Solid Phase Extraction Market Analysis

Global Solid Phase Extraction Market Overview

Solid Phase Extraction Market was valued at USD 0.34 billion in 2023 and is projected to grow from USD 0.4 billion in 2024 to USD 0.56 billion by 2032, exhibiting a CAGR of 3.90% during the forecast period (2024 - 2032). Growing generics market, government funding of academia and life sciences, and instrumentation technology advancements, are the key market drivers enhancing the market growth.

Type Secondary Research, Primary Research, MRFR Database and Analyst Review

Waters Corporation has introduced OligoWorks SPE (solid-phase extraction) kits and components in October 2023 to enhance the preparation of samples for LC-MS-based bioanalytical quantitation of therapeutic oligonucleotides. The oligonucleotide recovery from biofluids can now be enhanced by up to a twofold over competing products for pharma and biopharma companies that are developing oligonucleotide therapeutics, as well as the Contract Research Organizations (CROs) that support them. The packages provide increased LC-MS sensitivity and reproducibility, which reduces the necessity for repeat experiments and enables lower limits of quantitation. The pipeline for oligonucleotide therapeutics is expanding at a rapid pace, with 13 FDA-approved oligonucleotide therapeutics currently in circulation and over 500 more in the pipeline. Although efficacious, these highly modified oligonucleotides are difficult to precisely quantify during dosing, metabolism, and tissue distribution studies. OligoWorks SPE kits also employ an innovative, enzyme-enhanced, and detergent-free sample pretreatment that enables direct injection LC-MS analysis and lower limits of quantitation. This pretreatment reduces the number of rinsing steps and enhances mass spectrometer compatibility. Additionally, they can be entirely automated to enhance productivity or to assist scientists in reclaiming time by minimizing manual steps and oversight.

In an endeavor to assist in the detection and management of the COVID-19 pandemic, PHASE Scientific has announced the worldwide commercial launch of the PHASIFY VIRAL RNA Extraction Kit in October 2020. PHASIFY VIRAL concentrates and purifies viral RNA from patient viral transport media samples. Conventional solid phase extraction methods are outperformed by this innovative technology in terms of RNA yield and concentration. The performance limitations of conventional solid phase extraction technologies lead to substandard sample quality. SARS-CoV-2 RNA concentrations in patients' samples, particularly those from the early stages, are comparatively low, resulting in low PCR detection sensitivity, high false negative rates, and the need for repeated confirmation testing. PHASIFY enhances the detection of target molecules by concentrating them by 10-100 times. PHASIFY has the potential to enhance the affordability, efficiency, ease of use, and precision of any diagnostic test.

Solid Phase Extraction Market Trends

Growth in generics industry is driving the market growth

As a result of increased demand for drug development, the market for solid phase extraction equipment has expanded. As the generics sector is expected to account for more than 80% of the pharmaceutical market in the future years, the demand for SPE is projected to increase. For instance, Invest India (India) reports that generic drugs make up 71% of the Indian pharmaceutical business. The EU intends to establish laws that will significantly lower barriers for less priced biosimilars to enter the market, reducing the probability of future drug shortages, as was the case during the COVID-19 epidemic. According to Statista (Germany), over 65% of medications sold in European countries like Italy are generic.

The rising use of SPE consumables in the pharmaceutical industry is largely responsible for this market's growth. The growing demand for high-throughput sample analysis needs, LC-MS-MS techniques, and liquid chromatography-mass spectrometry (LC-MS) has led to a need for the SPE consumable in the pharmaceutical business. The rise in R&D spending in the medical industry has increased demand for SPE consumables. An further factor driving the growth of this market is the ongoing automation of the SPE processes that are replacing the older manual SPEs. Automated SPE has several benefits over manual SPE using a vacuum manifold, including increased laboratory productivity and a reduction in time and solvent use. These elements encourage market growth.

Furthermore, precision is quite important in the analysis. The necessity for automatic SPE is exacerbated by the manual SPE's variable precision from operator to operator, batch to batch, and sample to sample. However, issues with users' sample handling pose a significant barrier to the market's growth. The hefty initial setup expenses in addition to a workforce that lacks the requisite skills significantly restrict market expansion. However, ongoing advancements in SPE methods that have given rise to a new generation of SPE technologies are creating new chances for business growth. The SPE consumable business has a chance as research study funding from numerous organisations rises. For instance, in March 2018, the German Research Foundation gave four new sequencing sites in Germany more than USD 17 million.

Numerous technological developments have been made in the solid phase extraction (SPE) market in order to satisfy the requirements of the biotechnology and biopharmaceutical industries, as well as the food and beverage, chemical, semiconductor, and environmental testing sectors. These developments have made it possible to build compact, automated, and computerised devices. SPE gadgets are now easier to use and more practical thanks to technical improvements. Rising automation and technology development are anticipated to drive market expansion. For instance, in May 2019, Biotage (Sweden) unveiled its series of Atlantic ReadyDisk SPE discs. The ready-to-use SPE discs in this line save time by not requiring disc holders to be cleaned. The Strata-X-Drug B Plus SPE product for urine drug testing in forensic and clinical drug testing was made available by Phenomenex Inc. (US) in May 2018.

Thermo Scientific Dionex Auto Trace 280 PFAS SPE equipment, a fully automated SPE device for drinking water analysis, was also unveiled by Thermo Fisher Scientific Inc. (US) in March 2020. The OttoTM SPEcialist Positive Pressure Manifold, which tackles a weakness in current SPE devices by boosting dependability and reproducibility of results, was introduced by Waters Corp (US) in January 2021. Therefore, such product introductions and advancements are encouraging market expansion. Thus, driving the Solid Phase Extraction market revenue.

Solid Phase Extraction Market Segment Insights

Solid Phase Extraction Type Insights

The Solid Phase Extraction market segmentation, based on type, includes SPE disk, SPE cartridge, and others. SPE cartridge segment accounted for the largest revenue share in 2022. The SPE cartridge's rise is mostly attributed to its acceptance in the food, environmental protection, commodities inspection, and pesticide residues application industries. By avoiding voiding, clogging, and channelling, the use of SPE cartridges benefits the market by lowering the expense of expensive reanalysis of bioanalytical samples.

Solid Phase Extraction Application Insights

The Solid Phase Extraction market segmentation, based on application, includes pharmaceutical industries, academic & research institutes, environmental, hospitals & clinics, and others. Environmental segment dominated the  Solid Phase Extraction market in 2022. This is because there is a growing need for pretreatment due to the size of the water sample.

Figure 1 Solid Phase Extraction Market, by Application, 2022 & 2032 (USD Billion)

Type Secondary Research, Primary Research, MRFR Database and Analyst Review

Solid Phase Extraction Regional Insights

By region, the study provides the market insights into North America, Europe, Asia-Pacific and Rest of the World. The Asia Pacific Solid Phase Extraction market dominated this market in 2022 (45.80%). The most recent developments in instrumentation, shifting economic conditions, expanding biotechnology investment, and pharmaceutical research organisations in Asia-Pacific emerging countries are the key drivers of this increase. Moreover, China’s Solid Phase Extraction market held the largest market share, and the Indian Solid Phase Extraction market was the fastest growing market in the Asia-Pacific region.

Further, the major countries studied in the market report are The US, Canada, German, France, the UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil.

Figure 2 SOLID PHASE EXTRACTION MARKET SHARE BY REGION 2022 (USD Billion)

Type Secondary Research, Primary Research, MRFR Database and Analyst Review

The North America Solid Phase Extraction Market is expected to register significant growth from 2023 to 2032. This is mainly due to its growing use in a variety of sectors, including the pharmaceutical, biotechnology, agricultural, and other industries. Pharmaceutical companies in the United States have access to numerous contemporary laboratory and development facilities. In terms of worldwide market penetration and revenue generation, the United States and Canada are strong countries. Further, the U.S. Solid Phase Extraction market held the largest market share, and the Canada Solid Phase Extraction market was the fastest growing market in the North America region.

Europe Solid Phase Extraction market accounted for the healthy market share in 2022. SPE products are frequently used in the R&D of medications by research organisations and biopharmaceutical companies. The government's measures to support such projects are causing the market in the region to expand. Further, the German Solid Phase Extraction market held the largest market share, and the U.K Solid Phase Extraction market was the fastest growing market in the European region

Solid Phase Extraction Key Market Players & Competitive Insights

Leading market players are investing heavily in research and development in order to expand their product lines, which will help the Solid Phase Extraction market, grow even more. Market participants are also undertaking a variety of strategic activities to expand their  footprint, with important market developments including new product launches, contractual agreements, mergers and acquisitions, higher investments, and collaboration with other organizations. To expand and survive in a more competitive and rising market climate, Solid Phase Extraction industry must offer cost-effective items.

Manufacturing locally to minimize operational costs is one of the key business tactics used by manufacturers in the  Solid Phase Extraction industry to benefit clients and increase the market sector. In recent years, the Solid Phase Extraction industry has offered some of the most significant advantages to medicine. Major players in the Solid Phase Extraction market, including Thermo Fisher Scientific, PerkinElmer Inc., 3M, Gilson Incorporated, Gerstel GmbH & Co. KG, Merck KGaA, Agilent Technologies, GL Sciences Inc., Biotage AB, Waters Corporation, Tecan Trading AG, Cytiva, Pall Corporation, Phenomenex Inc., and Sigma-Aldrich, are attempting to increase market demand by investing in research and development operations.

Thermo Fisher Scientific Inc. (Thermo Fisher) delivers medical equipment, analytical instruments, reagents and consumables, software, and services to satisfy the demands of challenging analytical challenges in research, diagnostics, and clinical laboratories. It offers solutions for cellular biology, synthetic biology, and flow cytometry. Mass spectrometry, genetic sequencing, electron microscopy, protein, and molecular biology research equipment are just a few of the many products that the company sells. The company offers services to companies in the environmental, industrial quality, and process control sectors, as well as to academic and research institutes, governmental organisations, pharmaceutical and biotech companies, clinical diagnostic laboratories, and environmental companies. It provides its products and services through its direct sales force, online sales, and third-party distributors across the Americas, Asia-Pacific, and Europe. The headquarters of Thermo Fisher are located in Waltham, Massachusetts, in the US. In April 2020, Thermo Fisher Scientific unveiled Dionex AutoTrace 280 PFAS. The Thermo Scientific Dionex AutoTrace 280 PFAS Solid-Phase Extraction Instrument is a high-throughput solid-phase extraction (SPE) device.

Avantor Inc. (Avantor), a company in the healthcare industry, manufactures and distributes chemicals, reagents, and lab supplies. The company's product line includes amino acids, silicones, bioreagents, denaturants, gas, solvents, stains, colours, and minerals. Education, lab and production, sourcing and procurement, services for lab equipment, commercial kitting, and downstream optimisation are just a few of the services offered by Avantor. It also provides laboratory services. The company increased the range of products it offers under its portfolio of brands, which also includes the names of VWR, Nusil, J.T. Baker, Macron specialised chemicals, and Poch. Taiwan, Mexico, the Netherlands, Poland, India, Malaysia, and South Korea are among the countries where the company maintains offices. The corporate headquarters of Avantor are located in Radnor, Pennsylvania, in the US. In November 2017, Avantor acquired VWR Corporation, an independent supplier of products, supply chain services, and customer support for lab and production clients.

Key Companies in the Solid Phase Extraction market include

• Thermo Fisher Scientific


• PerkinElmer Inc.


• 3M


• Gilson Incorporated


• Gerstel GmbH & Co. KG


• Merck KGaA


• Agilent Technologies


• GL Sciences Inc.


• Biotage AB


• Waters Corporation


• Tecan Trading AG


• Cytiva


• Pall Corporation


• Phenomenex Inc.


• Sigma-Aldrich

Solid Phase Extraction Industry Developments

December 2022 A pioneer in automated sample preparation systems, Fluid Management Systems (FMS), and Agilent Technologies have partnered to develop and market workflows for the testing and analysis of POPs, such as PFAS, Dioxins, PCBs, and other emerging contaminants in environmental and food matrices.

Solid Phase Extraction Market Segmentation

Solid Phase Extraction Type Outlook

• SPE Disk


• SPE Cartridge


• Others

Solid Phase Extraction Application Outlook

• Pharmaceutical Industries


• Academic & Research Institutes


• Environmental


• Hospitals & Clinics


• Others

Solid Phase Extraction Regional Outlook

• North America
  
  
  
  • US
  
  
  • Canada
  
  
  
  


• Europe
  
  
  
  • Germany
  
  
  • France
  
  
  • UK
  
  
  • Italy
  
  
  • Spain
  
  
  • Rest of Europe
  
  
  
  


• Asia-Pacific
  
  
  
  • China
  
  
  • Japan
  
  
  • India
  
  
  • Australia
  
  
  • South Korea
  
  
  • Australia
  
  
  • Rest of Asia-Pacific
  
  
  
  


• Rest of the World
  
  
  
  • Middle East
  
  
  • Africa
  
  
  • Latin America