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    Hereditary Angioedema Treatment Market

    ID: MRFR/HC/35781-HCR
    100 Pages
    Rahul Gotadki
    September 2025

    Hereditary Angioedema Treatment Market Research Report By Type of Treatment (C1 Esterase Inhibitor Replacement Therapy, Bradykinin B2 Receptor Antagonists, Recombinant C1 Esterase Inhibitor, Blood Plasma Derived Therapies), By Route of Administration (Intravenous, Subcutaneous, Oral), By Patient Age Group (Pediatric, Adult, Geriatric), By Diagnosis Type (Acquired Hereditary Angioedema, Congenital Hereditary Angioedema, Idiopathic Angioedema) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Fore...

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    Hereditary Angioedema Treatment Market Research Report — Global Forecast till 2034 Infographic
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    Hereditary Angioedema Treatment Market Summary

    The global hereditary angioedema treatment market is projected to grow from 2.37 USD billion in 2024 to 4.38 USD billion by 2035.

    Key Market Trends & Highlights

    Hereditary Angioedema Treatment Key Trends and Highlights

    • The market is expected to experience a compound annual growth rate of 5.73 percent from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 4.38 USD billion, reflecting a substantial increase from 2.37 USD billion in 2024.
    • The growth trajectory indicates a rising demand for effective treatment options in the hereditary angioedema sector.
    • Growing adoption of advanced therapies due to increasing awareness of hereditary angioedema is a major market driver.

    Market Size & Forecast

    2024 Market Size 2.37 (USD Billion)
    2035 Market Size 4.38 (USD Billion)
    CAGR (2025-2035) 5.73%

    Major Players

    Ionis Pharmaceuticals, Pfizer, H Genzyme, Revance Therapeutics, Eurordis, Baxter, Sobi, Portola Pharmaceuticals, Amgen, Biocryst Pharmaceuticals, ViroPharma, Takeda, CSL Behring, Shire, Sanofi

    Hereditary Angioedema Treatment Market Trends

    The Hereditary Angioedema Treatment Market is witnessing significant growth driven by a variety of factors. The increasing prevalence of hereditary angioedema, a genetic disorder that leads to recurrent episodes of severe swelling, is a primary market driver. Advances in research and the development of targeted therapies are also contributing to market expansion. Heightened awareness among healthcare professionals and patients has led to more accurate diagnoses and treatment options, reflecting a positive shift in patient management.

    Additionally, the rise of telemedicine and digital health solutions enhances patient outreach and ensures better access to treatments.There are several opportunities to be explored in this market. The potential for new treatment modalities, including biologics and gene therapy, presents a frontier for innovation and enhanced patient outcomes.

    Expanding geographic reach, particularly in emerging markets where healthcare infrastructure is improving, provides an avenue for growth. Partnerships between pharmaceutical companies and research institutions can accelerate the development of new therapies and enhance clinical trial outcomes.  Recent trends indicate a growing focus on personalized medicine tailored to individual patient needs.

    The adoption of new technologies, such as artificial intelligence in drug discovery and patient management systems, is becoming more prevalent.There is also an increasing emphasis on patient education and support programs that empower individuals to manage their condition proactively.

    As regulatory frameworks evolve, companies are better positioned to bring their products to market efficiently. Collectively, these factors are shaping a dynamic landscape for the Hereditary Angioedema Treatment Market, paving the way for innovative solutions and improved patient care.

    The evolving landscape of therapeutic options for Hereditary Angioedema suggests a growing recognition of the condition's complexity and the need for tailored treatment strategies.

    National Institutes of Health (NIH)

    Hereditary Angioedema Treatment Market Drivers

    Rising Prevalence of Hereditary Angioedema

    The increasing incidence of hereditary angioedema (HAE) globally drives the Global Hereditary Angioedema Treatment Market Industry. Current estimates suggest that HAE affects approximately 1 in 50,000 individuals, leading to a growing patient population requiring effective treatment options. This rising prevalence is particularly notable in regions such as Europe and North America, where awareness and diagnosis rates have improved. As more individuals are diagnosed, the demand for therapies is expected to rise, contributing to the market's projected growth from 2.37 USD Billion in 2024 to 4.38 USD Billion by 2035, indicating a robust market trajectory.

    Market Segment Insights

    Hereditary Angioedema Treatment Market Type of Treatment Insights  

    The Hereditary Angioedema Treatment Market is characterized by a diverse array of treatment options designed to address the needs of patients suffering from this rare genetic condition. Over the years, the market has shown substantial growth, with an overall valuation of 2.12 USD Billion in 2023. Among the various treatment modalities, C1 Esterase Inhibitor Replacement Therapy stands out as a dominant force, accounting for a significant share of the market with a value of 0.85 USD Billion in 2023 and projected to reach 1.4 USD Billion by 2032.

    This therapy is paramount in managing acute attacks and preventing their occurrence, making it crucial for patients and healthcare providers alike.In addition to C1 Esterase Inhibitor Replacement Therapy, other treatment types are also gaining traction. Bradykinin B2 Receptor Antagonists, valued at 0.5 USD Billion in 2023, play an important role by blocking the effects of bradykinin, a peptide that contributes to angioedema.

    This option is expected to reach 0.8 USD Billion by 2032, showcasing its growing acceptance within the medical community. On the other hand, Recombinant C1 Esterase Inhibitor, valued at 0.42 USD Billion in 2023, is emerging rapidly as a viable alternative to traditional therapies, presenting a promising option for patients who require tailored treatments, with expectations of increasing to 0.67 USD Billion by 2032.Blood Plasma Derived Therapies also contribute to the treatment landscape, valued at 0.35 USD Billion in 2023 and anticipated to grow to 0.6 USD Billion by 2032.

    Although this segment holds the smallest share among the treatment types, it remains essential for patients who may not respond well to other therapies. The interplay of these treatment types underscores the significant dynamics within the Hereditary Angioedema Treatment Market, which reflects current advancements and ongoing research aimed at providing better management solutions.The market is witnessing trends driven by an increase in awareness, the prevalence of hereditary angioedema, and advancements in biotechnology.

    There are considerable opportunities for market growth owing to the continuous development of innovative therapies and enhanced patient access to treatments. Challenges persist, however, mostly around the pricing and reimbursement landscape which can affect patient access to necessary therapies. Overall, as the landscape evolves, the Hereditary Angioedema Treatment Market remains well-poised for sustained growth, marked by innovation and an increasing understanding of treatment efficacy and safety.

    Hereditary Angioedema Treatment Market Route of Administration Insights  

    The Hereditary Angioedema Treatment Market is projected to be valued at 2.12 USD Billion in 2023, showcasing robust growth in the healthcare sector focused on hereditary conditions. The market segmentation based on Route of Administration plays a crucial role in this expansion, encompassing methods such as Intravenous, Subcutaneous, and Oral. Among these, Intravenous administration often leads in preference due to its rapid onset of action, making it essential for acute treatment scenarios where immediate response is critical, thus highlighting its significance in emergency situations.

    Subcutaneous administration is growing increasingly popular, providing patients with greater convenience and ease of use, contributing to adherence to treatment protocols. The Oral route is valued for its non-invasive approach, making it a favorable option for long-term management.

    The diversity in Route of Administration underlines the importance of tailored treatment approaches, accommodating various patient needs and preferences while driving market growth. As of 2024, the market statistics indicate a steady rise in demand across these routes, suggesting that addressing diverse administration preferences will continue to be a driving factor for the industry.This alignment with patient-centric approaches offers substantial opportunities for innovation and market penetration.

    Hereditary Angioedema Treatment Market Patient Age Group Insights  

    In 2023, the Hereditary Angioedema Treatment Market is valued at 2.12 USD Billion, reflecting the growing importance of effective treatment options across various age groups. The market segmentation by Patient Age Group reveals distinct dynamics, with Pediatric, Adult, and Geriatric populations all requiring tailored therapeutic approaches. The Pediatric segment is crucial as early diagnosis and intervention can significantly improve health outcomes, making it a vital focus area for treatment strategies.

    Adults represent a significant portion of the market, often facing severe symptoms that necessitate ongoing management, thereby driving demand for advanced treatments.The Geriatric age group is also increasingly relevant due to the challenges of managing hereditary angioedema alongside comorbidities, highlighting the need for specialized therapies.

    As the Hereditary Angioedema Treatment Market continues to evolve, understanding the unique needs of each age group becomes paramount for stakeholders. The market growth is supported by advancements in medical research, increasing awareness among healthcare providers, and the development of new treatments tailored to these specific demographics, which collectively enhance the Hereditary Angioedema Treatment Market revenue and statistics.

    Hereditary Angioedema Treatment Market Diagnosis Type Insights  

    The Hereditary Angioedema Treatment Market, focusing on the Diagnosis Type segment, has portrayed a robust landscape with significant value attributed to its various categories. In 2023, the overall market was valued at approximately 2.12 billion USD, reflecting the increasing awareness and diagnosis of hereditary angioedema disorders. Among the different types, Congenital Hereditary Angioedema is notably prominent, as it is a genetic condition requiring ongoing management, thereby bolstering the market growth.

    Moreover, Acquired Hereditary Angioedema has gained attention due to its varied etiology and potential underlying conditions, contributing to a substantial share in the market.Moreover, Idiopathic Angioedema has emerged as a significant concern, presenting challenges in diagnosis and treatment, which are driving further research and development initiatives.

    The increasing prevalence of these conditions and advancements in diagnostic technologies are acting as primary growth drivers, alongside the ongoing demand for effective therapeutic solutions. Nevertheless, challenges such as diagnosis complexities and limited awareness in some regions may hinder market expansion. Overall, the Hereditary Angioedema Treatment Market data illustrates a favorable trend, supported by a constant need for improved treatment strategies across these diagnosis types.

    Get more detailed insights about Hereditary Angioedema Treatment Market Research Report — Global Forecast till 2034

    Regional Insights

    The Hereditary Angioedema Treatment Market is showing notable regional variances in market valuation and dynamics. In 2023, North America led the market with a valuation of 1.08 USD Billion, expected to grow to 1.85 USD Billion by 2032, underscoring its majority holding within the industry. Europe follows, with a market value of 0.75 USD Billion in 2023, predicted to reach 1.2 USD Billion in 2032, indicating its significant role in the treatment landscape.

    The APAC region, while currently valued at 0.23 USD Billion, is anticipated to expand to 0.45 USD Billion, reflecting a growing awareness and treatment adoption in hereditary angioedema.South America and MEA represent the smaller segments of the market, valued at 0.03 USD Billion each in 2023, with minor increases expected. Despite their lower market figures of 0.07 USD Billion and 0.05 USD Billion in 2032 respectively, they present opportunities for growth as healthcare infrastructure develops.

    The variation in market size across these regions reflects disparities in healthcare access, industry growth, and treatment availability, thus impacting the Hereditary Angioedema Treatment Market data and statistics across different geographical landscapes.

    Hereditary Angioedema Treatment Market Regional Insights

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Key Players and Competitive Insights

    The Hereditary Angioedema Treatment Market is witnessing significant competitive dynamics as key players strive to offer effective solutions for managing this rare genetic condition characterized by recurrent episodes of swelling. The market landscape has been shaped by the increasing prevalence of hereditary angioedema, heightened awareness among healthcare professionals, and advancements in treatment options. Companies are focusing on innovative therapies, including prophylactic treatments and on-demand therapies, to enhance patient outcomes.

    The emergence of novel biologics and targeted therapies is revolutionizing treatment paradigms, leading to stiff competition among established and emerging players. Furthermore, collaborations, partnerships, and strategic alliances are becoming more prevalent as organizations seek to tap into complementary capabilities to bolster their market positioning.

    Ionis Pharmaceuticals is recognized for its robust pipeline focused on RNA-targeted therapeutic modalities, which has allowed it to establish a formidable presence in the Hereditary Angioedema Treatment Market.

    The company leverages its expertise in antisense technology to develop therapies aimed at addressing the underlying genetic causes of hereditary angioedema. One of the key strengths of Ionis Pharmaceuticals lies in its ability to target specific molecular pathways associated with the disease, resulting in potentially groundbreaking treatment options that could offer significant benefits to patients. Furthermore, its commitment to research and development ensures a continuous flow of innovative products, enhancing its competitive edge in a market that demands effective and safe therapeutic alternatives.

    The company’s reputation for scientific excellence and its strategic focus on unmet medical needs further bolster its standing within the industry.Pfizer has carved out a strong niche within the Hereditary Angioedema Treatment Market, driven by its dedication to improving patient care through effective therapeutic solutions.

    The company’s wide-ranging portfolio and extensive experience in the biotechnology sector give it a competitive advantage, enabling it to offer comprehensive treatment options for hereditary angioedema. Pfizer's commitment to research and development is reflected in its robust clinical pipeline, which aims to deliver innovative therapies targeting various manifestations of the disease.

    Additionally, its established relationships with healthcare providers and payers enhance access to its products, ensuring broader market penetration. Pfizer’s reputation for quality and reliability, combined with its agile approach to market needs, positions it favorably against competitors, allowing for sustained growth and influence within this specialized therapeutic landscape.

    Key Companies in the Hereditary Angioedema Treatment Market market include

    Industry Developments

    • Q2 2025: World Hereditary Angioedema Day: New drug approvals expand treatment options In May 2025, garadacimab, a new long-term prophylactic treatment for hereditary angioedema, became available in Austria, allowing patients to self-administer the drug using a pen. The approval of donidalorsen as another treatment option is expected in the coming months, further expanding choices for patients who have not responded to previous therapies.

    Future Outlook

    Hereditary Angioedema Treatment Market Future Outlook

    The Hereditary Angioedema Treatment Market is projected to grow at a 5.73% CAGR from 2024 to 2035, driven by advancements in therapies, increased awareness, and enhanced diagnostic capabilities.

    New opportunities lie in:

    • Develop novel biologics targeting specific angioedema pathways.
    • Expand telehealth services for remote patient management.
    • Invest in educational programs to raise awareness among healthcare providers.

    By 2035, the market is expected to achieve substantial growth, reflecting enhanced treatment options and increased patient access.

    Market Segmentation

    Hereditary Angioedema Treatment Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Hereditary Angioedema Treatment Market Diagnosis Type Outlook

    • Acquired Hereditary Angioedema
    • Congenital Hereditary Angioedema
    • Idiopathic Angioedema

    Hereditary Angioedema Treatment Market Patient Age Group Outlook

    • Pediatric
    • Adult
    • Geriatric

    Hereditary Angioedema Treatment Market Type of Treatment Outlook

    • C1 Esterase Inhibitor Replacement Therapy
    • Bradykinin B2 Receptor Antagonists
    • Recombinant C1 Esterase Inhibitor
    • Blood Plasma Derived Therapies

    Hereditary Angioedema Treatment Market Route of Administration Outlook

    • Intravenous
    • Subcutaneous
    • Oral

    Report Scope

    Report Attribute/Metric Details
    Market Size 2024    2.37 (USD Billion)
    Market Size 2025    2.51 (USD Billion)
    Market Size 2034    4.14 (USD Billion)
    Compound Annual Growth Rate (CAGR)    5.71 % (2025 - 2034)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2024
    Market Forecast Period 2025 - 2034
    Historical Data 2020 - 2024
    Market Forecast Units USD Billion
    Key Companies Profiled Ionis Pharmaceuticals, Pfizer, H Genzyme, Revance Therapeutics, Eurordis, Baxter, Sobi, Portola Pharmaceuticals, Amgen, Biocryst Pharmaceuticals, ViroPharma, Takeda, CSL Behring, Shire, Sanofi
    Segments Covered Type of Treatment, Route of Administration, Patient Age Group, Diagnosis Type, Regional
    Key Market Opportunities Growing awareness and diagnosis, Innovative therapies and treatments, Expansion in emerging markets, Strategic collaborations and partnerships, Advancements in gene therapy options
    Key Market Dynamics Rising prevalence of HAE, Increasing awareness and diagnosis, Growing demand for effective treatments, Advances in biotechnology, Favorable regulatory environment
    Countries Covered North America, Europe, APAC, South America, MEA

    FAQs

    What is the expected market size of the Hereditary Angioedema Treatment Market by 2034?

    The Hereditary Angioedema Treatment Market is expected to be valued at 4.14 USD Billion by 2034.

    What is the projected CAGR for the Hereditary Angioedema Treatment Market from 2025 to 2034?

    The projected CAGR for the Hereditary Angioedema Treatment Market from 2025 to 2034 is 5.71%.

    Which region is expected to have the largest market share for the Hereditary Angioedema Treatment Market by 2032?

    North America is expected to have the largest market share, valued at 1.85 USD Billion by 2032.

    How much is the Hereditary Angioedema Treatment Market valued at in North America for 2023?

    The market in North America is valued at 1.08 USD Billion in 2023.

    What is the market size for C1 Esterase Inhibitor Replacement Therapy in 2032?

    The market size for C1 Esterase Inhibitor Replacement Therapy is projected to reach 1.4 USD Billion by 2032.

    What is the expected market value for Bradykinin B2 Receptor Antagonists in 2032?

    The expected market value for Bradykinin B2 Receptor Antagonists is 0.8 USD Billion by 2032.

    Who are the major players in the Hereditary Angioedema Treatment Market?

    Major players include Ionis Pharmaceuticals, Pfizer, and Biocryst Pharmaceuticals among others.

    What is the anticipated market size for Recombinant C1 Esterase Inhibitor by 2032?

    The market size for Recombinant C1 Esterase Inhibitor is anticipated to be 0.67 USD Billion by 2032.

    How much is the Hereditary Angioedema Treatment Market valued for Europe in 2023?

    The market for Europe is valued at 0.75 USD Billion in 2023.

    What is the market value for Blood Plasma Derived Therapies in 2032?

    The market value for Blood Plasma Derived Therapies is projected to be 0.6 USD Billion by 2032.

    Report Infographic
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