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    Acute Intermittent Porphyria Market

    ID: MRFR/Pharma/3291-HCR
    125 Pages
    Rahul Gotadki
    September 2025

    Acute Intermittent Porphyria Market Research Report Information: By Diagnosis (Blood, Urine, DNA, Serum), Treatment (Gonadotropin-Releasing Hormone Analogues, Prophylactic Hematin Infusions), End User (Hospitals & Clinics, Research Centers) - Forecast till 2032

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    Acute Intermittent Porphyria Market Research Report- Forecast till 2032 Infographic
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    Table of Contents

    Acute Intermittent Porphyria Market Summary

    The Global Acute Intermittent Porphyria Market is projected to grow significantly from 4.61 USD Billion in 2024 to 9.6 USD Billion by 2035.

    Key Market Trends & Highlights

    Acute Intermittent Porphyria Key Trends and Highlights

    • The market is expected to experience a compound annual growth rate (CAGR) of 6.9 percent from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 9.6 USD Billion, indicating robust growth potential.
    • In 2024, the market is valued at 4.61 USD Billion, reflecting the current demand for treatments and management options.
    • Growing adoption of advanced diagnostic techniques due to increased awareness of Acute Intermittent Porphyria is a major market driver.

    Market Size & Forecast

    2024 Market Size 4.61 (USD Billion)
    2035 Market Size 9.6 (USD Billion)
    CAGR (2025-2035) 6.9%

    Major Players

    Alnylam Pharmaceuticals, Recordati Rare Diseases Canada Inc., ACON Laboratories, Inc., Siemens AG, Dahaner, Bio-Rad Laboratories Inc., Sysmex Corporation, Hoffmann-La Roche Ltd, ARKRAY Inc.

    Acute Intermittent Porphyria Market Trends

    Drivers

    A few factors may drive the growth of the acute intermittent porphyria market share. The rising frequency of metabolic illnesses, gastrointestinal concerns, urinary tract issues, and health insurance coverage are driving the expansion of the market. Also, the growing elderly population will boost the market expansion.

    The rising awareness about severe intermittent porphyria and the expansion of the healthcare sector in emerging markets are the primary drivers that fuel the growth of the market. 

    Opportunities

    According to WHO evaluations, neurological diseases account for 4.5 percent -11 percent of all illnesses in poor and high-income countries. This is significantly more than the number of respiratory diseases, gastrointestinal diseases, or malignancies, and the burden is anticipated to grow even more in the future years. This is expected to fuel the acute intermittent porphyria market growth in the forecast years.

    Restraints

    There are a few factors that may hinder the growth of the market value. Some of the factors that may impede the development of the market during the projected period include the availability of pricey treatment and inadequate reimbursement policies in emerging countries of the world. 

    Challenges 

    In emerging regions, common knowledge and insufficient access to excellent healthcare are restricting acceptance. The disorder's asymptomatic form creates delays in diagnosis, limiting uptake in the areas and hindering the acute intermittent porphyria market growth.

    Cumulative Growth Analysis

    The acute intermittent porphyria market is anticipated to grow substantially in the years to come. The severe intermittent porphyria treatment market value is expected to grow at a CAGR of about 5.6%. The rising frequency of metabolic illnesses, gastrointestinal concerns, urinary tract issues, and health insurance coverage are driving the expansion of the market. Also, the growing elderly population will boost the market expansion.

    Value Chain Analysis

    Rapid advances in metabolic diseases diagnosis are expected to drive acute hepatic porphyria market growth. Moreover, increasing regulatory clearances to allow potentially life-saving therapeutic techniques is broadening the scope of the market growth for acute intermittent porphyria. APH treatments benefit greatly from the government's strong support for advanced research, which also fuels market growth in the long run. The rising awareness about severe intermittent porphyria and the expansion of the healthcare sector in emerging markets are the primary drivers that fuel the growth of the market. 

    The increasing recognition of Acute Intermittent Porphyria as a critical health concern is likely to drive advancements in diagnostic methods and therapeutic options, enhancing patient outcomes and awareness.

    National Institutes of Health (NIH)

    Acute Intermittent Porphyria Market Drivers

    Market Growth Projections

    Advancements in Diagnostic Technologies

    Innovations in diagnostic technologies are significantly influencing the Global Acute Intermittent Porphyria Market Industry. Enhanced methods for detecting porphyrin levels and genetic testing have improved the accuracy and speed of diagnosis. For instance, the introduction of next-generation sequencing has allowed for more precise identification of genetic mutations associated with acute intermittent porphyria. As these technologies become more accessible, healthcare providers are better equipped to diagnose and manage the condition, which could lead to an increase in treatment uptake and, consequently, market growth. The integration of these advancements is expected to play a crucial role in shaping the future of the industry.

    Regulatory Support for Treatment Approvals

    Regulatory support plays a pivotal role in the Global Acute Intermittent Porphyria Market Industry. Authorities are increasingly recognizing the need for expedited approval processes for therapies targeting rare diseases, including acute intermittent porphyria. This support facilitates faster access to innovative treatments for patients, thereby enhancing the overall treatment landscape. As regulatory bodies streamline approval pathways, pharmaceutical companies are more likely to invest in developing new therapies, which could lead to a broader range of options for patients. This trend is expected to positively impact market dynamics, fostering growth and improving patient outcomes.

    Rising Awareness and Education Initiatives

    The Global Acute Intermittent Porphyria Market Industry is witnessing growth driven by rising awareness and education initiatives. Organizations dedicated to porphyria are actively working to educate both healthcare professionals and the public about the condition. Increased awareness leads to earlier diagnosis and treatment, which is crucial for managing symptoms and preventing complications. Campaigns and educational programs are being implemented globally, which may contribute to a higher rate of diagnosis and treatment adherence. As awareness continues to grow, the market is likely to expand, reflecting the need for effective management solutions for affected individuals.

    Growing Investment in Research and Development

    The Global Acute Intermittent Porphyria Market Industry is benefiting from increased investment in research and development initiatives. Pharmaceutical companies are focusing on developing novel therapies aimed at alleviating symptoms and preventing attacks associated with acute intermittent porphyria. This trend is reflected in the projected market value, which is expected to reach 4.61 USD Billion in 2024 and 9.6 USD Billion by 2035, indicating a compound annual growth rate of 6.9% from 2025 to 2035. Such investments not only enhance treatment options but also foster collaborations between academic institutions and industry players, further propelling market growth.

    Rising Prevalence of Acute Intermittent Porphyria

    The Global Acute Intermittent Porphyria Market Industry is experiencing growth due to the increasing prevalence of this rare genetic disorder. It is estimated that the incidence rate of acute porphyrias is approximately 1 in 25,000 individuals, with a higher prevalence in certain populations. This rising incidence necessitates the development of targeted therapies and management strategies, thereby driving market expansion. As awareness of the condition grows among healthcare professionals and patients, the demand for diagnostic tools and treatment options is likely to increase, contributing to the overall market growth.

    Market Segment Insights

    Regional Insights

    The regional division of the acute intermittent porphyria market analysis comprises North America, Europe, Asia Pacific, and the rest of the world. The Americas rule over the global acute intermittent porphyria treatment market because of well-developed technology, increased patients with inherited metabolic abnormalities, high healthcare spending, and government funding for research and development. Also, the increased R&D efforts and the concentration of significant corporations have fueled market expansion in this area.

    Because of government support for R&D and the availability of research money, Europe ranks second in the global severe intermittent porphyria market. This is projected to drive the European market for the foreseeable future. Countries such as Germany and France, for example, are expanding their investments in healthcare.

    Because of rapidly increasing healthcare technology, a large patient population, and high healthcare spending, Asia Pacific is the fastest growing acute intermittent porphyria market. Furthermore, the rising demand for innovative treatment approaches in nations such as India and South Korea is expected to make them the world's fastest expanding markets.

    Furthermore, rising demand for high-quality medical devices is expected to enhance the adoption of modern equipment, fueling the expansion of the market in the area. On the other hand, blood disorders have become a major issue throughout the Middle East and Africa due to preliminary screening, disease ignorance, and restricted access to treatment.

    Key Players and Competitive Insights

    The acute intermittent porphyria industry is dominated by a few companies that play a vital role in the market growth. These acute intermittent porphyria treatment services companies are called key companies of the market. They contribute to the largest share of the market profit.

    The companies account for the market profits by adopting various acute intermittent porphyria market trends such as joint ventures, product launches, company expansions, and procurements.

    Key Companies in the Acute Intermittent Porphyria Market market include

    Industry Developments

    • Q2 2024: Alnylam Pharmaceuticals Announces FDA Approval of Supplemental New Drug Application for GIVLAARI® (givosiran) for Expanded Indication in Acute Intermittent Porphyria Alnylam Pharmaceuticals received FDA approval for a supplemental new drug application expanding the indication of GIVLAARI® (givosiran) to include additional patient populations with acute intermittent porphyria, marking a significant regulatory milestone for the company.
    • Q1 2024: Recordati Rare Diseases Announces European Commission Approval of Panhematin® for Acute Intermittent Porphyria Recordati Rare Diseases secured European Commission approval for Panhematin® as a treatment for acute intermittent porphyria, enabling broader access to the therapy across the European Union.
    • Q2 2024: Mitsubishi Tanabe Pharma Launches Phase 3 Clinical Trial of Novel RNAi Therapy for Acute Intermittent Porphyria Mitsubishi Tanabe Pharma initiated a Phase 3 clinical trial to evaluate the safety and efficacy of its investigational RNA interference (RNAi) therapy for patients with acute intermittent porphyria.
    • Q1 2024: Dicerna Pharmaceuticals Announces Strategic Partnership with Rare Disease Foundation to Advance Acute Intermittent Porphyria Research Dicerna Pharmaceuticals entered into a strategic partnership with a leading rare disease foundation to support research and development efforts focused on new therapies for acute intermittent porphyria.
    • Q3 2024: Alnylam Pharmaceuticals Appoints New Chief Medical Officer to Lead Rare Disease Portfolio Alnylam Pharmaceuticals appointed a new Chief Medical Officer to oversee its rare disease portfolio, including the acute intermittent porphyria program, as part of its executive leadership expansion.
    • Q2 2025: Recordati Rare Diseases Opens New Manufacturing Facility for Porphyria Treatments in Europe Recordati Rare Diseases inaugurated a new manufacturing facility in Europe dedicated to the production of treatments for acute intermittent porphyria, aiming to increase supply and improve distribution efficiency.
    • Q1 2025: Alnylam Pharmaceuticals Announces $150 Million Follow-on Public Offering to Fund Rare Disease Pipeline Alnylam Pharmaceuticals completed a $150 million follow-on public offering to support the continued development and commercialization of its rare disease pipeline, including therapies for acute intermittent porphyria.
    • Q2 2024: Mitsubishi Tanabe Pharma Receives Orphan Drug Designation from FDA for AIP Therapy Mitsubishi Tanabe Pharma was granted orphan drug designation by the U.S. FDA for its investigational therapy targeting acute intermittent porphyria, providing regulatory incentives for further development.
    • Q3 2024: Recordati Rare Diseases Signs Distribution Agreement with Major European Specialty Pharmacy for AIP Treatments Recordati Rare Diseases entered into a distribution agreement with a major European specialty pharmacy to expand access to its acute intermittent porphyria treatments across multiple countries.
    • Q1 2025: Alnylam Pharmaceuticals and Moderna Announce Collaboration to Develop mRNA-based Therapy for Acute Intermittent Porphyria Alnylam Pharmaceuticals and Moderna announced a collaboration to co-develop an mRNA-based therapy for acute intermittent porphyria, combining Alnylam's rare disease expertise with Moderna's mRNA technology.
    • Q2 2025: Mitsubishi Tanabe Pharma Expands Global Clinical Trial Sites for AIP Therapy to North America and Asia Mitsubishi Tanabe Pharma expanded its global clinical trial network for its acute intermittent porphyria therapy, adding new sites in North America and Asia to accelerate patient recruitment and data collection.
    • Q2 2024: Dicerna Pharmaceuticals Raises $80 Million in Series C Financing to Advance AIP Drug Candidate Dicerna Pharmaceuticals secured $80 million in Series C financing to support the clinical development of its lead drug candidate for acute intermittent porphyria.

    Future Outlook

    Acute Intermittent Porphyria Market Future Outlook

    The Global Acute Intermittent Porphyria Market is projected to grow at a 6.9% CAGR from 2024 to 2035, driven by advancements in diagnostics, increased awareness, and novel therapeutic developments.

    New opportunities lie in:

    • Develop targeted gene therapies to address underlying genetic causes of Acute Intermittent Porphyria.
    • Expand telemedicine services for remote patient monitoring and management.
    • Invest in educational programs to raise awareness among healthcare professionals and patients.

    By 2035, the market is expected to exhibit robust growth, reflecting enhanced treatment options and improved patient outcomes.

    Market Segmentation

    Acute Intermittent Porphyria Regional Outlook

    North America
    • US
    • Canada

    Acute Intermittent Porphyria End-user Outlook

    • Hospitals & clinics
    • Medical research centers
    • Others

    Acute Intermittent Porphyria Diagnosis Outlook

    • Urine Test
    • Blood test
    • Serum test
    • DNA test
    • Others

    Acute Intermittent Porphyria Treatment Outlook

    • Prophylactic Hematin Infusions
    • Gonadotropin-Releasing Hormone Analogues
    • Others

    Report Scope

    Report Attribute/Metric Details
    Market Size 2023 4.35 (USD Billion)
    Market Size 2024 4.61 (USD Billion)
    Market Size 2032 7.34 (USD Billion)
    Compound Annual Growth Rate (CAGR) 6.9 % (2024 - 2032)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2023
    Market Forecast Period 2024 - 2032
    Historical Data 2019 - 2023
      Geographies Covered   North America, Europe, Asia-Pacific, and Rest of the World (RoW)
      Key Vendors Dahaner (U.S.), F. Hoffmann-La Roche Ltd (Switzerland), Bio-Rad Laboratories, Inc.  (U.S.), Siemens AG (U.S.), ARKRAY, Inc. (Japan), Sysmex Corporation (Japan), and ACON Laboratories, Inc. (U.S.)
      Key Market Opportunities Develop innovative diagnostic tools and tests for the early and accurate detection of AIP.
      Key Market Drivers Increased awareness campaigns and patient advocacy efforts may lead to earlier detection of AIP and greater demand for treatment options.

    Market Highlights

    Author
    Rahul Gotadki
    Assistant Manager

    He holds an experience of about 7+ years in Market Research and Business Consulting, working under the spectrum of Life Sciences and Healthcare domains. Rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. His expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. In addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives

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    FAQs

    What is acute Intermittent Porphyria?

    Acute intermittent porphyria (AIP) is a genetic metabolic disorder. It affects the production of heme, the oxygen-binding prosthetic group of hemoglobin. Generally, it is characterized by a deficiency of the enzyme porphobilinogen deaminase.

    What is the CAGR of Global Acute Intermittent Porphyria Market?

    The market is expected to exhibit a strong 6.90% CAGR over the forecast period from 2024 to 2032.

    What is the major driver for the Acute Intermittent Porphyria Market?

    The growing awareness about porphyria and growth of the healthcare sector in emerging countries are the major drivers for the acute intermittent porphyria market.

    Which is the Leading Regional Acute Intermittent Porphyria Market?

    The Americas hold a dominant 44% share in the global market.

    What are the leading Acute Intermittent Porphyria Market Players?

    Leading players in the acute intermittent porphyria market include Danaher, Bio-Rad Laboratories, and ARKRAY, among others.

    1.  Table of Content    
    2.     Report
    3. Prologue    
    4.     Market Introduction  
      1.     Definition    
    5.  Scope of the Study    
      1.     Research
    6. Objective    
      1.     Assumptions  
        1.     Limitations    
    7.  Research Methodology
      1.     Introduction
    8.  Primary Research    
      1.     Secondary research  
      2.     Market Size Estimation
    9.     Market
    10. Dynamics
      1.     Drivers    
    11.  Restrains
      1.     Opportunities    
    12.  Challenges
      1.     Macroeconomic Indicators
    13.  Technology Trends & Assessment          
    14.     Market Factor Analysis
      1.     Porters
    15. Five Forces Analysis
      1.     Bargaining Power of Suppliers  
        1.     Bargaining Power of Buyers
    16.  Threat of New Entrants    
      1.     Threat
    17. of Substitutes    
      1.     Intensity of Rivalry  
      2.     Value Chain Analysis
      3.     Investment
    18. Feasibility Analysis    
      1.     Pricing Analysis
    19.     Global Acute Intermittent Porphyria Market, by Diagnosis
    20.      6.1    Introduction
    21.  Blood Test 
      1.     Market Estimates & Forecast,
      2.     Urine Test
        1.     Market
    22. Estimates & Forecast, 2020-2027
      1.     Serum Test
    23.  Market Estimates & Forecast, 2020-2027
      1.     DNA
    24. test
      1.     Market Estimates & Forecast, 2020-2027
    25.     Global Acute Intermittent Porphyria Market, by Treatment
    26.      7.1    Introduction
    27.  Gonadotropin-Releasing Hormone Analogues
      1.     Market
    28. Estimates & Forecast, 2020-2027
      1.     Prophylactic Hematin
    29. Infusions
      1.     Market Estimates & Forecast, 2020-2027
    30.     Global Acute Intermittent Porphyria Market, by End User
      1.     Introduction
      2.     Hospitals &
    31. Clinics
      1.     Market Estimates & Forecast, 2020-2027
      2.     Research centers
        1.     Market Estimates
    32. & Forecast, 2020-2027
    33.     Global Acute Intermittent Porphyria
    34. Market, by Region
      1.     Introduction
      2.     Americas
        1.     North America
    35.  Canada
      1.     South America
      2.     Europe
        1.     Western Europe
    36.  Italy
      1.     Spain
        1.     Rest
    37. of Western Europe
      1.     Eastern Europe
    38.  Asia Pacific
      1.     Japan
        1.     China
        2.     India
        3.     Australia
    39.  Republic of Korea
      1.     Rest of Asia Pacific
    40.  The Middle East & Africa
      1.     United Arab Emirates
        1.      Saudi Arabia
        2.     Oman
    41.  Kuwait
      1.     Qatar
        1.     Rest
    42. of the Middle East & Africa
    43.     Company Landscape  
      1.     Introduction    
    44.  Market Share Analysis    
      1.     Key Development
    45. & Strategies    
      1.     Key Developments  
    46.     Company Profiles    
    47.  Dahaner Corporation
      1.     Company Overview  
        1.     Product Overview    
    48.  Financials    
      1.     SWOT Analysis  
      2.     F. Hoffmann-La Roche Ltd
    49.  Company Overview    
      1.     Product
    50. Overview    
      1.     Financial Overview  
        1.     Key Developments    
    51.  SWOT Analysis    
      1.     Bio-Rad Laboratories,
    52. Inc    
      1.     Company Overview  
        1.     Product Overview    
    53.  Financial Overview
      1.     Key Development  
        1.     SWOT Analysis    
    54.   Siemens AG
      1.     Company Overview    
        1.     Product/Business Segment Overview    
        2.     Financial Overview    
    55.  Key Development    
      1.     SWOT Analysis  
      2.     ARKRAY, Inc.
        1.     Company
    56. Overview    
      1.     Product Overview  
        1.     Financial overview    
    57.  Key Developments    
      1.     Sysmex Corporation
        1.     Company Overview    
    58.  Product Overview    
      1.     Financial
    59. Overview    
      1.     Key Developments  
      2.     ACON Laboratories, Inc
    60.  Overview    
      1.     Product Overview  
        1.     Financials    
    61.  Key Developments    
      1.     SWOT Analysis  
    62.     11.8    Others
    63.  MRFR Conclusion    
      1.     Key Findings  
        1.     From CEO’s View Point    
        2.     Unmet Needs of the Market    
    64.  Key Companies to Watch    
      1.     Prediction
    65. of Pharmaceutical Industry
    66.     Appendix
    67. Industry Synopsis, 2020-2027
    68. Acute Intermittent Porphyria Market Estimates and Forecast, 2020-2027, (USD Million)
    69. Market by Region, 2020-2027, (USD Million)
    70.  Global Acute Intermittent Porphyria Market by Diagnosis, 2020-2027, (USD Million)
    71. Market by Treatment, 2020-2027, (USD Million)
    72.  Global Acute Intermittent Porphyria Market by End Users, 2020-2027, (USD Million)
    73. Porphyria Market by Diagnosis, 2020-2027, (USD Million)
    74.      North America Acute Intermittent Porphyria Market by Treatment,
    75. 2027, (USD Million)
    76. America Acute Intermittent Porphyria Market by End Users, 2020-2027, (USD Million)
    77. 2027, (USD Million)
    78. Market by Treatment, 2020-2027, (USD Million)
    79. Acute Intermittent Porphyria Market by End Users, 2020-2027, (USD Million)
    80.     Canada Acute Intermittent Porphyria Market by Diagnosis, 2020-2027,
    81. (USD Million)
    82. Market by Treatment, 2020-2027, (USD Million)
    83. Acute Intermittent Porphyria Market by End Users, 2020-2027, (USD Million)
    84.     South America Acute Intermittent Porphyria Market by Diagnosis,
    85. 2027, (USD Million)
    86. Porphyria Market by Treatment, 2020-2027, (USD Million)
    87.  South America Acute Intermittent Porphyria Market by End Users, 2020-2027,
    88. (USD Million)
    89. Market by Diagnosis, 2020-2027, (USD Million)
    90. Acute Intermittent Porphyria Market by Treatment, 2020-2027, (USD Million)
    91.     Europe Acute Intermittent Porphyria Market by End Users, 2020-2027,
    92. (USD Million)
    93. Porphyria Market by Diagnosis, 2020-2027, (USD Million)
    94.  Western Europe Acute Intermittent Porphyria Market by Treatment, 2020-2027,
    95. (USD Million)
    96. Porphyria Market by End Users, 2020-2027, (USD Million)
    97.  Eastern Europe Acute Intermittent Porphyria Market by Diagnosis, 2020-2027,
    98. (USD Million)
    99. Porphyria Market by Treatment, 2020-2027, (USD Million)
    100.  Eastern Europe Acute Intermittent Porphyria Market by End Users, 2020-2027,
    101. (USD Million)
    102. Market by Diagnosis, 2020-2027, (USD Million)
    103. Pacific Acute Intermittent Porphyria Market by Treatment, 2020-2027, (USD Million)
    104. End Users, 2020-2027, (USD Million)
    105. & Africa Acute Intermittent Porphyria Market by Diagnosis, 2020-2027, (USD Million)
    106. Market by Treatment, 2020-2027, (USD Million)
    107. East & Africa Acute Intermittent Porphyria Market by End Users, 2020-2027, (USD
    108. Million)
    109. Market
    110. Porphyria Market
    111. Market Share, by Diagnosis 2020
    112. Porphyria Market Share, by Treatment 2020
    113. Acute Intermittent Porphyria Market Share, by End Users, 2020
    114.  Global Acute Intermittent Porphyria Market Share, by Region, 2020
    115.     North America Acute Intermittent Porphyria Market Share, by
    116. Country, 2020
    117. Market Share, by Country, 2020
    118. Intermittent Porphyria Market Share, by Country, 2020
    119.  Middle East & Africa Acute Intermittent Porphyria Market Share, by Country,
    120. Company Share Analysis, 2020 (%)
    121. Key Financials
    122. Revenue
    123.     F. Hoffmann-La Roche Ltd: Segmental Revenue
    124.  F. Hoffmann-La Roche Ltd: Geographical Revenue
    125.  Bio-Rad Laboratories, Inc: Key Financials
    126. Laboratories, Inc: Segmental Revenue
    127. Inc: Geographical Revenue
    128.  Siemens AG: Geographical Revenue
    129. Inc..: Key Financials
    130.  Sysmex Corporation: Key Financials
    131. Corporation: Segmental Revenue
    132. Geographical Revenue
    133. Financials

    Acute Intermittent Porphyria Market Segmentation

    Market Segmentation Overview

    • Detailed segmentation data will be available in the full report
    • Comprehensive analysis by multiple parameters
    • Regional and country-level breakdowns
    • Market size forecasts by segment
    Acute Intermittent Porphyria Market Research Report- Forecast till 2032 Infographic
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