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CAR T Cell Therapy Market Analysis

ID: MRFR//6630-CR | 88 Pages | Author: Rahul Gotadki| February 2021

Exploring the Frontiers: Investigating CAR-T Therapy's Potential Across Hematologic and Solid Tumor Types

In the dynamic landscape of cancer treatment, Chimeric Antigen Receptor T-cell (CAR-T) therapy has emerged as a promising frontier, extending its reach beyond B cell lymphoma and Acute Lymphoblastic Leukemia (ALL). The spotlight is now on the investigation of CAR-T therapy for treating diverse malignancies, including pancreatic cancer. This exploration is not confined to a specific region but spans multiple countries engaged in extensive clinical trials. As pharmaceutical giants like Pfizer, Inc., Kite Pharma, and others spearhead the development of CAR-T therapies, a myriad of opportunities is unveiled for the market's growth.

Pancreatic Cancer: A Target for CAR-T Therapy

Pancreatic cancer, known for its aggressive nature and limited treatment options, is now under the scrutiny of CAR-T therapy. Clinical trials are underway globally, with a focus on the US, Canada, UK, France, Germany, China, Australia, Austria, Belgium, Russia, Israel, Singapore, Italy, Japan, Netherlands, Norway, Spain, Sweden, Switzerland, Thailand, and more. The intention is clear – to assess the efficacy of CAR-T therapy in combating pancreatic cancer and potentially revolutionize its treatment landscape.

Pivotal Players in CAR-T Therapy Development

Key players in the pharmaceutical realm, including Pfizer, Inc. and Kite Pharma, are at the forefront of developing CAR-T therapy-based products. Among these, Pfizer's UCART19, a Phase I pipeline product, and Kite Pharma's KTE-C19, a Phase II pipeline product, underscore the commitment to advancing CAR-T therapies. These initiatives transcend geographical boundaries, emphasizing a global collaborative effort to harness the full potential of CAR-T therapy.

Diversified Applications Unleash Market Opportunities

The exploration and diversified application of CAR-T therapy represent a beacon of opportunities for market growth. Beyond traditional realms, CAR-T therapy's adaptability is being tested across various tumor types. As clinical trials progress and demonstrate positive outcomes, the market stands poised for unprecedented expansion.

Global Clinical Trials: A Glimpse into CAR-T Therapy's Reach

Clinical trials serve as a litmus test for the viability and effectiveness of CAR-T therapy in diverse cancer types. From North America to Europe, Asia-Pacific, and beyond, the global clinical landscape is witnessing a surge in trials, reflecting the industry's commitment to pushing the boundaries of cancer treatment.

Market Dynamics: Navigating the Landscape of Possibilities

The investigation into CAR-T therapy for hematologic and solid tumor types has profound implications for market dynamics. The interplay between pharmaceutical innovation, clinical trial outcomes, and global market trends sets the stage for transformative shifts. The development of CAR-T therapies is not just a scientific endeavor; it is a strategic response to the evolving needs of cancer patients worldwide.

Unveiling Opportunities: The Growth Trajectory

As clinical investigations unfold and companies forge ahead with product development, the market trajectory is poised for significant growth. The potential applications of CAR-T therapy across a spectrum of cancers underscore its versatility and adaptability. The opportunities are not confined to a single segment but span the entire ecosystem, from research and development to commercialization.

Conclusion: Nurturing a Paradigm Shift in Cancer Treatment

In conclusion, the investigation of CAR-T therapy for hematologic and solid tumor types signifies a paradigm shift in cancer treatment. The relentless pursuit of solutions for pancreatic cancer and other malignancies reflects the industry's commitment to pushing the boundaries of what is possible. As clinical trials progress and innovations unfold, the market is set to undergo transformative growth, offering new hope and possibilities for cancer patients globally. The collaborative efforts of pharmaceutical leaders and researchers across the world are steering us towards a future where CAR-T therapy emerges as a cornerstone in the evolving landscape of cancer care.

Covered Aspects:

Report Attribute/Metric Details
Segment Outlook Target Antigen, Application and Region

CAR-T Cell Therapy Market Overview


The CAR T Cell Therapy market is projected to reach USD 7.2 Billion by 2032 at 14.5% CAGR during the forecast period 2024-2032. Chimeric Antigen Receptor (CAR)-T is a novel treatment that includes reengineering of the WBC’s of the patient to help in fighting the malignant cells by identifying them.


CAR T Cell Therapy Market


In 2024, the FDA approved a groundbreaking immunotherapy created by Iovance Biotherapeutics, bringing the T-cell therapy treatment class—which has revolutionized the treatment of certain blood cancers—to the solid tumor sector. The medication, known as Amtagvi, also known as lifileucel, is the first tailored tumor-infiltrating lymphocyte (TIL) therapy available on the market. For patients with metastatic melanoma who have previously had treatment with a PD-1 inhibitor—and a BRAF inhibitor if the tumor possesses a BRAF V600 mutation—the FDA on Friday awarded it an accelerated approval.


Kyverna Therapeutics, Inc. (Kyverna) is a patient-centered clinical-stage biopharmaceutical company that specializes in developing cell therapies for patients with autoimmune diseases. The company announced in 2024 that the FDA in the United States had cleared its application for an investigational new drug (IND).  KYV-101, a completely human CD19 chimeric antigen receptor (CAR) T-cell product candidate, is intended to be used as an MS therapy.


Max Healthcare and ImmunoACT collaborate to introduce CAR-T cell treatment in 2023.Referred to as a "living drug," this treatment offers long-lasting advantages and is suggested for individuals unable to receive a stem cell transplant or experiencing a relapse following a transplant. With an average of two weeks of in-patient care, this needs a brief, single-infusion treatment, which is less intrusive than conventional therapies and improves the quality of life for many patients.


COVID 19 Analysis


Owing to the advanced degree to which the global coronavirus pandemic is unfolding and the continuous variants and waves that have disrupted the lives of people across the globe, the industries, and market players are equally suffering the wrath. So much so, that some of the business players have given up and they are shutting their manufacturing and production units. Also, the imposed lockdown has not proved to be of any benefit as people are working from home which is disrupting both their personal and professional life, thus, resulting in an increased degree of unavailability of a skilled workforce that is further, hampering the ability to meet the demand quantum as a result of inefficient production. Also, the raw material available is no or very little quantity that is hampering the quality of products and it has become nearly impossible for the businesses to function amid a series of restrictions and cross-border difficulties.


Hence, the need of the hour is for the public sector to intervene and the governments of the global locations to enhance the funds that will help in the market’s revival. Also, it is important to understand that the population is increasing and the demands of people are different. The key market players should enhance their production ability and take it to the international market to launch a variety of products. Also, mergers and acquisitions are an important and innovative way to help the target audience choose from a variety of products and change their lifestyle preferences accordingly.


CAR-T Cell Therapy Market Dynamics


Drivers


The CAR-T cell therapy market companies are expected to thrive at an excellent rate during the ongoing forecast period of 2021-2027. The overall industry has a very dynamic approach and the key players belonging to the market are gaining access in the major CAR-T cell therapy market size. The companies are securing the treatment centers that will help in increasing patients owing to the development of a series of medical service demands.


Restraints


There have various growth restraints that emerge as major issues for the market while on its path of growth during the forecast period that ends in 2032. One of the major restraints that the market players tend to face is the lack of demand for treatment. The target population is too rigid and understands the native methods of treatment only. Also, the associated cost for treatment is very high that does not sit well with the people as they belong to different income groups and spending capacities. If the cost and prices are not reduced, the global CAR-T cell therapy market trends and operations are likely to pose major restraints for the market and bar the market from growing as per the predictions laid by the industry leaders and market experts during the forecast period of 2021-2032.


Technology Analysis


The rising rate of people being diagnosed with various types of cancer is one of the major reasons that lead to the death of the global population. Hence, the need of the hour is for the companies to evolve the conventional and cytotoxic immunotherapies that are available on the global market scale. The tumors are believed to have complex behaviors and the degree of involvement of a variety of cellular and genetic factors in metastasis and tumorigenesis is pushing the companies to divert their trends in the development of new treatment trends so that the main focus lays on tumors at both the stated levels.


Study Objectives



  • To understand the growth scope of the market during the ongoing forecast period that ends in 2032 considering the dynamics in the form of drivers and restraints that will impact the market of CAR-T cell therapy figures in form of the CAGR growth rate followed by the attainable market revenue by the ongoing forecast period after the pandemic year of 2020.

  • To analyze the scope of the CAR-T cell therapy market growth based on the bifurcation of the market in the form of segments that are spread in various global regions and catering to the need of the target audience in these regions during the period ending in 2032.

  • To study the attainable market growth rate of the CAR-T cell therapy based on the recent developments undertaken by the market players during the period and subsequently, draw a competitive graph amongst these players that are active in maintaining the supply chain mechanism of the global CAR-T cell therapy market.


CAR-T Cell Therapy Market Segment Overview


The CAR-T cell therapy market report shows that the market has been segmented based on the following:


CAR-T cell therapy Target antigen Insights


The global CAR-T cell therapy market by targeted antigen includes BCMA that is B-Cell maturation antigen, CD19/CD22, and others like PSCA, Lewis Y, ROR1, NKR-2, and MUC16 amongst others.


CAR-T cell therapy Application Insights


The application market segment of the CAR-T cell therapy includes Diffuse Large B-Cell Lymphoma, Acute Lymphoblastic Leukemia and Other.


CAR-T cell therapy Geography Insights


Based on the division of the target audience, types of equipment, and resources, the market of CAR-T cell therapy has been divided into 4 major regions namely North America, Europe, the APAC region, and the rest of the world.


CAR-T Cell Therapy Market Regional Analysis


The CAR-T cell gene therapy market analysis shows that the North American region shows signs of excellent growth during the period and is expected to grow at a global CAGR of 36.4%. Similarly, the changing trends in the European market and the increased use of proper technology will help the CAR-T cell therapy market grow at a significant rate. The recommended approvals of Yescarta and Kymriah by the European Medicine Agencies (EMA), are showing signs of positive attributes that will help the market boost its overall growth during the forecast period that ends in 2028.


Competitive Landscape


The rising degree of competition in the global market scenario of CAR-T cell therapy is the result of recent developments of CAR-T cell therapy companies. They are as follows:



  • Bluebird Bio (US)

  • Intellia Therapeutics (US)

  • Noile-Immune Biotech (Japan)

  • Celgene Corporation (US)

  • Bellicum Pharmaceuticals, Inc. (US)

  • Novartis International AG (Swiss)

  • Celyad (Belgium)

  • Cellectis (France)

  • Servier Laboratories (France)

  • Pfizer Inc. (US)

  • Caribou Biosciences, Inc. (US)

  • Mereck KGaA (Germany)

  • Amgen Inc. (US)


Recent Developments



  • The pharmaceutical and biotech companies are opening their doors towards mergers and acquisitions alongside showing their willingness to enter into partnerships. One of the main aims behind this intention is to win a competitive edge over the competitors in the international market scale. For instance, Celgene Corporation came forward and acquired Juno Therapeutics Inc.

  • The first approved therapy was in the field of pediatrics and young adults acute lymphoblastic leukemia (ALL). This is an ailment that has a huge unmet need. The CAR-T helps in indicating higher effectiveness having its representation in a small population chunk.

  • In February 2018, another prominent market player Gilead Sciences Inc. entered into a partnership with Sangamo Therapeutics Inc. The main idea behind this is for the gene-editing technology that is a major development for the treatment of diseases like cancer.


Report Overview


The curated reports aim to have a deep and helpful discussion of the global manufacturing of the CAR-T cell therapy in terms of the market trends and dynamics that will lead the market towards splendid growth during the ongoing forecast period that ends in 2032. The CAR-T cell therapy market report aims to help the market investors gain qualitative market insights related to the performance of the market segments and the growth strategies taken by the market players in various regions during the period that will help both the companies and the domestic regions to grow on the international market scale. Also, the report is a clear depiction of the rising competition amongst the key market players and the aim is to consider the recent developments undertaken during the ongoing forecast period that ends in 2032.

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