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    US RNA-Based Therapeutics Market

    ID: MRFR/HC/51011-HCR
    128 Pages
    Garvit Vyas
    September 2025

    US RNA-Based Therapeutics Market Research Report By Technology (RNA Interference, Antisense Oligonucleotides, mRNA Therapeutics, CRISPR Technology), By Application (Oncology, Infectious Diseases, Genetic Disorders, Cardiovascular Diseases), By End Use (Pharmaceutical Companies, Research Institutions, Contract Research Organizations) and By Delivery Method (Liposomes, Nanoparticles, Viral Vectors, Electroporation) - Forecast to 2035

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    US RNA-Based Therapeutics Market Research Report — Global Forecast till 2035 Infographic
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    Table of Contents

    US RNA-Based Therapeutics Market Summary

    The US RNA-Based Therapeutics market is projected to grow from 1.8 USD Billion in 2024 to 6.5 USD Billion by 2035.

    Key Market Trends & Highlights

    US RNA-Based Therapeutics Key Trends and Highlights

    • The market is expected to experience a compound annual growth rate (CAGR) of 12.38% from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 6.5 USD Billion, indicating robust growth potential.
    • In 2024, the market is valued at 1.8 USD Billion, reflecting the increasing interest in RNA-based therapies.
    • Growing adoption of RNA-based therapeutics due to advancements in gene editing technologies is a major market driver.

    Market Size & Forecast

    2024 Market Size 1.8 (USD Billion)
    2035 Market Size 6.5 (USD Billion)
    CAGR (2025-2035) 12.38%

    Major Players

    CureVac, BioNTech, Alnylam Pharmaceuticals, Ionis Pharmaceuticals, Regeneron Pharmaceuticals, Moderna, Sangamo Therapeutics, Pfizer, Novartis, Sanofi, Intellia Therapeutics, Vertex Pharmaceuticals, Wave Life Sciences, Translate Bio, Arcturus Therapeutics

    US RNA-Based Therapeutics Market Trends

    The US RNA-Based Therapeutics Market is experiencing significant growth, driven by the increasing incidence of genetic disorders and the rising demand for more effective treatment options. One of the key drivers in this market is the advancement in RNA technology, particularly in messenger RNA (mRNA) therapeutics, which has gained immense popularity following the success of mRNA vaccines during the COVID-19 pandemic.

    This technological evolution not only provides new avenues for personalized medicine but also enhances the development of targeted therapies for various diseases. Additionally, federal support through initiatives and funding from public health agencies is bolstering research and development activities in this sector, contributing to its rapid expansion.

    There are considerable opportunities to be explored in the US RNA-Based Therapeutics Market, especially in the fields of cancer treatment and rare diseases. The ongoing research into RNA interference (RNAi) and antisense oligonucleotides presents promising avenues for innovation. Furthermore, collaborations between biotech firms and research institutions are likely to yield new therapeutics and delivery methods.

    The evolving regulatory landscape in the US, along with accelerated approval pathways for RNA-based therapies, represents another opportunity that can be effectively captured by stakeholders in the market. Recently, the trend has shifted towards increasing investments in RNA-based platforms, as more companies seek to develop RNA therapeutics beyond vaccines.

    Several pharmaceutical companies are now investing in manufacturing processes that enhance the scalability and efficiency of nucleotide production. The rise of patient-centric approaches and the focus on precision medicine further emphasize the need for continued innovation in RNA therapeutics. As the US market continues to adapt and grow, ongoing advancements are expected to mark a transformative period for RNA-based treatments, promoting better health outcomes across various patient populations.

    US RNA-Based Therapeutics Market Drivers

    Market Segment Insights

    RNA-Based Therapeutics Market Technology Insights

    The Technology segment of the US RNA-Based Therapeutics Market is characterized by significant advancements and a diverse array of applications that demonstrate the potential of RNA technologies in treating various diseases. RNA Interference has emerged as a dominant force in the market, allowing for targeted gene silencing, which is crucial in addressing genetic disorders and reducing the prevalence of certain diseases.

    The ability to specifically inhibit gene expression not only has therapeutic implications but also provides a powerful tool in Research and Development studies for understanding gene functions. Antisense Oligonucleotides have garnered attention for their efficacy in modulating gene expression and are often used in the treatment of neurological conditions and rare genetic disorders.

    The ability to design these oligonucleotides to target the specific RNA sequence makes them an invaluable asset in tailoring personalized medicine approaches. mRNA Therapeutics have revolutionized treatment paradigms, especially highlighted during the recent pandemic with mRNA vaccines showcasing their rapid development capabilities. These technologies enable the delivery of genetic information into cells efficiently, generating an immune response or producing therapeutic proteins necessary for disease management.

    Furthermore, CRISPR Technology has redefined gene editing by providing precise and versatile tools for modifying genomes, which is essential for treating genetic disorders and advancing therapies in various fields such as oncology and agriculture. As the market evolves, these technologies drive innovation, presenting new opportunities while also facing challenges related to regulatory frameworks and ethical considerations.

    The growth of these segments within the US RNA-Based Therapeutics Market illustrates the dynamic interplay of scientific progress and clinical application, underscoring the transformative potential of RNA-based solutions in healthcare.

    RNA-Based Therapeutics Market Application Insights

    The US RNA-Based Therapeutics Market is rapidly evolving, with significant advancements in various applications including Oncology, Infectious Diseases, Genetic Disorders, and Cardiovascular Diseases. The demand for RNA-based treatments in Oncology is particularly strong due to the rising prevalence of cancer, driving research towards targeted therapies that improve patient outcomes. Infectious Diseases have also seen a surge in interest, especially highlighted by the recent global health crises, prompting the development of RNA therapies for efficient vaccine design and rapid responses.

    Genetic Disorders represent another critical area, as RNA technology holds promise for addressing previously untreatable conditions by targeting gene expression and providing innovative solutions. Cardiovascular Diseases, among the leading causes of mortality in the US, benefit from RNA-based approaches aimed at gene regulation and potential interventions. Each of these applications showcases a significant opportunity within the US RNA-Based Therapeutics Market, underpinned by ongoing research and development initiatives aimed at harnessing RNA technology to treat complex health challenges effectively.

    As the market progresses, these applications are likely to play a pivotal role in shaping the future of therapeutic interventions in the healthcare landscape.

    RNA-Based Therapeutics Market End Use Insights

    The US RNA-Based Therapeutics Market is seeing a considerable shift within its End Use segment, primarily influenced by the demand from Pharmaceutical Companies, Research Institutions, and Contract Research Organizations. Pharmaceutical Companies play a significant role in the development and commercialization of RNA-based therapies, often focusing on innovative treatment solutions that address critical medical needs. Research Institutions are crucial for advancing RNA technology and conducting essential studies that contribute to knowledge creation in this dynamic field.

    These institutions often collaborate with pharmaceutical firms, facilitating the translation of research into practical applications. Contract Research Organizations provide essential services that support both pharmaceutical companies and research institutions, enabling efficiency in clinical trials and regulatory processes. Their prominence in this market stems from the increasing complexity of drug development, requiring specialized expertise and resources. As the US government continues to invest in healthcare innovation, the entire RNA-based therapeutics ecosystem is poised for growth, fueled by advances in genetic research and personalized medicine.

    This segment's contributions are vital for driving market trends and enhancing patient outcomes across various therapeutic areas.

    RNA-Based Therapeutics Market Delivery Method Insights

    The Delivery Method segment of the US RNA-Based Therapeutics Market is crucial for the effective transport of therapeutic agents to target cells. Various techniques are utilized within this segment, including Liposomes, Nanoparticles, Viral Vectors, and Electroporation, each with its unique advantages. Liposomes often increase the stability and bioavailability of RNA-based drugs, enhancing their therapeutic efficacy. Nanoparticles are valued for their ability to facilitate cellular uptake and enable targeted delivery, overcoming barriers often faced by traditional delivery methods.

    Viral Vectors leverage the natural ability of viruses to deliver genetic material into cells, making them a powerful tool for gene therapy. Electroporation employs electric fields to enhance cell permeability, allowing for more efficient delivery of RNA molecules. The growth in this segment is supported by increasing investments in innovative drug delivery technologies and advances in Research and Development. Continued focus on improving delivery efficiency and patient outcomes indicates promising opportunities within the US RNA-Based Therapeutics Market, further emphasizing the significance of the Delivery Method segment in shaping future therapeutic landscapes.

    Get more detailed insights about US RNA-Based Therapeutics Market Research Report — Global Forecast till 2035

    Regional Insights

    Key Players and Competitive Insights

    The US RNA-Based Therapeutics Market has experienced a surge in innovation and competition, reflecting the growing significance of RNA technologies in drug development. This market encompasses a range of therapeutic modalities that utilize RNA as a central component in targeting diseases, particularly genetic disorders, cancers, and infectious diseases. Increasing investments from both public and private sectors, advancements in delivery mechanisms, and a favorable regulatory environment have contributed to the rapid growth of this market.

    Companies operating within this space have been focusing on developing novel therapeutics that leverage messenger RNA (mRNA), small interfering RNA (siRNA), and other RNA-based platforms to address unmet medical needs. As the landscape evolves, understanding the competitive dynamics among key players will be essential for stakeholders looking to navigate this promising market.

    CureVac has positioned itself as a notable player in the US RNA-Based Therapeutics Market, particularly with its focus on mRNA technology to develop innovative vaccines and therapeutics. The company’s strength lies in its proprietary mRNA technology platform, which is designed to enable the creation of a diverse range of treatments, including those for oncology and infectious diseases. CureVac has established a strong presence in the US through strategic collaborations with various biopharmaceutical firms and research institutions, allowing it to leverage additional expertise and resources.

    The company’s focus on achieving high efficacy and safety profiles in its RNA-based therapeutics has garnered attention from both investors and healthcare professionals, contributing to its continued growth and innovation in this competitive arena. BioNTech has emerged as a leading force in the US RNA-Based Therapeutics Market, particularly noted for its breakthrough mRNA therapies and vaccines. The company gained significant recognition with its rapid development of an mRNA-based COVID-19 vaccine, showcasing the potential of RNA technologies in responding to urgent public health challenges.

    BioNTech's strength lies not only in its cutting-edge scientific capabilities but also in its established partnerships with major pharmaceutical companies, enhancing its development and commercialization efforts in the US market. The company continues to expand its pipeline, targeting various therapeutic areas such as oncology and autoimmune diseases, providing a robust array of products that cater to diverse patient populations. BioNTech's strategic mergers and acquisitions have also enabled it to bolster its capabilities in RNA science, thereby reinforcing its competitive position in the US RNA-Based Therapeutics Market and ensuring a strong foothold as the landscape continues to evolve.

    Key Companies in the US RNA-Based Therapeutics Market market include

    Industry Developments

    The US RNA-Based Therapeutics Market has seen significant developments recently. Companies like Moderna and BioNTech continue to expand their mRNA technology beyond vaccines, focusing on treatments for a range of diseases, including cancer and rare genetic disorders. In November 2023, Alnylam Pharmaceuticals announced promising results from a Phase III trial for its RNA interference therapy, which has fueled investor interest and boosted its market valuation significantly.

    In terms of mergers and acquisitions, in September 2023, Sanofi completed the acquisition of Translate Bio, enhancing its capabilities in mRNA technology for therapeutic applications. Additionally, in October 2023, Pfizer announced a partnership with BioNTech to develop combined RNA-based therapies that target infectious diseases, reflecting a growing trend towards collaboration in this sector. Government initiatives are also supporting the RNA therapeutics field, with recent funding allocated for Research and Development in genetic medicine.

    Over the past few years, the US market's momentum has accelerated, fueled by an increased focus on personalized medicine and innovations in delivery systems for RNA-based drugs. With ongoing advancements and strategic collaborations, the outlook for the US RNA-Based Therapeutics Market remains robust.

    Market Segmentation

    RNA-Based Therapeutics Market End Use Outlook

    • Pharmaceutical Companies
    • Research Institutions
    • Contract Research Organizations

    RNA-Based Therapeutics Market Technology Outlook

    • RNA Interference
    • Antisense Oligonucleotides
    • mRNA Therapeutics
    • CRISPR Technology

    RNA-Based Therapeutics Market Application Outlook

    • Oncology
    • Infectious Diseases
    • Genetic Disorders
    • Cardiovascular Diseases

    RNA-Based Therapeutics Market Delivery Method Outlook

    • Liposomes
    • Nanoparticles
    • Viral Vectors
    • Electroporation

    Report Scope

    Report Attribute/Metric Details
    Market Size 2023 1.62(USD Billion)
    Market Size 2024 2.0(USD Billion)
    Market Size 2035 6.5(USD Billion)
    Compound Annual Growth Rate (CAGR) 11.31% (2025 - 2035)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2024
    Market Forecast Period 2025 - 2035
    Historical Data 2019 - 2024
    Market Forecast Units USD Billion
    Key Companies Profiled CureVac, BioNTech, Alnylam Pharmaceuticals, Ionis Pharmaceuticals, Regeneron Pharmaceuticals, Moderna, Sangamo Therapeutics, Pfizer, Novartis, Sanofi, Intellia Therapeutics, Vertex Pharmaceuticals, Wave Life Sciences, Translate Bio, Arcturus Therapeutics
    Segments Covered Technology, Application, End Use, Delivery Method
    Key Market Opportunities Increasing demand for gene therapies, Advancements in RNA delivery systems, Growing prevalence of genetic disorders, Rise in personalized medicine approaches, Expanding investment in biotech innovation
    Key Market Dynamics Increasing prevalence of genetic disorders, Advancements in delivery technologies, Growing investment in R&D, Regulatory support for innovation, Rising patient awareness and demand
    Countries Covered US

    Market Highlights

    Author
    Garvit Vyas
    Analyst

    Explore the profile of Garvit Vyas, one of our esteemed authors at Market Research Future, and access their expert research contributions in the field of market research and industry analysis

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    FAQs

    What is the expected market size of the US RNA-Based Therapeutics Market in 2024?

    The US RNA-Based Therapeutics Market is expected to be valued at 2.0 billion USD in 2024.

    What is the projected market value of the US RNA-Based Therapeutics Market by 2035?

    By 2035, the US RNA-Based Therapeutics Market is anticipated to reach a value of 6.5 billion USD.

    What is the expected CAGR for the US RNA-Based Therapeutics Market between 2025 to 2035?

    The US RNA-Based Therapeutics Market is expected to grow at a CAGR of 11.31% from 2025 to 2035.

    Who are the key players in the US RNA-Based Therapeutics Market?

    Major players in the market include CureVac, BioNTech, Alnylam Pharmaceuticals, and Moderna, among others.

    What is the market size for RNA Interference technology in 2024?

    The RNA Interference technology segment is valued at 0.6 billion USD in 2024.

    How much is the Antisense Oligonucleotides segment projected to be valued by 2035?

    The Antisense Oligonucleotides segment is expected to be valued at 1.3 billion USD by 2035.

    What is the projected market value for mRNA Therapeutics by 2035?

    The mRNA Therapeutics segment is projected to reach a market value of 2.6 billion USD by 2035.

    What market growth can be anticipated for CRISPR Technology by the year 2035?

    CRISPR Technology is projected to grow to a value of 0.6 billion USD by 2035.

    What trends are driving the growth of the US RNA-Based Therapeutics Market?

    Key trends include advancements in RNA technology and increasing investments in therapeutic applications.

    What are the main applications of RNA-Based Therapeutics in the US market?

    RNA-Based Therapeutics applications include innovative treatments for genetic disorders, cancer, and infectious diseases.

    1. 'TABLE OF CONTENTS
    2. EXECUTIVE SUMMARY
    3. Market Overview
      1. Key Findings
      2. Market Segmentation
    4. Competitive Landscape
      1. Challenges and Opportunities
      2. Future Outlook
    5. MARKET INTRODUCTION
      1. Definition
      2. Scope of the study
        1. Research Objective
        2. Assumption
        3. Limitations
    6. RESEARCH METHODOLOGY
      1. Overview
    7. Data Mining
      1. Secondary Research
      2. Primary Research
    8. Primary Interviews and Information Gathering Process
      1. Breakdown of Primary
    9. Respondents
      1. Forecasting Model
      2. Market Size Estimation
    10. Bottom-Up Approach
      1. Top-Down Approach
      2. Data Triangulation
      3. Validation
    11. MARKET DYNAMICS
      1. Overview
      2. Drivers
      3. Restraints
      4. Opportunities
    12. MARKET FACTOR ANALYSIS
      1. Value chain Analysis
      2. Porter''s Five Forces
    13. Analysis
      1. Bargaining Power of Suppliers
        1. Bargaining Power
    14. of Buyers
      1. Threat of New Entrants
        1. Threat of Substitutes
        2. Intensity of Rivalry
      2. COVID-19 Impact Analysis
    15. Market Impact Analysis
      1. Regional Impact
        1. Opportunity and
    16. Threat Analysis
    17. US RNA-BASED THERAPEUTICS MARKET, BY
    18. TECHNOLOGY (USD BILLION)
      1. RNA Interference
      2. Antisense Oligonucleotides
      3. mRNA Therapeutics
      4. CRISPR Technology
    19. US RNA-BASED
    20. THERAPEUTICS MARKET, BY APPLICATION (USD BILLION)
      1. Oncology
    21. Infectious Diseases
      1. Genetic Disorders
      2. Cardiovascular Diseases
    22. US RNA-BASED THERAPEUTICS MARKET, BY END USE (USD BILLION)
      1. Pharmaceutical
    23. Companies
      1. Research Institutions
      2. Contract Research Organizations
    24. US RNA-BASED THERAPEUTICS MARKET, BY DELIVERY METHOD (USD BILLION)
      1. Liposomes
      2. Nanoparticles
      3. Viral Vectors
      4. Electroporation
    25. COMPETITIVE LANDSCAPE
      1. Overview
    26. Competitive Analysis
      1. Market share Analysis
      2. Major Growth
    27. Strategy in the RNA-Based Therapeutics Market
      1. Competitive Benchmarking
      2. Leading Players in Terms of Number of Developments in the RNA-Based
    28. Therapeutics Market
      1. Key developments and growth strategies
    29. New Product Launch/Service Deployment
      1. Merger & Acquisitions
        1. Joint Ventures
      2. Major Players Financial Matrix
    30. Sales and Operating Income
      1. Major Players R&D Expenditure. 2023
    31. COMPANY PROFILES
      1. CureVac
        1. Financial Overview
        2. Products Offered
        3. Key Developments
        4. SWOT
    32. Analysis
      1. Key Strategies
      2. BioNTech
        1. Financial
    33. Overview
      1. Products Offered
        1. Key Developments
    34. SWOT Analysis
      1. Key Strategies
      2. Alnylam Pharmaceuticals
        1. Financial Overview
        2. Products Offered
        3. Key Developments
        4. SWOT Analysis
        5. Key Strategies
      3. Ionis Pharmaceuticals
        1. Financial Overview
        2. Products Offered
        3. Key
    35. Developments
      1. SWOT Analysis
        1. Key Strategies
    36. Regeneron Pharmaceuticals
      1. Financial Overview
        1. Products
    37. Offered
      1. Key Developments
        1. SWOT Analysis
    38. Key Strategies
      1. Moderna
        1. Financial Overview
    39. Products Offered
      1. Key Developments
        1. SWOT Analysis
        2. Key Strategies
      2. Sangamo Therapeutics
        1. Financial
    40. Overview
      1. Products Offered
        1. Key Developments
    41. SWOT Analysis
      1. Key Strategies
      2. Pfizer
        1. Financial
    42. Overview
      1. Products Offered
        1. Key Developments
    43. SWOT Analysis
      1. Key Strategies
      2. Novartis
        1. Financial
    44. Overview
      1. Products Offered
        1. Key Developments
    45. SWOT Analysis
      1. Key Strategies
      2. Sanofi
        1. Financial
    46. Overview
      1. Products Offered
        1. Key Developments
    47. SWOT Analysis
      1. Key Strategies
      2. Intellia Therapeutics
        1. Financial Overview
        2. Products Offered
        3. Key
    48. Developments
      1. SWOT Analysis
        1. Key Strategies
    49. Vertex Pharmaceuticals
      1. Financial Overview
        1. Products
    50. Offered
      1. Key Developments
        1. SWOT Analysis
    51. Key Strategies
      1. Wave Life Sciences
        1. Financial Overview
        2. Products Offered
        3. Key Developments
        4. SWOT
    52. Analysis
      1. Key Strategies
      2. Translate Bio
    53. Financial Overview
      1. Products Offered
        1. Key Developments
        2. SWOT Analysis
        3. Key Strategies
      2. Arcturus
    54. Therapeutics
      1. Financial Overview
        1. Products Offered
        2. Key Developments
        3. SWOT Analysis
        4. Key Strategies
    55. APPENDIX
      1. References
      2. Related Reports
    56. LIST
    57. OF TABLES
    58. MARKET SIZE ESTIMATES & FORECAST, BY TECHNOLOGY, 2019-2035 (USD BILLIONS)
    59. 2035 (USD BILLIONS)
    60. & FORECAST, BY END USE, 2019-2035 (USD BILLIONS)
    61. THERAPEUTICS MARKET SIZE ESTIMATES & FORECAST, BY DELIVERY METHOD, 2019-2035
    62. (USD BILLIONS)
    63. ACQUISITION/PARTNERSHIP
    64. SYNOPSIS
    65. US RNA-BASED THERAPEUTICS MARKET ANALYSIS BY END USE
    66. THERAPEUTICS MARKET ANALYSIS BY DELIVERY METHOD
    67. OF RNA-BASED THERAPEUTICS MARKET
    68. DRO ANALYSIS OF RNA-BASED THERAPEUTICS MARKET
    69. ANALYSIS: RNA-BASED THERAPEUTICS MARKET
    70. RNA-BASED THERAPEUTICS MARKET
    71. MARKET
    72. Billions)
    73. SHARE)
    74. (USD Billions)
    75. (% SHARE)
    76. (USD Billions)
    77. (% SHARE)
    78. TO 2035 (USD Billions)

    US RNA-Based Therapeutics Market Segmentation

     

     

     

    • RNA-Based Therapeutics Market By Technology (USD Billion, 2019-2035)
      • RNA Interference
      • Antisense Oligonucleotides
      • mRNA Therapeutics
      • CRISPR Technology

     

    • RNA-Based Therapeutics Market By Application (USD Billion, 2019-2035)
      • Oncology
      • Infectious Diseases
      • Genetic Disorders
      • Cardiovascular Diseases

     

    • RNA-Based Therapeutics Market By End Use (USD Billion, 2019-2035)
      • Pharmaceutical Companies
      • Research Institutions
      • Contract Research Organizations

     

    • RNA-Based Therapeutics Market By Delivery Method (USD Billion, 2019-2035)
      • Liposomes
      • Nanoparticles
      • Viral Vectors
      • Electroporation

     

     

     

     

     

     

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