Antisense Therapy Market Research Report Information By Application (Genetic Disease, Cancer, Infectious Disease, Neurodegenerative Disorders, Cardiometabolic & Renal Disorders, Ocular Disorders, Respiratory Disorders, Skin Disorders, Others), By Route of Administration (Intravenous Injections, Intrathecal Injections) And By Region (North America, Europe, Asia-Pacific, And Rest Of The World) –Market Forecast Till 2032

Global Antisense Therapy Market Overview

Antisense Therapy Market Size was valued at USD 3.1 Billion in 2022. The Antisense Therapy market industry is projected to grow from USD 3.7 Billion in 2023 to USD 15.5 Billion by 2032, exhibiting a compound annual growth rate (CAGR) of 19.60% during the forecast period (2024 - 2032). Increasing Demand for RNAi and Antisense Therapeutics and Growing Cancer Burden to Drive Market Growth are the key market drivers boosting the expansion of the market. 

Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

Antisense Therapy Market Trends

• Growing cancer burden is driving the market growth

Market CAGR for antisense therapy is being driven by the growing cancer burden. The selective and sequence-specific suppression of the expression of genes by single-stranded DNA oligonucleotides is known as antisense treatment. It controls how cells divide and operate as well as how they react to pressures and stimuli from the outside and inside the cell. In addition, Huntington's, Alzheimer's, and amyotrophic lateral sclerosis are treated with it. Conversely, double-stranded RNA (dsRNA) is the stimulus for RNA interference (RNAi) therapy, which results in sequence-specific breakdown of single-stranded targeted RNAs in response to dsRNA.

Additionally, one of the main factors propelling the market is the increasing need for RNAi and antisense therapies to treat rare neurological illnesses like familial ATTR amyloidosis. In addition, there is a increase in the need for disease management that controls gene expression through defective genes. This is fueling the market's expansion together with the expanding healthcare sector. Furthermore, major industry participants are heavily funding R&D endeavors in order to create compounds utilizing antisense technology. Additionally, they are partnering with contract research organizations (CROs) that focus on drug delivery, which is bolstering the market's expansion. Furthermore, the increasing need for antisense RNA to delay the development of disease and slow its progression is favorably impacting the.

Antisense oligonucleotides are currently advised for cancer therapy in part due to the increasing need for antisense and RNA interference (RNAi) medicines to address rare neurological disorders including hereditary ATTR amyloidosis. Despite challenges such as a poorly understood mechanism of action and customized administration for clinical settings, antisense oligonucleotides are making headway as anticancer medications. Clinical trial performance of these molecules is expected to be improved by continuing research into several chemical modifications that confer greater capabilities upon this nucleotides. The revolutionary advancement of CRISPR-CASs genome editing technology has had an impact on the field of biomedical science. The potential applications of antisense RNA treatments in immunotherapy, personalized medicine, genetics, and other fields mean that they will surely continue to be developed for many years to come.

For instance, the World Health Organization (WHO) estimates 25% of all deaths are attributable to cancer, with lung cancer accounting for 30% of these cases. Around 25% of new cases in men and around 25% in women are prostate and breast cancer, respectively, the most frequent cancers. Although it is rare (approximately 150 cases per million in the United States), leukemia is the most prevalent type of cancer that affects children and adolescents. About 230 cases per million occur in the United States during the first year of life, with neuroblastoma being the most prevalent, demand for Antisense Therapy supplements will increase due to Growing Cancer Burden. Thus, result in driving the Antisense Therapy market revenue.

Antisense Therapy Market Segment Insights

Antisense Therapy Application Insights

The Antisense Therapy market segmentation, based on application includes Genetic Disease, Cancer, Infectious Disease, Neurodegenerative Disorders, Cardiometabolic & Renal Disorders, Ocular Disorders, Respiratory Disorders, Skin Disorders, Others. The genetic disease segment dominated the market. Because of The use of oligonucleotide products is anticipated to be impacted by the growing need to treat and manage conditions such spinal muscular atrophy and Duchenne muscular dystrophy (DMD). The number of research studies on oligonucleotide therapeutics is increasing, indicating a rapid expansion of this field of study.

Antisense Therapy Route of Administration Insights

 The Antisense Therapy market segmentation, based on Route of Administration, includes Intravenous Injections, Intrathecal Injections. The intrathecal injections segment generated the most income. Because of It is a method of administering medication that involves injecting it into the spinal canal or subarachnoid space to reach the CSF. This method is applied in pain management, spinal anesthetic, chemotherapy, and the introduction of medications to fight particular infections, especially following neurosurgery procedures.

Figure1:Antisense Therapy Market, by Route of Administration,2022&2032(USD Billion) 

Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

Antisense Therapy Regional Insights

By region, the study provides the market insights into North America, Europe, Asia-Pacific and Rest of the World. The North American Antisense Therapy market area will dominate this market, owing to the increased need for efficient therapies as knowledge and diagnosis of certain illnesses rise. Research institutes and pharmaceutical corporations in the United States are making significant investments in the creation of antisense medicineswill boost market growth in this region.

Further, the major countries studied in the market report are The US, German, France, the UK, Canada, Italy, Spain, India, Australia, South Korea, China, Japan, and Brazil.

Figure2:ANTISENSE THERAPY MARKET SHARE BY REGION 2022 (USD Billion) 

Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

Europe Antisense Therapy market has the second-largest portion of the market due to the low cost rising accelerated through collaboration between biotech, pharmaceutical, and academic organizations. Through partnerships, companies can gain access to resources, knowledge. Further, the German Antisense Therapy market had the biggest market share, and the UK Antisense Therapy market was the fastest growing market in the European region

The Asia-Pacific Antisense Therapy Market is anticipated to expand between 2023 and 2032 at the quickest CAGR. This is due to the development and uptake of cutting-edge treatments like antisense technology is made possible by increased public and private sector. Moreover, China’s Antisense Therapy market had the biggest market share, and the Indian Antisense Therapy market was the fastest growing market in the Asia-Pacific region.

Antisense Therapy Key Market Players& Competitive Insights

Leading market players are putting a lot of money on R&D to expand their product lines, which will help the market for weight reduction products grow. Additionally, market players are engaging in a range of calculated initiatives to increase their worldwide presence, with important market developments involving the introduction of new products, contracts, M&A transactions, increased investment, and cooperation with other enterprises. To grow and endure in an increasingly cutthroat and dynamic market, Antisense Therapy industry must provide reasonably priced goods.

Manufacturing locally is one of the primary business techniques used by manufacturers to cut operational costs in the Antisense Therapy industry to help customers and expand the market segment. In recent years, the Antisense Therapy industry has provided some of the biggest benefits to medicine. Major players in the Antisense Therapy market, including GSK plc, Olix Pharmaceuticals, Inc., Sanofi, Alnylam Pharmaceuticals, Inc., Arbutus Biopharma, Benitec Biopharma Inc., Silence Therapeutics., and others, are attempting to increase market demand by investing in research and development operations.

Olix Pharmaceuticals works on the creation, production, distribution, and study of pharmaceutical products. Their areas of specialization could include cancer, neurology, cardiology, immunology, and infectious illnesses, among other therapeutic domains.This entails either creating whole new medications or refining those that already exist. It covers things like preclinical research, clinical trials, lead optimization, and target identification. In March 2023, In a Phase 1 clinical trial of an experimental RNAi therapy intended to treat age-related macular degeneration (AMD), OliX Pharmaceuticals, Inc. dosed the first patient.

The biopharmaceutical business Alnylam Pharmaceuticals, Inc. is well-known for its contributions to RNA interference (RNAi) treatments. Alnylam is a leader in the development of RNAi treatments, a state-of-the-art approach that "turns off" or silences particular genes linked to disease using small interfering RNA (siRNA). By focusing on the underlying genetic causes of a variety of diseases, this technique offers the potential to treat them all. In July 2023 Alnylam Pharmaceuticals, Inc. and Roche collaborated to create and commercialize zilebesiran, an RNA interference (RNAi) treatment under research for the treatment of hypertension.

Key Companies in the Antisense Therapy market include

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  GSK plc

  
  


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  Olix Pharmaceuticals, Inc.

  
  


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  Sanofi

  
  


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  Alnylam Pharmaceuticals, Inc.

  
  


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  Arbutus Biopharma

  
  


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  Benitec Biopharma Inc.

  
  


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  Silence Therapeutics

  
  


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  Ionis Pharmaceuticals, Inc

  
  


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  Bio-Path Holdings Inc.

  
  


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  Antisense Therapeutics Limited.

  
  

Antisense Therapy Industry Developments

December 2021:Leqvio (inclisiran) was approved by the Food and Drug Administration (FDA) for Novartis AG. In addition, a small interfering RNA (siRNA) medication called Leqvio has been approved to lower low-density lipoprotein cholesterol (LDL).

December 2021:International research and commercialization deal for the investigational antisense drug eplontersen was signed between AstraZeneca plc and Ionis Pharmaceuticals. Moreover, eplontersen is presently being investigated in phase II therapeutic trials for ATR-CM and ATR-PN, or amyloid transthyretin polyneuropathy and cardiomyopathy.

August 2023:Sirnaomics Ltd. declared that it has finished the first phase of clinical testing for STP707, an RNA interference treatment intended to treat several solid cancers.

Antisense Therapy Market Segmentation

Antisense Therapy Application Outlook

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  Genetic Disease

  
  


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  Cancer

  
  


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  Infectious Disease

  
  


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  Neurodegenerative Disorders

  
  


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  Cardiometabolic & Renal Disorders

  
  


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  Ocular Disorders

  
  


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  Respiratory Disorders

  
  


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  Skin Disorders

  
  


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  Others

  
  

Antisense Therapy Route of Administration Outlook

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  Intravenous Injections

  
  


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  Intrathecal Injections

  
  

Antisense Therapy Regional Outlook

• North America
  
  
  
  • US
  
  
  • Canada
  
  
  
  


• Europe
  
  
  
  • Germany
  
  
  • France
  
  
  • UK
  
  
  • Italy
  
  
  • Spain
  
  
  • Rest of Europe
  
  
  
  


• Asia-Pacific
  
  
  
  • China
  
  
  • Japan
  
  
  • India
  
  
  • Australia
  
  
  • South Korea
  
  
  • Rest of Asia-Pacific
  
  
  
  


• Rest of the World
  
  
  
  • Middle East
  
  
  • Africa
  
  
  • Latin America