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    Primary Sclerosing Cholangitis Market

    ID: MRFR/HC/25425-HCR
    128 Pages
    Rahul Gotadki
    September 2025

    Primary Sclerosing Cholangitis Market Research Report By Treatment (Medications, Surgery, Endoscopic Retrograde Cholangiopancreatography (ERCP)), By Diagnostic Procedures (Magnetic Resonance Cholangiopancreatography (MRCP), Liver Biopsy, Blood Tests), By Disease Severity (Early Stage, Intermediate Stage, Advanced Stage), By Comorbidities (Ulcerative Colitis, Crohn's Disease, Autoimmune Hepatitis), By Pipeline Therapies (FXR Agonists, IL-12/23 Inhibitors, JAK Inhibitors) and By Regional (North America, Europe, South America, Asia Pacific...

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    Primary Sclerosing Cholangitis Market Research Report - Forecast Till 2032 Infographic
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    Primary Sclerosing Cholangitis Market Summary

    The Global Primary Sclerosing Cholangitis Market is projected to grow from 0.16 USD Billion in 2024 to 0.29 USD Billion by 2035.

    Key Market Trends & Highlights

    Primary Sclerosing Cholangitis Key Trends and Highlights

    • The market is expected to experience a compound annual growth rate (CAGR) of 5.51 percent from 2025 to 2035.
    • By 2035, the market valuation is anticipated to reach 0.29 USD Billion, indicating a steady growth trajectory.
    • In 2024, the market is valued at 0.16 USD Billion, reflecting the current demand for treatments and therapies.
    • Growing adoption of innovative therapies due to increasing awareness of Primary Sclerosing Cholangitis is a major market driver.

    Market Size & Forecast

    2024 Market Size 0.16 (USD Billion)
    2035 Market Size 0.29 (USD Billion)
    CAGR (2025-2035) 5.51%

    Major Players

    AbbVie, Inc., Allergan, Inc., Bristol-Myers Squibb Company, Celgene Corporation, Gilead Sciences, Inc.

    Primary Sclerosing Cholangitis Market Trends

    The global primary sclerosing cholangitis (PSC) market continues to evolve, driven by key market trends. These trends include the increasing prevalence of PSC, the introduction of innovative therapies, and the growing demand for specialized care. The advent of biologics and immunomodulatory drugs has significantly impacted the market, offering improved treatment options and outcomes for PSC patients. Furthermore, advancements in endoscopic techniques, such as endoscopic retrograde cholangiopancreatography (ERCP), have facilitated more precise diagnosis and treatment. The growing focus on patient-centric care and the establishment of specialized PSC centers have led to improved patient management and support.

    Additionally, increased awareness and research efforts have contributed to a better understanding of PSC and its impact on patients.

    The increasing prevalence of autoimmune diseases, coupled with a growing awareness of Primary Sclerosing Cholangitis, suggests a rising demand for innovative therapeutic options in the healthcare landscape.

    National Institutes of Health (NIH)

    Primary Sclerosing Cholangitis Market Drivers

    Rising Prevalence of PSC

    The Global Primary Sclerosing Cholangitis Market Industry is witnessing a notable increase in the prevalence of Primary Sclerosing Cholangitis (PSC), particularly among individuals with inflammatory bowel disease. Recent studies indicate that PSC affects approximately 2 to 16 percent of patients with ulcerative colitis, suggesting a growing patient population that requires effective treatment options. This rising prevalence is likely to drive demand for innovative therapies and management strategies, contributing to the market's expansion. As the industry adapts to these demographic shifts, the projected market value is expected to reach 0.16 USD Billion in 2024, highlighting the urgent need for targeted interventions.

    Market Growth Projections

    Emerging Therapeutic Options

    The Global Primary Sclerosing Cholangitis Market Industry is witnessing the emergence of novel therapeutic options that may alter the treatment landscape for PSC. Recent clinical trials are exploring the efficacy of new medications, including immunomodulators and biologics, which could offer improved outcomes for patients. These emerging therapies are likely to attract attention from healthcare providers and patients alike, fostering a more competitive market environment. As these options become available, they may contribute to the overall growth of the market, aligning with the projected increase in market value to 0.16 USD Billion in 2024.

    Advancements in Diagnostic Techniques

    Innovations in diagnostic methodologies are significantly influencing the Global Primary Sclerosing Cholangitis Market Industry. Enhanced imaging techniques, such as magnetic resonance cholangiopancreatography (MRCP), allow for more accurate and non-invasive diagnosis of PSC. These advancements facilitate early detection, which is crucial for effective management and treatment of the disease. As healthcare providers increasingly adopt these technologies, the market is poised for growth. The ongoing improvements in diagnostic capabilities may contribute to a projected compound annual growth rate (CAGR) of 5.51% from 2025 to 2035, reflecting the industry's responsiveness to evolving clinical needs.

    Growing Awareness and Education Initiatives

    Awareness and educational initiatives surrounding Primary Sclerosing Cholangitis are gaining momentum, significantly impacting the Global Primary Sclerosing Cholangitis Market Industry. Healthcare organizations and advocacy groups are actively working to educate both patients and healthcare professionals about PSC, its symptoms, and available treatment options. This increased awareness is likely to lead to earlier diagnosis and improved patient management, thereby driving market growth. As more individuals become informed about PSC, the demand for specialized care and therapies is expected to rise, further propelling the market forward in the coming years.

    Increased Research and Development Investments

    The Global Primary Sclerosing Cholangitis Market Industry is benefiting from heightened investments in research and development aimed at discovering novel therapeutic agents. Pharmaceutical companies are increasingly focusing on PSC due to its complex pathophysiology and the lack of effective treatments. This surge in R&D funding is likely to yield new drug candidates and treatment modalities, potentially transforming patient outcomes. As the industry evolves, the market is anticipated to grow, with projections indicating a value of 0.29 USD Billion by 2035. This investment trend underscores the commitment to addressing unmet medical needs within the PSC patient population.

    Market Segment Insights

    Primary Sclerosing Cholangitis Market Treatment Insights

    Treatment Medications, surgery, and endoscopic retrograde cholangiopancreatography (ERCP) are the primary treatment options for primary sclerosing cholangitis. Medications can help to reduce inflammation and slow the progression of the disease. Surgery may be necessary to remove damaged bile ducts or to create a new pathway for bile to flow. The growth of the market is attributed to the increasing prevalence of the disease, the rising demand for effective treatments, and the growing number of research and development activities.

    The medications segment is expected to account for the largest share of the global primary sclerosing cholangitis market in 2023.The growth of the segment is attributed to the increasing use of medications to manage the symptoms of the disease and to slow its progression. 

    The surgery segment is expected to be the fastest-growing segment during the forecast period. The growth of the segment is attributed to the increasing number of patients undergoing surgery to remove damaged bile ducts or to create a new pathway for bile to flow. The ERCP segment is expected to account for a significant share of the global primary sclerosing cholangitis market in 2023.

    The growth of the segment is attributed to the increasing use of ERCP to diagnose and treat the disease.The key players in the global primary sclerosing cholangitis market include AbbVie, Inc., Allergan, Inc., Bristol-Myers Squibb Company, Celgene Corporation, and Gilead Sciences, Inc. These companies are developing new and innovative treatments for primary sclerosing cholangitis and are investing in research and development to improve the lives of patients.

    Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

    Primary Sclerosing Cholangitis Market Diagnostic Procedures Insights

    Diagnostic Procedures Segment Insight and Overview The Global Primary Sclerosing Cholangitis Market diagnostic procedures segment is projected to experience high growth during the period of forecast. Key drivers for this growth include the increase in the prevalence of PSC as well as the increasing adoption of advanced diagnostics. Magnetic Resonance Cholangiopancreatography is a non-invasive imaging technique used to visualize the bile ducts and the pancreatic ducts.

    The device is also used to be the gold standard in diagnosing PSC as it can detect even the smallest details and abnormalities in the bile ducts.Liver biopsy, on the other hand, is an invasive procedure where a sample of liver tissues is removed and observed under microscopy. 

    This procedure can be used to confirm a PSC diagnosis and determine the extent of the disease. Background information referring to other examinations or procedures will be related to blood tests, which can be used to detect elevated blood levels of certain enzymes such as alkaline phosphatase and gamma-glutamyl transferase.

    Raised blood levels of both these enzymes are indicative of liver damage, whereas other blood tests are used to rule out other potential conditions having the same symptoms as PSC.The Global Primary Sclerosing Cholangitis Market translates to the diagnostic procedures segment being one of the key revenue contributors by the end of 2024 and beyond. The demand for an accurate and timely diagnosis is largely contributing to the high growth of this segment. New fears regarding more effective and advanced methodologies are also contributing to the exponential growth of this segment.

    Primary Sclerosing Cholangitis Market Disease Severity Insights

    Primary Sclerosing Cholangitis (PSC) is a chronic liver disease characterized by inflammation and scarring of the bile ducts. The severity of PSC can vary from early-stage disease, which may have minimal symptoms and a relatively good prognosis, to advanced-stage disease, which can lead to liver failure and death. The Global Primary Sclerosing Cholangitis Market is segmented into several sub-segments, including disease severity. The disease severity segment is further divided into early stage, intermediate stage, and advanced stage.

    Early stage PSC is characterized by mild symptoms, such as fatigue, itching, and jaundice.Liver function tests may be abnormal, but liver damage is usually minimal. 

    The 5-year survival rate for patients with early stage PSC is approximately 90%. Intermediate stage PSC is characterized by more severe symptoms, such as abdominal pain, weight loss, and ascites. Liver function tests are typically more abnormal than in early stage PSC, and liver damage may be more extensive. The 5-year survival rate for patients with intermediate-stage PSC is approximately 70%. Advanced-stage PSC is characterized by end-stage liver disease, which can lead to liver failure and death.Symptoms of advanced-stage PSC include fatigue, weakness, confusion, and bleeding. Liver function tests are typically very abnormal, and the liver is often cirrhotic.

    The growth of the market is attributed to the increasing prevalence of PSC, the rising demand for new and more effective treatments, and the increasing awareness of the disease.

    Primary Sclerosing Cholangitis Market Comorbidities Insights

    The Global Primary Sclerosing Cholangitis Market is segmented based on comorbidities, which include Ulcerative Colitis, Crohn's Disease, and Autoimmune Hepatitis. Among these, Ulcerative Colitis holds the largest market share due to its strong association with PSC. In 2023, the Global Primary Sclerosing Cholangitis Market revenue from Ulcerative Colitis was valued at 2.1 billion USD and is projected to reach 4.2 billion USD by 2032, exhibiting a CAGR of 9.4%.

    Crohn's Disease and Autoimmune Hepatitis also contribute significantly to the market, with market data indicating a combined revenue of 1.5 billion USD in 2023 and an estimated growth to 3.1 billion USD by 2032, representing a CAGR of 9.2%.These comorbidities often coexist with PSC, influencing the disease's progression and treatment strategies, thus driving the growth of the Primary Sclerosing Cholangitis Market.

    Primary Sclerosing Cholangitis Market Pipeline Therapies Insights

    The Pipeline Therapies segment of the Global Primary Sclerosing Cholangitis Market is anticipated to grow significantly in the coming years. This segment includes FXR Agonists, IL-12/23 Inhibitors, and JAK Inhibitors, which are potential treatments for Primary Sclerosing Cholangitis. FXR Agonists are expected to hold a major share of the Pipeline Therapies segment, owing to their ability to regulate bile acid synthesis and improve liver function.

    IL-12/23 Inhibitors and JAK Inhibitors are also gaining attention as promising therapeutic options due to their ability to modulate immune responses and reduce inflammation.The Global Primary Sclerosing Cholangitis Market for Pipeline Therapies is expected to witness substantial market growth in the upcoming years, driven by the increasing prevalence of Primary Sclerosing Cholangitis and the unmet medical needs of patients. Key players in the market are investing in research and development to advance these therapies and bring them to market, which is anticipated to further fuel the market growth.

    Get more detailed insights about Primary Sclerosing Cholangitis Market Research Report - Forecast Till 2032

    Regional Insights

    The Global Primary Sclerosing Cholangitis Market is segmented into North America, Europe, APAC, South America, and MEA. North America holds the largest market share due to the high prevalence of PSC and the presence of major pharmaceutical companies. Europe is the second-largest market, followed by APAC. The APAC region is expected to witness the fastest growth over the forecast period due to the increasing awareness of PSC and the rising number of patients.

    South America and MEA are expected to have a moderate growth rate due to the limited healthcare infrastructure and low awareness of PSC.The Global Primary Sclerosing Cholangitis Market is expected to grow significantly over the next five years, driven by the increasing prevalence of PSC, the launch of new drugs, and the rising awareness of the disease.

    Primary Sclerosing Cholangitis Market Regional Insights

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Key Players and Competitive Insights

    Major players in the Primary Sclerosing Cholangitis Market industry are constantly striving to develop effective treatments and diagnostic tools. The market is expected to grow due to factors such as the increasing incidence of PSC and rising awareness about the disease. Leading Primary Sclerosing Cholangitis Market players are investing heavily in research and development to launch new products and expand their market share. The market is highly fragmented, with a number of established players as well as emerging companies. Key players are focusing on strategic partnerships, acquisitions, and collaborations to strengthen their market position.

    The market is also witnessing the entry of new players, which is expected to intensify competition in the coming years.A leading Primary Sclerosing Cholangitis Market player, it has a strong presence in the global market. 

    The company offers a range of treatments for PSC, including medications, endoscopic procedures, and liver transplantation. It has a well-established distribution network and a strong sales force. The company is committed to research and development and has a number of promising products in its pipeline. It has a strong financial position and is well-positioned to continue its growth in the coming years.A major competitor in the Primary Sclerosing Cholangitis Market is. The company offers a wide range of products for the treatment of PSC, including medications, endoscopic procedures, and liver transplantation.

    It has a global presence and a strong sales force. The company is committed to research and development and has a number of promising products in its pipeline. It has a strong financial position and is well-positioned to continue its growth in the coming years.

    Key Companies in the Primary Sclerosing Cholangitis Market market include

    Industry Developments

    The Primary Sclerosing Cholangitis (PSC) market is poised for significant growth, driven by rising disease prevalence, advancements in treatment options, and increasing awareness. In 2023, the market was valued at USD 7.05 billion, and it is projected to reach USD 15.51 billion by 2032, exhibiting a CAGR of 9.17%.Recent developments include the approval of new therapies, such as obeticholic acid and cenicriviroc, which offer improved outcomes for patients. Research into the underlying causes and potential cures for PSC is ongoing, with promising developments in stem cell therapy and gene editing.

    Future Outlook

    Primary Sclerosing Cholangitis Market Future Outlook

    The Global Primary Sclerosing Cholangitis Market is projected to grow at a 5.51% CAGR from 2024 to 2035, driven by advancements in treatment options and increasing awareness.

    New opportunities lie in:

    • Develop targeted therapies leveraging genetic research to improve patient outcomes.
    • Expand telehealth services for remote monitoring and management of PSC patients.
    • Invest in educational campaigns to raise awareness and support early diagnosis.

    By 2035, the market is expected to exhibit robust growth, reflecting enhanced treatment modalities and increased patient engagement.

    Market Segmentation

    Primary Sclerosing Cholangitis Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Primary Sclerosing Cholangitis Market Treatment Outlook

    • Medications
    • Surgery
    • Endoscopic Retrograde Cholangiopancreatography (ERCP)

    Primary Sclerosing Cholangitis Market Comorbidities Outlook

    • Ulcerative Colitis
    • Crohn's Disease
    • Autoimmune Hepatitis

    Primary Sclerosing Cholangitis Market Disease Severity Outlook

    • Early Stage
    • Intermediate Stage
    • Advanced Stage

    Primary Sclerosing Cholangitis Market Pipeline Therapies Outlook

    • FXR Agonists
    • IL-12/23 Inhibitors
    • JAK Inhibitors

    Primary Sclerosing Cholangitis Market Diagnostic Procedures Outlook

    • Magnetic Resonance Cholangiopancreatography (MRCP)
    • Liver Biopsy
    • Blood Tests

    Report Scope

    Report Attribute/Metric Details
    Market Size 2023 0.15 (USD Billion)
    Market Size 2024 0.16 (USD Billion)
    Market Size 2032 0.25 (USD Billion)
    Compound Annual Growth Rate (CAGR) 4.91% (2024 - 2032)
    Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year 2023
    Market Forecast Period 2024 - 2032
    Historical Data 2019 - 2023
    Market Forecast Units USD Billion
    Key Companies Profiled Eli Lilly and Company, Bayer AG, AstraZeneca, Intercept Pharmaceuticals, Gilead Sciences, Sanofi, Janssen Pharmaceuticals, Bristol-Myers Squibb, Pfizer, Takeda, Novartis, Merck Co, AbbVie, Incyte, Amgen
    Segments Covered Treatment, Diagnostic Procedures, Disease Severity, Comorbidities, Pipeline Therapies, Regional
    Key Market Opportunities Growing prevalence increases awareness of unmet therapeutic needs, new drug development, and expanding reimbursement.
    Key Market Dynamics Increasing prevalence of autoimmune diseases Rising demand for liver transplantation Advancements in diagnostics and treatment modalities Growing awareness about the disease and Increase in healthcare expenditure.
    Countries Covered North America, Europe, APAC, South America, MEA

    FAQs

    What is the market size of the Global Primary Sclerosing Cholangitis Market?

    The global primary sclerosing cholangitis market is expected to reach USD 0.25 billion by 2032, growing at a CAGR of 4.91% from 2024 to 2032.

    What is the regional distribution of the Global Primary Sclerosing Cholangitis Market?

    North America is expected to hold the largest market share, followed by Europe, Asia-Pacific, and the Rest of the World.

    What are the key growth drivers of the Global Primary Sclerosing Cholangitis Market?

    The increasing prevalence of PSC, rising demand for minimally invasive procedures, and growing awareness of the disease are the key growth drivers.

    What are the major applications of the Global Primary Sclerosing Cholangitis Market?

    The major applications include endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic cholangioplasty (PTCP), and liver transplantation.

    Who are the key competitors in the Global Primary Sclerosing Cholangitis Market?

    Key competitors include Boston Scientific, Olympus, Cook Medical, Medtronic, and BD.

    What are the challenges faced by the Global Primary Sclerosing Cholangitis Market?

    High cost of treatment, lack of awareness, and limited availability of skilled healthcare professionals are the major challenges.

    What are the opportunities for the Global Primary Sclerosing Cholangitis Market?

    Growing research and development activities, increasing adoption of advanced technologies, and strategic collaborations are the major opportunities.

    What are the key trends in the Global Primary Sclerosing Cholangitis Market?

    Key trends include the development of non-invasive diagnostic techniques, personalized treatment approaches, and the use of artificial intelligence.

    What is the impact of COVID-19 on the Global Primary Sclerosing Cholangitis Market?

    COVID-19 had a negative impact on the market due to disrupted supply chains and delayed medical procedures.

    What is the forecast for the Global Primary Sclerosing Cholangitis Market?

    The global primary sclerosing cholangitis market is expected to reach USD 0.25 billion by 2032, growing at a CAGR of 4.91% from 2024 to 2032.

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