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    Immortalized Cell Line Market Analysis

    ID: MRFR/LS/0267-CR
    130 Pages
    Rahul Gotadki
    August 2019

    Immortalized Cell Line Market Research Report Information by Method (Virus Induction, HTERT Expression, Inactivation of Tumor Suppression Genes and others), Application (Diagnostics, Drug Discovery, Vaccine Production, Tissue Engineering and Regenerative Medicines and others), End User (Pharmaceutical and Biopharmaceutical Companies, Contract Research Organizations and Research Laboratories) an...

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    Market Analysis

    In-depth Analysis of Immortalized Cell Line Market Industry Landscape

    In the contemporary landscape, the global ban on conducting clinical trials using animals as test subjects poses a significant challenge for pharmaceutical and cosmetic companies seeking to test their drugs. To navigate this obstacle, the use of cell lines for in vivo drug testing has emerged as a potential solution. The cosmetic sector, in particular, remains largely unexplored in this context, presenting a significant opportunity for the application of cell line culture to study toxicological effects before progressing to clinical trials.

    The ban on animal testing has compelled industries to explore alternative methods, with cell line culture standing out as a promising avenue. While the initial years of implementing this approach faced challenges related to effectiveness and efficiency, the utilization of cell line culture in the cosmetics sector is poised to benefit the market for immortalized cell lines.

    Cell lines serve a wide range of applications, encompassing cell therapy, disease pathology, tissue morphogenesis and engineering, gene and protein expression, regenerative medicine, drug discovery, and tissue engineering. Notably, they have found a newfound role in stem cell and cancer research, addressing the need for more effective models to study cancer mechanisms.

    In cancer research, the use of immortalized cell lines proves instrumental in understanding cell morphology through cell alteration. Cell lines cultivated in a culture setting result in enhanced gene expression, leading to modified cell morphology, accelerated proliferation rates, and the development of drug resistance—characteristics that contribute to a more representative cancer tissue model.

    The application of cell line culture in cancer research holds the potential to significantly enhance our understanding of cancer biology, eliminate poor drug candidates, and identify new, physiologically relevant targets that might be overlooked in traditional 2D screens. The establishment of a 3D model system within cell line culture has proven effective, saving both time and costs while producing more realistic results. The increasing demand for 3D cell culture is attributed to its heightened effectiveness and efficiency in replicating physiological conditions, making it a preferred choice in various research endeavors.

    Market Summary

    The Global Immortalized Cell Line Market is projected to grow from 4.51 USD Billion in 2024 to 9.18 USD Billion by 2035.

    Key Market Trends & Highlights

    Immortalized Cell Line Key Trends and Highlights

    • The market is expected to witness a compound annual growth rate (CAGR) of 6.67% from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 9.18 USD Billion, indicating robust growth.
    • In 2024, the market is valued at 4.51 USD Billion, reflecting a strong foundation for future expansion.
    • Growing adoption of immortalized cell lines due to their advantages in drug development is a major market driver.

    Market Size & Forecast

    2024 Market Size 4.51 (USD Billion)
    2035 Market Size 9.18 (USD Billion)
    CAGR (2025-2035) 6.67%
    Largest Regional Market Share in 2024 latin_america)

    Major Players

    Thermo Fisher Scientific (US), ATCC (American Type Culture Collection Inc.) (US), Valneva (France), Sartorius AG (Germany), Lonza Group, AG (Switzerland), Merck KGaA (Germany), Selexis SA (Switzerland), WuXi App Tec (China), European Collection of Authenticated Cell Cultures (ECACC) (Europe), Corning Incorporated (US)

    Market Trends

    The increasing demand for organ donation due to scarcity in the availability of organs is driving the need for artificially created biological cells. For instance, according to the US Department of Health & Human Services Organ Procurement and Transplantation Network (OPTN), as of November 2016, 121,678 patients were waiting for a life-saving organ transplant. This rising demand for an

    organ transplant

    is expected to drive the growth of the market during the forecast period. Additionally, increasing application in biotech and pharmaceutical companies and hospitals and rise in the patient population affected by cancer are likely to support market growth. On the other hand, the high cost of equipment and developing a stable strain of cell line and maintaining and preventing it from contamination is anticipated to hamper the market growth.

    The increasing demand for advanced therapeutic solutions and personalized medicine appears to be driving the growth of the immortalized cell line market, as these cell lines provide essential tools for drug discovery and development.

    National Institutes of Health (NIH)

    Immortalized Cell Line Market Market Drivers

    Rising Demand for Biopharmaceuticals

    The increasing demand for biopharmaceuticals is a primary driver of the Global Immortalized Cell Line Market Industry. As the biopharmaceutical sector expands, the need for reliable and consistent cell lines for drug development and production intensifies. Immortalized cell lines provide a stable and reproducible platform for research and manufacturing, which is crucial for the development of therapeutic proteins and monoclonal antibodies. In 2024, the market is projected to reach 4.51 USD Billion, reflecting the growing reliance on these cell lines in biopharmaceutical applications. This trend is likely to continue as the industry evolves, potentially leading to a market size of 9.18 USD Billion by 2035.

    Emerging Markets and Global Expansion

    Emerging markets are becoming increasingly important in the Global Immortalized Cell Line Market Industry. Countries in Asia-Pacific and Latin America are witnessing rapid growth in their biopharmaceutical sectors, driven by rising healthcare expenditures and increasing research activities. This expansion presents significant opportunities for the adoption of immortalized cell lines in these regions. As global players seek to establish a presence in these markets, the demand for reliable cell lines is expected to surge. This trend is likely to contribute to the overall growth of the market, as companies adapt their strategies to cater to the unique needs of emerging economies.

    Advancements in Cell Line Technologies

    Technological advancements in cell line development are significantly influencing the Global Immortalized Cell Line Market Industry. Innovations such as CRISPR-Cas9 gene editing and improved culture techniques enhance the efficiency and reliability of immortalized cell lines. These advancements enable researchers to create cell lines with specific genetic modifications, facilitating targeted drug discovery and personalized medicine approaches. As these technologies become more accessible, the market is expected to grow at a CAGR of 6.67% from 2025 to 2035. This growth is indicative of the increasing integration of advanced technologies in cell line research and development.

    Growing Focus on Personalized Medicine

    The shift towards personalized medicine is reshaping the Global Immortalized Cell Line Market Industry. Immortalized cell lines play a crucial role in understanding individual responses to therapies, allowing for the development of tailored treatment strategies. This focus on personalized approaches is driving research and development efforts, as pharmaceutical companies seek to create more effective and targeted therapies. The market's growth is supported by the increasing investment in personalized medicine initiatives, which is expected to further propel the demand for immortalized cell lines in the coming years. As a result, the industry is poised for substantial growth as it aligns with evolving healthcare paradigms.

    Regulatory Support for Cell Line Research

    Regulatory bodies are increasingly recognizing the importance of immortalized cell lines in research and development, providing a favorable environment for the Global Immortalized Cell Line Market Industry. Guidelines and frameworks established by organizations such as the FDA and EMA facilitate the use of these cell lines in drug development and testing. This regulatory support not only ensures the safety and efficacy of biopharmaceutical products but also encourages investment in cell line research. As regulations evolve to accommodate advancements in cell line technology, the market is likely to experience sustained growth, further solidifying the role of immortalized cell lines in the biopharmaceutical landscape.

    Market Segment Insights

    Immortalized Cell Line Method Insights

    Based on the method, the global market has been segmented into virus induction, hTERT expression, inactivation of tumor suppression genes, and others. The virus induction segment is further divided into EBV genes, SV40 T antigen, HPV-16 E6/6 gene, and others. The hTERT expression segment is sub-segmented into P53 and Myc T58A.

    The immortalized cell line market, based on application, is segmented into diagnostics, drug discovery, vaccine production, 

    and regenerative medicine, and others.

    Immortalized Cell Line End User Insights

    Based on end user, the global market is segmented into pharmaceutical and biopharmaceutical companies, Contract Research Organizations (CROs), and research laboratories. The pharmaceutical and biopharmaceutical companies segment accounted for a market value of USD 1,323.79 million in 2017.  

    Some of the key strategies followed by the players operating in the immortalized cell line market are innovation, product development, acquisition, and expansion.

    Get more detailed insights about Immortalized Cell Line Market Research Report - Global Forecast till 2032

    Regional Insights

    Key Companies in the Immortalized Cell Line Market market include

    Industry Developments

    In January 2024,

    Thermo Fisher Scientific Launched new Gibco™ Advanced DMEM/F12 media optimized for immortalized cell lines, claiming improved growth and performance.

    In September2023,

    Lonza Group AG Announced partnership with CStone Pharmaceuticals to optimize and manufacture immortalized cell lines for CAR-T cell therapy development.

    Future Outlook

    Immortalized Cell Line Market Future Outlook

    The Immortalized Cell Line Market is projected to grow at a 6.67% CAGR from 2024 to 2035, driven by advancements in biotechnology, increasing demand for drug discovery, and personalized medicine.

    New opportunities lie in:

    • Invest in developing novel immortalized cell lines for specific therapeutic applications.
    • Leverage automation technologies to enhance production efficiency and reduce costs.
    • Expand into emerging markets with tailored solutions for local research needs.

    By 2035, the Immortalized Cell Line Market is expected to achieve substantial growth, reflecting its critical role in biomedical research.

    Market Segmentation

    Immortalized Cell Line Method Outlook

    • Virus Induction
    • EBV genes
    • SV40 T antigen
    • HPV-16 E6/6 gene
    • Others 
    • HTERT Expression
    • P53
    • Myc T58A
    • Inactivation of Tumour Suppression Genes
    • Others

    Immortalized Cell Line End User Outlook

    • Pharmaceutical and Biopharmaceutical Companies
    • Contract Research Organizations
    • Research Laboratories

    Immortalized Cell Line Regional Outlook

    • Americas
    • North America
    • US
    • Canada
    • South America
    • Europe
    • Western Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Rest of Western Europe
    • Eastern Europe
    • Asia-Pacific
    • China
    • Japan
    • India
    • South Korea
    • Rest of Asia-Pacific
    • Middle East & Africa
    • Middle East
    • Africa
    • Research and development (R&D) companies
    • Government research institutes
    • Academic institutes and universities

    Immortalized Cell Line Application Outlook

    • Diagnostics
    • Drug Discovery
    • Vaccine Production
    • Tissue Engineering and Regenerative Medicines
    • Others

    Report Scope

    Attribute/Metric Details
      Market Size 2032   USD 7.56 Billion
      CAGR   6.67% (2024-2032)
      Base Year   2023
      Forecast Period   2024-2032
      Historical Data   2020
      Forecast Units   Value (USD Billion)
      Report Coverage   Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
      Segments Covered   Method, Application, End User and Region
      Geographies Covered   North America, Europe, Asia-Pacific, and Rest of the World (RoW)
      Key Vendors  Virus Induction, EBV genes, SV40 T antigen, HPV-16 E6/6 gene, HTERT Expression, Myc T58A, Inactivation of Tumour Suppression Genes
      Key Market Opportunities   Increasing demand for organ donation due to scarcity in the availability of organs
      Key Market Drivers   Increasing government support, well-developed technology

    Market Highlights

    Author

    Rahul Gotadki
    Assistant Manager

    She holds an experience of about 6+ years in market research and business consulting, working under the spectrum of information communication technology, telecommunications and semiconductor domains. aarti conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. her expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc.

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    FAQs

    What will be the value of the Immortalized Cell Line Market during the forecast period?

    Immortalized Cell Line Market is predicted to touch USD 7.56 Billion by 2032.

    At what CAGR is the Immortalized Cell Line Market projected to grow during the forecast period?

    Immortalized Cell Line Market is projected to grow at a 6.67% CAGR between 2024-2032.

    Which region is projected to dominate the Immortalized Cell Line Market?

    North America is projected to dominate the Immortalized Cell Line Market.

    Which end user segment will dominate the Immortalized Cell Line Market?

    Pharmaceutical & biopharmaceutical companies will dominate the Immortalized Cell Line Market.

    What are the key factors boosting the Immortalized Cell Line Market growth?

    Increasing prevalence of cancer, growing need for organ transplantation, and rising application in hospitals, pharmaceutical & biotech companies are boosting market growth.

    1. Report Prologue
    2. Executive Summary
    3. Market Introduction
      1. Scope of Study 19
      2. Research Objective 19
      3. List of Assumptions
      4. Market Structure 20
    4. Research Methodology
      1. Research Process
      2. Primary Research 23
      3. Secondary Research 24
      4. Market Size
      5. Forecast Model 25
    5. Market Dynamics
      1. Introduction
      2. Drivers 28
        1. Increasing Application in Biotech & Pharmaceutical
        2. Growing Number of Patients in Need of Organ
        3. Rise in the Patient Population Affected by Cancer
      3. Restraints 29
        1. High Cost of Equipment 29
        2. Developing
      4. Opportunities 30
        1. Entering
        2. Increasing Use of cell Line Culture in Cancer and
    6. Market Factor Analysis
      1. Porters Five Forces
        1. Bargaining Power of Suppliers 32
        2. Bargaining Power
        3. Threat of New Entrants 32
        4. Threat of Substitutes
        5. Intensity of Rivalry 33
      2. Supply Chain Analysis 33
        1. Manufacturing 33
        2. Distribution & Sales 34
        3. Post-Sales Monitoring 34
      3. Investment Opportunities 34
      4. Pricing
    7. Immortalized Cell Line Market, by Method
      1. Overview 36
        1. Virus Induction 38
        2. HTERT Expression 39
        3. Inactivation
        4. Others 40
    8. Immortalized Cell Line
      1. Overview 42
        1. Diagnostics 43
        2. Vaccine Production 44
        3. Tissue Engineering
        4. Others 45
    9. Immortalized Cell Line
      1. Overview 47
        1. Introduction 47
        2. Pharmaceutical
        3. Contract Research Organizations 48
        4. Research Laboratories 49
    10. Global Immortalized Cell Line Market, By
      1. Overview 51
      2. Americas 52
        1. North America 54
        2. South America 60
      3. Europe 62
        1. Western Europe 65
        2. Eastern Europe 78
      4. Asia-Pacific 80
        1. Japan 82
        2. China 84
        3. India 86
        4. South Korea 87
        5. Rest of Asia-Pacific 89
      5. Middle East
    11. Competitive
      1. Company Market Share Analysis 98
        1. Introduction 98
      2. Competitive Landscape 99
        1. Introduction 99
      3. Key Developments
    12. Company Profiles
      1. Thermo Fisher Scientific 102
        1. Financial Overview 102
        2. Products Offered
        3. Key Developments 103
        4. SWOT Analysis 103
        5. Key
      2. ATCC (American Type Culture Collection Inc.) 105
        1. Financial Overview 105
        2. Products Offered
        3. Key Developments 106
        4. SWOT Analysis 107
        5. Key
      3. Valneva 108
        1. Company Overview 108
        2. Products Offered 108
        3. Key Developments
        4. SWOT Analysis 109
        5. Key Strategies 109
      4. Sartorius
        1. Company Overview 110
        2. Financial Overview 110
        3. Key Developments 111
        4. SWOT Analysis
        5. Key Strategies 111
      5. Lonza Group, AG 112
        1. Company
        2. Financial Overview 112
        3. Products Offered 112
        4. Key Developments 113
        5. Swot Analysis 113
        6. Key Strategies
      6. Merck KGaA 114
        1. Company Overview 114
        2. Financial
        3. Products Offered 115
        4. Key Developments 115
        5. SWOT Analysis 115
        6. Key Strategies 115
      7. Selexis SA 116
        1. Company Overview 116
        2. Financial Overview 116
        3. Products
        4. Key Developments 116
        5. SWOT Analysis 117
      8. Wuxi App Tec 118
        1. Company Overview 118
        2. Financial Overview 118
        3. Products Offered 119
        4. Key
        5. SWOT Analysis 119
        6. Key Strategies 119
      9. European Collection of Authenticated Cell Cultures (ECACC) 120
        1. Financial Overview 120
        2. Products Offered
        3. Key Developments 120
        4. SWOT Analysis 121
        5. Key
      10. Corning Incorporated 122
        1. Company Overview
        2. Financial Overview 122
        3. Products Offered 123
        4. SWOT Analysis 123
        5. Key Strategies
    13. Appendix
      1. Discussion Blue Print 125
    14. List of Tables
    15. GLOBAL IMMORTALIZED CELL LINE MARKET FOR VIRUS INDUCTION, BY TYPE 2020–2027
    16. GLOBAL IMMORTALIZED CELL LINE MARKET FOR HTERT EXPRESSION, BY REGION 2020–2027
    17. GLOBAL IMMORTALIZED CELL LINE MARKET, BY APPLICATION 2020–2027 (USD MILLION)
    18. GLOBAL IMMORTALIZED CELL LINE MARKET, BY END-USERS 2020–2027 (USD MILLION)
    19. AMERICAS IMMORTALIZED CELL LINE MARKET, BY REGION 2020–2027 (USD MILLION)
    20. NORTH AMERICAS IMMORTALIZED CELL LINE MARKET FOR VIRUS INDUCTION, BY TYPE 2020–2027
    21. US IMMORTALIZED CELL LINE MARKET, BY APPLICATION 2020–2027 (USD MILLION)
    22. EUROPE IMMORTALIZED CELL LINE MARKET, BY APPLICATION 2020–2027 (USD MILLION)
    23. ITALY IMMORTALIZED CELL LINE MARKET, BY APPLICATION 2020–2027 (USD MILLION)
    24. SPAIN IMMORTALIZED CELL LINE MARKET, BY APPLICATION 2020–2027 (USD MILLION)
    25. JAPAN IMMORTALIZED CELL LINE MARKET, BY APPLICATION 2020–2027 (USD MILLION)
    26. CHINA IMMORTALIZED CELL LINE MARKET, BY APPLICATION 2020–2027 (USD MILLION)
    27. INDIA IMMORTALIZED CELL LINE MARKET, BY APPLICATION 2020–2027 (USD MILLION)
    28. SOUTH KOREA IMMORTALIZED CELL LINE MARKET FOR HTERT EXPRESSION, BY TYPE 2020–2027
    29. REST OF ASIA-PACIFIC IMMORTALIZED CELL LINE MARKET FOR VIRUS INDUCTION, BY TYPE
    30. MIDDLE EAST AND AFRICA IMMORTALIZED CELL LINE MARKET, BY METHOD 2020–2027
    31. List of Figures
    32. (%) 65

    Immortalized Cell Line Market Segmentation

    Market Segmentation Overview

    • Detailed segmentation data will be available in the full report
    • Comprehensive analysis by multiple parameters
    • Regional and country-level breakdowns
    • Market size forecasts by segment
    Infographic

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