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Liquid Biopsy Market Share

ID: MRFR//0239-CR | 171 Pages | Author: Kinjoll Dey| February 2023

Liquid biopsy plays a pivotal role in the identification of specific genomic alterations, offering valuable insights for guiding treatment decisions. This innovative approach allows for real-time monitoring of tumor burden, enabling precise evaluation of recurrence risks in diseases like cancer. The qualitative and quantitative information obtained through liquid biopsy aids healthcare professionals in comprehending any potential resistance mechanisms to drugs. This detailed knowledge assists in determining the most effective course of action for drug regimens, facilitating the creation of customized and personalized treatment plans based on the genetic profiling obtained through liquid biopsy.
The global cancer burden is expected to escalate significantly, with a predicted 50% increase, reaching 15 million new cases by 2020, according to the World Cancer Report by the World Health Organization (WHO). In 2012 alone, there were 14 million new cases and 8.2 million cancer-related deaths worldwide, a number projected to reach 22 million within the next two decades. Africa, Asia, and Central and South America collectively account for two-thirds of cases and three-fourths of deaths. Specific cancers projected to experience growth include breast cancer, lung and bronchus cancer, prostate cancer, colon and rectum cancer, bladder cancer, melanoma of the skin, non-Hodgkin lymphoma, thyroid cancer, kidney and renal pelvis cancer, leukemia, endometrial cancer, and pancreatic cancer. Considering the rising prevalence of these cancers, liquid biopsy emerges as an effective tool with substantial growth potential.

Cardiovascular diseases (CVDs) currently lead in global mortality rates, with an estimated 17.5 million people succumbing to CVDs in 2012, representing one-third of all global deaths. The effectiveness of liquid biopsy in treating these prevalent diseases underscores its growth potential.

The WHO underscores that tobacco use is the foremost avoidable risk factor for cancer mortality globally, claiming around 6 million lives annually from cancer and other related diseases. Additional environmental factors, such as certain infections (hepatitis, human papillomavirus), exposure to ionizing radiation, and pollutants, further contribute to the spread of diseases like cancer and cardiovascular diseases, creating a conducive environment for the application of liquid biopsy.

Comparing liquid biopsy to traditional tissue biopsies reveals significant advantages. Traditional tissue biopsies, costing between US$15,000 to US$60,000 with a failure rate of approximately 25%, are outperformed by liquid biopsy in terms of sensitivity, detection rates, and lower failure rates. The Polymerase Chain Reaction (PCR) technology employed in liquid biopsies represents a substantial advancement over the Sanger sequencing utilized in tissue biopsies, particularly for detecting low-frequency variants. Moreover, liquid biopsies have substantially reduced the costs associated with traditional tissue biopsies. For instance, Pathway Genomics introduced its first liquid biopsy, Cancer Intercept, priced at a mere $299, while Guardant360 is available for $5,800, presenting a cost-effective alternative to traditional biopsy methods.

In summary, liquid biopsy's ability to offer real-time monitoring, personalized treatment plans, and cost-effectiveness positions it as a critical player in the diagnosis and treatment of prevalent diseases like cancer and cardiovascular diseases. As these health challenges continue to rise globally, liquid biopsy stands out as a valuable and increasingly accessible tool in the medical field.



Covered Aspects:

Report Attribute/Metric Details
Base Year For Estimation 2021
Historical Data 2018 & 2020
Forecast Period 2023-2032
Growth Rate 18.9% (2023-2032)

Global Liquid Biopsy Market Overview


Liquid Biopsy Market Valued at USD 6.1 billion in 2023, projected to grow from USD 6.7 billion in 2024 to USD 12.94 billion by 2032, at a CAGR of 10.50% during the forecast period (2024 - 2032). Surging demand for advanced diagnosing equipment coupled with the rising number of research laboratories in the developing economies are the key market drivers enhancing the market growth.


Liquid Biopsy Market Overview


Source: Secondary Research, Primary Research, MRFR Database and Analyst Review


Liquid Biopsy Market Trends



  • Government investments on healthcare infrastructure to boost market growth


The increase in the funding by the federal government is set to drive the market growth rate. Growth and expansion of healthcare industry being driven by both public and private players especially in the developing economies will create lucrative market growth opportunities. Also, high return on investments assured by the research activities will also work in the favor of the market. Initiatives by the government to spread awareness especially in the developing economies, surge in the personal disposable income level, introduction of technologically driven products in hospitals, increasing investment for the development of advanced medical products and devices and increase in demand for non-invasive surgical procedures, positively enhanced the market CAGR of liquid biopsy across the globe in the recent years. There are some other type of biopsies like kidney biopsy, needle biopsy and liver biopsy


 Further, in the past decade, governments in various countries and  health organizations have undertaken several initiatives to spread awareness about cancer. For instance, the WHO's National Cancer Control program is a public health program that aims to reduce the number of cancer deaths and improve the quality of life of cancer patients. Similarly, the National Breast and Cervical Cancer Early Detection Program (NBCCEDP), initiated by the US Centers for Diseases and Prevention (CDC) in 1991, provides breast cancer screening and diagnosis for uninsured and low-income patients in the US every year. In 2020, this program provided breast cancer screening and diagnostic services to 260,143 women. This program also provided cervical cancer screening and diagnostic services to 116,562 women in the same year.


Additionally, the increased awareness about the cancer is boosting the liquid biopsy market growth as liquid biopsy technique can detect the cancer early, can monitor progression of tumor, and can assess clinical prognosis. Moreover, the proliferation of advanced technologies has boosted the demand for the non-invasive diagnosis and treatments that is expected to spur the demand for the liquid biopsy in the forthcoming years. The rising investments by the market players in the clinical trials for the development of innovative diagnostic solutions is exponentially contributing towards the growth of the liquid biopsy market revenue.


However, rising expenditure for research and development proficiencies especially in the developed and developing economies pertaining to the medical instruments and devices will further create lucrative market growth opportunities. Research and development proficiencies being conducted by pharmaceutical and biopharmaceutical countries for the integration of advanced technologies in the healthcare facilities is also bolstering the market growth rate.


Liquid Biopsy Market Segment Insights


Liquid Biopsy Biomarker Types Insights


The market segments of liquid biopsy, based on biomarker types, includes circulating tumor cells, circulating tumor DNA, extracellular vesicles, and other biomarker. The circulating tumor DNA segment held the majority share in 2021 to the  market revenue of liquid biopsy. Over the recent years, ctDNA-based liquid biopsy analysis has created new opportunities in molecular diagnosis and monitoring of cancer. It is capable of precisely determining tumor progression, prognosis, and assisting in targeted therapy. However, other biomarker is the fastest-growing category due to rise in the adoption of exosomes as a liquid biopsy in oncology clinical diagnosis coupled with the introduction of novel products drives the segment growth.


September 2021: miR Scientific presented data for its miR Sentinel Prostate Cancer Test at the American Urological Association’s (AUA) 2021 Annual Meeting. This exosome-based liquid biopsy test uses a single urine sample to detect prostate cancer with an accuracy of 90%.


Liquid Biopsy Application Insights


The liquid biopsy market data has been bifurcated by application into cancer therapeutic application, reproductive health, and other therapeutic. The cancer therapeutic segment dominated the market in 2021 and is projected to be the faster-growing segment during the forecast period, 2022-2030. The use of liquid biopsy products has been particularly significant in understanding cancer signatures and developing customized therapies. Liquid biopsy is one of the many emerging technologies developed to address the growing cancer prevalence. However, reproductive health is the fastest-growing category due to the increased adoption of the liquid biopsy techniques for the


Figure 2:  Liquid Biopsy Market, by Application, 2021 & 2030 (USD Million)Liquid Biopsy Market, by Application, 2021 & 2030


Source: Secondary Research, Primary Research, MRFR Database and Analyst Review


Liquid Biopsy Sample Insights


Based on sample, the  liquid biopsy industry has been segmented into blood sample, urine sample, and other. Blood sample held the largest segment share in 2021. A blood-based test is non-invasive, has no risk, and is painless. In addition, it reduces the cost and time taken for diagnosis. CTCs, cfDNAs, and exosomes, as well as microvesicles, can be detected in the blood sample, thus increasing the adoption of blood-based liquid biopsy. However, urine sample is the fastest-growing category as liquid biopsy test uses a single urine sample to detect various type of cancer.


Liquid Biopsy Regional Insights


By Region, the study provides the market insights into North America, Europe, Asia-Pacific and Rest of the World. North America liquid biopsy market accounted for USD 1.39 billion in 2021 and is expected to exhibit a significant CAGR growth during the study period. This is owing to greater investments and the presence of a number of biotechnology companies developing the tests. Various organizations, such as the American Society of Clinical Oncology (ASCO), aid the implementation of liquid handling system. Moreover, US liquid biopsy market held the largest market share, and the Canada liquid biopsy market was the fastest growing market in the North America region


Further, the major countries studied in the market report are: The U.S, Canada, Germany, France, UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil.


Figure 3:  LIQUID BIOPSY MARKET SHARE BY REGION 2021 (%)LIQUID BIOPSY MARKET SHARE BY REGION 2021


Source: Secondary Research, Primary Research, MRFR Database and Analyst Review


Europe liquid biopsy market accounts for the second-largest market share due to increasing number of research studies for the discovery & development of novel cancer biomarkers, presence of many pharmaceutical companies. Further, the Germany market of liquid biopsy held the largest market share, and the UK market of liquid biopsy was the fastest growing market in the European region


The Asia-Pacific liquid biopsy market is expected to grow at the fastest CAGR from 2022 to 2030. This is due to rising investment from key players in the growth of the advanced devices, growing number of processes pertaining to drug development, stringent regulatory scenario in the pharmaceutical industry and rising number of research activities in this region.  Moreover, China market of liquid biopsy held the largest market share, and the India market of liquid biopsy was the fastest growing market in the Asia-Pacific region.


Liquid Biopsy Key Market Players & Competitive Insights


Major market players are spending a lot of money on R&D to increase their product lines, which will help the liquid biopsy market grow even more. Market participants are also taking a range of strategic initiatives to grow their worldwide footprint, with key market developments such as new product launches, contractual agreements, mergers and acquisitions, increased investments, and collaboration with other organizations. Competitors in the liquid biopsy industry must offer cost-effective items to expand and survive in an increasingly competitive and rising market environment.


One of the primary business strategies adopted by manufacturers in the  liquid biopsy industry to benefit clients and expand the market sector is to manufacture locally to reduce operating costs. The liquid biopsy market major player such as F. Hoffmann-La Roche Ltd. (Switzerland), Myriad Genetics, Inc. (US), QIAGEN (Netherlands), and others are working to expand the market demand by investing in research and development activities.


BioMark Diagnostics Inc. operates as an oncology-focused company. The Company develops and owns multiple intellectual properties in detection and quantitation of metabolites. BioMark Diagnostics serves patients in Canada. In June 2021, BioMark Diagnostic Solutions, Inc. received USD 825,000 funding to develop BioMark’s liquid biopsy assay for screening lung cancer. A major part of the funding is being issued by Consortium for Industrial Research and Innovation in Medical Technology and Spark grants from the Canadian Cancer Society, Brain Canada Foundation, and Canadian Institutes of Health Research - Institute of Cancer Research.


Also, Thermo Fisher Scientific, Inc. manufactures scientific instruments, consumables, and chemicals. The Company offers analytical instruments, laboratory equipment, software, services, consumables, reagents, chemicals, and supplies to pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions, and government agencies. In August 2022, Thermo Fisher Scientific Inc. (US) launched the first NGS-based tests to support both DNA and RNA input. The lon Torrent Oncomine Myeloid MRD Assays (RUO) provide comprehensive and highly sensitive myeloid measurable residual (MDR) assessments from blood and bone marrow samples.


Key Companies in the market of liquid biopsy includes



  • Hoffmann-La Roche Ltd. (Switzerland),

  • Myriad Genetics, Inc. (US),

  • QIAGEN (Netherlands),

  • Thermo Fisher Scientific, Inc. (US),

  • Guardant Health, Inc. (US),

  • MDxHealth SA (Belgium),

  • Exact Sciences Corporation (US),

  • Illumina Inc. (US),

  • Sysmex Inostics (US),

  • Biocept, Inc. (US),

  • NeoGenomics, Inc. (US),

  • ANGLE plc (UK),

  • Menarini-Silicon Biosystems (Italy),

  • Vortex Biosciences, Inc. (US),

  • Exosome Diagnostics, Inc. (US),

  • Agena Bioscience, Inc. (US),

  • MedGenome Inc. (US),

  • Epigenomics AG (Germany),

  • Personal Genome Diagnostics, Inc. (US), among others


Liquid Biopsy Industry Developments


May 2020: BRACAnalysis CDx test by Myriad Genetics was approved by FDA for use as a companion diagnostic by clinicians to detect metastatic castration-resistant prostate cancer in men.


Liquid Biopsy Market Segmentation


Liquid Biopsy Biomarker Types Outlook



  • Circulating Tumor Cells

  • Circulating Tumor DNA

  • Extracellular Vesicles

  • Other Biomarker


Liquid Biopsy Application Outlook



  • Cancer Therapeutic Application

  • Reproductive Health

  • Other Therapeutic


Liquid Biopsy Sample Outlook



  • Blood Sample

  • Urine Sample

  • Other


Liquid Biopsy Regional Outlook



  • North America

    • US

    • Canada



  • Europe

    • Germany

    • France

    • UK

    • Italy

    • Spain

    • Rest of Europe



  • Asia-Pacific

    • China

    • Japan

    • India

    • Australia

    • South Korea

    • Australia

    • Rest of Asia-Pacific



  • Rest of the World

    • Middle East

    • Africa

    • Latin America



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