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In the contemporary landscape, the global ban on conducting clinical trials using animals as test subjects poses a significant challenge for pharmaceutical and cosmetic companies seeking to test their drugs. To navigate this obstacle, the use of cell lines for in vivo drug testing has emerged as a potential solution. The cosmetic sector, in particular, remains largely unexplored in this context, presenting a significant opportunity for the application of cell line culture to study toxicological effects before progressing to clinical trials.
The ban on animal testing has compelled industries to explore alternative methods, with cell line culture standing out as a promising avenue. While the initial years of implementing this approach faced challenges related to effectiveness and efficiency, the utilization of cell line culture in the cosmetics sector is poised to benefit the market for immortalized cell lines.
Cell lines serve a wide range of applications, encompassing cell therapy, disease pathology, tissue morphogenesis and engineering, gene and protein expression, regenerative medicine, drug discovery, and tissue engineering. Notably, they have found a newfound role in stem cell and cancer research, addressing the need for more effective models to study cancer mechanisms.
In cancer research, the use of immortalized cell lines proves instrumental in understanding cell morphology through cell alteration. Cell lines cultivated in a culture setting result in enhanced gene expression, leading to modified cell morphology, accelerated proliferation rates, and the development of drug resistance—characteristics that contribute to a more representative cancer tissue model.
The application of cell line culture in cancer research holds the potential to significantly enhance our understanding of cancer biology, eliminate poor drug candidates, and identify new, physiologically relevant targets that might be overlooked in traditional 2D screens. The establishment of a 3D model system within cell line culture has proven effective, saving both time and costs while producing more realistic results. The increasing demand for 3D cell culture is attributed to its heightened effectiveness and efficiency in replicating physiological conditions, making it a preferred choice in various research endeavors.
Immortalized Cell Line Market Highlights:
Global Immortalized Cell Line Market Overview
The Immortalized Cell Line Market Size was valued at USD 4.23 Billion in 2023. The Global Immortalized Cell Line industry is projected to grow from USD 4.51 Billion in 2024 to USD 7.56 Billion by 2032, exhibiting a compound annual growth rate (CAGR) of 6.67% during the forecast period (2024 - 2032). Immortalized cell lines are either tumorous cells that do not stop dividing or cells that have been artificially manipulated to proliferate indefinitely and can, thus, be cultured over several generations. These cell lines are expected to grow due to the rise in vaccine production and innovative technologies. Besides, the ability of cell line culture to provide more physiologically relevant information and more accurate data in-vitro tests has led cell line culture systems to become acceptable in comparison to media culture.
The increasing application in biotech and pharmaceutical companies and hospitals, a growing number of patients in need of organ transplantation, and the rise in the patient population affected by cancer are the major drivers propelling market growth. However, the high cost of equipment and developing a stable strain of cell line and maintaining and preventing it from contamination may hinder the growth of the market.
February 2024
For the first time ever, the revolutionary spontaneously immortalized bovine myoblast cell line known as PROFUSE-B8 has been formally introduced, and it is now available for licensing. In announcing its official debut, ProFuse Technology is glad to share the news. This recent achievement, which marks a significant milestone in the field of farmed meat, has resulted in the introduction of a paradigm shift in the efficient growth of muscle tissue that is rich in protein.
The PROFUSE-B8 cell line, which has been the subject of significant study and testing over the course of a full two-year period, provides cultured meat manufacturers with a solid and robust foundation for the establishment of scalable, repeatable, and cost-competitive production processes. This has been accomplished by testing and researching the cell line over the course of two years. It is important to note that B8 is able to do this without using any method that includes genetic alteration. This ensures that it is in complete accordance with the preferences and consent of customers.
Its revolutionary features are complimented by the fact that, when taken with the PROFUSE-S1 muscle differentiation media supplement, the synthesis of muscle tissue is speed up, which results in increased productivity in a shorter length of time. This is a significant advantage.
ProFuse Technology is 100% committed to advancing the cultured meat business by providing cutting-edge solutions for the production of muscle-related goods. This commitment is steadfast. At the same time, the company is making significant progress toward the development of other muscle production-optimized cell lines that are tailored to the unique requirements of chicken, hog, lamb, and fish for specialized purposes.
According to Dr. Tamar Eigler-Hirsh, Chief Technology Officer and Co-Founder of ProFuse Technology, in a statement, "We are thrilled to introduce PROFUSE-B8 as a transformative solution for the cultivated meat industry." "Our dedication to innovation and productivity is evident in the development of this breakthrough cell line, and we are confident it will shape the future of cell based protein production."
Immortalized Cell Line Market Trends
The increasing demand for organ donation due to scarcity in the availability of organs is driving the need for artificially created biological cells. For instance, according to the US Department of Health & Human Services Organ Procurement and Transplantation Network (OPTN), as of November 2016, 121,678 patients were waiting for a life-saving organ transplant. This rising demand for an organ transplant is expected to drive the growth of the market during the forecast period. Additionally, increasing application in biotech and pharmaceutical companies and hospitals and rise in the patient population affected by cancer are likely to support market growth. On the other hand, the high cost of equipment and developing a stable strain of cell line and maintaining and preventing it from contamination is anticipated to hamper the market growth.
Immortalized Cell Line Market Segment Insights
The immortalized cell line market has been segmented into method, application, and end user.
Immortalized Cell Line Method Insights
Based on the method, the global market has been segmented into virus induction, hTERT expression, inactivation of tumor suppression genes, and others. The virus induction segment is further divided into EBV genes, SV40 T antigen, HPV-16 E6/6 gene, and others. The hTERT expression segment is sub-segmented into P53 and Myc T58A.
Immortalized Cell Line Application Insights
The immortalized cell line market, based on application, is segmented into diagnostics, drug discovery, vaccine production, tissue engineering and regenerative medicine, and others.
Immortalized Cell Line End User Insights
Based on end user, the global market is segmented into pharmaceutical and biopharmaceutical companies, Contract Research Organizations (CROs), and research laboratories. The pharmaceutical and biopharmaceutical companies segment accounted for a market value of USD 1,323.79 million in 2017.
Some of the key strategies followed by the players operating in the immortalized cell line market are innovation, product development, acquisition, and expansion.
Immortalized Clinell Line Market Regional Insights
The immortalized cell e market, based on region, is segmented into the Americas, Europe, Asia-Pacific, and the Middle East & Africa.
The Americas is estimated to dominate the immortalized cell line market during the forecast period. This is attributed to an increase in the occurrence of cancer, the presence of well-established pharmaceutical and biotechnology industry, increasing awareness of immortalized cell lines, and strong research funding.
The European market for immortalized cell line is expected to be the second-largest during the forecast period. Increasing government support, well-developed technology, and rising cases of cancer are expected to boost the growth of the market in this region.
Asia-Pacific is estimated to be the fastest-growing market due to the increasing expenditure on healthcare by government and private sector companies. Moreover, the growing awareness about healthcare and large untapped patient population have led to the increased focus of key players on expansion in this region. Furthermore, the region accounted for a market share of 17.8% in 2017.
The immortalized cell line market in the Middle East & Africa is expected to hold the least market share.
Immortalized Cell Line Market Key Players
The prominent players in the immortalized cell line market are
- Thermo Fisher Scientific (US)
- ATCC (American Type Culture Collection Inc.) (US)
- Valneva (France),
- Sartorius AG (Germany)
- Lonza Group, AG (Switzerland)
- Merck KGaA (Germany)
- Selexis SA (Switzerland)
- WuXi App Tec (China)
- European Collection of Authenticated Cell Cultures (ECACC) (Europe)
- Corning Incorporated (US)
Immortalized Cell Line Industry Developments
In January 2024,Thermo Fisher Scientific Launched new Gibco™ Advanced DMEM/F12 media optimized for immortalized cell lines, claiming improved growth and performance.
In September2023,Lonza Group AG Announced partnership with CStone Pharmaceuticals to optimize and manufacture immortalized cell lines for CAR-T cell therapy development.
Immortalized Cell Line Market Segmentation
Immortalized Cell Line Method Outlook
- Virus Induction
- EBV genes
- SV40 T antigen
- HPV-16 E6/6 gene
- Others
- HTERT Expression
- P53
- Myc T58A
- Inactivation of Tumour Suppression Genes
- Others
Immortalized Cell Line Application Outlook
- Diagnostics
- Drug Discovery
- Vaccine Production
- Tissue Engineering and Regenerative Medicines
- Others
Immortalized Cell Line End User Outlook
- Pharmaceutical and Biopharmaceutical Companies
- Contract Research Organizations
- Research Laboratories
Immortalized Cell Line Regional Outlook
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Americas
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North America
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US
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Canada
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South America
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Europe
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Western Europe
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Germany
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UK
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France
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Italy
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Spain
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Rest of Western Europe
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Eastern Europe
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Asia-Pacific
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China
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Japan
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India
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South Korea
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Rest of Asia-Pacific
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Middle East & Africa
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Middle East
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Africa
Intended Audience
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Research and development (R&D) companies
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Government research institutes
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Academic institutes and universities
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