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    NGS based RNA sequencing Market

    ID: MRFR/HC/20519-HCR
    128 Pages
    Rahul Gotadki
    October 2025

    NGS-based RNA-sequencing Market Research Report Information By Product and Service (Sample Preparation Products, Sequencing Platforms and Consumables, Sequencing Services and Data Analysis, Storage and Management), By Technology (Sequencing by Synthesis (SBS), Ion Semiconductor Sequencing, Single-molecule Real-time Sequencing (SMRT), Nanopore Sequencing), By Application (Expression Profiling Analysis, Small RNA Sequencing, De Novo Transcriptome Assembly, Variant Calling and Transcriptome Epigenetics), By End-User (Research and Academia, Hosp...

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    NGS based RNA sequencing Market Summary

    As per MRFR analysis, the NGS-based RNA-sequencing Market Size was estimated at 3.2 USD Billion in 2024. The NGS-based RNA-sequencing industry is projected to grow from 3.872 USD Billion in 2025 to 26.05 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 21.0 during the forecast period 2025 - 2035.

    Key Market Trends & Highlights

    The NGS-based RNA-sequencing market is poised for substantial growth driven by technological advancements and increasing applications in personalized medicine.

    • North America remains the largest market for NGS-based RNA-sequencing, reflecting a robust demand for innovative sequencing technologies.
    • The Asia-Pacific region is emerging as the fastest-growing market, fueled by increasing investments in genomic research and healthcare infrastructure.
    • Sequencing services dominate the market, while sample preparation products are experiencing the fastest growth due to rising demand for efficient workflows.
    • Technological advancements in sequencing technologies and a heightened focus on personalized medicine are key drivers propelling market expansion.

    Market Size & Forecast

    2024 Market Size 3.2 (USD Billion)
    2035 Market Size 26.05 (USD Billion)
    CAGR (2025 - 2035) 21.0%

    Major Players

    Illumina (US), Thermo Fisher Scientific (US), Roche (CH), Qiagen (DE), PerkinElmer (US), BGI (CN), Agilent Technologies (US), Oxford Nanopore Technologies (GB), Macrogen (KR)

    NGS based RNA sequencing Market Trends

    The NGS-based RNA-sequencing Market is currently experiencing a transformative phase, driven by advancements in technology and increasing applications in various fields such as genomics, transcriptomics, and personalized medicine. The integration of next-generation sequencing technologies has enabled researchers to conduct comprehensive analyses of RNA, facilitating a deeper understanding of gene expression and regulation. This evolution is further supported by the growing demand for high-throughput sequencing solutions, which are essential for large-scale studies and clinical applications. As a result, the market is witnessing a surge in investments from both public and private sectors, aiming to enhance research capabilities and improve healthcare outcomes. Moreover, the NGS-based RNA-sequencing Market is characterized by a diverse range of products and services, including sequencing platforms, reagents, and bioinformatics tools. The increasing focus on precision medicine is likely to propel the adoption of RNA-sequencing technologies, as they provide critical insights into disease mechanisms and therapeutic targets. Additionally, collaborations between academic institutions and biotechnology companies appear to be fostering innovation and accelerating the development of novel applications. Overall, the market is poised for substantial growth, driven by technological advancements and an expanding array of applications in research and clinical settings.

    Technological Advancements

    The NGS-based RNA-sequencing Market is witnessing rapid technological innovations that enhance sequencing accuracy and efficiency. Newer platforms are emerging, offering improved throughput and reduced costs, which may lead to broader adoption across various research sectors.

    Increased Focus on Personalized Medicine

    There is a growing emphasis on personalized medicine within the NGS-based RNA-sequencing Market. This trend suggests that tailored therapies based on individual genetic profiles could become more prevalent, driving demand for RNA-sequencing technologies.

    Collaborative Research Initiatives

    Collaborations between academic institutions and industry players are becoming more common in the NGS-based RNA-sequencing Market. These partnerships may facilitate the development of innovative solutions and accelerate the translation of research findings into clinical applications.

    The increasing accessibility of next-generation sequencing technologies is poised to revolutionize RNA analysis, enabling unprecedented insights into gene expression and regulation.

    National Institutes of Health (NIH)

    NGS based RNA sequencing Market Drivers

    Collaborative Research Initiatives

    The NGS-based RNA-sequencing Market is benefiting from collaborative research initiatives among academic institutions, healthcare organizations, and biotechnology companies. These partnerships facilitate the sharing of resources, expertise, and data, accelerating the pace of research and development in RNA sequencing technologies. Notably, large-scale projects, such as the Human Genome Project, have laid the groundwork for collaborative efforts in RNA sequencing. Such initiatives not only enhance the quality of research but also drive innovation in sequencing methodologies. As collaboration continues to grow, the market is expected to see increased funding and support, further propelling the adoption of NGS-based RNA sequencing solutions.

    Rising Demand for Biomarker Discovery

    The NGS-based RNA-sequencing Market is significantly influenced by the rising demand for biomarker discovery. Biomarkers are essential for early disease detection, prognosis, and treatment monitoring, particularly in cancer and genetic disorders. RNA sequencing provides comprehensive insights into gene expression profiles, enabling researchers to identify novel biomarkers with high specificity and sensitivity. The market for biomarker discovery is projected to grow at a CAGR of 15% over the next few years, driven by the increasing need for precision medicine. As pharmaceutical companies and research institutions invest in NGS technologies for biomarker identification, the NGS-based RNA sequencing market is likely to expand in tandem.

    Increased Focus on Personalized Medicine

    The NGS-based RNA-sequencing Market is being propelled by the growing emphasis on personalized medicine. As healthcare shifts towards tailored treatment approaches, RNA sequencing plays a crucial role in understanding individual genetic profiles and disease mechanisms. This trend is particularly evident in oncology, where RNA sequencing is utilized to identify specific mutations and gene expressions that inform targeted therapies. The market is expected to reach a valuation of USD 5 billion by 2026, reflecting the increasing investment in personalized healthcare solutions. Consequently, the demand for NGS-based RNA sequencing technologies is likely to surge as healthcare providers seek to implement more effective and individualized treatment plans.

    Growing Applications in Clinical Diagnostics

    The NGS-based RNA-sequencing Market is witnessing a surge in applications within clinical diagnostics. The ability of RNA sequencing to provide detailed insights into gene expression and transcriptomic profiles is transforming diagnostic practices. Healthcare providers are increasingly utilizing NGS technologies for the diagnosis of various diseases, including infectious diseases, genetic disorders, and cancers. The market for clinical diagnostics is anticipated to grow significantly, with RNA sequencing becoming a standard tool in diagnostic laboratories. This trend is likely to be supported by regulatory approvals and the establishment of clinical guidelines advocating the use of NGS-based RNA sequencing in routine diagnostics, thereby expanding the market further.

    Technological Advancements in Sequencing Technologies

    The NGS-based RNA-sequencing Market is experiencing rapid growth due to continuous technological advancements. Innovations in sequencing technologies, such as improvements in accuracy, speed, and cost-effectiveness, are driving market expansion. For instance, the introduction of third-generation sequencing platforms has significantly reduced the time required for RNA sequencing, making it more accessible for research and clinical applications. Furthermore, the integration of artificial intelligence and machine learning in data analysis is enhancing the interpretation of complex RNA sequencing data. As a result, the market is projected to witness a compound annual growth rate (CAGR) of approximately 20% over the next five years, indicating a robust demand for advanced sequencing solutions.

    Market Segment Insights

    By Product and Service: Sequencing Services (Largest) vs. Sample Preparation Products (Fastest-Growing)

    In the NGS-based RNA-sequencing market, the distribution of market share across product and service categories reveals that Sequencing Services currently holds the largest share. This can be attributed to the increasing demand for accurate genomic insights in various applications such as clinical diagnostics, research, and drug development. Sample Preparation Products, on the other hand, is rapidly gaining traction, driven by the continuous advancements in technology that enhance the efficiency and effectiveness of RNA sample processing. As the field of genomic research expands, the demand for sophisticated sequencing methodologies is rising, leading to a surge in growth for both Sequencing Services and Sample Preparation Products. The emphasis on personalized medicine and targeted therapies is particularly propelling the growth of services, while innovations in sample preparation technology are enabling faster and more reliable results, positioning them as a critical component for future advancements in NGS applications.

    Sample Preparation Products (Dominant) vs. Data Analysis, Storage and Management (Emerging)

    Sample Preparation Products represent a dominant segment within the NGS-based RNA-sequencing market, as they are vital for ensuring the quality and integrity of RNA samples prior to sequencing. These products include reagents and kits designed to facilitate the efficient extraction, purification, and library preparation of RNA, which are essential to achieving reliable sequencing results. Due to the increasing focus on high-throughput sequencing applications, providers of sample preparation products are seeing strong demand. Conversely, Data Analysis, Storage and Management is an emerging segment that is gaining importance due to the exponential increase in the volume of sequencing data generated. As more organizations undertake NGS projects, the need for robust data management solutions that facilitate effective storage, analysis, and interpretation of genomic data is becoming critical. This segment's growth is spurred by advancements in bioinformatics tools and the integration of cloud-based storage solutions, which streamline the handling of large datasets.

    By Technology: Sequencing by Synthesis (Largest) vs. Ion Semiconductor Sequencing (Fastest-Growing)

    In the NGS-based RNA-sequencing market, Sequencing by Synthesis (SBS) dominates, accounting for a significant share of the technology segment. This method has been widely adopted due to its high accuracy and reliability. Following SBS, Ion Semiconductor Sequencing has emerged as the fastest-growing technology, appealing to users seeking real-time data processing capabilities that enhance throughput and decrease time-to-result for various applications in genomics and transcriptomics.

    Technology: SBS (Dominant) vs. Ion Semiconductor Sequencing (Emerging)

    SBS technology remains the dominant choice among researchers due to its established protocols, comprehensive support, and versatility in applications from whole-genome sequencing to targeted panels. However, Ion Semiconductor Sequencing is rapidly gaining attention, offering a cost-effective solution without sacrificing quality, making it ideal for high-throughput environments. Users appreciate the quick turnaround time and the ability to conduct sequencing in a more compact setup. Both technologies contribute substantially to advancing RNA-sequencing capabilities, yet SBS retains a pivotal role as the foundation upon which newer methodologies are built.

    By Application: Expression Profiling Analysis (Largest) vs. Small RNA Sequencing (Fastest-Growing)

    The NGS-based RNA-sequencing market reveals notable distinctions in market share among various application segments. Expression Profiling Analysis stands as the largest segment, reflecting its pivotal role in understanding gene expression dynamics. In contrast, Small RNA Sequencing, while traditionally smaller in market share, is emerging rapidly due to its significance in studying microRNAs and other small regulatory RNAs.

    Application: Expression Profiling Analysis (Dominant) vs. Small RNA Sequencing (Emerging)

    Expression Profiling Analysis is characterized by its extensive use in various research fields, enabling comprehensive insights into gene expression patterns and their variations. This application serves a crucial role in both basic and applied research, leading it to dominate the NGS-based RNA-sequencing market. Conversely, Small RNA Sequencing, although currently less prevalent, is fast gaining traction as researchers increasingly focus on understanding the regulatory roles of small RNAs. The rapid advancements in sequencing technologies and decreasing costs are fuelling this growth, positioning small RNA sequencing as an emerging force in genetic research.

    By End-User: Pharmaceutical and Biotechnology Companies (Largest) vs. Hospitals and Clinics (Fastest-Growing)

    In the NGS-based RNA-sequencing market, the distribution of market share among end-users reveals that pharmaceutical and biotechnology companies hold the largest share, driven by their extensive reliance on advanced sequencing technologies for drug discovery and development. Research and academia are also significant contributors but are surpassed by the investments made by these companies. Conversely, hospitals and clinics are observing rapid growth, attributed to their emerging roles in personalized medicine and diagnostics, highlighting the evolving landscape of end-user applications.

    End-User Insights: Pharmaceutical and Biotechnology Companies (Dominant) vs. Hospitals and Clinics (Emerging)

    Pharmaceutical and biotechnology companies dominate the NGS-based RNA-sequencing market, leveraging these technologies to enhance their R&D pipelines and accelerate the development of targeted therapies. These companies often invest heavily in innovative sequencing solutions, employing them for genomics, transcriptomics, and epigenomics research, solidifying their market leadership. Meanwhile, hospitals and clinics represent the emerging segment as they increasingly adopt NGS for clinical applications such as cancer genomics and hereditary disease analysis. This growth is fueled by the increasing push for precision medicine and the need for efficient diagnostic tools, making hospitals and clinics vital players in the expanding NGS landscape.

    Get more detailed insights about NGS based RNA sequencing Market

    Regional Insights

    By region, the study provides the market insights into North America, Europe, Asia-Pacific and the Rest of the World. North America is predicted to have the greatest revenue share during the projection period. The presence of well-established healthcare infrastructure, high healthcare spending, and an increasing prevalence of chronic diseases all contribute to market revenue growth in this region. This region also has a large concentration of major biopharmaceutical companies and sequencing service suppliers. The usage of personalized treatment methods and precision medicine is also fuelling regional market revenue growth.

    Further, the major countries studied in the market report are the US, Canada, Germany, France, the UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil.

    Figure 2: NGS-Based RNA-Sequencing Market Share By Region 2023 (USD Billion)

    NGS-Based RNA-Sequencing Market Share By Region 2023 (USD Billion)

    Source: Secondary Research, Primary Research, Market Research Future Database and Analyst Review

    Europe NGS-based RNA-sequencing Market accounts for the second-largest market share. The sector is driven by factors such as the proliferation of academic and research institutes, as well as an increase in demand for personalized therapy. Further, the German NGS-based RNA-sequencing Market held the largest market share, and the UK NGS-based RNA-sequencing Market was the fastest-growing market in the European region.

    The Asia-Pacific NGS-based RNA-sequencing Market is expected to grow at the fastest CAGR from 2024 to 2032. The market is being pushed by an increase in genetic research programs, increased healthcare infrastructure expenditure, and growing public awareness of the benefits of personalized treatment. Moreover, China’s NGS-based RNA-sequencing Market held the largest market share, and the Indian NGS-based RNA-sequencing Market was the fastest-growing market in the Asia-Pacific region.

    Key Players and Competitive Insights

    Leading market players are investing heavily in research and development in order to expand their product lines, which will help the NGS-based RNA-sequencing Market, grow even more. Market participants are also undertaking a variety of strategic activities to expand their global footprint, with important market developments including new product launches, contractual agreements, mergers and acquisitions, higher investments, and collaboration with other organizations. To expand and survive in a more competitive and rising market climate, the NGS-based RNA-sequencing industry must offer cost-effective items.

    Manufacturing locally to minimize operational costs is one of the key business tactics used by manufacturers in the global NGS-based RNA-sequencing industry to benefit clients and increase the market sector. In recent years, the NGS-based RNA-sequencing industry has offered some of the most significant advantages to medicine. Major players in the NGS-based RNA-sequencing Market, including Illumina (the U.S.), Thermo Fischer Scientific (the U.S.), Oxford Nanopore Agilent Technologies, Inc. (the U.S.) and others, are attempting to increase market demand by investing in research and development operations.

    Thermo Fisher Scientific Inc. is an American company that provides analytical equipment, life sciences solutions, specialty diagnostics, laboratory, pharmaceutical, and biotechnology services. Thermo Fisher, headquartered in Waltham, Massachusetts, was created in 2006 when Thermo Electron and Fisher Scientific merged. In February 2024, BGI and Berry Genomics announced a collaboration to develop an AI-powered platform for analyzing RNA-seq data. This platform aims to improve the accuracy and efficiency of RNA-seq data analysis, leading to faster and more precise diagnosis and treatment methods.

    QIAGEN N.V. is a German-based international company that develops sample and assay technologies for molecular diagnostics, applied testing, academic research, and pharmaceutical research. The company has around 35 offices throughout 25 countries. QIAGEN N.V., the QIAGEN group's global headquarters, is based in Venlo, Netherlands. The major operational headquarters are in Hilden, Germany. The European, American, Chinese, and Asian-Pacific regional headquarters are located in Hilden, Germany; Germantown, Maryland, United States; Shanghai, China; and Singapore. In June 2020, Qiagen launched the QIAcube Connect, a completely automated sample preparation system for NGS and other molecular biology applications.

    The system is intended to deliver high-quality, reproducible outcomes with minimal human participation.

    Key Companies in the NGS based RNA sequencing Market market include

    Industry Developments

    • Q2 2024: Illumina launches NovaSeq X Plus, advancing high-throughput RNA sequencing capabilities Illumina announced the launch of NovaSeq X Plus, a new sequencing platform designed to enhance throughput and accuracy for NGS-based RNA-sequencing applications, targeting clinical and research markets.
    • Q2 2024: Thermo Fisher Scientific unveils Ion Torrent Genexus System for automated RNA sequencing Thermo Fisher Scientific introduced the Ion Torrent Genexus System, an automated NGS platform aimed at streamlining RNA-sequencing workflows for translational research and clinical diagnostics.
    • Q3 2024: Roche partners with Genentech to develop NGS-based RNA-sequencing diagnostics Roche announced a strategic partnership with Genentech to co-develop NGS-based RNA-sequencing diagnostic assays for oncology and rare disease applications.
    • Q3 2024: Bio-Rad Laboratories launches new RNA-seq library preparation kit for NGS platforms Bio-Rad Laboratories released a new RNA-seq library preparation kit optimized for next-generation sequencing, aiming to improve sensitivity and reproducibility in transcriptome analysis.
    • Q4 2024: Agilent Technologies opens new NGS innovation center in Singapore Agilent Technologies inaugurated a new facility in Singapore dedicated to research and development of NGS-based RNA-sequencing technologies, expanding its global footprint in precision genomics.
    • Q4 2024: Pacific Biosciences raises $150M in public offering to expand NGS-based RNA-sequencing portfolio Pacific Biosciences completed a $150 million public offering, with proceeds earmarked for accelerating development of its NGS-based RNA-sequencing products and expanding commercial operations.
    • Q1 2025: Oxford Nanopore Technologies announces partnership with AstraZeneca for RNA-sequencing in drug discovery Oxford Nanopore Technologies entered a partnership with AstraZeneca to deploy NGS-based RNA-sequencing platforms in drug discovery and biomarker identification programs.
    • Q1 2025: Qiagen launches QIAseq FastSelect RNA-seq kit for improved transcriptome profiling Qiagen introduced the QIAseq FastSelect RNA-seq kit, designed to enhance transcriptome profiling efficiency and accuracy for NGS-based RNA-sequencing applications.
    • Q2 2025: BGI Genomics files for $200M IPO to expand NGS-based RNA-sequencing services globally BGI Genomics filed for a $200 million initial public offering, aiming to fund the expansion of its NGS-based RNA-sequencing service offerings in international markets.
    • Q2 2025: Thermo Fisher Scientific acquires Combinati to strengthen NGS-based RNA-sequencing portfolio Thermo Fisher Scientific completed the acquisition of Combinati, a company specializing in digital PCR and RNA-sequencing technologies, to bolster its NGS-based RNA-sequencing product suite.
    • Q3 2025: Illumina appoints new Chief Technology Officer to lead NGS-based RNA-sequencing innovation Illumina announced the appointment of a new Chief Technology Officer, tasked with driving innovation in NGS-based RNA-sequencing platforms and applications.
    • Q3 2025: Agilent Technologies secures contract with major US hospital network for NGS-based RNA-sequencing solutions Agilent Technologies won a contract to supply NGS-based RNA-sequencing solutions to a leading US hospital network, supporting clinical diagnostics and translational research initiatives.

    Future Outlook

    NGS based RNA sequencing Market Future Outlook

    The NGS-based RNA-sequencing market is projected to grow at a 21.0% CAGR from 2024 to 2035, driven by advancements in technology, increasing research funding, and rising demand for personalized medicine.

    New opportunities lie in:

    • Development of integrated bioinformatics platforms for data analysis.
    • Expansion of RNA-sequencing services in emerging markets.
    • Partnerships with pharmaceutical companies for drug discovery applications.

    By 2035, the NGS-based RNA-sequencing market is expected to be a pivotal component of genomic research and personalized healthcare.

    Market Segmentation

    NGS based RNA sequencing Market End-User Outlook

    • Research and Academia
    • Hospitals and Clinics
    • Pharmaceutical and Biotechnology Companies

    NGS based RNA sequencing Market Technology Outlook

    • Sequencing by Synthesis (SBS)
    • Ion Semiconductor Sequencing
    • Single-molecule Real-time Sequencing (SMRT)
    • Nanopore Sequencing

    NGS based RNA sequencing Market Application Outlook

    • Expression Profiling Analysis
    • Small RNA Sequencing
    • De Novo Transcriptome Assembly
    • Variant Calling
    • Transcriptome Epigenetics

    NGS based RNA sequencing Market Product and Service Outlook

    • Sample Preparation Products
    • Sequencing Platforms and Consumables
    • Sequencing Services
    • Data Analysis, Storage and Management

    Report Scope

    MARKET SIZE 20243.2(USD Billion)
    MARKET SIZE 20253.872(USD Billion)
    MARKET SIZE 203526.05(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR)21.0% (2024 - 2035)
    REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR2024
    Market Forecast Period2025 - 2035
    Historical Data2019 - 2024
    Market Forecast UnitsUSD Billion
    Key Companies ProfiledMarket analysis in progress
    Segments CoveredMarket segmentation analysis in progress
    Key Market OpportunitiesAdvancements in bioinformatics tools enhance data analysis capabilities in the NGS-based RNA-sequencing Market.
    Key Market DynamicsTechnological advancements and regulatory changes drive competitive dynamics in the NGS-based RNA-sequencing market.
    Countries CoveredNorth America, Europe, APAC, South America, MEA

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    FAQs

    What is the projected growth of the NGS-based RNA-sequencing market?

    The NGS-based RNA-sequencing market is the expected increase in total market value of 26.05 USD billion over a defined forecast period 2025–2035. It is driven by factors such as demand trends, technological advances, regulatory changes, and geographic expansion.

    What is the size of the NGS-based RNA-sequencing market?

    NGS-based RNA-sequencing market size was valued at approximately 3.2 billion USD in 2024. This figure will reach 26.05 billion USD covering all regions (America, Europe, Asia, MEA and ROW), focusing its segments / services / distribution channels till 2035.

    What is the CAGR of the NGS-based RNA-sequencing market?

    NGS-based RNA-sequencing market is expected to grow at a CAGR of 21% between 2025 and 2035.

    How much will the NGS-based RNA-sequencing market be worth by 2035?

    NGS-based RNA-sequencing market is expected to be worth of 26.05 billion USD, reflecting growth driven by usage, technology and global demands by the end of 2035.

    How will the NGS-based RNA-sequencing market perform over the next 10 years?

    Over the next 10 years the NGS-based RNA-sequencing market is expected to shift from usd billion 3.2 to 26.05 billion USD, led by adoption of advanced tech, demographic trends, regulatory approvals, with potential headwinds from 2025 to 2035.

    Which region held the largest market share in the NGS-based RNA-sequencing Market?

    North America had the largest share in the global market

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