Bio-Based Platform Chemical Market
November 2023- Enveric Biosciences, a biotechnology company dedicated to the development of novel neuropathogenic small-molecule therapeutics for the treatment of depression, anxiety, and addiction disorders, on November 26 announced the presentation of two posters at the Canadian Chemical Engineering Conference (CSChE 2023) which was held October 29 to November 1, 2023. The first poster, entitled "Biocatalytic production of MDMA and other phenylpropylamine derivatives," presented an alternative process for MDMA production integrating yeast-based bioconversion and biocatalytic steps. First, the Enveric research team achieved the production of milligram quantities of pure compounds in small-scale batch fermentations. The second step of MDMA bioproduction involved transamination and was achieved using a biocatalytic approach, which proved to be more efficient compared with yeast-based conversion. The purified transamination products were converted to methamphetamine derivatives, including MDMA, by chemical reduction and N-methylation. The second poster, entitled "A synthetic biology platform for the production of novel indolethylamine derivatives as drug candidates to treat anxiety and depression," presented bioproduction platforms, which offer an emerging alternative to the traditional chemical synthesis of psychedelic-inspired molecules with a reduced hallucinogenic potential and sustained therapeutic benefits. The presentation described a collection of biosynthetic tools, including known and previously unidentified biocatalysts, enabling the production of >350 indolethylamine derivatives from simple indolic precursors. Collections of enzymes with known activities, including tryptophan synthases, tryptophan decarboxylases (TDCs), halogenases, prenyltransferases, hydroxylases, kinases, N-acetyltransferases, and N-methyltransferases were screened for performance in E. coli and substrate promiscuity. Using the synthetic biology platform, Enveric researchers were able to produce several previously undescribed, wholly novel products with important activities at target receptors.
Key Companies in the Bio-based Platform Chemicals Market include
- Braskem
- GFBiochemicals Ltd
- Reverdia
- GC Innovation America
- Cargill, Incorporated
- Mitsubishi Chemical Corporation
- AVA Biochem AG
- LyondellBasell Industries NV
- Royal DSM NV
- BASF SE
- BioAmber Inc.
- Qingdao Kehai Biochemistry Co., Ltd
- Itaconix PLC
- Braskem