Acute Intermittent Porphyria Market Trends

Global Acute Intermittent Porphyria Market Overview 

Acute Intermittent Porphyria Market Size was valued at USD 4.35 Billion in 2023. The Global Acute Intermittent Porphyria industry is projected to grow from USD 4.61 Billion in 2024 to USD 7.34 Billion by 2032, exhibiting a compound annual growth rate (CAGR) of 6.90% during the forecast period (2024 - 2032).

The rising frequency of metabolic illnesses, gastrointestinal concerns, urinary tract issues, and health insurance coverage are driving the expansion of the market. Also, the growing elderly population will boost the market expansion.

Acute intermittent porphyria (AIP) is a metabolic condition caused by a genetic mutation. It affects the formation of heme, hemoglobin's oxygen-binding prosthetic group. It is characterized by a lack of the enzyme porphobilinogen deaminase. Acute intermittent porphyria is caused mostly by aberrant urine color, anorexia, sleeplessness, myalgia, and urinary retention. AIP can cause liver cancer (hepatocellular carcinoma) and renal failure in some people. Other symptoms include gastrointestinal problems, urinary tract problems, neurological problems, and psychological problems.

The rising prevalence of lifestyle-related disorders such as obesity is propelling the target market forward. Furthermore, the increased availability of money and fast-expanding government support for R&D will create several potential prospects for the acute intermittent porphyria market throughout the forecast years.

Alnylam Pharmaceuticals (Nasdaq: ALNY), a leader in RNAi therapeutics, announced in November 2019 that GIVLAARI™ (givosiran) injection for subcutaneous use has been approved by the U.S. Food and Drug Administration (FDA) to treat adults with acute hepatic porphyria (AHP). AHP represents a collection of rare genetic disorders, which are usually characterized by severe and life-threatening attacks as well as ongoing symptoms in some patients, depriving them of the possibility of functioning normally and leading their usual life. Chronic neuropathic pain, hypertension, chronic kidney disease, and liver disease are long-term complications of AHP. Those who took GIVLAARI had significantly lower attack rates compared to those who were hospitalized because of porphyria attacks or required urgent healthcare visits or IV hemin administration at home.

In November 2018, Recordati Rare Diseases Canada Inc., which is a biopharmaceutical company offering orphan treatments to patients with rare diseases, announced the market roll-out of PANHEMATIN®, the first Health Canada-authorized drug used in treating recurrent attacks of acute intermittent porphyria (AIP). Acute intermittent porphyria (AIP) is an uncommon metabolic disorder resulting in reduced heme-producing activities caused by the dysfunction of several enzymes. Most symptoms occur as severe abdominal pain episodes along with many other varied gastrointestinal system abnormalities, cardiovascular events, psychiatric events, or neurological events that may be fatal or progress to irreversible neuronal damage.

COVID-19 Analysis

With the rise of the Covid-19 impact, many large-scale businesses and industries suffered, except healthcare and life support products. The lockdown and physical distancing protocols have affected millions of small and big business institutions alike. The acute intermittent porphyria market saw a slight downfall post the pandemic due to the lockdown and physical distancing.

The pandemic has severely hindered the market growth, which has affected the forecast market value significantly. However, the pandemic situation is expected to wear off in the coming years. Hence, the severe intermittent porphyria market will see steady growth in the forecast years.

Acute Intermittent Porphyria Market Trends

Drivers

A few factors may drive the growth of the acute intermittent porphyria market share. The rising frequency of metabolic illnesses, gastrointestinal concerns, urinary tract issues, and health insurance coverage are driving the expansion of the market. Also, the growing elderly population will boost the market expansion.

The rising awareness about severe intermittent porphyria and the expansion of the healthcare sector in emerging markets are the primary drivers that fuel the growth of the market. 

Opportunities

According to WHO evaluations, neurological diseases account for 4.5 percent -11 percent of all illnesses in poor and high-income countries. This is significantly more than the number of respiratory diseases, gastrointestinal diseases, or malignancies, and the burden is anticipated to grow even more in the future years. This is expected to fuel the acute intermittent porphyria market growth in the forecast years.

Restraints

There are a few factors that may hinder the growth of the market value. Some of the factors that may impede the development of the market during the projected period include the availability of pricey treatment and inadequate reimbursement policies in emerging countries of the world. 

Challenges 

In emerging regions, common knowledge and insufficient access to excellent healthcare are restricting acceptance. The disorder's asymptomatic form creates delays in diagnosis, limiting uptake in the areas and hindering the acute intermittent porphyria market growth.

Cumulative Growth Analysis

The acute intermittent porphyria market is anticipated to grow substantially in the years to come. The severe intermittent porphyria treatment market value is expected to grow at a CAGR of about 5.6%. The rising frequency of metabolic illnesses, gastrointestinal concerns, urinary tract issues, and health insurance coverage are driving the expansion of the market. Also, the growing elderly population will boost the market expansion.

Value Chain Analysis

Rapid advances in metabolic diseases diagnosis are expected to drive acute hepatic porphyria market growth. Moreover, increasing regulatory clearances to allow potentially life-saving therapeutic techniques is broadening the scope of the market growth for acute intermittent porphyria. APH treatments benefit greatly from the government's strong support for advanced research, which also fuels market growth in the long run. The rising awareness about severe intermittent porphyria and the expansion of the healthcare sector in emerging markets are the primary drivers that fuel the growth of the market. 

Acute Intermittent Porphyria Market Segment Insights

The acute intermittent porphyria market is classified into many segments such as diagnosis, treatment, and end-user. Listed below are the severe intermittent porphyria market segments:

Acute Intermittent Porphyria Market Regional Insights

The regional division of the acute intermittent porphyria market analysis comprises North America, Europe, Asia Pacific, and the rest of the world. The Americas rule over the global acute intermittent porphyria treatment market because of well-developed technology, increased patients with inherited metabolic abnormalities, high healthcare spending, and government funding for research and development. Also, the increased R&D efforts and the concentration of significant corporations have fueled market expansion in this area.

Because of government support for R&D and the availability of research money, Europe ranks second in the global severe intermittent porphyria market. This is projected to drive the European market for the foreseeable future. Countries such as Germany and France, for example, are expanding their investments in healthcare.

Because of rapidly increasing healthcare technology, a large patient population, and high healthcare spending, Asia Pacific is the fastest growing acute intermittent porphyria market. Furthermore, the rising demand for innovative treatment approaches in nations such as India and South Korea is expected to make them the world's fastest expanding markets.

Furthermore, rising demand for high-quality medical devices is expected to enhance the adoption of modern equipment, fueling the expansion of the market in the area. On the other hand, blood disorders have become a major issue throughout the Middle East and Africa due to preliminary screening, disease ignorance, and restricted access to treatment.

Acute Intermittent Porphyria Key Market players & Competitive Insights

The acute intermittent porphyria industry is dominated by a few companies that play a vital role in the market growth. These acute intermittent porphyria treatment services companies are called key companies of the market. They contribute to the largest share of the market profit.

The companies account for the market profits by adopting various acute intermittent porphyria market trends such as joint ventures, product launches, company expansions, and procurements.

Below are the key companies that offer acute intermittent porphyria treatment services in the global market, with the location of their headquarters:

• ACON Laboratories, Inc. (US)


• Siemens AG (US)


• Dahaner (US)


• Bio-Rad Laboratories Inc. (US)


• Sysmex Corporation (Japan)


• Hoffmann-La Roche Ltd (Switzerland)


• ARKRAY Inc. (Japan)

Acute Intermittent Porphyria Market Segmentation

Acute Intermittent Porphyria Diagnosis Outlook

• Urine Test


• Blood test


• Serum test


• DNA test


• Others

Acute Intermittent Porphyria Treatment Outlook

• Prophylactic Hematin Infusions


• Gonadotropin-Releasing Hormone Analogues


• Others

Acute Intermittent Porphyria End-user Outlook

• Hospitals & clinics


• Medical research centers


• Others

Acute Intermittent Porphyria Regional Outlook

• North America
  
  
  
  • US
  
  
  • Canada
  
  
  
  


• Europe
  
  
  
  • Germany
  
  
  • France
  
  
  • UK
  
  
  • Italy
  
  
  • Spain
  
  
  • Rest of Europe
  
  
  
  


• Asia-Pacific
  
  
  
  • China
  
  
  • Japan
  
  
  • India
  
  
  • Australia
  
  
  • South Korea
  
  
  • Australia
  
  
  • Rest of Asia-Pacific
  
  
  
  


• Rest of the World
  
  
  
  • Middle East
  
  
  • Africa
  
  
  • Latin America
  
  
  
  

Recent Developments

• Recordati Rare Diseases Inc. is assisting the European Porphyria Network in the development of patient and family information. This allows people to notice symptoms early on and take appropriate preventive steps to lessen their effects.


• The PinpointAHP platform is available from Alnylam Pharmaceuticals Inc. This forum offers a range of materials to patients and caregivers to assist them in understanding the many forms of acute hepatic porphyria and detecting the signs and symptoms.

Report Overview

This report delivers all the information about the acute intermittent porphyria market size in the forecast period. It also contains different sections of the market analysis to help obtain detailed information such as opportunities, challenges, drivers, Covid-19 analysis, regional analysis, competitive landscape, and others. Moreover, all the information is collected from verified primary and secondary sources to provide the expected market outlook.