Pentaerythritol companies focus on the production of this versatile polyol, which is used in the manufacturing of paints, coatings, lubricants, and other products. Companies like Perstorp and Celanese are key players in the pentaerythritol industry, supplying high-quality products to meet the demands of various end-user industries.
March 2023
Recent research from the Materials Research Centre (MRC) and Department of Organic Chemistry (OC) at the Indian Institute of Science (IISc) demonstrates that surface modifications of two-dimensional molybdenum disulfide (2D-MoS2) nanosheets can render them highly efficient for uses such as drug delivery to diseased cells.
In the latest work, thiol (sulfur-containing) ligands of the Pentaerythritol type were used to alter the surface of 2D-MoS2 nanosheets. They discovered that these thiols can be swapped out for thiols that are found naturally in biological systems, which may enable the release of medications bonded to these nanosheets. It was also discovered that using these chemically altered nanosheets inside of living cells is safe.
To create a functionalized version of the 2D-MoS2 nanosheets, the team first modified the surface using a fluorescent thiol known as boron-dipyrromethene (BOD-SH). (BOD-MoS2). Then, they used glutathione (GSH), a naturally occurring thiol that is abundant in cancer cells, to test the possibility of thiol-to-thiol exchange on BOD-MoS2. Using fluorescence techniques, they confirmed that GSH molecules exchanged places with BOD-SH on the nanosheet's surface.
The researchers discovered that thiol exchange could also occur between GSH and DOX, enabling DOX to be dropped off at the diseased site, when they adhered the anti-cancer medication doxorubicin (DOX) to the nanosheet surface.
Drugs like DOX can be delivered specifically to cancer cells without affecting normal cells because the exchange only occurs in the presence of high concentrations of GSH found in diseased cells. This may also lessen any potential side effects.
Key Companies in the Pentaerythritol market include
Pentaerythritol Market Highlights:
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