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July 2023: A prospective FDA-reviewed lower-cost alternative to an ex vivo SCD therapy has prompted Sanofi and Scribe Therapeutics to form a collaboration with a maximum value of over $1.2 billion in order to develop an in vivo genome editing therapy for the genetic disorder. The organizations formed a partnership with the potential to invest up to $1 billion in CRISPR-based cell therapies for cancer research last year. This collaboration has advanced; inquiries regarding particulars are being directed to Sanofi. Scribe and Sanofi intend to extend their most recent collaboration to the development of therapies for additional genomic diseases should they both achieve success in SCD. However, the number of such diseases is not specified by the companies. Scribe utilizes genetic modification platforms to construct and implement its array of CRISPR technologies in the treatment of hematopoietic disorders and other therapeutic domains in order to advance CRISPR-based therapies. Neurodegenerative diseases, ophthalmological diseases, and multisystem, muscle, and metabolic disorders are included in this category.

September 2023: Former Novartis CEO Joe Jimenez and former President of the Novartis Institutes for BioMedical Research (NIBR) Dr. Mark Fishman cofounded Aditum Bio in 2019. Today, the firm announced the formation of Celexor Bio, a portfolio company dedicated to the development of innovative therapies for inflammatory disorders. The in-licensing of a depleting antibody that targets immunoglobulin-like transcript 7 (ILT7), a highly specific cell surface marker present on plasmacytoid dendritic cells (pDCs), is facilitating the formation of Celexor Bio. The closure of the in-licensing is expected to occur later this month. The compound (IMG-018) will be renamed CLXR-901 pending licensing from Inmagene Biopharmaceuticals.

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