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    US Neuropathic Pain Market

    ID: MRFR/HC/17923-HCR
    100 Pages
    Garvit Vyas
    October 2025

    US Neuropathic Pain Market Research Report By Type of Neuropathic Pain (Diabetic Neuropathy, Postherpetic Neuralgia, Trigeminal Neuralgia, Chemotherapy-Induced Peripheral Neuropathy), By Treatment Type (Medications, Physical Therapy, Surgical Procedures, Electrical Stimulation), By Route of Administration (Oral, Topical, Injectable) and By End User (Hospitals, Clinics, Home Care) - Forecast to 2035

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    US Neuropathic Pain Market Infographic
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    US Neuropathic Pain Market Summary

    As per MRFR analysis, the US neuropathic pain market size was estimated at 1911.0 USD Million in 2024. The US neuropathic pain market is projected to grow from 2040.18 USD Million in 2025 to 3926.0 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 6.76% during the forecast period 2025 - 2035.

    Key Market Trends & Highlights

    The US neuropathic pain market is experiencing transformative growth driven by innovative treatment approaches and demographic shifts.

    • Advancements in treatment modalities are reshaping the landscape of neuropathic pain management.
    • Personalized medicine approaches are gaining traction, enhancing patient outcomes and satisfaction.
    • Telehealth integration is facilitating access to care, particularly for patients in remote areas.
    • The rising prevalence of neuropathic disorders and increased awareness are key drivers propelling market expansion.

    Market Size & Forecast

    2024 Market Size 1911.0 (USD Million)
    2035 Market Size 3926.0 (USD Million)

    Major Players

    Pfizer Inc (US), Eli Lilly and Company (US), Astellas Pharma Inc (JP), Boehringer Ingelheim GmbH (DE), Teva Pharmaceutical Industries Ltd (IL), Novartis AG (CH), Johnson & Johnson (US), AbbVie Inc (US)

    US Neuropathic Pain Market Trends

    The neuropathic pain market is currently experiencing notable developments driven by advancements in treatment options and a growing understanding of pain mechanisms. Recent research indicates that neuropathic pain affects a significant portion of the population, leading to increased demand for effective therapies. This market is characterized by a diverse range of treatment modalities, including pharmacological interventions, physical therapies, and emerging technologies such as neuromodulation. The integration of personalized medicine approaches appears to be gaining traction, as healthcare providers seek to tailor treatments to individual patient profiles, potentially enhancing outcomes. Moreover, the regulatory landscape is evolving, with agencies focusing on the approval of innovative therapies that address unmet needs in neuropathic pain management. This shift may encourage pharmaceutical companies to invest in research and development, fostering a competitive environment. Additionally, the rise of telehealth services is likely to transform how patients access care, making it easier for individuals to receive timely interventions. As awareness of neuropathic pain continues to grow, stakeholders in the healthcare sector are expected to prioritize education and resources to improve patient outcomes and quality of life.

    Advancements in Treatment Modalities

    The neuropathic pain market is witnessing a surge in innovative treatment options, including novel pharmacological agents and non-pharmacological therapies. These advancements aim to provide more effective pain relief and improve patient quality of life. As research progresses, new therapies are likely to emerge, offering hope for those suffering from chronic pain.

    Personalized Medicine Approaches

    There is a growing emphasis on personalized medicine within the neuropathic pain market. Tailoring treatments to individual patient characteristics may enhance therapeutic efficacy and minimize adverse effects. This trend suggests a shift towards more patient-centered care, where treatment plans are customized based on genetic, environmental, and lifestyle factors.

    Telehealth Integration

    The integration of telehealth services is transforming the neuropathic pain market by facilitating remote consultations and follow-ups. This trend enhances accessibility to care, particularly for patients in underserved areas. As telehealth continues to evolve, it may play a crucial role in managing neuropathic pain effectively and efficiently.

    US Neuropathic Pain Market Drivers

    Growing Geriatric Population

    The aging population in the US is a significant factor influencing the neuropathic pain market. As individuals age, they become more susceptible to various neuropathic conditions, including diabetic neuropathy and post-surgical pain. The US Census Bureau projects that by 2030, approximately 20% of the population will be aged 65 and older, which correlates with an increased prevalence of neuropathic pain. This demographic shift is likely to drive demand for effective pain management solutions, thereby expanding the neuropathic pain market. Healthcare systems will need to adapt to this growing need, potentially leading to increased investment in research and treatment options tailored for older adults.

    Increased Awareness and Diagnosis

    There is a notable increase in awareness regarding neuropathic pain and its associated conditions among both healthcare professionals and the general public. Enhanced education and training for clinicians have led to improved diagnostic capabilities, allowing for earlier identification of neuropathic pain. This trend is crucial as timely diagnosis can significantly impact treatment outcomes. The neuropathic pain market benefits from this heightened awareness, as more patients seek medical attention for their symptoms. Furthermore, the implementation of standardized diagnostic criteria has facilitated better recognition of neuropathic pain, potentially increasing the market size as more individuals are diagnosed and treated.

    Regulatory Support for Pain Management

    Regulatory bodies in the US are increasingly recognizing the importance of effective pain management, which is positively impacting the neuropathic pain market. Initiatives aimed at improving access to pain relief therapies, including streamlined approval processes for new medications, are being implemented. The Food and Drug Administration (FDA) has been actively involved in promoting research and development of innovative pain management solutions. This regulatory support is likely to enhance the availability of effective treatments for neuropathic pain, thereby fostering market growth. As regulations evolve to support better pain management practices, the neuropathic pain market is expected to benefit from increased investment and innovation.

    Advancements in Pharmaceutical Research

    Ongoing advancements in pharmaceutical research are driving innovation within the neuropathic pain market. The development of new analgesics, including novel classes of medications such as cannabinoids and gene therapies, is expanding treatment options for patients. Recent studies indicate that the neuropathic pain market could reach a valuation of approximately $5 billion by 2027, driven by these innovative therapies. Additionally, the focus on understanding the underlying mechanisms of neuropathic pain is likely to yield more effective treatments, further stimulating market growth. As pharmaceutical companies invest in research and development, the landscape of available therapies is expected to evolve, providing patients with more choices.

    Rising Prevalence of Neuropathic Disorders

    The increasing incidence of neuropathic disorders in the US is a primary driver for the neuropathic pain market. Conditions such as diabetic neuropathy, postherpetic neuralgia, and multiple sclerosis are becoming more common, affecting millions of individuals. According to recent estimates, approximately 7-10% of the US population suffers from neuropathic pain, which translates to around 20 million people. This growing patient population necessitates the development and availability of effective treatment options, thereby propelling the neuropathic pain market forward. As healthcare providers seek to address this rising demand, the industry is likely to witness significant growth in both pharmaceutical and non-pharmaceutical interventions, including novel analgesics and alternative therapies.

    Market Segment Insights

    By Type of Neuropathic Pain: Diabetic Neuropathy (Largest) vs. Postherpetic Neuralgia (Fastest-Growing)

    In the US neuropathic pain market, the segment of Diabetic Neuropathy holds the largest market share, largely due to the rising incidence of diabetes and the significant number of patients experiencing neuropathic complications. Following closely is Postherpetic Neuralgia, which is witnessing impressive growth as awareness and diagnosis improve, alongside treatment advancements. Trigeminal Neuralgia and Chemotherapy-Induced Peripheral Neuropathy also contribute to the market but remain smaller in comparison. The growth trends for these segments are influenced by several key factors. The increasing prevalence of diabetes and related conditions drives the demand for effective management of Diabetic Neuropathy. Meanwhile, Postherpetic Neuralgia is gaining traction due to the aging population and the impact of shingles. Moreover, ongoing research and development in new treatment modalities are expected to further boost growth in these segments, with improvements in patient outcomes being a significant driver.

    Diabetic Neuropathy (Dominant) vs. Postherpetic Neuralgia (Emerging)

    Diabetic Neuropathy is currently the dominant segment in the US neuropathic pain market, characterized by long-term complications arising from diabetes leading to significant nerve damage. Patients commonly experience symptoms such as pain, numbness, and tingling, prompting a critical need for effective treatment options, which have evolved significantly in recent years. In contrast, Postherpetic Neuralgia is emerging rapidly, particularly due to its association with herpes zoster infection. This segment is distinguished by its chronic pain lasting long after the rash has cleared, affecting quality of life. The healthcare sector is responding to these needs through innovative therapies and comprehensive pain management strategies, enhancing the profiles of both conditions in the market.

    By Treatment Type: Medications (Largest) vs. Electrical Stimulation (Fastest-Growing)

    In the treatment type segment of the US neuropathic pain market, medications hold the largest market share due to their widespread acceptance and varied formulations, which appeal to a broad range of patients. Physical therapy and surgical procedures follow, each capturing unique patient bases with specific requirements. Conversely, electrical stimulation is rapidly gaining traction as a modern alternative that aligns with current healthcare trends emphasizing non-invasive solutions. Growth trends indicate that the US neuropathic pain market is witnessing a shift towards personalized and multidisciplinary approaches to treatment. Medications continue to evolve with new formulations and delivery methods, while electrical stimulation technologies are emerging as a safe, effective choice. Increased awareness, advancements in technology, and a growing focus on holistic care are substantial drivers of growth, particularly in the electrical stimulation segment.

    Medications (Dominant) vs. Electrical Stimulation (Emerging)

    Medications for neuropathic pain are characterized by their established efficacy and a wide range of options, including opioids, anticonvulsants, and antidepressants. This segment is well-supported by clinical guidelines and has become the first line of treatment for many patients. In contrast, electrical stimulation represents an emerging methodology, focusing on non-pharmacological interventions. This approach offers patients a viable alternative, particularly when traditional medications fail or lead to undesirable side effects. The growing body of clinical evidence supporting electrical stimulation, along with increasing investments in technological advancements, positions it as a rapidly growing segment that complements traditional medication approaches.

    By Route of Administration: Oral (Largest) vs. Topical (Fastest-Growing)

    In the US neuropathic pain market, the route of administration segment comprises three main categories: Oral, Topical, and Injectable. Oral administration holds the largest share due to its widespread acceptance, convenience, and ease of dosing. On the other hand, Topical administration, while smaller in share, is rapidly gaining popularity as it offers targeted relief with reduced systemic effects. Injectable administration, though less common, plays a crucial role in severe pain management where immediate relief is necessary. Recent growth trends indicate a significant shift towards non-invasive options such as Topical formulations, driven by patient preference for ease and fewer side effects. Innovations in drug delivery methods are enhancing the efficacy of Topical and Injectable treatments. Additionally, the rising prevalence of neuropathic pain conditions and increased awareness about effective pain management strategies are key factors fueling the growth of these segments in the market.

    Oral (Dominant) vs. Topical (Emerging)

    The Oral route of administration remains dominant in the US neuropathic pain market, primarily due to its familiarity among patients and healthcare providers. It enables easy self-administration and has a wide range of formulations available, which contributes to patient compliance. In contrast, the Topical route is emerging as a favorable alternative, especially for patients seeking localized relief without systemic exposure. The advancements in transdermal technologies are improving the absorption and efficacy of Topical products, making them increasingly attractive for managing neuropathic pain. As patient-centric care becomes integral to pain management, the competition between Oral and Topical routes will intensify, leading to a more dynamic market landscape.

    By End User: Hospitals (Largest) vs. Home Care (Fastest-Growing)

    In the US neuropathic pain market, hospitals represent the largest segment in the end user category, driven by their comprehensive resources and ability to provide advanced care for complex pain conditions. Clinics also hold a significant share, catering to outpatient needs and offering specialized services, while home care has emerged as a growing segment, appealing to patients seeking convenience and personalized management of neuropathic pain. The growth trends within this segment are largely influenced by the increasing prevalence of neuropathic pain, coupled with a rise in awareness about pain management strategies. Home care is particularly gaining traction due to the aging population and advancements in telehealth, allowing for better patient monitoring and support in non-hospital settings. The demand for more accessible, flexible care solutions is expected to drive further growth in this segment.

    Hospitals (Dominant) vs. Home Care (Emerging)

    Hospitals serve as the dominant end user in the US neuropathic pain market, offering extensive treatment options and multi-disciplinary approaches. They provide access to specialized medical professionals and advanced technology needed for diagnosis and treatment. In contrast, the home care segment is emerging rapidly as it addresses the needs of patients preferring home management of their conditions. This shift is facilitated by increased patient uptake of digital health solutions and a growing emphasis on personalized care. Both segments complement each other, with hospitals handling severe cases and home care supporting ongoing management, highlighting the evolving landscape of neuropathic pain treatment.

    Get more detailed insights about US Neuropathic Pain Market

    Key Players and Competitive Insights

    the neuropathic pain market is characterized by innovation, strategic partnerships, and a focus on patient-centric solutions. Key players such as Pfizer Inc (US), Eli Lilly and Company (US), and AbbVie Inc (US) are actively engaged in enhancing their product portfolios and expanding their market reach. Pfizer Inc (US) has been focusing on the development of novel therapies that target specific neuropathic pain pathways, which appears to position the company favorably in a market that demands precision medicine. Meanwhile, Eli Lilly and Company (US) has been pursuing strategic collaborations with technology firms to integrate digital health solutions into their treatment offerings, thereby enhancing patient engagement and adherence. AbbVie Inc (US) is also investing in research and development to innovate its existing pain management products, indicating a collective trend among these companies to leverage advanced technologies and partnerships to strengthen their competitive edge.

    In terms of business tactics, companies are increasingly localizing manufacturing and optimizing supply chains to enhance efficiency and reduce costs. The competitive structure of the neuropathic pain market is moderately fragmented, with several players vying for market share. However, the influence of major companies is substantial, as they often set the pace for innovation and market trends. This dynamic creates a competitive environment where smaller firms may struggle to keep up with the rapid advancements and strategic maneuvers of larger entities.

    In October 2025, Pfizer Inc (US) announced a collaboration with a leading biotech firm to develop a new class of pain relief medications that target neuropathic pain more effectively. This strategic move is likely to enhance Pfizer's portfolio and could potentially lead to breakthroughs in treatment efficacy, thereby solidifying its position in the market. Similarly, in September 2025, Eli Lilly and Company (US) launched a digital platform aimed at providing personalized pain management solutions, which may significantly improve patient outcomes and adherence to treatment regimens. This initiative reflects a growing trend towards integrating technology into healthcare, which could reshape patient experiences in the neuropathic pain sector.

    In August 2025, AbbVie Inc (US) expanded its research capabilities by acquiring a small pharmaceutical company specializing in neuromodulation therapies. This acquisition is indicative of AbbVie's commitment to diversifying its pain management offerings and underscores the importance of innovation in maintaining competitive advantage. Furthermore, in July 2025, Teva Pharmaceutical Industries Ltd (IL) announced a partnership with a tech startup to develop AI-driven solutions for pain assessment and management, which may enhance the precision of treatment plans and improve patient care.

    As of November 2025, the competitive trends in the neuropathic pain market are increasingly defined by digitalization, sustainability, and the integration of artificial intelligence. Strategic alliances are becoming more prevalent, as companies recognize the value of collaboration in driving innovation and improving patient outcomes. Looking ahead, it appears that competitive differentiation will evolve from traditional price-based competition to a focus on technological advancements, innovative treatment solutions, and reliable supply chains. This shift may ultimately lead to a more patient-centric approach in the neuropathic pain market, where companies that prioritize innovation and technology are likely to thrive.

    Key Companies in the US Neuropathic Pain Market market include

    Industry Developments

    Recent developments in the US Neuropathic Pain Market have been significant, with various pharmaceutical companies making strides in Research and Development. Bristol Myers Squibb and Eli Lilly are actively engaged in enhancing treatment options for neuropathic pain, focusing on innovative mechanisms of action. As of October 2023, major companies like Pfizer and AbbVie have reported growth in market valuation, positively influencing the competitive landscape.

    In terms of mergers and acquisitions, Amgen announced the acquisition of Horizon Therapeutics in September 2023, which has a strong focus on pain management therapies, further consolidating its position in the market. Moreover, Novartis launched a new clinical trial aimed at targeting chronic neuropathic pain, emphasizing the evolving treatment paradigms. Notable advancements in the last two years also include Teva Pharmaceutical's efforts to expand its generics portfolio for neuropathic pain medications, thereby ensuring affordability and wider accessibility.

    The increasing prevalence of diabetic neuropathy adds pressure on companies to innovate, reflecting an urgent need for effective pain management solutions, as the National Institutes of Health reported a rise in cases, driving the demand for novel therapies.

    Future Outlook

    US Neuropathic Pain Market Future Outlook

    The neuropathic pain market is projected to grow at a 6.76% CAGR from 2024 to 2035, driven by increasing prevalence, advancements in treatment options, and rising awareness.

    New opportunities lie in:

    • Development of telehealth platforms for remote pain management solutions.
    • Investment in AI-driven diagnostics for personalized treatment plans.
    • Expansion of over-the-counter neuropathic pain relief products in retail pharmacies.

    By 2035, the neuropathic pain market is expected to achieve substantial growth and innovation.

    Market Segmentation

    US Neuropathic Pain Market End User Outlook

    • Hospitals
    • Clinics
    • Home Care

    US Neuropathic Pain Market Treatment Type Outlook

    • Medications
    • Physical Therapy
    • Surgical Procedures
    • Electrical Stimulation

    US Neuropathic Pain Market Route of Administration Outlook

    • Oral
    • Topical
    • Injectable

    US Neuropathic Pain Market Type of Neuropathic Pain Outlook

    • Diabetic Neuropathy
    • Postherpetic Neuralgia
    • Trigeminal Neuralgia
    • Chemotherapy-Induced Peripheral Neuropathy

    Report Scope

    MARKET SIZE 2024 1911.0(USD Million)
    MARKET SIZE 2025 2040.18(USD Million)
    MARKET SIZE 2035 3926.0(USD Million)
    COMPOUND ANNUAL GROWTH RATE (CAGR) 6.76% (2024 - 2035)
    REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR 2024
    Market Forecast Period 2025 - 2035
    Historical Data 2019 - 2024
    Market Forecast Units USD Million
    Key Companies Profiled Pfizer Inc (US), Eli Lilly and Company (US), Astellas Pharma Inc (JP), Boehringer Ingelheim GmbH (DE), Teva Pharmaceutical Industries Ltd (IL), Novartis AG (CH), Johnson & Johnson (US), AbbVie Inc (US)
    Segments Covered Type of Neuropathic Pain, Treatment Type, Route of Administration, End User
    Key Market Opportunities Advancements in digital therapeutics and personalized medicine enhance treatment options in the neuropathic pain market.
    Key Market Dynamics Rising demand for innovative therapies drives competition and regulatory scrutiny in the neuropathic pain market.
    Countries Covered US

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    FAQs

    What is the projected market size of the US Neuropathic Pain Market in 2024?

    The US Neuropathic Pain Market is expected to be valued at 1.6 billion USD in 2024.

    What is the expected market size of the US Neuropathic Pain Market by 2035?

    By 2035, the market is anticipated to reach a value of 3.1 billion USD.

    What is the forecasted CAGR for the US Neuropathic Pain Market from 2025 to 2035?

    The expected CAGR for the US Neuropathic Pain Market during this period is 6.197 percent.

    Which segment of the US Neuropathic Pain Market holds the largest value in 2024?

    In 2024, Diabetic Neuropathy is valued at 0.72 billion USD, making it the largest segment.

    What is the market size for Postherpetic Neuralgia in the US Neuropathic Pain Market in 2035?

    The market for Postherpetic Neuralgia is projected to reach 0.79 billion USD by 2035.

    Who are the key players in the US Neuropathic Pain Market?

    Major players include Bristol Myers Squibb, Novartis, Cephalon, Eli Lilly, and Pfizer.

    What is the expected market size for Trigeminal Neuralgia in 2024?

    The Trigeminal Neuralgia segment is expected to be valued at 0.26 billion USD in 2024.

    What does the US Neuropathic Pain Market forecast indicate for Chemotherapy-Induced Peripheral Neuropathy by 2035?

    By 2035, the market for Chemotherapy-Induced Peripheral Neuropathy is expected to be valued at 0.23 billion USD.

    What challenges does the US Neuropathic Pain Market face in achieving growth?

    Challenges include regulatory hurdles and the high cost of treatment options.

    How do current trends influence the US Neuropathic Pain Market growth?

    Emerging trends such as personalized medicine and advanced therapies significantly bolster market growth.

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