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    US Drug Device Combination Market

    ID: MRFR/MED/13133-HCR
    100 Pages
    Rahul Gotadki
    September 2025

    US Drug-Device Combination Market Research Report By Product Type (Drug-Eluting Stents, Drug-Eluting Balloons, Transdermal Drug Delivery Systems, Inhalation Drug Delivery Devices), By Application (Cardiovascular, Orthopedics, Oncology, Neurology), By End Use (Hospitals, Ambulatory Surgical Centers, Homecare) and By Distribution Channel (Direct Sales, Distributors, Online Sales) - Forecast to 2035

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    US Drug Device Combination Market Research Report - Forecast to 2035 Infographic
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    Table of Contents

    US Drug Device Combination Market Summary

    The US Drug-Device Combination market is projected to grow from 8.1 USD Billion in 2024 to 14.1 USD Billion by 2035.

    Key Market Trends & Highlights

    US Drug-Device Combination Key Trends and Highlights

    • The market is expected to experience a compound annual growth rate (CAGR) of 5.17 percent from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 14.1 USD Billion, reflecting robust growth opportunities.
    • In 2024, the market is valued at 8.1 USD Billion, indicating a strong foundation for future expansion.
    • Growing adoption of innovative drug-device combinations due to increasing patient demand is a major market driver.

    Market Size & Forecast

    2024 Market Size 8.1 (USD Billion)
    2035 Market Size 14.1 (USD Billion)
    CAGR (2025-2035) 5.17%

    Major Players

    Merck and Co., BristolMyers Squibb, Boston Scientific, Medtronic, Abbott Laboratories, Gilead Sciences, Eli Lilly and Company, Novo Nordisk, Pfizer, Stryker Corporation, Amgen, Roche, Sanofi, Johnson and Johnson, Bayer AG

    US Drug Device Combination Market Trends

    The US Drug-Device Combination Market is experiencing several important trends. One key market driver is the increasing demand for advanced therapeutic solutions that combine pharmacological and medical device functionalities. This demand stems from the necessity to improve patient outcomes and ensure more precise drug delivery methods. The rise of chronic diseases and the aging population in the US are also contributing to the growth of this sector, as innovative solutions become vital for managing complex health conditions effectively.

    Recently, there has been a notable trend toward personalization in drug-device combinations. Tailored therapies that cater specifically to individual patient needs are gaining traction, as healthcare providers focus on enhancing the overall treatment experience.Regulatory bodies like the FDA are adapting their frameworks to facilitate faster approvals for these combinations, which further drives innovation and market growth. Opportunities within the US Drug-Device Combination Market are abundant, particularly in developing new solutions that address unmet medical needs.

    Companies are exploring ways to enhance patient adherence through user-friendly designs and integrated monitoring technologies. The collaboration between pharmaceutical and device manufacturers is becoming more prevalent, creating synergies that lead to more effective products. Additionally, increasing investment in research and development provides room for breakthroughs in materials and technologies that can fundamentally improve treatment methodologies.Overall, the focus on improving therapeutic efficacy, optimizing patient experience, and leveraging regulatory support fundamentally shapes the dynamics of the Drug-Device Combination Market in the US, making it a rapidly evolving landscape.

    US Drug Device Combination Market Drivers

    Market Segment Insights

    Drug-Device Combination Market Product Type Insights

    The US Drug-Device Combination Market has evolved significantly, with a notable focus on the various Product Types that comprise this complex segment. This market is characterized by distinct product innovations and applications that cater to different therapeutic areas. Drug-Eluting Stents play a crucial role in the treatment of coronary artery disease, providing sustained drug release to inhibit neointimal hyperplasia, a significant concern during vascular interventions.

    Their increasing adoption stems from their ability to enhance patient outcomes while reducing the need for repeat procedures, which is pivotal as cardiovascular diseases remain a leading cause of mortality in the United States. Similarly, Drug-Eluting Balloons have gained traction due to their effectiveness in treating peripheral artery disease by delivering medication directly to the vascular wall during angioplasty. This direct approach not only mitigates the risks associated with traditional balloon angioplasty but also addresses restenosis effectively.

    Additionally, these devices have shown promise in providing localized delivery, making them a preferred choice for specific patient populations. Transdermal Drug Delivery Systems are another key component, as they offer a non-invasive route for drug administration, enhancing patient compliance, especially for chronic conditions requiring long-term therapy. This system provides controlled drug release at a steady rate, minimizing the peak and trough levels typically associated with oral medications.

    The rise in chronic illnesses and the growing demand for patient-centric solutions are driving innovations in this area, leading to a diversification of formulations and delivery technologies.Lastly, Inhalation Drug Delivery Devices are paramount for respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). The ability to deliver drugs directly to the lungs enhances the therapeutic effect while reducing systemic side effects, making them invaluable in managing such conditions. With ongoing advancements in inhalation technology, these devices continue to evolve, providing more efficient and effective solutions tailored to patient needs.

    Overall, these various Product TypesDrug-Eluting Stents, Drug-Eluting Balloons, Transdermal Drug Delivery Systems, and Inhalation Drug Delivery Devicesare instrumental in shaping the US Drug-Device Combination Market landscape. They bring forward innovative treatment options that not only improve patient outcomes but also address the challenges faced in managing complex health issues across diverse populations. As the market adapts and grows, these devices will remain at the forefront, guided by technological advancements and increasing patient demand for effective healthcare solutions.

    Drug-Device Combination Market Application Insights

    The Application segment of the US Drug-Device Combination Market presents a diverse landscape, crucial for addressing various health conditions through integrated solutions. Notably, the Cardiovascular application remains vital due to the increasing prevalence of heart diseases, representing a significant share of healthcare expenditures in the US. Orthopedic applications also play a critical role, particularly in the aging population, where joint replacements and pain management solutions are in high demand.

    Similarly, Oncology applications are significant as they address the growing incidence of cancer and the need for effective treatment options that combine therapeutic drugs with innovative delivery mechanisms.Furthermore, the Neurology segment has gained importance as advances in technology have led to the development of drug-device combinations for neurological disorders, enhancing patient outcomes. Overall, these applications converge to reflect a trend towards personalized medicine, with the potential to improve efficacy and patient compliance in treatment protocols, making them indispensable in the evolving landscape of healthcare delivery in the US.

    Drug-Device Combination Market End Use Insights

    The US Drug-Device Combination Market is experiencing significant expansion, with the End Use segment playing a crucial role in this growth. Hospitals are currently the leading end-users, as they continue to adopt advanced drug-device combinations for improved patient outcomes and streamlined treatments. These facilities utilize these innovations for a variety of applications, including surgical procedures and chronic disease management, which drive the demand for effective and efficient healthcare solutions.

    Ambulatory Surgical Centers have emerged as important contributors, offering minimally invasive surgical options that enhance patient recovery times and reduce healthcare costs, thus making healthcare more accessible.Homecare has also gained traction, particularly with the rise of telemedicine and remote patient monitoring technologies, enabling patients to receive care in a familiar environment while maintaining adherence to treatment protocols.

    The ongoing trends in the healthcare landscape, such as an aging population and increasing prevalence of chronic diseases, further underpin the significance of these end-users in the US Drug-Device Combination Market, highlighting the importance of continuous innovation to address evolving patient needs effectively.Insights into the US Drug-Device Combination Market data reveal that these segments are integral in shaping market trends and opportunities for growth in the industry as healthcare continues to prioritize patient-centric solutions.

    Drug-Device Combination Market Distribution Channel Insights

    The Distribution Channel segment of the US Drug-Device Combination Market plays a pivotal role in ensuring accessibility and efficiency within the healthcare landscape. This market segment encompasses various pathways through which drug-device combinations are delivered to end-users, primarily including Direct Sales, Distributors, and Online Sales. In the US, Direct Sales are favored for high-value products where personalized service can be a key differentiator, allowing manufacturers to maintain direct relationships with healthcare providers.

    Distributors, on the other hand, hold significant importance as they provide widespread distribution networks, facilitating quicker delivery and extensive market reach, which is critical given the complexity and regulatory nuances associated with drug-device combinations.Meanwhile, Online Sales are growing substantially in popularity, particularly due to the increasing consumer reliance on e-commerce platforms and the ongoing digital transformation within healthcare. This shift is driven by the convenience of online access and the need for maintaining supply chain continuity, especially in light of recent global health challenges.

    The evolving dynamics within the US Drug-Device Combination Market reflect a response to the demands for efficient healthcare solutions, affordability, and accessibility, ultimately improving patient outcomes and streamlining distribution processes.

    Get more detailed insights about US Drug Device Combination Market Research Report - Forecast to 2035

    Regional Insights

    Key Players and Competitive Insights

    The US Drug-Device Combination Market is a rapidly evolving sector characterized by the integration of pharmaceuticals and medical devices to create innovative therapeutic solutions. This market demonstrates a unique competitive landscape shaped by technological advancements, regulatory considerations, and collaborations between pharmaceutical manufacturers and medical device developers. As healthcare undergoes continual transformation, drug-device combinations are increasingly being recognized for their potential to enhance patient care, improve drug efficacy, and simplify treatment regimens.

    These combinations often address complex medical conditions by delivering drugs in conjunction with devices that facilitate their administration or enhance their functionality, thereby creating a competitive edge that companies strive to maintain.Merck and Co. is a formidable player in the US Drug-Device Combination Market, leveraging its substantial research and development capabilities to produce innovative solutions that meet the growing demands of patients and healthcare providers. The company's strength lies in its extensive experience in pharmaceuticals and commitment to combining drug therapies with complementary devices.

    Through its robust product pipeline, Merck and Co. consistently delivers high-quality combinations that demonstrate effective delivery, increased patient compliance, and improved outcomes. Moreover, the firm’s strong market presence, backed by a well-established distribution network and comprehensive marketing strategies, allows it to effectively address the needs of healthcare professionals and patients alike. This combination of research prowess and strategic market positioning places Merck and Co. at the forefront of the US industry.

    BristolMyers Squibb holds a significant position in the US Drug-Device Combination Market, showcasing a diverse range of offerings that include targeted therapies and biologics integrated with specialized delivery systems. The company consistently focuses on addressing unmet medical needs, particularly in oncology and immunology, where its drug-device combinations have shown significant promise. BristolMyers Squibb's key products often involve advanced drug formulation techniques paired with innovative devices to optimize therapeutic delivery.

    The firm has also engaged in strategic mergers and acquisitions to bolster its capabilities and market presence, allowing it to tap into synergistic innovations and expand its portfolio. Through these efforts, BristolMyers Squibb successfully enhances its competitive advantage, driving growth and expanding its footprint in the US Drug-Device Combination Market, thereby reinforcing its reputation as a leader in the development of pioneering healthcare solutions.

    Key Companies in the US Drug Device Combination Market market include

    Industry Developments

    Recent developments in the US Drug-Device Combination Market include significant expansions and investments by major companies such as Merck and Co. and Gilead Sciences, which have been focusing on innovative therapies integrating drug delivery mechanisms with medical devices. Bristol-Myers Squibb announced collaborations aimed at enhancing their product line in combination therapies, while Abbott Laboratories is promoting advancements in continuous glucose monitoring systems that blend pharmaceuticals and devices for diabetic patients.

    In terms of mergers and acquisitions, Medtronic completed its acquisition of Mazor Robotics in October 2022, adding robotic-assisted surgery capabilities, which falls under the drug-device combination category. Johnson and Johnson also made headlines with its acquisition of Auris Health in March 2019, integrating innovative robotics into their surgical solutions portfolio. Growth in this market segment is influenced by technological advancements such as 3D printing and digital health solutions.

    The pandemic has accelerated the demand for hybrid therapeutic approaches, which is positively impacting the market valuation of these firms. Overall, the Drug-Device Combination Market in the US is rapidly evolving, driven by innovation and strategic partnerships among leading companies in the pharmaceutical and medical device sectors.

    Market Segmentation

    Drug-Device Combination Market End Use Outlook

    • Hospitals
    • Ambulatory Surgical Centers
    • Homecare

    Drug-Device Combination Market Application Outlook

    • Cardiovascular
    • Orthopedics
    • Oncology
    • Neurology

    Drug-Device Combination Market Product Type Outlook

    • Drug-Eluting Stents
    • Drug-Eluting Balloons
    • Transdermal Drug Delivery Systems
    • Inhalation Drug Delivery Devices

    Drug-Device Combination Market Distribution Channel Outlook

    • Direct Sales
    • Distributors
    • Online Sales

    Report Scope

    Report Attribute/Metric Source: Details
    MARKET SIZE 2018 7.22(USD Billion)
    MARKET SIZE 2024 8.1(USD Billion)
    MARKET SIZE 2035 14.1(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR) 5.168% (2025 - 2035)
    REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR 2024
    MARKET FORECAST PERIOD 2025 - 2035
    HISTORICAL DATA 2019 - 2024
    MARKET FORECAST UNITS USD Billion
    KEY COMPANIES PROFILED Merck and Co., BristolMyers Squibb, Boston Scientific, Medtronic, Abbott Laboratories, Gilead Sciences, Eli Lilly and Company, Novo Nordisk, Pfizer, Stryker Corporation, Amgen, Roche, Sanofi, Johnson and Johnson, Bayer AG
    SEGMENTS COVERED Product Type, Application, End Use, Distribution Channel
    KEY MARKET OPPORTUNITIES Wearable drug-delivery devices, Biologic and biosimilar integration, Personalized medicine advancements, Digital health integration, Regulatory streamlining initiatives
    KEY MARKET DYNAMICS Regulatory compliance challenges, Increasing prevalence of chronic diseases, Rising demand for personalized medicine, Technological advancements in drug delivery, Strategic partnerships and collaborations
    COUNTRIES COVERED US

    Market Highlights

    Author
    Rahul Gotadki
    Assistant Manager

    He holds an experience of about 7+ years in Market Research and Business Consulting, working under the spectrum of Life Sciences and Healthcare domains. Rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. His expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. In addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives

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    FAQs

    What is the projected market size of the US Drug-Device Combination Market by 2035?

    The US Drug-Device Combination Market is projected to be valued at 14.1 USD Billion by 2035.

    What was the market size of the US Drug-Device Combination Market in 2024?

    In 2024, the market size of the US Drug-Device Combination Market is expected to be valued at 8.1 USD Billion.

    What is the expected CAGR of the US Drug-Device Combination Market from 2025 to 2035?

    The expected CAGR for the US Drug-Device Combination Market from 2025 to 2035 is 5.168%.

    Which product type holds the largest market share in the US Drug-Device Combination Market?

    Drug-Eluting Stents hold the largest market share, valued at 2.5 USD Billion in 2024.

    What is the expected market size for Drug-Eluting Balloons by 2035?

    The expected market size for Drug-Eluting Balloons is projected to be 3.2 USD Billion by 2035.

    Who are the key players in the US Drug-Device Combination Market?

    Key players in the market include Merck and Co., BristolMyers Squibb, Boston Scientific, and Medtronic.

    How much is the market for Transdermal Drug Delivery Systems expected to grow by 2035?

    The market for Transdermal Drug Delivery Systems is expected to grow to 3.8 USD Billion by 2035.

    What market size is anticipated for Inhalation Drug Delivery Devices in 2024?

    Inhalation Drug Delivery Devices are anticipated to have a market size of 1.6 USD Billion in 2024.

    What are the growth opportunities in the US Drug-Device Combination Market?

    The growth opportunities in the market arise from advancements in technology and increasing demand for innovative therapeutic solutions.

    What challenges are currently impacting the US Drug-Device Combination Market?

    Challenges impacting the market include regulatory hurdles and the high cost of research and development.

    1. EXECUTIVE SUMMARY
    2. Market Overview
    3. Key Findings
    4. Market Segmentation
    5. Competitive Landscape
    6. Challenges and Opportunities
    7. Future Outlook
    8. MARKET INTRODUCTION
    9. Definition
    10. Scope of the study
    11. Research Objective
    12. Assumption
    13. Limitations
    14. RESEARCH METHODOLOGY
    15. Overview
    16. Data Mining
    17. Secondary Research
    18. Primary Research
    19. Primary Interviews and Information Gathering Process
    20. Breakdown of Primary Respondents
    21. Forecasting Model
    22. Market Size Estimation
    23. Bottom-Up Approach
    24. Top-Down Approach
    25. Data Triangulation
    26. Validation
    27. MARKET DYNAMICS
    28. Overview
    29. Drivers
    30. Restraints
    31. Opportunities
    32. MARKET FACTOR ANALYSIS
    33. Value chain Analysis
    34. Porter's Five Forces Analysis
    35. Bargaining Power of Suppliers
    36. Bargaining Power of Buyers
    37. Threat of New Entrants
    38. Threat of Substitutes
    39. Intensity of Rivalry
    40. COVID-19 Impact Analysis
    41. Market Impact Analysis
    42. Regional Impact
    43. Opportunity and Threat Analysis
    44. US Drug-Device Combination Market, BY Product Type (USD Billion)
    45. Drug-Eluting Stents
    46. Drug-Eluting Balloons
    47. Transdermal Drug Delivery Systems
    48. Inhalation Drug Delivery Devices
    49. US Drug-Device Combination Market, BY Application (USD Billion)
    50. Cardiovascular
    51. Orthopedics
    52. Oncology
    53. Neurology
    54. US Drug-Device Combination Market, BY End Use (USD Billion)
    55. Hospitals
    56. Ambulatory Surgical Centers
    57. Homecare
    58. US Drug-Device Combination Market, BY Distribution Channel (USD Billion)
    59. Direct Sales
    60. Distributors
    61. Online Sales
    62. Competitive Landscape
    63. Overview
    64. Competitive Analysis
    65. Market share Analysis
    66. Major Growth Strategy in the Drug-Device Combination Market
    67. Competitive Benchmarking
    68. Leading Players in Terms of Number of Developments in the Drug-Device Combination Market
    69. Key developments and growth strategies
    70. New Product Launch/Service Deployment
    71. Merger & Acquisitions
    72. Joint Ventures
    73. Major Players Financial Matrix
    74. Sales and Operating Income
    75. Major Players R&D Expenditure. 2023
    76. Company Profiles
    77. Merck and Co.
    78. Financial Overview
    79. Products Offered
    80. Key Developments
    81. SWOT Analysis
    82. Key Strategies
    83. BristolMyers Squibb
    84. Financial Overview
    85. Products Offered
    86. Key Developments
    87. SWOT Analysis
    88. Key Strategies
    89. Boston Scientific
    90. Financial Overview
    91. Products Offered
    92. Key Developments
    93. SWOT Analysis
    94. Key Strategies
    95. Medtronic
    96. Financial Overview
    97. Products Offered
    98. Key Developments
    99. SWOT Analysis
    100. Key Strategies
    101. Abbott Laboratories
    102. Financial Overview
    103. Products Offered
    104. Key Developments
    105. SWOT Analysis
    106. Key Strategies
    107. Gilead Sciences
    108. Financial Overview
    109. Products Offered
    110. Key Developments
    111. SWOT Analysis
    112. Key Strategies
    113. Eli Lilly and Company
    114. Financial Overview
    115. Products Offered
    116. Key Developments
    117. SWOT Analysis
    118. Key Strategies
    119. Novo Nordisk
    120. Financial Overview
    121. Products Offered
    122. Key Developments
    123. SWOT Analysis
    124. Key Strategies
    125. Pfizer
    126. Financial Overview
    127. Products Offered
    128. Key Developments
    129. SWOT Analysis
    130. Key Strategies
    131. Stryker Corporation
    132. Financial Overview
    133. Products Offered
    134. Key Developments
    135. SWOT Analysis
    136. Key Strategies
    137. Amgen
    138. Financial Overview
    139. Products Offered
    140. Key Developments
    141. SWOT Analysis
    142. Key Strategies
    143. Roche
    144. Financial Overview
    145. Products Offered
    146. Key Developments
    147. SWOT Analysis
    148. Key Strategies
    149. Sanofi
    150. Financial Overview
    151. Products Offered
    152. Key Developments
    153. SWOT Analysis
    154. Key Strategies
    155. Johnson and Johnson
    156. Financial Overview
    157. Products Offered
    158. Key Developments
    159. SWOT Analysis
    160. Key Strategies
    161. Bayer AG
    162. Financial Overview
    163. Products Offered
    164. Key Developments
    165. SWOT Analysis
    166. Key Strategies
    167. References
    168. Related Reports
    169. US Drug-Device Combination Market SIZE ESTIMATES & FORECAST, BY PRODUCT TYPE, 2019-2035 (USD Billions)
    170. US Drug-Device Combination Market SIZE ESTIMATES & FORECAST, BY APPLICATION, 2019-2035 (USD Billions)
    171. US Drug-Device Combination Market SIZE ESTIMATES & FORECAST, BY END USE, 2019-2035 (USD Billions)
    172. US Drug-Device Combination Market SIZE ESTIMATES & FORECAST, BY DISTRIBUTION CHANNEL, 2019-2035 (USD Billions)
    173. PRODUCT LAUNCH/PRODUCT DEVELOPMENT/APPROVAL
    174. ACQUISITION/PARTNERSHIP
    175. MARKET SYNOPSIS
    176. US DRUG-DEVICE COMBINATION MARKET ANALYSIS BY PRODUCT TYPE
    177. US DRUG-DEVICE COMBINATION MARKET ANALYSIS BY APPLICATION
    178. US DRUG-DEVICE COMBINATION MARKET ANALYSIS BY END USE
    179. US DRUG-DEVICE COMBINATION MARKET ANALYSIS BY DISTRIBUTION CHANNEL
    180. KEY BUYING CRITERIA OF DRUG-DEVICE COMBINATION MARKET
    181. RESEARCH PROCESS OF MRFR
    182. DRO ANALYSIS OF DRUG-DEVICE COMBINATION MARKET
    183. DRIVERS IMPACT ANALYSIS: DRUG-DEVICE COMBINATION MARKET
    184. RESTRAINTS IMPACT ANALYSIS: DRUG-DEVICE COMBINATION MARKET
    185. SUPPLY / VALUE CHAIN: DRUG-DEVICE COMBINATION MARKET
    186. DRUG-DEVICE COMBINATION MARKET, BY PRODUCT TYPE, 2025 (% SHARE)
    187. DRUG-DEVICE COMBINATION MARKET, BY PRODUCT TYPE, 2019 TO 2035 (USD Billions)
    188. DRUG-DEVICE COMBINATION MARKET, BY APPLICATION, 2025 (% SHARE)
    189. DRUG-DEVICE COMBINATION MARKET, BY APPLICATION, 2019 TO 2035 (USD Billions)
    190. DRUG-DEVICE COMBINATION MARKET, BY END USE, 2025 (% SHARE)
    191. DRUG-DEVICE COMBINATION MARKET, BY END USE, 2019 TO 2035 (USD Billions)
    192. DRUG-DEVICE COMBINATION MARKET, BY DISTRIBUTION CHANNEL, 2025 (% SHARE)
    193. DRUG-DEVICE COMBINATION MARKET, BY DISTRIBUTION CHANNEL, 2019 TO 2035 (USD Billions)
    194. BENCHMARKING OF MAJOR COMPETITORS

    US Drug-Device Combination Market Segmentation

     

     

     

    • Drug-Device Combination Market By Product Type (USD Billion, 2019-2035)

      • Drug-Eluting Stents
      • Drug-Eluting Balloons
      • Transdermal Drug Delivery Systems
      • Inhalation Drug Delivery Devices

     

    • Drug-Device Combination Market By Application (USD Billion, 2019-2035)

      • Cardiovascular
      • Orthopedics
      • Oncology
      • Neurology

     

    • Drug-Device Combination Market By End Use (USD Billion, 2019-2035)

      • Hospitals
      • Ambulatory Surgical Centers
      • Homecare

     

    • Drug-Device Combination Market By Distribution Channel (USD Billion, 2019-2035)

      • Direct Sales
      • Distributors
      • Online Sales

     

     

     

     

     

     

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