Chromatography Resin Market is predicted to reach USD 22,750.0 million at a CAGR of 6.96% during the forecast period

Pune, India, Oct 2022, MRFR Press Release/Market Research Future has published a Cooked Research Report on the Global Chromatography Resin Market.

Market Synopsis

The global chromatography resin market was valued at USD  12,771.5 million in 2021 and is projected to reach USD  22,750.0 million by 2030 at a CAGR of 6.96%.Chromatography is a process to split or separate a blend of colored components into individual elements. Chromatography resins help in the isolation of desired components from a mixture of compounds. They are incorporated into chromatography devices and are used in diagnostic test development and separation of biomolecules. Choice of resins is very crucial to ensure an effective and accurate separation of individual components.Chromatography resins are media used to capture and polish mAbs, antibody fragments, vaccines, and other biomolecules using a stationary phase. There are multiple types of ion-exchange resin. Most commercial resins are made of polystyrene sulfonate.Competitive LandscapeChromatography resin market is expected to register healthy growth throughout the forecast period. The market represents strong numbers in terms of consumption and is expected to grow year on year. Chromatography resin market is highly fragmented, with presence of numerous tier-1, tier-2, and unorganized players.Some of the key players operating in chromatography resin market Tosoh Corporation (Japan), Thermo Fisher Scientific Inc (US), Repligen Corporation (US), Avantor Performance Materials Inc (US), Merck KGaA (Germany), Bio-Rad Laboratories Inc (US), Pall Corporation (US), Mitsubishi Chemical Corporation (Japan), GE Healthcare (US), R.Grace & Co (US) and Purolite Corporation (US).SegmentationBy Type

• Natural Resin: Natural polymer used in chromatography techniques is extracted from living cells such as plant and bacteria cells. The most frequent natural polymers used as resins in chromatography applications are agarose, cellulose, chitosan, and dextran. The hydrophilic characteristic of these natural polymers, which contain a large number of hydroxyl groups in their structure, is their main advantage. These serve as functional sites for the binding of appropriate ligands. The mechanical stability of natural polymeric resins is lower than that of synthetic resins. Additionally, natural plant-based resins exhibit a better heat and fire resistance compared to synthetic resins.


• Synthetic Resin: Synthetic resins are a broad category of synthetic compounds that share some physical characteristics with natural resins but differ chemically. Polymethacrylate, polystyrene, and polyacrylamide are commonly used synthetic polymer resins in chromatography. Resins are usually made from the polystyrene polymer backbone and differ only by their specific functional groups. The ion exchange systems are usually regenerated with sodium chloride. The strength of the solution depends on the strength of the adsorption bond.


• Inorganic Media: The most popular stationary phases used in the separation of lipid mixtures by normal-phase chromatography are silica gel, alumina, and kieselguhr, with silica gel being the most extensively used. Alumina is a polar column chromatography adsorbent and will give separations by polar interactions. Silica gel and alumina are both polar adsorbents, but silica gel is less polar than alumina. Alumina is widely used for the separation of aldehydes, ketones, quinones, esters, lactones, and glucosides.

By Technique

• Ion exchange chromatography: Ion exchange chromatography involves sorting ionizable compounds by total charge. Because the charge carried by the molecule of interest can be easily changed by adjusting buffer pH, this technique allows the separation of comparable types of molecules that would be difficult to separate using other techniques. Ion exchange chromatography is commonly used to separate charged biological molecules such as proteins, peptides, amino acids, or nucleotides. Common matrices are cellulose, agarose, polymethacrylate, polystyrene, and polyacrylamide.


• Affinity chromatography: Affinity chromatography offers high selectivity, resolution, and capacity in most protein purification schemes. It has the advantage of utilizing a protein's biological structure or function for purification. As a result, purifications that would otherwise be time-consuming and complicated can often be easily achieved with affinity chromatography.


• Hydrophobic interaction chromatography: Hydrophobic interaction chromatography separates molecules based on their hydrophobicity. It is a widely used separation technique for purifying proteins while maintaining biological activity due to the use of conditions and matrices that operate under less denaturing conditions. Hydrophobic interaction chromatography can be used for capture, intermediate purification, or polishing steps.


• Size exclusion chromatography: Size exclusion chromatography separates molecules based on their size by filtration through a gel. The gel consists of spherical beads containing pores of specific size distribution. Separation occurs when molecules of different sizes are included or excluded from the pores within the matrix. The technique is also called gel filtration. This technique is widely used for the separation and purification of proteins. According to standard proteins, this technique is also useful for the determination of molecular weight and particle size.


• Multi-modal chronatography: Multi-modal or mixed-mode protein chromatography is based on media supports that have been functionalized with ligands capable of multiple modes of interaction: ion exchange, hydroxyapatite, affinity, size exclusion, and hydrophobic interactions. The ability to combine these separation methods can enhance selectivity in a protein purification process. Mixed-mode media effectively combine complementary chromatography methods within a single media and can reduce the total number of column steps needed in a purification process.


• Others: The others segment includes low-pressure chromatography, gravity chromatography, thin-layer chromatography, medium pressure chromatography, dye-ligand chromatography, etc. Low-pressure chromatography is often used for simple protein separations that do not require high resolution. Low-pressure systems range from basic to semi-automated and can be equipped with gradient capabilities, detectors, valves, and fraction collectors.

By Application

• Pharmaceutical and Biotechnology: Chromatography techniques are used in the pharmaceutical industry for a variety of purposes, such as identifying and analyzing samples for the presence of chemicals or trace elements, preparing large quantities of extremely pure materials, separating chiral compounds, detecting mixture purity, and unknown compounds present, and drug development. They are extensively used in drug research and development, drug impurity analysis, assay, content uniformity, and drug method development and validation.


• Food and Beverges: Chromatography is widely used in the food industry to detect pollutants and poisons in food, separate and analyze amino acids, proteins, vitamins, and preservatives, detect additives, detect spoilage, and evaluate nutritional value. Chromatography can be used at various stages of the food chain, from determining the quality of food to detecting additives, pesticides, and other harmful contaminants.


• Water and environmental analysis: Chromatography can also be used to examine and monitor aspects of environmental quality. Pollutant concentrations in water, soil, and air are routinely evaluated first by using chromatography to separate mixtures, followed by other characterization techniques such as mass spectrometry.


• Academicas and Research:Chromatography is widely used in biochemical research for the separation and identification of chemical compounds of biological origin. Chromatography offers precise separation, analyses, and purification processes using a low sample volume.


• Others: The others segment includes agriculture, forensic, clinical tests, etc. In forensics, chromatography is used in forensic pathology and crime scene testing, such as examining blood and hair samples discovered at the crime scene. It can also be used to determine cocaine and other drugs of abuse in blood, urine, etc

By Region

• North America: North America accounted for a largest market share in 2021. The North American market has been divided into the US and Canada. The growth in the region is attributed to the growth of the pharmaceutical & biotechnology industry in the US.


• Europe Europe has accounted for the second largest market share. The European market has been segmented into Germany, Russia, Italy, France, the UK, Spain, Poland, the Netherlands, Belgium, and the rest of Europe.


• Asia Pacific: Asia-Pacific has accounted for the second largest market share The Asia Pacific region offers huge growth potential for the chromatography resin market. The growth of the region can be associated with the growth of the pharmaceutical industry in China, India, and Japan. China's healthcare industry has risen quickly, allowing it to move from a pharmaceutical manufacturing base to a vital R&D hub.


• Latin America: The Latin American market is divided into Brazil, Mexico, and Argentina are the major contributors in the region.


• Middle East & Africa: In the Middle East & Africa, South Africa is the leading country in the region followed by Turkey.

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