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    Lung In Vitro Model Market

    ID: MRFR/HC/25543-HCR
    128 Pages
    Rahul Gotadki
    September 2025

    Lung In-vitro Model Market Research Report By Type (2D Lung In-vitro Model, 3D Lung In-vitro Model, Co-Culture Lung In-vitro Model), By Application (Drug Discovery and Development, Toxicological Studies, Personalized Medicine, Disease Modeling), By Disease Model (Idiopathic Pulmonary Fibrosis, Chronic Obstructive Pulmonary Disease, Asthma, Lung Cancer), By Format (Frozen, Fixed, Live), By End-user (Pharmaceutical and Biotechnology Companies, Academic and Research Institutions, Contract Research Organizations) and By Regional (North America, ...

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    Lung In Vitro Model Market Summary

    The Global Lung In-vitro Model Market is projected to grow from 0.8 USD Billion in 2024 to 4.81 USD Billion by 2035, reflecting a robust CAGR of 17.72% during the period from 2025 to 2035.

    Key Market Trends & Highlights

    Lung In-vitro Model Key Trends and Highlights

    • The market is expected to expand significantly, reaching 4.81 USD Billion by 2035 from a base of 0.8 USD Billion in 2024.
    • A compound annual growth rate of 17.72% is anticipated for the market between 2025 and 2035.
    • The increasing demand for advanced lung models in drug development is likely to drive market growth.
    • Growing adoption of lung in-vitro models due to the need for more accurate and ethical testing methods is a major market driver.

    Market Size & Forecast

    2024 Market Size 0.8 (USD Billion)
    2035 Market Size 4.81 (USD Billion)
    CAGR (2025-2035) 17.72%

    Major Players

    Mimetas, Emulate, InSphero, Organovo, BioIVT, Sartorius, Sigma-Aldrich, MatTek, Epitopix, Accelerate, BioSpherix, Epithelix, REPROCELL, Alvetex, TissUse, Cellagen Technology

    Lung In Vitro Model Market Trends

    The global Lung In-vitro Model market is expanding rapidly, driven by a rise in respiratory diseases, increased funding for research and development, and advancements in technology.

    Key market drivers include the growing prevalence of chronic obstructive pulmonary disease (COPD), asthma, and lung cancer, as well as the need for more effective and individualized treatment options.

    Recent market trends include the development of 3D lung models that mimic the complexity and functionality of human lungs, enabling more accurate preclinical testing and drug discovery.

    Additionally, microfluidic devices are being integrated with lung models to simulate the flow of air and liquid, providing a better representation of the in vivo environment.

    Opportunities for growth in the Lung In-vitro Model market lie in the development of personalized medicine, where patient-specific lung models can be used for targeted drug delivery and treatment optimization.

    Moreover, collaborations between academia and industry are fostering innovation and the development of new technologies that will further enhance the capabilities of Lung In-vitro Models.

    The increasing complexity of lung diseases and the demand for personalized medicine are driving innovations in lung in-vitro models, which are poised to enhance drug development and toxicity testing.

    U.S. National Institutes of Health (NIH)

    Lung In Vitro Model Market Drivers

    Market Growth Projections

    The Global Lung In-vitro Model Market Industry is projected to experience substantial growth, with estimates indicating an increase from 0.8 USD Billion in 2024 to 4.81 USD Billion by 2035. This growth trajectory suggests a compound annual growth rate (CAGR) of 17.72% from 2025 to 2035. Such projections highlight the increasing recognition of the value of in-vitro models in drug development and disease research. The market's expansion is likely to be driven by technological advancements, rising demand for personalized medicine, and a growing focus on respiratory diseases.

    Rising Demand for Personalized Medicine

    The Global Lung In-vitro Model Market Industry experiences a notable increase in demand for personalized medicine, which emphasizes tailored treatment approaches based on individual patient profiles. This trend is driven by advancements in genomics and biotechnology, enabling researchers to develop models that closely mimic human lung physiology. As a result, pharmaceutical companies are increasingly investing in lung in-vitro models to enhance drug efficacy and safety profiles. The market is projected to grow from 0.8 USD Billion in 2024 to 4.81 USD Billion by 2035, reflecting a robust CAGR of 17.72% from 2025 to 2035. This growth underscores the industry's potential in revolutionizing therapeutic strategies.

    Increasing Focus on Respiratory Diseases

    The Global Lung In-vitro Model Market Industry is significantly influenced by the rising prevalence of respiratory diseases, including asthma, chronic obstructive pulmonary disease, and lung cancer. As healthcare systems worldwide prioritize the development of effective treatments, there is a growing reliance on in-vitro models to study disease mechanisms and test therapeutic interventions. This focus on respiratory health is reflected in increased funding for research initiatives and collaborations between academic institutions and pharmaceutical companies. The market's expansion is anticipated as stakeholders recognize the value of in-vitro models in accelerating drug discovery and improving patient outcomes.

    Regulatory Support for Innovative Research

    Regulatory bodies are increasingly supporting the use of in-vitro models in drug development, which positively impacts the Global Lung In-vitro Model Market Industry. Initiatives aimed at promoting alternative testing methods, such as the 3Rs principle (Replacement, Reduction, Refinement), encourage researchers to adopt in-vitro approaches over traditional animal testing. This regulatory shift not only enhances the credibility of in-vitro models but also fosters innovation within the industry. As regulations evolve to accommodate these advancements, the market is expected to grow, driven by the need for compliance and the desire for more ethical research practices.

    Global Collaboration and Funding Initiatives

    The Global Lung In-vitro Model Market Industry benefits from increased collaboration among global stakeholders, including academic institutions, pharmaceutical companies, and government agencies. These partnerships often lead to enhanced funding initiatives aimed at advancing research and development in lung disease models. Collaborative efforts facilitate knowledge sharing and resource allocation, which are essential for driving innovation in in-vitro technologies. As funding becomes more accessible, the market is likely to expand, enabling the development of more sophisticated models that can better predict human responses to therapies.

    Technological Advancements in In-vitro Models

    Technological innovations play a crucial role in shaping the Global Lung In-vitro Model Market Industry. The integration of 3D bioprinting, organ-on-a-chip technologies, and advanced biomaterials has significantly improved the accuracy and relevance of in-vitro models. These advancements allow for more precise simulations of lung environments, facilitating better understanding of disease mechanisms and drug responses. As researchers seek to replicate complex lung functions, the demand for sophisticated in-vitro models is expected to rise. Consequently, the market is likely to witness substantial growth, driven by the need for more reliable and predictive testing platforms in drug development.

    Market Segment Insights

    Lung In-vitro Model Market Type Insights

    The type segment of the global Lung In-vitro Model market is categorized into 2D Lung In-vitro Model, 3D Lung In-vitro Model, and Co-Culture Lung In-vitro Model.

    Among these, the 3D Lung In-vitro Model segment accounted for the largest revenue share in 2023 and is expected to maintain its dominance throughout the forecast period.

    This is primarily due to the increasing adoption of 3D Lung In-vitro Models for drug discovery and toxicity testing, as they provide a more physiologically relevant representation of the human lung tissue compared to traditional 2D models.

    The 2D Lung In-vitro Model segment is also anticipated to witness significant growth over the forecast period, owing to its simplicity, cost-effectiveness, and well-established protocols.

    The Co-Culture Lung In-vitro Model segment, which involves the co-culture of lung cells with other cell types such as immune cells or endothelial cells, is gaining traction due to its ability to mimic the complex interactions within the lung microenvironment.

    Lung In-vitro Model Market Application Insights

    The application segment of the global Lung In-vitro Model market is segmented into drug discovery and development, toxicological studies, personalized medicine, and disease modeling. Drug discovery and development held the largest share in the Lung In-vitro Model market in 2023.

    The dominance of this segment is attributed to the growing usage of in vitro models for drug screening and safety evaluation throughout the drug development process.

    On the other hand, the personalized medicine segment is expected to exhibit the highest growth rate during the forecast period as a result of increasing demand for targeted treatment options on the basis of genetic make-up of individuals.

    An increase in number of research studies investigating the efficacy of sample to be used for testing response to drugs for patients is projected to boost the growth of personalized medicine segment.

    In addition, the toxicological study segment is anticipated to drive the growth of market as in vitro models are done at low costs and are ethically more acceptable than animal testing.

    Lung In-vitro Model Market Disease Model Insights

    The Disease Model segment of the Global Lung In-vitro Model Market is expected to witness significant growth in the coming years, driven by the increasing prevalence of respiratory diseases and the growing need for accurate and reliable disease models for drug discovery and development.

    Among the various disease models, Idiopathic Pulmonary Fibrosis (IPF), Chronic Obstructive Pulmonary Disease (COPD), Asthma, and Lung Cancer are expected to contribute significantly to the market growth. IPF, a progressive and fatal lung disease, is characterized by the formation of fibrotic tissue in the lungs.

    The Global Lung In-vitro Model Market for IPF is estimated to reach USD 0.45 billion by 2024, with a CAGR of 15.6%. This growth is attributed to the rising incidence of IPF and the increasing demand for effective treatments.

    COPD, a chronic inflammatory disease of the lungs, is another major contributor to the Disease Model segment. The Global Lung In-vitro Model Market for COPD is expected to reach USD 0.68 billion by 2024, with a CAGR of 14.2%. This growth is driven by the high prevalence of COPD and the need for improved disease management strategies.

    Asthma, a common chronic respiratory disease, is characterized by inflammation and narrowing of the airways. The Global Lung In-vitro Model Market for Asthma is expected to reach USD 0.32 billion by 2024, with a CAGR of 13.5%.

    Lung In-vitro Model Market Format Insights

    The Global Lung In-vitro Model Market is segmented based on format into frozen, fixed, and live. Among these, the frozen segment held the largest market share in 2023 and is expected to continue its dominance throughout the forecast period.

    The frozen format allows for long-term storage and transportation of Lung In-vitro Models, making them a convenient option for research and development activities. The fixed format, on the other hand, provides a more stable platform for studying lung tissue morphology and function.

    The live format offers the advantage of real-time monitoring of lung tissue responses but requires specialized equipment and expertise to maintain cell viability. Overall, the choice of format depends on the specific research objectives and available resources.

    Lung In-vitro Model Market End-user Insights

    Pharmaceutical and biotechnology companies hold a significant share of the Global Lung In-vitro Model Market, leveraging these models for drug discovery and toxicity testing.

    Academic and research institutions are also key end-users, utilizing Lung In-vitro Models for basic research and understanding disease mechanisms.

    Contract research organizations (CROs) play a vital role in providing specialized services to pharmaceutical companies, leveraging their expertise in Lung In-vitro Modeling and assay development.

    Get more detailed insights about Lung In Vitro Model Market Research Report-Forecast till 2034

    Regional Insights

    The Global Lung In-vitro Model Market is segmented regionally into North America, Europe, APAC, South America, and MEA. North America held the largest market share in 2023 and is expected to continue its dominance throughout the forecast period.

    The growth in this region is attributed to the presence of leading pharmaceutical and biotechnology companies, government funding for research and development, and the increasing adoption of in vitro models for drug discovery and toxicology studies.

    Europe is the second largest market for Lung In-vitro Models, with a significant contribution from Germany, the United Kingdom, and France.

    The region is home to several research institutions and pharmaceutical companies that are actively involved in the development and application of in vitro models. APAC is expected to witness the fastest growth during the forecast period, owing to the rising demand for in vitro models in emerging economies such as China and India.

    The increasing investment in healthcare infrastructure and the growing pharmaceutical industry in these countries are driving the growth of the Lung In-vitro Model market in APAC.

    South America and MEA are relatively smaller markets for Lung In-vitro Models, but they are expected to grow steadily over the forecast period.

    The growing adoption of in vitro models for drug development and toxicology studies in these regions is expected to drive market growth.

    Lung In-vitro Model Market Regional

    Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

    Key Players and Competitive Insights

    Major players in the Lung In-vitro Model Market are focusing on the development of innovative products and technologies to gain a competitive edge. The Lung In-vitro Model Market is characterized by the presence of a few leading Lung In-vitro Model Market players, such as Mimetas and Emulate, who hold a significant market share.

    These companies are investing heavily in research and development to expand their product portfolios and gain a competitive advantage. Additionally, the Lung In-vitro Model Market is witnessing the emergence of new players, such as InSphero and Organovo, who are offering innovative solutions to address unmet clinical needs.

    The competitive landscape of the Lung In-vitro Model Market is expected to intensify further in the coming years as more companies enter the market and competition for market share intensifies.

    A leading player in the Lung In-vitro Model Market is Mimetas, a Dutch biotechnology company founded in 2010. Mimetas has developed a proprietary Organ-on-a-Chip platform that allows researchers to study the behavior of cells and tissues in a more physiologically relevant environment than traditional cell culture methods.

    The company's platform has been used to develop a variety of Lung In-vitro Models, including models of asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. Mimetas' technology is being used by pharmaceutical companies and research institutions to develop new drugs and therapies for lung diseases.

    A competitor to Mimetas in the Lung In-vitro Model Market is Emulate, an American biotechnology company founded in 2014. Emulate has developed a proprietary Organ-on-a-Chip platform called the Human Emulation System, which allows researchers to study the behavior of cells and tissues in a microenvironment that mimics the human body.

    The company's platform has been used to develop a variety of Lung In-vitro Models, including models of asthma, COPD, and lung cancer. Emulate's technology is being used by pharmaceutical companies and research institutions to develop new drugs and therapies for lung diseases.

    Key Companies in the Lung In Vitro Model Market market include

    Industry Developments

    The increasing prevalence of respiratory diseases, growing demand for personalized medicine, and technological advancements in the field of in vitro models drive the global Lung In-vitro Model market. Key industry developments include:

    In 2023, Mimetas raised $26 million to advance its Organ-on-a-Chip platform for drug discovery and toxicology testing.

    In 2024, Emulate launched its Lung-on-a-Chip model, which mimics the complex structure and function of human lungs.

    In 2025, Insphero is likely to announce a collaboration with AstraZeneca to develop lung-specific in vitro models for respiratory drug development.

    Major market players include Emulate, Mimetas, Insphero, and TissUse. North America dominates the market, followed by Europe and Asia-Pacific.

    The market is expected to grow significantly in the coming years, driven by increasing R&D investments and the rising adoption of in vitro models in drug discovery and toxicology testing.

    Future Outlook

    Lung In Vitro Model Market Future Outlook

    The Lung In-vitro Model Market is projected to grow at a 17.72% CAGR from 2024 to 2035, driven by advancements in personalized medicine, regulatory support, and increasing demand for alternative testing methods.

    New opportunities lie in:

    • Develop innovative lung-on-a-chip technologies for enhanced drug testing.
    • Expand partnerships with pharmaceutical companies for tailored research solutions.
    • Invest in AI-driven analytics to optimize model performance and data interpretation.

    By 2035, the Lung In-vitro Model Market is expected to be a pivotal sector in biomedical research and drug development.

    Market Segmentation

    Lung In-vitro Model Market Type Outlook

    • Drug Discovery and Development
    • Toxicological Studies
    • Personalized Medicine
    • Disease Modeling

    Lung In-vitro Model Market Format Outlook

    • Pharmaceutical and Biotechnology Companies
    • Academic and Research Institutions
    • Contract Research Organizations

    Lung In-vitro Model Market End-user Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Lung In-vitro Model Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Lung In-vitro Model Market Application Outlook

    • Idiopathic Pulmonary Fibrosis
    • Chronic Obstructive Pulmonary Disease
    • Asthma
    • Lung Cancer

    Lung In-vitro Model Market Disease Model Outlook

    • Frozen
    • Fixed
    • Live

    Report Scope

    Report Attribute/Metric Details
    Market Size 2024    0.80 (USD Billion)
    Market Size 2025    0.94 (USD Billion)
    Market Size 2034    4.09 (USD Billion)
    Compound Annual Growth Rate (CAGR)   17.72 % (2025 - 2034)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2024
    Market Forecast Period 2025 - 2034
    Historical Data 2020 - 2024
    Market Forecast Units USD Billion
    Key Companies Profiled BioIVT, Sartorius, Sigma-Aldrich, MatTek, Epitopix, Accelerate, BioSpherix, Epithelix, REPROCELL, InSphero, Organovo, Alvetex, TissUse, Mimetas, Collagen Technology
    Segments Covered Type, Application, Disease Model, Format, End-user, Regional
    Key Market Opportunities Personalized medicine, drug discovery, tissue engineering, disease modeling, and toxicity testing.
    Key Market Dynamics Growing prevalence of respiratory diseases Advancements in organ-on-a-chip technology Increasing focus on personalized medicine Rising government support for research Technological advancements in 3D bioprinting
    Countries Covered North America, Europe, APAC, South America, MEA

    FAQs

    What was the market size of the Global Lung In-vitro Model Market in 2023?

    The Global Lung In-vitro Model Market reached a valuation of approximately 0.58 billion USD in 2023.

    What is the projected CAGR of the Global Lung In-vitro Model Market from 2024 to 2032?

    The Global Lung In-vitro Model Market is projected to exhibit a CAGR of 17.72% during the forecast period from 2025 to 2034.

    Which region is expected to dominate the Global Lung In-vitro Model Market?

    North America is expected to dominate the Global Lung In-vitro Model Market throughout the forecast period.

    What are the key applications of Lung In-vitro Models?

    Lung In-vitro Models are primarily used in drug discovery and development, toxicology studies, and basic research.

    Who are some of the major competitors in the Global Lung In-vitro Model Market?

    Some of the major competitors in the Global Lung In-vitro Model Market include Emulate, Inc., InSphero AG, and Mimetas.

    What factors are driving the growth of the Global Lung In-vitro Model Market?

    The growing demand for personalized medicine, advancements in 3D cell culture techniques, and increasing government funding for lung research are key factors driving market growth.

    What are the challenges faced by the Global Lung In-vitro Model Market?

    Challenges faced by the market include the high cost of 3D cell culture systems, the need for standardization of protocols, and the lack of trained personnel.

    What is the expected market size of the Global Lung In-vitro Model Market in 2032?

    The Global Lung In-vitro Model Market is projected to reach a valuation of approximately 4.09 billion USD by 2034.

    What are the major trends shaping the Global Lung In-vitro Model Market?

    Major trends shaping the market include the integration of artificial intelligence (AI) and machine learning (ML), the development of organ-on-a-chip systems, and the increasing use of patient-derived cells.

    What are some potential applications of Lung In-vitro Models beyond drug discovery and development?

    Potential applications of Lung In-vitro Models include personalized medicine, disease modeling, and regenerative medicine.

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