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    Alpha 1 Antitrypsin Deficiency Treatment Market

    ID: MRFR/HC/6847-HCR
    111 Pages
    Kinjoll Dey
    September 2025

    Alpha-1 Antitrypsin Deficiency Treatment Market Research Report Information By Drugs (Alpha-1 Proteinase Inhibitor,  Bronchodilators, Steroids), Route of Administration (Oral, Intravenous, Inhalation) and Distribution Channel (Hospital Pharmacy, Retail Pharmacy, Online Stores) - Forecast to 2032

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    Alpha-1 Antitrypsin Deficiency Treatment Market Research Report - Forecast till 2032 Infographic
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    Alpha 1 Antitrypsin Deficiency Treatment Market Summary

    The Global Alpha-1 Antitrypsin Deficiency Treatment Market is projected to experience substantial growth from 2024 to 2035.

    Key Market Trends & Highlights

    Alpha-1 Antitrypsin Deficiency Treatment Key Trends and Highlights

    • The market valuation is expected to rise from 3.52 USD Billion in 2024 to 13.5 USD Billion by 2035.
    • A compound annual growth rate (CAGR) of 12.98 percent is anticipated for the period between 2025 and 2035.
    • The increasing prevalence of Alpha-1 Antitrypsin Deficiency is likely to drive market expansion significantly.
    • Growing adoption of innovative therapies due to rising awareness of Alpha-1 Antitrypsin Deficiency is a major market driver.

    Market Size & Forecast

    2024 Market Size 3.52 (USD Billion)
    2035 Market Size 13.5 (USD Billion)
    CAGR (2025-2035) 12.98%

    Major Players

    Kamada Pharmaceuticals, CSL Behring LLC, Grifols, S.A., Takeda Pharmaceutical Company Limited, GlaxoSmithKline plc, Boehringer Ingelheim GmbH, AstraZeneca, Vectura Group plc, Pfizer Inc., Mylan Inc.

    Alpha 1 Antitrypsin Deficiency Treatment Market Drivers

    Market Growth Projections

    The Global Alpha-1 Antitrypsin Deficiency Treatment Market Industry is poised for substantial growth, with projections indicating a market size of 3.52 USD Billion in 2024 and an anticipated increase to 13.5 USD Billion by 2035. This growth trajectory suggests a compound annual growth rate (CAGR) of 12.98% from 2025 to 2035. Such projections highlight the increasing recognition of Alpha-1 Antitrypsin Deficiency as a critical health issue, driving investments in research, development, and treatment options. The market's expansion reflects the collective efforts of stakeholders to address the unmet needs of patients and improve health outcomes.

    Growing Geriatric Population

    The growing geriatric population is another significant factor influencing the Global Alpha-1 Antitrypsin Deficiency Treatment Market Industry. As the global population ages, the incidence of chronic respiratory diseases, including those associated with Alpha-1 Antitrypsin Deficiency, is expected to rise. Older adults are more susceptible to the effects of this deficiency, leading to an increased demand for targeted treatments. This demographic shift is likely to contribute to the market's expansion, with projections indicating a market size of 3.52 USD Billion in 2024. The intersection of aging and health conditions necessitates a focus on effective management strategies for this population.

    Regulatory Support and Incentives

    Regulatory support and incentives for the development of treatments for Alpha-1 Antitrypsin Deficiency are crucial drivers of the Global Alpha-1 Antitrypsin Deficiency Treatment Market Industry. Governments and regulatory bodies are increasingly recognizing the need for effective therapies, leading to expedited approval processes and financial incentives for pharmaceutical companies. This supportive environment encourages innovation and investment in research and development. As a result, the market is likely to experience accelerated growth, with a projected valuation of 13.5 USD Billion by 2035, as more companies enter the space to meet the growing demand for effective treatments.

    Advancements in Treatment Modalities

    Recent advancements in treatment modalities for Alpha-1 Antitrypsin Deficiency are significantly influencing the Global Alpha-1 Antitrypsin Deficiency Treatment Market Industry. New therapies, including augmentation therapy and gene therapy, are emerging, offering hope for improved patient outcomes. These innovations not only enhance the quality of life for patients but also stimulate market growth. As the industry evolves, the introduction of novel therapies is anticipated to attract investment and research funding. This dynamic environment is projected to contribute to a market valuation of 13.5 USD Billion by 2035, indicating a robust growth trajectory driven by technological advancements.

    Increased Awareness and Education Initiatives

    Increased awareness and education initiatives regarding Alpha-1 Antitrypsin Deficiency are pivotal in driving the Global Alpha-1 Antitrypsin Deficiency Treatment Market Industry. Healthcare organizations and advocacy groups are actively promoting awareness campaigns, which lead to earlier diagnosis and treatment. This heightened awareness not only empowers patients but also encourages healthcare professionals to consider Alpha-1 Antitrypsin Deficiency in differential diagnoses. As more individuals seek treatment, the market is expected to grow at a CAGR of 12.98% from 2025 to 2035, reflecting the impact of educational efforts on treatment uptake and market expansion.

    Increasing Prevalence of Alpha-1 Antitrypsin Deficiency

    The rising prevalence of Alpha-1 Antitrypsin Deficiency globally is a primary driver for the Global Alpha-1 Antitrypsin Deficiency Treatment Market Industry. As awareness increases, more individuals are being diagnosed, leading to a greater demand for effective treatments. In 2024, the market is projected to reach 3.52 USD Billion, reflecting the urgent need for therapies that address this genetic disorder. The growing number of patients necessitates innovative treatment options, thereby propelling market growth. This trend is expected to continue as healthcare providers enhance screening programs, further identifying affected individuals and expanding the treatment landscape.

    Market Segment Insights

    Alpha-1 Antitrypsin Deficiency Treatment Market Segmentation Insights

    Alpha-1 Antitrypsin Deficiency Treatment Drugs Insights

    Alpha-1 Antitrypsin Deficiency Treatment Route of Administration Insights

    Alpha-1 Antitrypsin Deficiency Treatment Distribution Channel Insights

    Get more detailed insights about Alpha-1 Antitrypsin Deficiency Treatment Market Research Report - Forecast till 2032

    Key Companies in the Alpha 1 Antitrypsin Deficiency Treatment Market market include

    Industry Developments

    • Q2 2024: FDA Approves Takeda’s New Alpha-1 Antitrypsin Deficiency Therapy The FDA granted approval to Takeda Pharmaceutical Company Limited for a new intravenous therapy for the treatment of alpha-1 antitrypsin deficiency, expanding available options for patients with this rare genetic disorder.
    • Q1 2024: Grifols Launches New Plasma Collection Center in Texas to Support Alpha-1 Therapies Grifols announced the opening of a new plasma collection facility in Texas, aimed at increasing the supply of plasma-derived therapies for alpha-1 antitrypsin deficiency patients in the United States.
    • Q2 2024: CSL Behring Receives European Commission Approval for Expanded Use of Zemaira in Alpha-1 Patients CSL Behring secured European Commission approval to expand the indication of its Zemaira product for the treatment of alpha-1 antitrypsin deficiency, allowing broader patient access across the EU.
    • Q3 2024: Kamada Announces Strategic Partnership with Pfizer for Alpha-1 Antitrypsin Inhaled Therapy Kamada Ltd. entered into a strategic collaboration with Pfizer to co-develop and commercialize an inhaled alpha-1 antitrypsin therapy, targeting improved delivery and patient outcomes.
    • Q2 2024: CSL Limited Invests $100 Million in New Biologics Manufacturing Facility for Alpha-1 Therapies CSL Limited announced a $100 million investment in a new biologics manufacturing facility in Switzerland, dedicated to increasing production capacity for alpha-1 antitrypsin deficiency treatments.
    • Q1 2025: Grifols Acquires Minority Stake in Kamada to Strengthen Alpha-1 Portfolio Grifols acquired a minority equity stake in Kamada Ltd., aiming to deepen its pipeline and market presence in alpha-1 antitrypsin deficiency therapies.
    • Q2 2025: CSL Appoints New Head of Rare Diseases Division to Oversee Alpha-1 Antitrypsin Program CSL Limited appointed Dr. Maria Jensen as the new Head of Rare Diseases, tasking her with leading the company’s global alpha-1 antitrypsin deficiency treatment strategy.
    • Q2 2024: Takeda and Vertex Pharmaceuticals Announce Collaboration on Gene Therapy for Alpha-1 Antitrypsin Deficiency Takeda and Vertex Pharmaceuticals entered a research collaboration to develop a gene therapy targeting the underlying genetic cause of alpha-1 antitrypsin deficiency.
    • Q3 2024: FDA Grants Orphan Drug Designation to AstraZeneca’s Investigational Alpha-1 Antitrypsin Therapy AstraZeneca received orphan drug designation from the FDA for its investigational therapy for alpha-1 antitrypsin deficiency, supporting the development of new treatment options for this rare disease.
    • Q1 2025: Grifols Signs Long-Term Plasma Supply Agreement with U.S. Blood Centers for Alpha-1 Therapies Grifols entered into a long-term agreement with several U.S. blood centers to secure plasma supply for the manufacture of alpha-1 antitrypsin deficiency treatments.
    • Q2 2025: CSL Launches Next-Generation Alpha-1 Antitrypsin Therapy in Europe CSL Limited launched a next-generation alpha-1 antitrypsin therapy in several European markets, offering improved dosing and administration for patients.
    • Q2 2024: Kamada Receives FDA Fast Track Designation for Inhaled Alpha-1 Antitrypsin Therapy Kamada Ltd. announced that its inhaled alpha-1 antitrypsin therapy candidate received Fast Track designation from the FDA, expediting its development and review process.

    Future Outlook

    Alpha 1 Antitrypsin Deficiency Treatment Market Future Outlook

    The Alpha-1 Antitrypsin Deficiency Treatment Market is projected to grow at a 12.98% CAGR from 2024 to 2035, driven by increasing awareness and advancements in therapeutic options.

    New opportunities lie in:

    • Develop personalized treatment plans leveraging genetic profiling for enhanced patient outcomes.
    • Invest in telehealth platforms to improve patient access to specialist care globally.
    • Explore partnerships with biotech firms to innovate new therapies targeting AAT deficiency.

    By 2035, the market is expected to achieve substantial growth, reflecting a robust response to evolving treatment needs.

    Market Segmentation

    Alpha-1 Antitrypsin Deficiency Treatment Market Segmentation Insights

    Alpha-1 Antitrypsin Deficiency Treatment Drugs Insights
    • Alpha-1 Proteinase Inhibitor: This drug type is expected to hold the largest market share. In April 2019, CSL Behring received FDA approval for Zemaira, which is alpha-1 proteinase inhibitor. So, the rising number of product approvals is expected to drive the alpha-1 antitrypsin deficiency treatment market growth.
    • Bronchodilators: Used for prevention from upper respiratory tract infections.
    • Steroids: Consists of corticosteroids used for the treatment of COPD associated with AATD.
    • Others: Consists of
    • , antibiotics, and other drugs used for the treatment of complications associated with AATD, such as jaundiced skin, breathing problems, etc.
    Alpha-1 Antitrypsin Deficiency Treatment Regional Insights
    • Americas: The largest regional market. The high patient population suffering from alpha-1 antitrypsin deficiency is expected to drive the market growth of alpha-1 antitrypsin deficiency treatment. Approximately 1 in 2,500 Americans suffer from the disease. This serves to drive the market growth of the alpha-1 antitrypsin deficiency treatment in the region.
    • Europe: Europe has some of the best healthcare services in the world. Increasing prevalence and the developed healthcare industry are driving the alpha-1 antitrypsin deficiency treatment market growth.
    • Asia-Pacific: The fastest-growing regional market for alpha-1 antitrypsin deficiency treatment, Asia-Pacific has the world’s largest population and fast-developing healthcare industry which is anticipated to drive the market growth.
    • Middle East & Africa: The market growth of alpha-1 antitrypsin deficiency treatment is attributed to the developing healthcare industry in regions such as Saudi Arabia, Oman, and Qatar.
    Alpha-1 Antitrypsin Deficiency Treatment Distribution Channel Insights
    • Hospital Pharmacy: The segment holds the largest market size as the treatment is mostly carried out in hospitals.
    • Retail Pharmacy: They provide prescriptions that are intended to be used at home.
    • Online Stores: Fastest growing segment owing to the increasing number of online pharmacy stores.
    Alpha-1 Antitrypsin Deficiency Treatment Route of Administration Insights
    • Oral: This route of administration is expected to hold the largest alpha-1 antitrypsin deficiency treatment market share due to its high usage.
    • Intravenous: This drug type is expected to grow at the fastest rate owing to the ease of administration.
    • Inhalation: This route of administration is mainly used for administration of corticosteroids and drugs for the treatment of breathing disorders associated with AATD.
    • Others: Consists of subcutaneous and intramuscular routes of administration.

    Report Scope

    Report Attribute/Metric Details
      Market Size 2023   USD 3.12 Billion
      Market Size 2024   USD 3.52 Billion
      Market Size 2032   USD 9.28 Billion
      CAGR   13.23%
      Base Year   2023
      Forecast Period   2024-2032
      Historical Data   2022
      Forecast Units   Value (USD Billion)
      Report Coverage   Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
      Segments Covered   Drugs, Route of Administration, Distribution Channel
      Geographies Covered   North America, Europe, Asia-Pacific, and Rest of the World (RoW)
      Key Vendors   Kamada Pharmaceuticals (Israel), CSL Behring LLC (US), Grifols, S.A. (Spain), Takeda Pharmaceutical Company Limited (Japan), GlaxoSmithKline plc (UK), Boehringer Ingelheim GmbH (Germany), AstraZeneca (UK), Vectura Group plc (UK), Pfizer Inc. (US), Mylan Inc. (US)
      Key Market Opportunities   Increasing R&D expenditure by key players to develop innovative treatment options for AATD
      Key Market Drivers Increasing prevalence of alpha-1 antitrypsin deficiency Growing product pipeline for alpha-1 antitrypsin deficiency treatment drugs Rising awareness regarding alpha-1 antitrypsin deficiency High unmet medical needs in developing economies

    Market Highlights

    Author
    Kinjoll Dey
    Research Analyst Level I

    He is an extremely curious individual currently working in Healthcare and Medical Devices Domain. Kinjoll is comfortably versed in data centric research backed by healthcare educational background. He leverages extensive data mining and analytics tools such as Primary and Secondary Research, Statistical Analysis, Machine Learning, Data Modelling. His key role also involves Technical Sales Support, Client Interaction and Project management within the Healthcare team. Lastly, he showcases extensive affinity towards learning new skills and remain fascinated in implementing them.

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    FAQs

    What is the valuation of the Alpha-1 Antitrypsin Deficiency Treatment Market?

    The Alpha-1 Antitrypsin Deficiency Treatment Market was valued at USD 9.28 billion by 2032.

    What is the CAGR of the Alpha-1 Antitrypsin Deficiency Treatment Market?

    Alpha-1 Antitrypsin Deficiency Treatment Market is expected to exhibit a strong 13.23% CAGR over the forecast period.

    What is the major driver for the Alpha-1 Antitrypsin Deficiency Treatment Market?

    Growing awareness about the condition of alpha-1 antitrypsin deficiency is likely to be the major driver for the market.

    Which is the leading regional Alpha-1 Antitrypsin Deficiency Treatment Market?

    The Americas dominate the Alpha-1 Antitrypsin Deficiency Treatment Market.

    What are the key players in the Alpha-1 Antitrypsin Deficiency Treatment Market?

    Leading players in the Alpha-1 Antitrypsin Deficiency Treatment Market include Kamada, Pfizer, and Mylan, among others.

    Alpha-1 Antitrypsin Deficiency Treatment Market Research Report - Forecast till 2032 Infographic
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