for effective treatment options. Educational initiatives and advocacy efforts are contributing to a better understanding of the condition, encouraging individuals to seek medical advice and appropriate therapies.

    Regulatory Support for Innovation

    The regulatory environment appears to be increasingly supportive of innovation within the Bradykinin Mediated Angioedema Market. Streamlined approval processes for new therapies may enhance the availability of advanced treatment options, ultimately benefiting patients and healthcare providers alike.

    The increasing recognition of bradykinin-mediated angioedema as a distinct clinical entity is likely to drive advancements in therapeutic options and improve patient outcomes.

    National Institutes of Health (NIH)

    Bradykinin Mediated Angioedema Market Drivers

    Increased Research Funding

    The allocation of research funding for bradykinin mediated angioedema is a critical driver for the Bradykinin Mediated Angioedema Market. Government and private organizations are increasingly investing in studies aimed at understanding the underlying mechanisms of angioedema and developing effective treatments. This influx of funding is expected to accelerate the pace of innovation, leading to the discovery of new therapeutic agents. Furthermore, as research progresses, the identification of novel biomarkers may enhance diagnostic accuracy and treatment efficacy. The commitment to advancing knowledge in this field is likely to bolster the growth trajectory of the Bradykinin Mediated Angioedema Market.

    Rising Incidence of Angioedema

    The increasing prevalence of bradykinin mediated angioedema is a notable driver for the Bradykinin Mediated Angioedema Market. Recent studies indicate that the incidence of hereditary angioedema is approximately 1 in 50,000 individuals, while acquired forms are becoming more recognized. This rise in cases necessitates effective treatment options, thereby propelling market growth. As awareness of the condition expands, healthcare providers are more likely to diagnose and treat patients, further contributing to the market's expansion. The growing patient population is expected to drive demand for innovative therapies, which may lead to increased investments in research and development within the Bradykinin Mediated Angioedema Market.

    Growing Patient Advocacy Groups

    The emergence of patient advocacy groups dedicated to bradykinin mediated angioedema is fostering awareness and support within the Bradykinin Mediated Angioedema Market. These organizations play a pivotal role in educating patients and healthcare professionals about the condition, thereby promoting timely diagnosis and treatment. Their efforts in raising awareness can lead to increased demand for therapies, as more individuals seek medical assistance. Additionally, these groups often collaborate with pharmaceutical companies to facilitate clinical trials, which can expedite the development of new treatments. The influence of patient advocacy is likely to enhance the visibility of the Bradykinin Mediated Angioedema Market.

    Advancements in Therapeutic Options

    Innovations in therapeutic approaches for bradykinin mediated angioedema are significantly influencing the Bradykinin Mediated Angioedema Market. The introduction of novel therapies, such as C1-inhibitor replacement therapies and bradykinin receptor antagonists, has transformed treatment paradigms. These advancements not only improve patient outcomes but also enhance the overall market landscape. For instance, the approval of new drugs has led to a surge in treatment options, catering to diverse patient needs. As the market continues to evolve, the development of targeted therapies is likely to attract further investment, thereby fostering growth within the Bradykinin Mediated Angioedema Market.

    Regulatory Incentives for Drug Development

    Regulatory bodies are increasingly providing incentives for the development of treatments for bradykinin mediated angioedema, which serves as a significant driver for the Bradykinin Mediated Angioedema Market. Initiatives such as orphan drug designations and fast-track approvals are designed to encourage pharmaceutical companies to invest in this niche market. These regulatory frameworks not only reduce the time and cost associated with bringing new therapies to market but also enhance the attractiveness of the sector for investors. As more companies enter the market, the competitive landscape is likely to evolve, leading to a broader array of treatment options for patients suffering from bradykinin mediated angioedema.

    Market Segment Insights

    By Type: Hereditary Angioedema (Largest) vs. Acquired Angioedema (Fastest-Growing)

    In the Bradykinin Mediated Angioedema Market, the distribution of market share among the different types of angioedema reveals a significant predominance of Hereditary Angioedema. This segment continues to hold the largest market share due to the increasing awareness and diagnosis rates among populations, coupled with advancements in treatment options tailored for hereditary conditions. Contrarily, Acquired Angioedema is rapidly emerging, gaining traction among healthcare providers owing to a growing recognition of its different etiologies and triggers, leading to expanded research and treatment opportunities.

    Hereditary Angioedema (Dominant) vs. Acquired Angioedema (Emerging)

    Hereditary Angioedema remains the dominant segment within the Bradykinin Mediated Angioedema Market due to its hereditary nature and well-established treatment protocols, including specific therapies that cater to this chronic condition. Patients often require long-term management to prevent attacks, which sustains the demand for specialized treatments. On the other hand, Acquired Angioedema is emerging as a significant segment driven by heightened clinical understanding and diagnosis of the condition. The growing number of cases attributed to various factors such as medications or associated diseases is prompting healthcare systems to focus more on tailored interventions for acquired cases, thus shaping a competitive landscape that favors innovative therapy development.

    By Treatment Options: C1-Inhibitor Replacement Therapy (Largest) vs. Bradykinin B2 Receptor Antagonists (Fastest-Growing)

    In the Bradykinin Mediated Angioedema Market, the market share distribution reveals that C1-Inhibitor Replacement Therapy stands as the largest segment, accounting for a substantial portion of the overall market. This established position is driven by its efficacy in restoring C1 inhibitor levels, making it a preferred choice among clinicians and patients. On the other hand, Bradykinin B2 Receptor Antagonists are rapidly gaining traction, emerging as the fastest-growing treatment option due to their novel mechanism targeting bradykinin receptors directly, thereby attracting interest from both medical professionals and pharmaceutical companies. The growth trends within this segment are remarkably influenced by increasing awareness of Bradykinin Mediated Angioedema and innovative treatment approaches. Factors such as the rising incidence of angioedema, advancements in drug formulations, and expanding clinical trials for new therapies are contributing to the growth of both existing and emerging treatment options. The expansion of treatment protocols and supportive guidelines aimed at improving patient outcomes further encourages the adoption of these therapies in clinical practice.

    C1-Inhibitor Replacement Therapy (Dominant) vs. Bradykinin B2 Receptor Antagonists (Emerging)

    C1-Inhibitor Replacement Therapy is recognized as the dominant treatment option in the Bradykinin Mediated Angioedema Market due to its long-standing use and established efficacy. It effectively replaces the deficient C1 inhibitor in patients, addressing the underlying cause of the condition. This treatment is often preferred in acute and prophylactic settings, making it a mainstay in therapeutic regimens. Conversely, Bradykinin B2 Receptor Antagonists represent an emerging treatment class that targets bradykinin receptors, offering a different mode of action. Their rapid development underscores the growing interest in targeted therapies and provides a potential alternative for patients who may not respond adequately to traditional therapies. The ongoing research and clinical trials are expected to enhance their market presence significantly in the coming years.

    By Route of Administration: Subcutaneous (Largest) vs. Intravenous (Fastest-Growing)

    In the Bradykinin Mediated Angioedema Market, the route of administration plays a pivotal role in treatment preference and efficacy. Subcutaneous administration currently holds the largest share due to its ease of use, patient compliance, and effective delivery of therapeutics. Intravenous administration, although lower in share, is gaining traction due to its rapid onset of action, especially in acute scenarios, catering to a segment of patients with severe manifestations.

    Administration Method: Subcutaneous (Dominant) vs. Intravenous (Emerging)

    The subcutaneous route for administering treatments in the Bradykinin Mediated Angioedema Market remains dominant, as it offers patients an easier, less invasive option that fits well with home-use scenarios. This method allows individuals to manage their condition with minimal professional supervision. On the other hand, intravenous administration is emerging as a significant alternative, particularly for patients requiring immediate relief in acute angioedema episodes. This method ensures that medications are delivered rapidly into the bloodstream, resulting in quicker effectiveness, which is critical for life-threatening situations.

    By Patient Demographics: Adult Patients (Largest) vs. Pediatric Patients (Fastest-Growing)

    In the Bradykinin Mediated Angioedema Market, the demographic distribution reveals that adult patients constitute the largest segment, reflecting their higher prevalence of chronic conditions that can lead to this type of angioedema. Meanwhile, pediatric patients represent the fastest-growing segment due to increasing awareness and improved diagnosis of bradykinin-mediated conditions in younger populations, alongside enhanced treatment options available for children. As healthcare providers focus on early interventions, the pediatric segment is seeing a significant uptick in reported cases. The growth is also fueled by advocacy for better health insights for children, along with greater engagement in research dedicated to understanding angioedema in pediatric populations. This shift highlights the importance of tailored treatment approaches for diverse age groups in managing this condition.

    Adult Patients (Dominant) vs. Geriatric Patients (Emerging)

    Adult patients dominate the Bradykinin Mediated Angioedema Market, primarily due to their higher susceptibility and existing health conditions that can exacerbate angioedema symptoms. The adult demographic qualifies as the main focus of pharmaceutical developments, where advancements in treatments cater extensively to their needs. In contrast, geriatric patients emerge as an important demographic, driven by the aging population and related health complexities. While they may represent a smaller market share currently, the growing recognition of atypical angioedema challenges and the need for specialized treatment options for the elderly are likely to bolster their market presence. As medical research evolves, tailored therapies for geriatric patients will become pivotal, addressing unique responses and interactions associated with aging.

    Get more detailed insights about Bradykinin Mediated Angioedema Market

    Regional Insights

    North America : Leading Market for Treatments

    North America is the largest market for Bradykinin Mediated Angioedema, accounting for approximately 60% of the global market share. The region's growth is driven by increasing awareness of the condition, advancements in treatment options, and supportive regulatory frameworks. The FDA's approval of new therapies has catalyzed market expansion, with a growing demand for effective management solutions. The United States is the primary contributor, with significant investments from key players like Takeda Pharmaceutical Company Limited and BioCryst Pharmaceuticals, Inc. Canada also plays a vital role, focusing on improving healthcare access and treatment options. The competitive landscape is characterized by a mix of established companies and emerging players, fostering innovation and collaboration in the sector.

    Europe : Emerging Market with Potential

    Europe is witnessing a significant rise in the Bradykinin Mediated Angioedema market, holding approximately 25% of the global share. The region's growth is fueled by increasing patient awareness, advancements in biotechnology, and supportive healthcare policies. Regulatory bodies are actively promoting research and development, which is expected to enhance treatment availability and accessibility across member states. Leading countries such as Germany, France, and the UK are at the forefront, with a robust presence of key players like Pharming Group N.V. and Sobi AB. The competitive landscape is evolving, with collaborations between pharmaceutical companies and research institutions aimed at developing innovative therapies. The European Medicines Agency continues to support initiatives that enhance treatment options for patients.

    Asia-Pacific : Rapidly Evolving Healthcare Sector

    The Asia-Pacific region is emerging as a significant player in the Bradykinin Mediated Angioedema market, accounting for about 10% of the global share. The growth is driven by increasing healthcare expenditure, rising awareness of rare diseases, and the introduction of innovative therapies. Countries like Japan and Australia are leading the charge, supported by favorable regulatory environments that encourage research and development in this area. Japan is home to key players such as Eisai Co., Ltd., while Australia is witnessing a surge in clinical trials and partnerships aimed at enhancing treatment options. The competitive landscape is characterized by a mix of local and international companies, fostering a collaborative environment for innovation. As the region continues to develop, the demand for effective management solutions is expected to rise significantly.

    Middle East and Africa : Untapped Market Opportunities

    The Middle East and Africa region is currently the smallest market for Bradykinin Mediated Angioedema, holding approximately 5% of the global share. However, the region presents untapped opportunities for growth, driven by increasing healthcare investments and a rising prevalence of rare diseases. Governments are beginning to recognize the importance of addressing these conditions, leading to improved healthcare policies and funding for research initiatives. Countries like South Africa and the UAE are emerging as key players in the market, with a growing interest from international pharmaceutical companies. The competitive landscape is still developing, with local firms collaborating with global entities to enhance treatment availability. As awareness increases, the demand for effective therapies is expected to grow, paving the way for future market expansion.

    Key Players and Competitive Insights

    The Bradykinin Mediated Angioedema Market is characterized by a dynamic competitive landscape, driven by increasing awareness of the condition and advancements in therapeutic options. Key players such as Takeda Pharmaceutical Company Limited (Japan), BioCryst Pharmaceuticals, Inc. (US), and Pharming Group N.V. (Netherlands) are at the forefront, each adopting distinct strategies to enhance their market presence. Takeda (Japan) focuses on innovation through the development of novel therapies, while BioCryst Pharmaceuticals, Inc. (US) emphasizes strategic partnerships to bolster its research capabilities. Pharming Group N.V. (Netherlands) appears to be concentrating on expanding its global footprint, particularly in emerging markets, thereby shaping a competitive environment that is increasingly collaborative yet fiercely competitive.

    In terms of business tactics, companies are localizing manufacturing and optimizing supply chains to enhance efficiency and responsiveness to market demands. The market structure is moderately fragmented, with a mix of established players and emerging biotech firms. This fragmentation allows for diverse approaches to treatment and patient care, while the collective influence of key players drives innovation and competitive differentiation.

    In August 2025, Takeda Pharmaceutical Company Limited (Japan) announced a strategic collaboration with a leading research institution to accelerate the development of its next-generation therapies for angioedema. This partnership is likely to enhance Takeda's research capabilities and expedite the introduction of innovative treatments, positioning the company as a leader in the therapeutic landscape.

    In September 2025, BioCryst Pharmaceuticals, Inc. (US) launched a new digital platform aimed at improving patient engagement and adherence to treatment protocols. This initiative not only reflects the company's commitment to patient-centric care but also indicates a broader trend towards digital transformation in the healthcare sector, which may enhance treatment outcomes and patient satisfaction.

    In July 2025, Pharming Group N.V. (Netherlands) secured regulatory approval for its latest product aimed at treating hereditary angioedema, marking a significant milestone in its product pipeline. This approval is expected to strengthen Pharming's market position and expand its therapeutic offerings, potentially increasing its share in the competitive landscape.

    As of October 2025, current trends in the Bradykinin Mediated Angioedema Market are increasingly defined by digitalization, sustainability, and the integration of artificial intelligence in treatment protocols. Strategic alliances among key players are shaping the landscape, fostering innovation and enhancing supply chain reliability. Looking ahead, competitive differentiation is likely to evolve from traditional price-based competition towards a focus on technological advancements and innovative treatment solutions, underscoring the importance of agility and responsiveness in a rapidly changing market.

    Key Companies in the Bradykinin Mediated Angioedema Market market include

    Industry Developments

    • Q2 2025: Pharvaris Presents Promising Data on Deucrictibant for Bradykinin-Mediated Angioedema at EAACI Congress 2025 Pharvaris presented new clinical data on deucrictibant, an oral bradykinin B2 receptor antagonist, at the EAACI Congress 2025, showing significant attack reduction and improved quality of life for hereditary angioedema patients. The company also announced advancement into Phase 3 trials for both prophylactic and on-demand treatment indications.
    • Q2 2025: Pharvaris AGM 2025: A Pivotal Moment for Braking into the Angioedema Market Pharvaris N.V. announced that its lead drug candidate, deucrictibant, is approaching pivotal clinical readouts and regulatory milestones, with the company preparing for its June 27, 2025 Annual General Meeting. The oral therapy targets both hereditary and acquired bradykinin-mediated angioedema, with Phase 3 trials underway.
    • Q1 2025: Pharvaris Outlines 2025 Strategic Priorities Pharvaris announced the initiation of CHAPTER-3, a pivotal Phase 3 study of deucrictibant for prophylaxis against hereditary angioedema attacks, and confirmed ongoing preparations for regulatory submission and commercialization pending trial results.

    Future Outlook

    Bradykinin Mediated Angioedema Market Future Outlook

    The Bradykinin Mediated Angioedema Market is projected to grow at 11.62% CAGR from 2024 to 2035, driven by increasing awareness, innovative therapies, and rising patient populations.

    New opportunities lie in:

    • Development of targeted biologics for personalized treatment plans.
    • Expansion of telehealth services for remote patient monitoring.
    • Investment in educational programs for healthcare professionals on angioedema management.

    By 2035, the market is expected to achieve substantial growth, positioning itself as a leader in innovative therapeutic solutions.

    Market Segmentation

    Bradykinin Mediated Angioedema Market Type Outlook

    • Hereditary Angioedema
    • Acquired Angioedema
    • Idiopathic Angioedema

    Bradykinin Mediated Angioedema Market Treatment Options Outlook

    • C1-Inhibitor Replacement Therapy
    • Bradykinin B2 Receptor Antagonists
    • Kalinate Therapy
    • Antifibrinolytic Agents

    Bradykinin Mediated Angioedema Market Patient Demographics Outlook

    • Pediatric Patients
    • Adult Patients
    • Geriatric Patients

    Bradykinin Mediated Angioedema Market Route of Administration Outlook

    • Subcutaneous
    • Intravenous
    • Oral

    Report Scope

    MARKET SIZE 20241.154(USD Billion)
    MARKET SIZE 20251.288(USD Billion)
    MARKET SIZE 20353.868(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR)11.62% (2024 - 2035)
    REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR2024
    Market Forecast Period2025 - 2035
    Historical Data2019 - 2024
    Market Forecast UnitsUSD Billion
    Key Companies ProfiledMarket analysis in progress
    Segments CoveredMarket segmentation analysis in progress
    Key Market OpportunitiesAdvancements in targeted therapies and personalized medicine enhance treatment options in the Bradykinin Mediated Angioedema Market.
    Key Market DynamicsRising demand for targeted therapies drives innovation and competition in the Bradykinin Mediated Angioedema market.
    Countries CoveredNorth America, Europe, APAC, South America, MEA

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    FAQs

    What is the projected market valuation for Bradykinin Mediated Angioedema by 2035?

    The projected market valuation for Bradykinin Mediated Angioedema is expected to reach 3.868 USD Billion by 2035.

    What was the market valuation for Bradykinin Mediated Angioedema in 2024?

    The market valuation for Bradykinin Mediated Angioedema was 1.154 USD Billion in 2024.

    What is the expected CAGR for the Bradykinin Mediated Angioedema Market during the forecast period 2025 - 2035?

    The expected CAGR for the Bradykinin Mediated Angioedema Market during the forecast period 2025 - 2035 is 11.62%.

    Which companies are key players in the Bradykinin Mediated Angioedema Market?

    Key players in the Bradykinin Mediated Angioedema Market include Takeda Pharmaceutical Company Limited, CSL Behring LLC, and Pharming Group N.V.

    What are the main types of angioedema segments in the market?

    The main types of angioedema segments include Hereditary Angioedema, Acquired Angioedema, and Idiopathic Angioedema.

    What was the market size for Hereditary Angioedema in 2024?

    The market size for Hereditary Angioedema was 0.462 USD Billion in 2024.

    What treatment options are available for Bradykinin Mediated Angioedema?

    Available treatment options include C1-Inhibitor Replacement Therapy, Bradykinin B2 Receptor Antagonists, and Antifibrinolytic Agents.

    What is the projected market size for C1-Inhibitor Replacement Therapy by 2035?

    The projected market size for C1-Inhibitor Replacement Therapy is expected to reach 1.577 USD Billion by 2035.

    How does the route of administration impact the Bradykinin Mediated Angioedema Market?

    The route of administration includes Subcutaneous, Intravenous, and Oral, with Subcutaneous expected to reach 1.615 USD Billion by 2035.

    What demographic segments are considered in the Bradykinin Mediated Angioedema Market?

    Demographic segments include Pediatric Patients, Adult Patients, and Geriatric Patients, with Adult Patients projected to reach 1.949 USD Billion by 2035.

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