Closed System Drug Transfer Device Market Trends

Global Closed System Drug Transfer Device Market Overview

The Closed System Drug Transfer Device Market was valued at USD 1.07 billion in 2023. The industry is projected to grow from USD 1.20 billion in 2024 to USD 2.87 billion by 2032, exhibiting a compound annual growth rate (CAGR) of 10.17% during the forecast period (2024 - 2032). The increasing incidences of cancer across the globe and stringent regulatory requirements within the healthcare industry are driving the market growth.

Source: Secondary Research, Primary Research, MRFR Database, and Analyst Review

Closed System Drug Transfer Device Market Trends

Increasing incidences of cancer across the globe

The increasing incidences of cancer across the globe are significantly driving the global closed-system drug transfer device (CSTD) market. This is because cancer treatment often requires hazardous drugs that can be harmful to healthcare workers handling them. The system provides a closed and leak-proof system that helps the escape of these hazardous drugs into the environment. Further, the cancer burden is rising across the globe due to factors such as an aging population, environmental factors, better diagnostic capabilities, and lifestyle changes that are fostering market growth.

For instance, according to the International Agency for Research on Cancer, there were cancer cases of nearly 9,826,539 in Asia, 4,471,422 in Europe, 2,673 174 in Northern America, 1,551,060 in Latin America and the Caribbean, 1,185,216 in Africa, and 269 088 in Oceania in 2022. As per the International Agency for Research on Cancer, there were 192,020 breast cancer cases, 143,759 lips, oral cavity, 127,526 cervix uteri, 81,748 lung, 70,637 esophagus, 70,038 colorectum, and 727,588 cancer cases of others. The growing focus on occupational safety, coupled with technological advancements in CSTD functionality and design, is accelerating its adoption across healthcare facilities worldwide. Also, healthcare providers prioritize both provider's and patients’ health; the demand for CSTDs is expected to continue in response to the escalating cancer burden worldwide.

Closed System Drug Transfer Device Market Segment Insights:

Global Closed System Drug Transfer Device Type Insight

Based on type, the global closed-system drug transfer device market has been segmented into membrane-to-membrane systems and needless systems. The membrane-to-membrane systems segment dominated the market in 2023, and needless systems is projected to be the fastest-growing segment during the forecast period, 2024–2032.

In 2023, the Membrane-to-Membrane Systems segment dominated the global closed-system transfer device market. The membrane-to-membrane drug transfer devices use a dual membrane system between the syringe and vial to isolate the medical product. Factors such as reduced contamination risk and ease of use of double-membrane systems indicate the safety of membrane-to-membrane drug transfer devices, which is expected to boost their adoption in the coming years. Furthermore, the rising awareness of CSTD devices for the treatment of chronic diseases and growing adoption of membrane-to-membrane safety devices owing to prevention from exposure to harmful substances by creating a barrier between hazardous drugs and healthcare professional are driving Membrane-to-Membrane Systems segment.

The needless system is expected to be the fastest growing segment throughout the forecast period owing to advantages such as needle free drug delivery. Additionally, new product launches and adoption of eco-friendly designs which minimize the single use plastics and other disposable material are projected to add to the rapid expansion of needleless systems.

FIGURE 2: CLOSED SYSTEM DRUG TRANSFER DEVICE MARKET SIZE, BY TYPE, 2023 & 2032 (USD BILLION)

Source: Secondary Research, Primary Research, MRFR Database, and Analyst Review

Global Closed System Drug Transfer Device Component Insight

Based on component, the Closed System Drug Transfer Device Market has been segmented into vial access devices, syringe safety devices, bag/line access devices, and accessories. The syringe safety devices segment dominated the market in 2023, and accessories is projected to be the fastest-growing segment during the forecast period, 2024–2032.

The bag/line access devices segment includes products such as connectors, tubing sets, plugs, and many others utilized for drug delivery safety. Increasing demand for bag/line access devices for cancer, respiratory illnesses, and other ailments will drive market expansion throughout the forecast period.

Vial access components are essential for maintaining the integrity of drug transfer procedures in closed systems, which reduces the possibility of contamination and hazardous material exposure for patients and healthcare personnel. Due to strict regulations and increased awareness of the significance of safe drug administration, the increasing use of CSTDs in a variety of healthcare settings is expected to drive demand for vial access components, which will support their high CAGR in the closed system transfer devices market. Additionally, there are several types of vial access devices available, including needle-free models that automatically balance vial pressure by lowering aerosols, stopping medication vaporization and leakage, and releasing the required amount of medication from the device.

Moreover, the closed syringe safety devices facilitate the transfer of fluid using a syringe and various components through dedicated device connections. These devices prevent the wastage of drugs which provides an easy method to deliver hazardous drugs and reduce confusion. Companies such as B. Braun Medical Inc. offer OnGuard syringe adaptor, a closed system drug transfer device for easy delivery of drug to the patient.

Global Closed System Drug Transfer Device Closing Mechanism Insight

Based on closing mechanism, the Closed System Drug Transfer Device Market has been segmented into push to turn system, color-to-color alignment system, leur lock systems, and click-to lock system.

Color-to-color alignment systems allow for the exact and efficient movement of materials in closed settings, ensuring safety and precision in industries such as pharmaceuticals, biotechnology, and chemical manufacturing. With a growing emphasis on contamination control and severe regulatory requirements, demand for closed-system transfer devices with color-to-color alignment systems is likely to rise. As companies prioritize safety and efficiency in their operations, color-to-color alignment systems within closed-system transfer devices are expected to see significant expansion in the near future.

It is easier for healthcare professionals to use a push-to-turn connection mechanism system with a one-step straight-push mechanism. Patient safety is just as vital as health care professional safety. The number of firms producing airtight and leak-proof connections for transporting and administering drugs within a closed system is growing. Corvida Medical, headquartered in the greater Iowa City area, develops technology that is intended to represent better solutions for the safe handling of hazardous pharmaceuticals as well as quality in design. The company manufactures Halo, a smarter closed-system transfer device solution for chemotherapy and hazardous drugs.

Moreover, a Luer lock syringe enables a needle to be twisted onto the tip and locked into place, providing a secure connection, and preventing accidental removal of the needle and injection of contents. Luer lock fittings are securely joined by means of a tabbed hub on the female fitting which screws into threads in a sleeve on the male fitting. It allows a needle to be twisted onto the tip and then locked in place. An increasing number of manufacturers are producing new and refined drug-delivery products. For instance, Simplivia Healthcare Ltd. (Israel) manufactures Tevadaptor luer lock adaptor which converts any standard female luer lock port (e.g., patient access port) to a safe and closed Tevadaptor connection. The other CSTD closing mechanism includes click to lock systems. Increasing number of cancer incidence globally and the need of such devices to reduce the risk associated while handling hazardous drugs is propelling the market growth for this segment.

In addition to that, push-to-turn systems will witness the fastest growing market in the forecast period as these systems are increasingly being used for the safe transmission of hazardous medical substances. The large revenue share of closed-system transfer devices is mostly due to increased research and development activities in closed-system transfer devices for oncology medication transfer.

Furthermore, click to lock systems features a precise locking mechanism that ensures a tight and sealed connection between the device and drug vials or IV bags. This mechanism typically involves a straightforward click-to-lock action, which effectively seals off any potential leakage points and prevents the escape of hazardous substances. The design prioritizes user-friendliness and safety, allowing healthcare professionals to confidently handle medications without the risk of exposure to harmful vapors or particles. Additionally, CSTDs often incorporate supplementary features such as integrated filters or secondary seals to further enhance containment capabilities and ensure compliance with rigorous safety standards.

Global Closed System Drug Transfer Device Closing Technology Insight

Based on technology, the Closed System Drug Transfer Device Market has been segmented into compartmentalize devices, diaphragm-based devices, and air filtration devices. The diaphragm-based devices segment dominated the market in 2023, and air filtration devices are projected to be the fastest-growing segment during the forecast period, 2023–2032.

The expansion of the compartmentalized device category is mostly due to the devices' simplicity of operation and safety. Furthermore, Diaphragm-based devices are expected to grow at the highest CAGR in the closed system transfer devices market. This growth projection is primarily related to their exceptional performance in assuring the safe and efficient transfer of hazardous substances, drugs, and fluids, hence limiting the danger of contamination and exposure among healthcare professionals and patients. Diaphragm-based systems are becoming more popular for a variety of applications in healthcare settings due to their increased dependability, precision, and usability. With a growing emphasis on patient safety, together with technological developments and increased awareness of the relevance of CSTDs, demand for diaphragm-based solutions is predicted to skyrocket, accelerating their market growth at a rapid pace.

In addition, closed system medication transfer systems prohibit pollutants from entering the system via a physical barrier or air filtering technology. The CSTD air-cleaning technology is based on an activated carbon filter and a membrane that allows the medicine to be kept sterile by filtration of air entering the vial during pressure equalization.

Global Closed System Drug Transfer Device Closing End User Insight

Based on end user, the Closed System Drug Transfer Device Market has been segmented into hospitals & clinics, specialty centers, and others. The hospitals & clinics segment dominated the market in 2023, and specialty centers is projected to be the fastest-growing segment during the forecast period, 2024–2032.

The hospitals and clinics segment accounted for the largest market share. The high adoption of CSTD systems in hospitals & clinics is due to the high purchasing power of big hospitals and the growing healthcare infrastructure. While hospitals and clinics are the primary facilities where patients who need a variety of medical treatments and procedures seek treatment, there is a greater need for safety precautions such as closed system transfer devices to avoid drug exposure and contamination. In addition, hospitals and clinics have to invest in cutting-edge technology like CSTDs to ensure patient safety and compliance with the strict regulatory standards that are imposed in healthcare facilities. These regulations require the adoption of safe handling methods. As a result, hospitals and clinics' combined demand plays a major role in their significant share in the closed system drug transfer device market.

The specialty centers segment is expected to be the fastest-growing end user segment. This is attributed to the growing awareness and adoption of CSTD devices for the delivery of many diseases as well as the increasing number of patients suffering from chronic diseases. Furthermore, others include academic and healthcare institutions and research laboratories. Moreover, factors such as advancements in academic research and the rising demand from healthcare institutions for safer and more effective drug delivery methods will drive the market growth during the forecast period.

Global Closed System Drug Transfer Device Regional Insights

Based on region, the Closed System Drug Transfer Device Market has been segmented into North America, Europe, Asia-Pacific, and the Rest of the World. North America accounted for the largest market share in 2023 and is anticipated to reach USD 9.92 billion by 2032, registering a CAGR of 9.10% during the forecast period.

North America accounted for the largest market share of 38.14% and is estimated to dominate the global CSTD market. This large market share is due to the increasing prevalence of cancer cases and the strong research and development infrastructure. For instance, In the United States in 2020, there were 1,603,844 new cancer cases reported and 602,347 cancer deaths. There were 403 new cancer cases reported for every 100,000 people, and 144 people died from cancer. Moreover, Technological advancements in CSTDs are further driving market growth. Modern devices incorporate innovative features such as air filtration systems, leak-proof connectors, and enhanced compatibility with various drug delivery systems, thereby improving their effectiveness and usability in clinical settings

The Americas region is followed by Europe, which accounted for the second largest closed system drug transfer device market share. One of the primary drivers is the increasing prevalence of chronic diseases across the region, which necessitates efficient and safe drug delivery mechanisms. This demographic trend is fueling demand for advanced drug transfer devices that offer enhanced safety and precision in medication administration. Additionally, stringent regulations and guidelines pertaining to healthcare worker safety are pushing healthcare facilities to adopt closed-system drug transfer devices (CSTDs) to minimize occupational exposure to hazardous drugs. Moreover, technological advancements in drug transfer devices, such as the integration of smart features and materials that ensure compatibility with a wide range of medications, are further propelling market expansion. These factors collectively contribute to a favorable landscape for growth in the Europe drug transfer devices market, promising continued innovation and adoption in the years ahead.

Asia-Pacific is expected to witness significant growth and is projected to be the fastest growing region over the forecast period due to the increasing number of new vendors involved in the drug-device system, as many regional/small market players are trying to leverage the market share. In 2019, there were only 62 dedicated cancer care hospitals in India, including both regional and national facilities, according to the National Institute of Health. The estimated number of cancer incidents in India for the year 2022 was 14,61,427 (crude rate: 100.4 per 100,000). In India, one in every nine people will develop cancer during their lifetime. Lung and breast cancers were the most common cancer sites in men and women, respectively. Thus, the increasing cancer patient pool will propel the demand for closed drug delivery systems which will boost the market growth in the region. Additionally, the availability of skilled workforce and low production cost in the region portrays an opportunity for global players to enter untapped markets in Asia-Pacific.

FIGURE 3: CLOSED SYSTEM DRUG TRANSFER DEVICE MARKET BY REGION 2023 & 2032 (USD BILLION)

Global Closed System Drug Transfer Device Key Market Players & Competitive Insights

The Closed System Drug Transfer Device Market is characterized by the presence of many global, regional, and local vendors. The market is highly competitive, with all the players competing to gain maximum market share. Intense competition, frequent changes in government policies, and regulations are key factors that impact market growth. The vendors compete based on cost, product quality, reliability, and aftermarket services.

Product launch and approvals were also observed to expand the company's product portfolio. The growth of prominent industry players is dependent on various factors, such as market conditions, product differentiation and innovation, and pricing strategies. It is also projected that increasing investment in healthcare infrastructure and rising awareness and education associated with the closed system drug transfer device (CSTDs) benefits will also boost the market's growth in the upcoming future. 

Major players in the Closed System Drug Transfer Device Market, including Becton, Dickson, and Company, Inc, Baxter International Inc., ICU Medical, Inc., JMS Co.Ltd, B. Braun SE, Equashield, and others are making investments in R&D activities to boost market demand.

Braun is a healthcare supplier and manufacturer that offers its products to hospitals, surgical units, private practices (medical care and doctors' offices), and extracorporeal blood treatments. The company operates through three major business segments: Hospital Care, Aesculap, and Avitum. Furthermore, B. Braun offers a wide range of medical devices and systems for hospitals and healthcare facilities. They invest significantly in research and development (R&D) to introduce new products, improve existing ones, and address unmet medical needs.

Moreover, In December 2021, B. Braun Medical Inc. has introduced the next generation OnGuard 2 CSTD in the United States. Building on the strengths of its predecessor, OnGuard 2 incorporates upgraded materials and enhanced features aimed at improving usability while retaining all the existing advantages of the original OnGuard device.

Key Companies in the Closed System Drug Transfer Device Market include.

• Braun SE (Germany)


• JMS Co., Ltd. (Japan)


• ICU Medical, Inc. (US)


• Simplivia (Israel)


• Equashield (US)


• Becton, Dickinson and Company (US)


• Baxter International Inc. (US)


• Cormed (US)


• Yukon Medical (US)


• Caragen Ltd. (Ireland)

Global Closed System Drug Transfer Device Industry Developments

December 2023: Equashield announced the launch of its latest product, the Mundus Mini HD. Leveraging Equashield’s CSTDs, the Mundus Mini HD aims to minimize contamination, exposure, and errors, thereby enhancing compounding safety and efficiency.

October 2023: The EQUASHIELD Syringe Unit has received additional FDA clearance for full volume use.

April 2022: Simplivia has launched Chemfort, its latest closed system transfer device (CSTD). Chemfort is designed to significantly minimize the risk of exposure for healthcare professionals during the preparation and administration of hazardous drugs.

December 2021: B. Braun SE introduced the next generation OnGuard 2 CSTD in the US. Building on the strengths of its predecessor, OnGuard 2 incorporates upgraded materials and enhanced features aimed at improving usability while retaining all the existing advantages of the original OnGuard device.

Closed System Drug Transfer Device Market Segmentation:

Global Closed System Drug Transfer Device Type Outlook

• Membrane-To-Membrane Systems


• Needleless Systems

Global Closed System Drug Transfer Component Outlook

• Vial Access Devices


• Syringe Safety Devices


• Bag/Line Access Devices


• Accessories

Global Closed System Drug Transfer Closing Mechanism Outlook

• Push To Turn System


• Color-To-Color Alignment System


• Leur Lock Systems


• Click-To Lock System

Global Closed System Drug Transfer Technology Outlook

• Compartmentalize Devices


• Diaphragm-Based Devices


• Air Filtration Devices

Global Closed System Drug Transfer End Users Outlook

• Hospitals & clinics


• Specialty centers


• Others

Global Closed System Drug Transfer Regional Outlook

North America

• US


• Canada


• Mexico

Europe

• Germany


• France


• UK


• Italy


• Spain


• Rest of Europe

Asia-Pacific

• China


• Japan


• India


• South Korea


• Australia


• Rest of Asia-Pacific

Rest of the World

• 
  

  Middle East & Africa

  
  


• 
  

  South America