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CAR T Cell Therapy Market Share

ID: MRFR//6630-CR | 88 Pages | Author: Rahul Gotadki| February 2021

Rising Cancer Cases: A Driving Force for CAR T-Cell Therapy

Cancer, a formidable adversary to human health, is on the rise globally, necessitating more effective treatment solutions. The prevalence of various cancer types, including lung, blood, breast, and liver cancers, is escalating at an alarming rate. In 2020, according to estimates from GLOBOCAN 2020 by the International Agency for Research on Cancer (IARC), the world witnessed approximately 19.3 million new cancer cases and around 10.0 million cancer-related deaths. Closer to home, the National Cancer Institute reported a staggering 1,735,350 new cancer cases and 609,640 deaths in the United States in 2018.

Contributing Factors to the Surge in Cancer Cases

Several factors contribute to the surge in cancer cases on a global scale. High levels of smoking, coupled with the consumption of alcohol and tobacco, are major contributors to the growing cancer burden. These lifestyle choices significantly elevate the risk of developing various forms of cancer. Additionally, the rising incidence of obesity has been identified as another significant factor associated with an increased susceptibility to cancer. The World Health Organization (WHO) and various health agencies have sounded the alarm about the escalating rates of obesity worldwide, highlighting its role as a key risk factor for multiple cancers.

The Impact of Smoking, Alcohol, and Tobacco Consumption

Excessive smoking and the consumption of alcohol and tobacco contribute significantly to the increasing prevalence of cancer across the world. The adverse health effects of tobacco are well-documented, and the WHO's 2018 fact sheet highlighted that excessive tobacco use is responsible for a staggering 7 million deaths annually. Lung cancer, in particular, emerges as the leading cause of global deaths, accounting for a substantial 37% of the total. The correlation between smoking, alcohol consumption, and the rising incidence of cancer underscores the urgent need for comprehensive strategies to address these modifiable risk factors.

Obesity as a Contributing Factor

The global rise in obesity rates has added another layer to the complex landscape of cancer causation. Obesity is intricately linked to an increased risk of developing various types of cancers, including breast, colorectal, ovarian, pancreatic, and liver cancers. The World Cancer Research Fund identifies the role of excess body fat, particularly abdominal fat, as a major risk factor for cancer development. As urbanization, sedentary lifestyles, and poor dietary habits contribute to the obesity epidemic, the correlation between obesity and cancer becomes more pronounced.

CAR T-Cell Therapy: A Response to Escalating Cancer Cases

As the world grapples with a growing population struggling with obesity and engaging in high-risk behaviors, the demand for advanced treatment options becomes more urgent. CAR T-cell therapy, a groundbreaking immunotherapy, stands out as a promising solution in the fight against cancer. This innovative approach involves isolating T cells from a patient's body, genetically modifying them with the Chimeric Antigen Receptor (CAR) gene, and reintroducing them into the patient. The modified T cells, now equipped with specific receptors targeting cancer cells, work to eliminate the cancerous cells.

The Role of CAR T-Cell Therapy in Addressing the Growing Cancer Burden

The escalating number of individuals contending with cancer underscores the critical need for advanced and targeted therapies. CAR T-cell therapy has emerged as a revolutionary approach that holds significant promise in treating various types of cancer. Its success in treating B-cell lymphoma and Acute Lymphoblastic Leukemia (ALL) has paved the way for exploring its application in other malignant tumors.

The Global Impact of CAR T-Cell Therapy

CAR T-cell therapy is not confined to specific regions; it is undergoing extensive clinical trials globally. Countries such as the US, Canada, UK, France, Germany, China, Australia, and several others are actively engaged in researching the potential of CAR T-cell therapy for various cancers. Leading pharmaceutical companies, including Pfizer, Inc., and Kite Pharma, are investing in the development of CAR T-cell therapy-based products. Examples include Pfizer's Phase I pipeline product, UCART19, and Kite Pharma's Phase II pipeline product, KTE-C19.

In conclusion, as the prevalence of cancer continues to grow due to lifestyle choices, environmental factors, and the global obesity epidemic, the demand for advanced treatments intensifies. CAR T-cell therapy, with its ability to target specific cancer cells, offers hope and improved outcomes for patients worldwide. The innovative strides in this therapy, coupled with ongoing research and clinical trials, position it as a pivotal player in shaping the trajectory of cancer treatment, providing a beacon of hope in the face of a rising global cancer burden.

Covered Aspects:

Report Attribute/Metric Details
Base Year For Estimation   2022
Historical Data 2021
Forecast Period   2023-2032
Growth Rate   14.5%

CAR-T Cell Therapy Market Overview


The CAR T Cell Therapy market is projected to reach USD 7.2 Billion by 2032 at 14.5% CAGR during the forecast period 2024-2032. Chimeric Antigen Receptor (CAR)-T is a novel treatment that includes reengineering of the WBC’s of the patient to help in fighting the malignant cells by identifying them.


CAR T Cell Therapy Market


In 2024, the FDA approved a groundbreaking immunotherapy created by Iovance Biotherapeutics, bringing the T-cell therapy treatment class—which has revolutionized the treatment of certain blood cancers—to the solid tumor sector. The medication, known as Amtagvi, also known as lifileucel, is the first tailored tumor-infiltrating lymphocyte (TIL) therapy available on the market. For patients with metastatic melanoma who have previously had treatment with a PD-1 inhibitor—and a BRAF inhibitor if the tumor possesses a BRAF V600 mutation—the FDA on Friday awarded it an accelerated approval.


Kyverna Therapeutics, Inc. (Kyverna) is a patient-centered clinical-stage biopharmaceutical company that specializes in developing cell therapies for patients with autoimmune diseases. The company announced in 2024 that the FDA in the United States had cleared its application for an investigational new drug (IND).  KYV-101, a completely human CD19 chimeric antigen receptor (CAR) T-cell product candidate, is intended to be used as an MS therapy.


Max Healthcare and ImmunoACT collaborate to introduce CAR-T cell treatment in 2023.Referred to as a "living drug," this treatment offers long-lasting advantages and is suggested for individuals unable to receive a stem cell transplant or experiencing a relapse following a transplant. With an average of two weeks of in-patient care, this needs a brief, single-infusion treatment, which is less intrusive than conventional therapies and improves the quality of life for many patients.


COVID 19 Analysis


Owing to the advanced degree to which the global coronavirus pandemic is unfolding and the continuous variants and waves that have disrupted the lives of people across the globe, the industries, and market players are equally suffering the wrath. So much so, that some of the business players have given up and they are shutting their manufacturing and production units. Also, the imposed lockdown has not proved to be of any benefit as people are working from home which is disrupting both their personal and professional life, thus, resulting in an increased degree of unavailability of a skilled workforce that is further, hampering the ability to meet the demand quantum as a result of inefficient production. Also, the raw material available is no or very little quantity that is hampering the quality of products and it has become nearly impossible for the businesses to function amid a series of restrictions and cross-border difficulties.


Hence, the need of the hour is for the public sector to intervene and the governments of the global locations to enhance the funds that will help in the market’s revival. Also, it is important to understand that the population is increasing and the demands of people are different. The key market players should enhance their production ability and take it to the international market to launch a variety of products. Also, mergers and acquisitions are an important and innovative way to help the target audience choose from a variety of products and change their lifestyle preferences accordingly.


CAR-T Cell Therapy Market Dynamics


Drivers


The CAR-T cell therapy market companies are expected to thrive at an excellent rate during the ongoing forecast period of 2021-2027. The overall industry has a very dynamic approach and the key players belonging to the market are gaining access in the major CAR-T cell therapy market size. The companies are securing the treatment centers that will help in increasing patients owing to the development of a series of medical service demands.


Restraints


There have various growth restraints that emerge as major issues for the market while on its path of growth during the forecast period that ends in 2032. One of the major restraints that the market players tend to face is the lack of demand for treatment. The target population is too rigid and understands the native methods of treatment only. Also, the associated cost for treatment is very high that does not sit well with the people as they belong to different income groups and spending capacities. If the cost and prices are not reduced, the global CAR-T cell therapy market trends and operations are likely to pose major restraints for the market and bar the market from growing as per the predictions laid by the industry leaders and market experts during the forecast period of 2021-2032.


Technology Analysis


The rising rate of people being diagnosed with various types of cancer is one of the major reasons that lead to the death of the global population. Hence, the need of the hour is for the companies to evolve the conventional and cytotoxic immunotherapies that are available on the global market scale. The tumors are believed to have complex behaviors and the degree of involvement of a variety of cellular and genetic factors in metastasis and tumorigenesis is pushing the companies to divert their trends in the development of new treatment trends so that the main focus lays on tumors at both the stated levels.


Study Objectives



  • To understand the growth scope of the market during the ongoing forecast period that ends in 2032 considering the dynamics in the form of drivers and restraints that will impact the market of CAR-T cell therapy figures in form of the CAGR growth rate followed by the attainable market revenue by the ongoing forecast period after the pandemic year of 2020.

  • To analyze the scope of the CAR-T cell therapy market growth based on the bifurcation of the market in the form of segments that are spread in various global regions and catering to the need of the target audience in these regions during the period ending in 2032.

  • To study the attainable market growth rate of the CAR-T cell therapy based on the recent developments undertaken by the market players during the period and subsequently, draw a competitive graph amongst these players that are active in maintaining the supply chain mechanism of the global CAR-T cell therapy market.


CAR-T Cell Therapy Market Segment Overview


The CAR-T cell therapy market report shows that the market has been segmented based on the following:


CAR-T cell therapy Target antigen Insights


The global CAR-T cell therapy market by targeted antigen includes BCMA that is B-Cell maturation antigen, CD19/CD22, and others like PSCA, Lewis Y, ROR1, NKR-2, and MUC16 amongst others.


CAR-T cell therapy Application Insights


The application market segment of the CAR-T cell therapy includes Diffuse Large B-Cell Lymphoma, Acute Lymphoblastic Leukemia and Other.


CAR-T cell therapy Geography Insights


Based on the division of the target audience, types of equipment, and resources, the market of CAR-T cell therapy has been divided into 4 major regions namely North America, Europe, the APAC region, and the rest of the world.


CAR-T Cell Therapy Market Regional Analysis


The CAR-T cell gene therapy market analysis shows that the North American region shows signs of excellent growth during the period and is expected to grow at a global CAGR of 36.4%. Similarly, the changing trends in the European market and the increased use of proper technology will help the CAR-T cell therapy market grow at a significant rate. The recommended approvals of Yescarta and Kymriah by the European Medicine Agencies (EMA), are showing signs of positive attributes that will help the market boost its overall growth during the forecast period that ends in 2028.


Competitive Landscape


The rising degree of competition in the global market scenario of CAR-T cell therapy is the result of recent developments of CAR-T cell therapy companies. They are as follows:



  • Bluebird Bio (US)

  • Intellia Therapeutics (US)

  • Noile-Immune Biotech (Japan)

  • Celgene Corporation (US)

  • Bellicum Pharmaceuticals, Inc. (US)

  • Novartis International AG (Swiss)

  • Celyad (Belgium)

  • Cellectis (France)

  • Servier Laboratories (France)

  • Pfizer Inc. (US)

  • Caribou Biosciences, Inc. (US)

  • Mereck KGaA (Germany)

  • Amgen Inc. (US)


Recent Developments



  • The pharmaceutical and biotech companies are opening their doors towards mergers and acquisitions alongside showing their willingness to enter into partnerships. One of the main aims behind this intention is to win a competitive edge over the competitors in the international market scale. For instance, Celgene Corporation came forward and acquired Juno Therapeutics Inc.

  • The first approved therapy was in the field of pediatrics and young adults acute lymphoblastic leukemia (ALL). This is an ailment that has a huge unmet need. The CAR-T helps in indicating higher effectiveness having its representation in a small population chunk.

  • In February 2018, another prominent market player Gilead Sciences Inc. entered into a partnership with Sangamo Therapeutics Inc. The main idea behind this is for the gene-editing technology that is a major development for the treatment of diseases like cancer.


Report Overview


The curated reports aim to have a deep and helpful discussion of the global manufacturing of the CAR-T cell therapy in terms of the market trends and dynamics that will lead the market towards splendid growth during the ongoing forecast period that ends in 2032. The CAR-T cell therapy market report aims to help the market investors gain qualitative market insights related to the performance of the market segments and the growth strategies taken by the market players in various regions during the period that will help both the companies and the domestic regions to grow on the international market scale. Also, the report is a clear depiction of the rising competition amongst the key market players and the aim is to consider the recent developments undertaken during the ongoing forecast period that ends in 2032.

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