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    Automated Closed Cell Therapy Processing System Market

    ID: MRFR/HC/29451-HCR
    128 Pages
    Kinjoll Dey
    October 2025

    Automated And Closed Cell Therapy Processing System Market Research Report By Cell Therapy (CAR T-Cell Therapies, TCR Gene-Edited Cell Therapies, NK Cell Therapies), By Application (Oncology, Hematology, Immunology, Neurology), By System Capability (Single-Use, Multi-Use, Closed, Semi-Closed, Open), By Scale of Production (Benchtop, Pilot Scale, Commercial Scale), By Device Type (Cell Isolators, Cell Expanders, Cell Culture Vessels, Cell Dispensers) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) ...

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    Automated Closed Cell Therapy Processing System Market Summary

    As per MRFR analysis, the Automated And Closed Cell Therapy Processing System Market was estimated at 1.261 USD Billion in 2024. The Automated And Closed Cell Therapy Processing System industry is projected to grow from 1.391 USD Billion in 2025 to 3.705 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 10.29 during the forecast period 2025 - 2035.

    Key Market Trends & Highlights

    The Automated and Closed Cell Therapy Processing System Market is poised for substantial growth driven by technological advancements and increasing demand for personalized medicine.

    • Technological advancements are enhancing the efficiency and precision of automated cell therapy processing systems.
    • North America remains the largest market, while the Asia-Pacific region is emerging as the fastest-growing area for cell therapy innovations.
    • CAR T-Cell therapies dominate the market, whereas TCR gene-edited cell therapies are experiencing rapid growth.
    • The rising demand for cell therapies and increased investment in research and development are key drivers propelling market expansion.

    Market Size & Forecast

    2024 Market Size 1.261 (USD Billion)
    2035 Market Size 3.705 (USD Billion)
    CAGR (2025 - 2035) 10.29%

    Major Players

    Thermo Fisher Scientific (US), Miltenyi Biotec (DE), Beckman Coulter (US), Fresenius Kabi (DE), Lonza (CH), Merck KGaA (DE), STEMCELL Technologies (CA), Cytiva (US), Becton Dickinson (US)

    Automated Closed Cell Therapy Processing System Market Trends

    The Automated And Closed Cell Therapy Processing System Market is currently experiencing a transformative phase, driven by advancements in technology and increasing demand for efficient therapeutic solutions. This market encompasses systems designed to streamline the processing of cell therapies, enhancing the overall efficacy and safety of treatments. As healthcare providers seek to improve patient outcomes, the integration of automation in cell therapy processing appears to be a pivotal factor. The growing emphasis on personalized medicine further propels the need for sophisticated processing systems that can adapt to individual patient requirements. Moreover, regulatory bodies are increasingly recognizing the importance of standardized processing methods, which may lead to a more structured market environment. The focus on quality assurance and compliance is likely to shape the development of new technologies within this sector. As stakeholders, including manufacturers and healthcare institutions, collaborate to refine these systems, the Automated And Closed Cell Therapy Processing System Market is poised for substantial growth. The interplay between innovation, regulatory frameworks, and market demand suggests a dynamic landscape that could redefine therapeutic approaches in the near future.

    Technological Advancements

    Recent innovations in automation technology are reshaping the Automated And Closed Cell Therapy Processing System Market. Enhanced software and hardware solutions are streamlining workflows, reducing human error, and increasing processing speed. This trend indicates a shift towards more efficient and reliable systems that can handle complex cell therapies.

    Regulatory Compliance

    The increasing focus on regulatory compliance is influencing the design and implementation of processing systems. As regulatory bodies establish stricter guidelines, manufacturers are adapting their technologies to meet these standards. This trend suggests a growing emphasis on quality control and safety in the Automated And Closed Cell Therapy Processing System Market.

    Personalized Medicine

    The rise of personalized medicine is driving demand for tailored cell therapy solutions. As healthcare providers aim to deliver customized treatments, the need for flexible and adaptable processing systems becomes apparent. This trend highlights the importance of innovation in meeting diverse patient needs within the Automated And Closed Cell Therapy Processing System Market.

    The evolution of automated and closed cell therapy processing systems appears to be reshaping the landscape of regenerative medicine, enhancing efficiency and precision in therapeutic applications.

    U.S. Food and Drug Administration (FDA)

    Automated Closed Cell Therapy Processing System Market Drivers

    Technological Innovations

    Technological advancements play a pivotal role in shaping the Automated And Closed Cell Therapy Processing System Market. Innovations such as automation, artificial intelligence, and machine learning are revolutionizing the way cell therapies are processed. These technologies enhance efficiency, reduce human error, and improve the overall quality of cell products. For instance, automated systems can streamline workflows, allowing for faster processing times and increased throughput. As a result, the market is witnessing a shift towards more sophisticated processing systems that can meet the growing demands of the healthcare sector, indicating a robust future for the Automated And Closed Cell Therapy Processing System Market.

    Rising Demand for Cell Therapies

    The increasing prevalence of chronic diseases and genetic disorders drives the demand for innovative treatment options, particularly in the Automated And Closed Cell Therapy Processing System Market. As healthcare providers seek to enhance patient outcomes, the adoption of cell therapies is on the rise. According to recent data, the market for cell therapies is projected to grow significantly, with estimates suggesting a compound annual growth rate of over 20% in the coming years. This surge in demand necessitates efficient processing systems that can handle the complexities of cell therapy production, thereby propelling the growth of the Automated And Closed Cell Therapy Processing System Market.

    Regulatory Support and Frameworks

    Regulatory bodies are increasingly establishing supportive frameworks for the development and commercialization of cell therapies, which significantly impacts the Automated And Closed Cell Therapy Processing System Market. These regulations aim to ensure the safety and efficacy of cell-based treatments while facilitating faster approval processes. As regulatory environments become more conducive to innovation, companies are more inclined to invest in automated processing systems that comply with these standards. This alignment between regulatory support and technological advancement is expected to drive market growth, as stakeholders seek to navigate the complexities of compliance while delivering high-quality cell therapies.

    Growing Focus on Personalized Medicine

    The shift towards personalized medicine is reshaping the landscape of the Automated And Closed Cell Therapy Processing System Market. As healthcare moves away from one-size-fits-all approaches, there is a growing emphasis on tailoring treatments to individual patient needs. This trend necessitates advanced processing systems capable of handling diverse cell types and customization requirements. The ability to efficiently process and manufacture personalized therapies is becoming a competitive advantage for companies in the market. Consequently, the demand for automated and closed cell therapy processing systems is likely to increase, reflecting the broader movement towards personalized healthcare solutions.

    Increased Investment in Research and Development

    Investment in research and development is a critical driver for the Automated And Closed Cell Therapy Processing System Market. Pharmaceutical companies and research institutions are allocating substantial resources to explore new cell therapies and improve existing ones. This trend is evident in the rising number of clinical trials and collaborations aimed at advancing cell therapy technologies. The financial commitment to R&D not only fosters innovation but also enhances the capabilities of automated processing systems, ensuring they can accommodate the evolving needs of the market. As a result, the industry is likely to experience sustained growth fueled by these investments.

    Market Segment Insights

    By Cell Therapy: CAR T-Cell Therapies (Largest) vs. TCR Gene-Edited Cell Therapies (Fastest-Growing)

    The Automated and Closed Cell Therapy Processing System Market features a dynamic landscape of cell therapies. Among these, CAR T-Cell Therapies hold the largest market share, benefiting from extensive clinical validation and successful treatment outcomes in hematological malignancies. TCR Gene-Edited Cell Therapies, while not as dominant currently, are rapidly gaining traction due to innovative advancements and a growing understanding of T cell functions, promising a shift in market dynamics in the near future.

    Cell Therapy: CAR T-Cell Therapies (Dominant) vs. NK Cell Therapies (Emerging)

    CAR T-Cell Therapies are characterized by their proven effectiveness against certain blood cancers and their established regulatory pathways, positioning them as the dominant player in the market. In contrast, NK Cell Therapies are considered emerging entities that leverage the innate immune response to target tumors, offering a unique therapeutic approach. While still in the early stages compared to CAR T-Cell therapies, NK Cell therapies are gaining attention for their potential in solid tumors and chronic infections, attracting significant research and investment aimed at overcoming existing challenges.

    By Application: Oncology (Largest) vs. Immunology (Fastest-Growing)

    The Automated And Closed Cell Therapy Processing System Market showcases a dynamic distribution among various applications, with Oncology dominating the segment. As a well-established field, Oncology commands significant attention from both practitioners and researchers, driving the demand for innovative processing systems. Following closely, Hematology and Neurology hold substantial shares, but their market presence is eclipsed by Oncology's robust growth. Immunology, while currently a smaller segment, demonstrates promising potential due to increasing immunotherapy advancements that leverage these processing systems. Growth trends indicate a strategic shift towards Immunology as the fastest-growing application in the market. This surge is fueled by groundbreaking research and clinical trials focused on immune-based therapies, positioning Immunology favorably for future growth prospects. Meanwhile, Oncology remains a cornerstone of the market, benefitting from continuous technological advancements that enhance treatment outcomes. The convergence of these trends signifies an evolving landscape within the Automated And Closed Cell Therapy Processing System Market, with a noteworthy influence of research investments and regulatory support championing the progression of both fields.

    Hematology (Dominant) vs. Neurology (Emerging)

    Hematology has established itself as a dominant player in the Automated And Closed Cell Therapy Processing System Market, attributed to its critical applications in blood-related disorders and innovative therapies. The segment is characterized by a comprehensive range of processing systems designed to improve cell handling and purification, significantly enhancing therapeutic efficacy. Conversely, Neurology represents an emerging segment, gaining traction due to an increased focus on neurodegenerative diseases and novel treatment modalities in the realm of cell therapy. The Neurology segment presents unique challenges and opportunities, as it requires the adaptation of processing systems to handle complex cellular needs. Together, these segments highlight the evolving demands within the market, reflecting diverse therapeutic areas that benefit significantly from advancements in automated processing solutions.

    By System Capability: Single-Use (Largest) vs. Multi-Use (Fastest-Growing)

    The Automated And Closed Cell Therapy Processing System Market is increasingly dominated by the Single-Use segment, which has captured a significant portion of the market share due to its flexibility and cost-effectiveness. The adoption of Single-Use systems allows for enhanced operational efficiency and reduced risk of cross-contamination, making it a preferred choice for many manufacturers in the processing of cell-based therapeutics. Conversely, the Multi-Use systems are gaining traction, specifically with companies looking for sustainable solutions, yet they still hold a smaller share compared to Single-Use systems. Growth trends in this segment indicate a shift towards more innovative technologies, with an emphasis on market needs for automation and efficiency. Companies are investing in Multi-Use systems as they explore new therapeutic applications, leading to rapid advancements and growing acceptance within the market. Additionally, the rising demand for personalized medicine is driving the development of closed and semi-closed systems, which offer enhanced control over the processing environment and further align with stringent regulatory standards.

    Closed (Dominant) vs. Semi-Closed (Emerging)

    Closed systems are currently the dominant solution in the Automated And Closed Cell Therapy Processing System Market due to their ability to provide a fully enclosed processing environment, minimizing the risk of contamination. They offer greater control over the cell processing conditions, which is essential for maintaining the viability and efficacy of cell therapies. On the other hand, Semi-Closed systems, which allow for some level of operator interaction, are emerging rapidly as they strike a balance between accessibility and sterility, appealing to manufacturers seeking operational flexibility. Both systems cater to advanced therapeutic processes but differ in their operational constraints, with Closed systems being preferred for critical applications where contamination risk is paramount.

    By Scale of Production: Commercial Scale (Largest) vs. Pilot Scale (Fastest-Growing)

    In the Automated And Closed Cell Therapy Processing System Market, the distribution of market share among the different scales of production reveals a strong preference towards commercial scale implementation. This segment has captured the largest share, driven by the increasing demand for scalable solutions that meet the needs of larger manufacturers. The benchtop systems, while significant, appear to cater to niche markets or smaller operations, demonstrating a limited share in the overall landscape.

    Commercial Scale (Dominant) vs. Pilot Scale (Emerging)

    The Commercial Scale segment stands out as the dominant force within the market, catering to organizations that require high throughput and efficiency in cell therapy processing. Characterized by advanced automation, reliability, and the ability to handle substantial volumes, commercial scale production systems have become essential for meeting the growing demands of large-scale biopharmaceutical operations. In contrast, the Pilot Scale segment emerges as a vital entry point for companies looking to validate processes before full-scale commercialization. These systems enable flexibility and experimentation, making them attractive options for research institutions and startups, thereby ensuring their rapid growth within the market.

    By Device Type: Cell Isolators (Largest) vs. Cell Expanders (Fastest-Growing)

    In the Automated and Closed Cell Therapy Processing System Market, the device type segment shows a diversified distribution among various product types. Cell Isolators hold the largest market share due to their essential role in providing sterile environments for cellular processing. Meanwhile, Cell Expanders, crucial for scaling up cell production, are emerging as the fastest-growing segment, reflecting the increasing demand for larger quantities of therapeutic cells.

    Cell Isolators (Dominant) vs. Cell Culture Vessels (Emerging)

    Cell Isolators are pivotal in ensuring contamination-free environments for cell processing, thus dominating the Automated and Closed Cell Therapy Processing System market. Their significance is underscored by stringent regulatory requirements for cell processing, driving widespread adoption in research and clinical applications. In contrast, Cell Culture Vessels are becoming increasingly important as emerging technologies for cell growth and manipulation evolve. They are designed to optimize nutrient delivery and facilitate uniform cell distribution, making them integral to the development of advanced therapies.

    Get more detailed insights about Automated Closed Cell Therapy Processing System Market

    Regional Insights

    North America is expected to account for the largest share of the market in 2023, and is expected to continue to dominate the market over the forecast period. This is due to the increasing adoption of automated and closed cell therapy processing systems in the region, as well as the presence of major market players in the region. Europe is expected to account for the second largest market share in 2023, and is expected to grow at a CAGR of around 10.5% over the forecast period.

    This is due to the increasing demand for automated and closed cell therapy processing systems in the region, as well as the presence of major market players in the region.

    Asia Pacific is expected to account for the third largest market share in 2023, and is expected to grow at a CAGR of around 11.0% over the forecast period. This is due to the increasing demand for automated and closed cell therapy processing systems in the region, as well as the presence of major market players in the region. South America and the Middle East and Africa are expected to account for the smallest market share in 2023, and are expected to grow at a CAGR of around 10.0% and 10.5%, respectively, over the forecast period.

    Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

    Key Players and Competitive Insights

    Major players in Automated And Closed Cell Therapy Processing System Market industry are consistently striving to enhance their product portfolios and expand their global presence. Leading Automated And Closed Cell Therapy Processing System Market players are actively involved in strategic collaborations, mergers, and acquisitions to gain a competitive edge. The Automated And Closed Cell Therapy Processing System Market industry is characterized by intense competition among established players, as well as emerging startups that are introducing innovative technologies and solutions.

    The competitive landscape is expected to remain dynamic over the forecast period, as players continue to invest in research and development and seek opportunities for growth.

    One of the leading companies in the Automated And Closed Cell Therapy Processing System Market is Terumo BCT. The company offers a comprehensive range of automated and closed cell therapy processing systems, including the Spectra Optia and Quantum systems. Terumo BCT has a strong global presence and is continuously expanding its operations through strategic partnerships and acquisitions. The company is committed to providing innovative solutions that improve the safety and efficiency of cell therapy processing.

    A competitor company in the Automated And Closed Cell Therapy Processing System Market is Fresenius Kabi. The company offers a range of automated cell processing systems, including the Sepax and Cryostar systems. Fresenius Kabi has a strong focus on research and development and is constantly innovating to meet the evolving needs of the cell therapy industry. The company has a global presence and is committed to providing high-quality products and services to its customers.

    Key Companies in the Automated Closed Cell Therapy Processing System Market market include

    Industry Developments

    • Q2 2024: Miltenyi Biotec Launches CliniMACS Prodigy® T Cell Transduction Process for Automated CAR-T Manufacturing Miltenyi Biotec announced the launch of its CliniMACS Prodigy® T Cell Transduction Process, an automated closed system designed to streamline CAR-T cell manufacturing and improve process consistency for cell therapy developers.
    • Q1 2024: Thermo Fisher Scientific Expands Cell Therapy Manufacturing Capabilities with New Automated Platform Thermo Fisher Scientific unveiled a new automated closed cell therapy processing system aimed at increasing scalability and reducing contamination risks in cell therapy production.
    • Q2 2024: Fujifilm Irvine Scientific Opens New Cell Culture Media Manufacturing Facility in Europe Fujifilm Irvine Scientific opened a new manufacturing facility in Tilburg, Netherlands, to support the production of cell culture media for automated closed cell therapy processing systems.
    • Q1 2024: Lonza Announces Strategic Partnership with CellPoint to Advance Automated Cell Therapy Manufacturing Lonza entered a strategic partnership with CellPoint to co-develop and commercialize automated closed cell therapy processing platforms for decentralized manufacturing.
    • Q2 2024: BioNTech Acquires InstaDeep to Accelerate AI-Driven Automation in Cell Therapy Manufacturing BioNTech completed the acquisition of InstaDeep, aiming to integrate AI-driven automation into its closed cell therapy processing systems to enhance manufacturing efficiency.
    • Q1 2025: Cytiva Launches New FlexFactory Platform for Automated Cell Therapy Processing Cytiva introduced the FlexFactory platform, a modular automated closed system designed to support scalable cell therapy manufacturing and improve process control.
    • Q2 2025: Sartorius Invests $100 Million in New Cell Therapy Automation Facility in the U.S. Sartorius announced a $100 million investment to build a new facility in Massachusetts dedicated to automated closed cell therapy processing systems.
    • Q1 2025: Terumo BCT Receives FDA Clearance for Automated Cell Therapy Processing Device Terumo BCT received FDA clearance for its new automated closed cell therapy processing device, enabling streamlined and compliant manufacturing for cell therapy products.
    • Q2 2024: GE HealthCare Unveils New Automated Cell Therapy Manufacturing Suite GE HealthCare launched a new suite of automated closed cell therapy processing systems designed to support high-throughput manufacturing for clinical and commercial cell therapies.
    • Q1 2025: CellGenix Secures €30 Million Series B Funding to Expand Automated Cell Therapy Processing Solutions CellGenix raised €30 million in Series B funding to accelerate the development and commercialization of its automated closed cell therapy processing platforms.
    • Q2 2025: BioNTech Opens New Automated Cell Therapy Manufacturing Facility in Germany BioNTech inaugurated a new facility in Mainz, Germany, dedicated to automated closed cell therapy processing, expanding its manufacturing capacity for advanced therapies.
    • Q1 2024: ScaleReady Announces Partnership with Thermo Fisher Scientific to Advance Automated Cell Therapy Processing ScaleReady and Thermo Fisher Scientific formed a partnership to co-develop automated closed cell therapy processing systems, aiming to improve scalability and reduce costs for cell therapy manufacturers.

    Automated And Closed Cell Therapy Processing System Market Segmentation Insights

    Automated And Closed Cell Therapy Processing System Market Cell Therapy Outlook

      • CAR T-Cell Therapies
      • TCR Gene-Edited Cell Therapies
      • NK Cell Therapies

    Automated And Closed Cell Therapy Processing System Market Application Outlook

    Automated And Closed Cell Therapy Processing System Market System Capability Outlook

      • Single-Use
      • Multi-Use
      • Closed
      • Semi-Closed
      • Open

    Automated And Closed Cell Therapy Processing System Market Scale of Production Outlook

      • Benchtop
      • Pilot Scale
      • Commercial Scale

    Automated And Closed Cell Therapy Processing System Market Device Type Outlook

      • Cell Isolators
      • Cell Expanders
      • Cell Culture Vessels
      • Cell Dispensers

    Automated And Closed Cell Therapy Processing System Market Regional Outlook

      • North America
      • Europe
      • South America
      • Asia Pacific
      • Middle East and Africa

    Future Outlook

    Automated Closed Cell Therapy Processing System Market Future Outlook

    The Automated And Closed Cell Therapy Processing System Market is projected to grow at a 10.29% CAGR from 2024 to 2035, driven by technological advancements and increasing demand for personalized medicine.

    New opportunities lie in:

    • Integration of AI-driven analytics for process optimization.
    • Development of mobile processing units for remote therapies.
    • Expansion into emerging markets with tailored solutions.

    By 2035, the market is expected to be robust, reflecting substantial growth and innovation.

    Market Segmentation

    Automated Closed Cell Therapy Processing System Market Application Outlook

    • Oncology
    • Hematology
    • Immunology
    • Neurology

    Automated Closed Cell Therapy Processing System Market Device Type Outlook

    • Cell Isolators
    • Cell Expanders
    • Cell Culture Vessels
    • Cell Dispensers

    Automated Closed Cell Therapy Processing System Market Cell Therapy Outlook

    • CAR T-Cell Therapies
    • TCR Gene-Edited Cell Therapies
    • NK Cell Therapies

    Automated Closed Cell Therapy Processing System Market System Capability Outlook

    • Single-Use
    • Multi-Use
    • Closed
    • Semi-Closed
    • Open

    Automated Closed Cell Therapy Processing System Market Scale of Production Outlook

    • Benchtop
    • Pilot Scale
    • Commercial Scale

    Report Scope

    MARKET SIZE 20241.261(USD Billion)
    MARKET SIZE 20251.391(USD Billion)
    MARKET SIZE 20353.705(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR)10.29% (2024 - 2035)
    REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR2024
    Market Forecast Period2025 - 2035
    Historical Data2019 - 2024
    Market Forecast UnitsUSD Billion
    Key Companies ProfiledMarket analysis in progress
    Segments CoveredMarket segmentation analysis in progress
    Key Market OpportunitiesAdvancements in automation technology enhance efficiency in the Automated And Closed Cell Therapy Processing System Market.
    Key Market DynamicsTechnological advancements drive efficiency and precision in automated closed cell therapy processing systems, reshaping market dynamics.
    Countries CoveredNorth America, Europe, APAC, South America, MEA

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    FAQs

    What is the projected growth of the Automated And Closed Cell Therapy Processing System market?

    The Automated And Closed Cell Therapy Processing System market is the expected increase in total market value of 3.7 USD billion over a defined forecast period 2025–2035. It is driven by factors such as demand trends, technological advances, regulatory changes, and geographic expansion.

    What is the size of the Automated And Closed Cell Therapy Processing System market?

    Automated And Closed Cell Therapy Processing System market size was valued at approximately 1.26 billion USD in 2024. This figure will reach 3.7 billion USD covering all regions (America, Europe, Asia, MEA and ROW), focusing its segments / services / distribution channels till 2035.

    What is the CAGR of the Automated And Closed Cell Therapy Processing System market?

    Automated And Closed Cell Therapy Processing System market is expected to grow at a CAGR of 10.29% between 2025 and 2035.

    How much will the Automated And Closed Cell Therapy Processing System market be worth by 2035?

    Automated And Closed Cell Therapy Processing System market is expected to be worth of 3.7 billion USD, reflecting growth driven by usage, technology and global demands by the end of 2035.

    How will the Automated And Closed Cell Therapy Processing System market perform over the next 10 years?

    Over the next 10 years the Automated And Closed Cell Therapy Processing System market is expected to shift from usd billion 1.26 to 3.7 billion USD, led by adoption of advanced tech, demographic trends, regulatory approvals, with potential headwinds from 2025 to 2035.

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