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    US Geographic Atrophy GA Market

    ID: MRFR/HC/14260-HCR
    100 Pages
    Rahul Gotadki
    October 2025

    US Geographic Atrophy GA Market Research Report By Age Group (Above 60 Years, Above 75 Years), By Diagnosis (Fundus Autofluorescence, Optical Coherence Tomography Angiography, Multifocal Electroretinography) and By Therapeutic Agents Clinical Phase (Late-Stage, Phase II, Phase I, Pre-Clinical Stage, Discovery Candidates) - Forecast to 2035

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    US Geographic Atrophy GA Market Infographic
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    US Geographic Atrophy GA Market Summary

    As per MRFR analysis, the US geographic atrophy market size was estimated at 5000.0 USD Million in 2024. The US geographic atrophy-ga market is projected to grow from 5371.5 USD Million in 2025 to 11000.0 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 7.43% during the forecast period 2025 - 2035.

    Key Market Trends & Highlights

    The US geographic atrophy market is poised for growth driven by innovative therapies and increased funding.

    • The emergence of novel therapies is reshaping treatment paradigms in the geographic atrophy market.
    • Increased research funding is facilitating advancements in understanding and managing geographic atrophy.
    • Digital health solutions are being integrated into patient care, enhancing monitoring and treatment adherence.
    • The rising prevalence of age-related macular degeneration and advancements in diagnostic technologies are key drivers of market growth.

    Market Size & Forecast

    2024 Market Size 5000.0 (USD Million)
    2035 Market Size 11000.0 (USD Million)

    Major Players

    Novartis (CH), Regeneron Pharmaceuticals (US), Roche (CH), Bayer (DE), Apellis Pharmaceuticals (US), Alcon (CH), Santen Pharmaceutical (JP), Genentech (CH)

    US Geographic Atrophy GA Market Trends

    The geographic atrophy-ga market is currently experiencing notable developments, driven by an increasing prevalence of age-related macular degeneration (AMD) among the aging population. This condition, characterized by the progressive degeneration of retinal cells, leads to significant vision impairment. As the demographic landscape shifts, healthcare providers and pharmaceutical companies are focusing on innovative treatment options. The rise of advanced therapies, including gene therapy and novel pharmacological agents, appears to be reshaping the therapeutic landscape. Furthermore, the integration of digital health technologies is enhancing patient monitoring and engagement, potentially improving treatment adherence and outcomes. In addition, regulatory bodies are actively working to streamline the approval processes for new therapies, which may facilitate quicker access to innovative treatments for patients. The growing awareness of geographic atrophy and its impact on quality of life is prompting increased funding for research initiatives. This heightened focus on the condition suggests a promising future for the geographic atrophy-ga market, as stakeholders aim to address unmet medical needs and improve patient care. Overall, the market is poised for growth, driven by advancements in treatment modalities and a commitment to enhancing patient outcomes.

    Emergence of Novel Therapies

    Recent advancements in treatment options for geographic atrophy are noteworthy. Innovative therapies, including gene therapies and targeted pharmacological agents, are being developed to address the underlying mechanisms of the disease. These emerging treatments may offer new hope for patients, potentially altering the course of the condition.

    Increased Research Funding

    There is a growing trend towards increased funding for research focused on geographic atrophy. This influx of financial support is likely to accelerate the development of new therapies and enhance understanding of the disease. As research initiatives expand, they may lead to breakthroughs that improve patient outcomes.

    Integration of Digital Health Solutions

    The integration of digital health technologies into the management of geographic atrophy is becoming more prevalent. These solutions may facilitate better patient monitoring and engagement, potentially leading to improved treatment adherence. As technology continues to evolve, it could play a crucial role in enhancing care for individuals affected by this condition.

    US Geographic Atrophy GA Market Drivers

    Advancements in Diagnostic Technologies

    Technological advancements in diagnostic tools are transforming the landscape of the geographic atrophy-ga market. Enhanced imaging techniques, such as optical coherence tomography (OCT) and fundus autofluorescence, allow for earlier and more accurate detection of geographic atrophy. These innovations facilitate timely intervention, which is crucial for managing the progression of the disease. As diagnostic capabilities improve, healthcare providers are better equipped to identify at-risk patients, leading to increased treatment initiation rates. The market for diagnostic devices is expected to grow, with estimates indicating a potential increase of 15% annually. This growth in diagnostic technology not only enhances patient outcomes but also stimulates demand for therapeutic solutions within the geographic atrophy-ga market.

    Growing Investment in Ophthalmic Research

    The geographic atrophy-ga market is experiencing a surge in investment directed towards ophthalmic research. Public and private funding initiatives are increasingly focusing on the development of novel therapies and treatment modalities for retinal diseases. In recent years, funding for ophthalmic research has seen an uptick, with estimates suggesting an increase of over 20% in research grants allocated to retinal diseases. This influx of capital is likely to accelerate the pace of clinical trials and the introduction of innovative therapies. As researchers explore new avenues for treatment, the geographic atrophy-ga market stands to benefit from a broader array of therapeutic options, ultimately enhancing patient care and outcomes.

    Regulatory Support for Innovative Treatments

    Regulatory bodies are increasingly supportive of innovative treatments for geographic atrophy, which is likely to drive market growth. Initiatives such as expedited review processes and orphan drug designations are designed to encourage the development of therapies for rare diseases, including geographic atrophy. The U.S. Food and Drug Administration (FDA) has implemented programs that facilitate faster access to new treatments, which may lead to a quicker introduction of effective therapies into the market. This regulatory environment fosters innovation and investment in the geographic atrophy-ga market, as companies are incentivized to develop and bring new solutions to patients in need.

    Increased Awareness and Education Initiatives

    Raising awareness about geographic atrophy and its implications is becoming a pivotal driver in the market. Educational campaigns aimed at both healthcare professionals and the general public are essential for improving understanding of the disease. As awareness grows, patients are more likely to seek medical advice and treatment, which could lead to an increase in diagnosed cases. Recent surveys indicate that nearly 60% of individuals over 50 are unaware of geographic atrophy, highlighting a significant opportunity for educational outreach. This increased awareness is expected to translate into higher demand for therapies, thereby positively impacting the geographic atrophy-ga market.

    Rising Prevalence of Age-Related Macular Degeneration

    The increasing incidence of age-related macular degeneration (AMD) is a critical driver for the geographic atrophy-ga market. As the population ages, particularly among individuals aged 65 and older, the prevalence of AMD is projected to rise significantly. Current estimates suggest that approximately 2.1 million Americans are affected by AMD, with a notable portion developing geographic atrophy. This demographic shift indicates a growing patient population that requires effective treatment options. Consequently, pharmaceutical companies are likely to invest in research and development to address this unmet medical need, thereby propelling the geographic atrophy-ga market forward. The aging population, combined with the increasing awareness of eye health, suggests a robust demand for innovative therapies targeting geographic atrophy.

    Market Segment Insights

    By Age Group: Above 60 Years (Largest) vs. Above 75 Years (Fastest-Growing)

    In the US geographic atrophy-ga market, the age group above 60 years holds the largest market share. This segment captures a significant portion due to the increasing prevalence of geographic atrophy among older populations, driven by age-related health issues. Meanwhile, the above 75 years segment is rapidly gaining traction, showcasing a notable increase in market engagement and awareness of treatment options specific to older adults. The growth for the above 75 years segment is primarily fueled by demographic shifts and heightened focus on age-related diseases. As healthcare providers become more attuned to the needs of older patients, innovations in treatment are becoming accessible, leading to an increase in diagnosis and management. Public health initiatives aimed at educating and engaging older adults further contribute to the expanding footprint of this demographic in the market.

    Above 60 Years (Dominant) vs. Above 75 Years (Emerging)

    The age group above 60 years is the dominant segment in the US geographic atrophy-ga market, characterized by a large, well-established patient base and a broad range of available treatment options. This group benefits from significant healthcare infrastructure and support systems designed to cater to their needs. Conversely, the segment above 75 years is emerging, showing rapid growth as healthcare providers recognize the unique challenges faced by this older demographic. With an increasing focus on personalized care for older adults, this segment is positioned to expand significantly, driven by advancements in treatment protocols and greater patient advocacy. The distinct characteristics of these age groups emphasize the importance of tailored approaches in addressing geographic atrophy.

    By Diagnosis: Fundus Autofluorescence (Largest) vs. Optical Coherence Tomography Angiography (Fastest-Growing)

    In the US geographic atrophy-ga market, the Fundus Autofluorescence (FAF) segment holds a significant share due to its established role in diagnosing and monitoring retinal diseases. This traditional imaging technique has been the go-to method for detecting geographic atrophy and continues to dominate the market. Meanwhile, Optical Coherence Tomography Angiography (OCT-A) is rapidly gaining traction, providing deeper insights into choroidal and retinal blood flow, appealing to healthcare providers seeking comprehensive diagnostic tools. The growth trends in this segment are primarily driven by the increasing prevalence of age-related macular degeneration and advancements in imaging technologies. The demand for non-invasive diagnostics has fueled interest in OCT-A, positioning it as an emerging favorite among clinicians. As awareness of these diagnostic tools expands, both FAF and OCT-A are expected to play pivotal roles in shaping the future landscape of ophthalmic diagnostics in the market.

    Fundus Autofluorescence (Dominant) vs. Optical Coherence Tomography Angiography (Emerging)

    Fundus Autofluorescence (FAF) remains the dominant technique in the US geographic atrophy-ga market, renowned for its ability to highlight lipofuscin accumulation in retinal cells, thereby aiding in the diagnosis of various retinal pathologies. Its longstanding presence in clinical practice makes it a reliable choice for practitioners. In contrast, Optical Coherence Tomography Angiography (OCT-A) is an emerging technology that offers unparalleled visualization of the retinal and choroidal vasculature with minimal invasiveness. This innovative imaging method not only enhances diagnostic accuracy but also aids in monitoring disease progression, making it a key player as it gains acceptance among ophthalmologists and is poised for rapid growth in adoption.

    By Therapeutic Agents Clinical Phase: Late-Stage (Largest) vs. Phase II (Fastest-Growing)

    The US geographic atrophy-ga market is witnessing significant activity across various therapeutic agents in different clinical phases. Among them, the Late-Stage (Phase III) segment commands the largest share, reflecting a mature stage of development where solutions are ready for final efficacy testing. In contrast, the Phase II segment is rapidly gaining momentum, showcasing promising results that could enhance its market position in the upcoming years. Growth trends in this segment are heavily influenced by advancements in clinical research methodologies, an increase in investment towards innovative treatments, and the urgency to address unmet needs of patients. The rising prevalence of geographic atrophy and the potential for long-lasting benefits from new therapeutic agents are vital drivers contributing to the expanding Phase II segment, which is now recognized as the fastest-growing path within the therapeutic landscape.

    Late-Stage (Dominant) vs. Phase II (Emerging)

    The Late-Stage (Phase III) segment remains the dominant force in the therapeutic agents landscape, characterized by its robust pipeline of drugs awaiting approval and market launch. This stage typically involves large clinical trials that ascertain the safety and efficacy of treatments, making it a critical juncture that attracts significant investment and regulatory attention. On the other hand, the Phase II segment, while currently smaller in market share, is emerging as a pivotal phase where therapies frequently demonstrate promising efficacy. The focus on innovative treatment mechanisms, adaptive trial designs, and patient-centric approaches are facilitating rapid advancements in the Phase II stage, signaling a dynamic environment poised for future growth against the backdrop of an increasing demand for effective geographic atrophy solutions.

    Get more detailed insights about US Geographic Atrophy GA Market

    Key Players and Competitive Insights

    The geographic atrophy-ga market is characterized by a dynamic competitive landscape, driven by increasing prevalence rates and a growing demand for innovative treatment options. Key players such as Novartis (CH), Regeneron Pharmaceuticals (US), and Apellis Pharmaceuticals (US) are actively shaping the market through strategic initiatives. Novartis (CH) focuses on advancing its research and development capabilities, particularly in gene therapy, which may enhance its competitive edge. Regeneron Pharmaceuticals (US) appears to be leveraging its strong pipeline of biologics, aiming to address unmet needs in the treatment of geographic atrophy. Meanwhile, Apellis Pharmaceuticals (US) is concentrating on expanding its commercial footprint, particularly in the U.S. market, which could significantly influence market dynamics.

    The business tactics employed by these companies include localizing manufacturing and optimizing supply chains to enhance efficiency and reduce costs. The market structure is moderately fragmented, with several players vying for market share. However, the collective influence of these key players is substantial, as they drive innovation and set industry standards, thereby shaping the competitive environment.

    In October 2025, Novartis (CH) announced a strategic partnership with a leading biotechnology firm to co-develop a novel treatment for geographic atrophy. This collaboration is expected to accelerate the development timeline and enhance the therapeutic options available to patients, indicating Novartis's commitment to innovation and collaboration in addressing this challenging condition.

    In September 2025, Regeneron Pharmaceuticals (US) reported positive results from a pivotal clinical trial for its new biologic therapy targeting geographic atrophy. The promising data not only strengthens Regeneron's position in the market but also highlights the potential for biologics to transform treatment paradigms, suggesting a shift towards more targeted therapies in the future.

    In August 2025, Apellis Pharmaceuticals (US) launched a comprehensive awareness campaign aimed at educating healthcare providers and patients about geographic atrophy. This initiative underscores Apellis's focus on market penetration and patient engagement, which may enhance its competitive positioning as it seeks to establish itself as a leader in this therapeutic area.

    As of November 2025, current trends in the geographic atrophy-ga market include a pronounced emphasis on digitalization, sustainability, and the integration of artificial intelligence in drug development processes. Strategic alliances are increasingly shaping the competitive landscape, fostering innovation and collaboration among key players. Looking ahead, it appears that competitive differentiation will evolve, with a notable shift from price-based competition to a focus on innovation, technological advancements, and supply chain reliability, which may redefine success in this market.

    Key Companies in the US Geographic Atrophy GA Market market include

    Industry Developments

    The US Geographic Atrophy (GA) Market has seen significant developments recently. In April 2023, Iveric Bio announced positive results from its Phase 3 trials for Zimura, a novel treatment targeting GA, which has since garnered attention for its therapeutic potential. In May 2023, Apellis Pharmaceuticals also reported promising data for Syfovre, its innovative therapy for GA, indicating substantial strides in the treatment landscape.

    Meanwhile, Genentech is actively advancing its pipeline with new compounds, focusing on innovative approaches to address retinal diseases, which has influenced market dynamics. In terms of acquisitions, in August 2023, Novartis completed its acquisition of AveXis, enhancing its capabilities in gene therapies, which may have implications for future GA treatment modalities.

    The market valuation for companies within the GA sector, including EyePoint Pharmaceuticals and Regeneron Pharmaceuticals, has experienced overall growth driven by advancements in Research and Development and positive clinical trial outcomes. Regulatory changes focusing on accelerated approval pathways have also fueled investor interest and market expansion, laying a promising foundation for future innovations in the US Geographic Atrophy Market.

    Future Outlook

    US Geographic Atrophy GA Market Future Outlook

    The geographic atrophy-ga market is projected to grow at a 7.43% CAGR from 2024 to 2035, driven by advancements in treatment options and increasing patient awareness.

    New opportunities lie in:

    • Development of personalized treatment plans leveraging AI technology.
    • Expansion of telehealth services for remote patient monitoring.
    • Investment in clinical trials for novel therapeutic agents.

    By 2035, the market is expected to achieve substantial growth, driven by innovative solutions and increased demand.

    Market Segmentation

    US Geographic Atrophy GA Market Age Group Outlook

    • Above 60 Years
    • Above 75 Years

    US Geographic Atrophy GA Market Diagnosis Outlook

    • Fundus Autofluorescence (FAF)
    • Optical Coherence Tomography Angiography (OCT-A)
    • Multifocal Electroretinography (MfERG)

    US Geographic Atrophy GA Market Therapeutic Agents Clinical Phase Outlook

    • Late-Stage (Phase III)
    • Phase II
    • Phase I
    • Pre-Clinical Stage & Discovery Candidates

    Report Scope

    MARKET SIZE 2024 5000.0(USD Million)
    MARKET SIZE 2025 5371.5(USD Million)
    MARKET SIZE 2035 11000.0(USD Million)
    COMPOUND ANNUAL GROWTH RATE (CAGR) 7.43% (2024 - 2035)
    REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR 2024
    Market Forecast Period 2025 - 2035
    Historical Data 2019 - 2024
    Market Forecast Units USD Million
    Key Companies Profiled Novartis (CH), Regeneron Pharmaceuticals (US), Roche (CH), Bayer (DE), Apellis Pharmaceuticals (US), Alcon (CH), Santen Pharmaceutical (JP), Genentech (CH)
    Segments Covered Age Group, Diagnosis, Therapeutic Agents Clinical Phase
    Key Market Opportunities Advancements in gene therapy and novel treatment modalities present growth potential in the geographic atrophy-ga market.
    Key Market Dynamics Rising demand for innovative therapies drives competition and regulatory scrutiny in the geographic atrophy market.
    Countries Covered US

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    FAQs

    What is the expected overall market size of the US Geographic Atrophy GA Market in 2024?

    The expected overall market size of the US Geographic Atrophy GA Market in 2024 is valued at 5.75 billion USD.

    What will the market size of the US Geographic Atrophy GA Market be in 2035?

    In 2035, the market size of the US Geographic Atrophy GA Market is expected to reach 12.5 billion USD.

    What is the expected CAGR for the US Geographic Atrophy GA Market from 2025 to 2035?

    The expected CAGR for the US Geographic Atrophy GA Market from 2025 to 2035 is 7.314%.

    What is the market size for the age group above 60 years in 2024?

    For the age group above 60 years, the market size is valued at 3.45 billion USD in 2024.

    What will the market size for the age group above 75 years be in 2035?

    In 2035, the market size for the age group above 75 years is expected to reach 5.0 billion USD.

    Who are the major players in the US Geographic Atrophy GA Market?

    Key players in the US Geographic Atrophy GA Market include Genentech, Novartis, Santen Pharmaceutical, and Regeneron Pharmaceuticals.

    What are the growth opportunities in the US Geographic Atrophy GA Market?

    The growth opportunities in the US Geographic Atrophy GA Market are driven by an increasing elderly population and advancements in treatment strategies.

    How is the market for US Geographic Atrophy GA expected to change due to regional trends?

    Regional trends indicate significant growth in the US due to an aging population and increased awareness of ophthalmic conditions.

    What is the projected market size for the age group above 60 years in 2035?

    The projected market size for the age group above 60 years is anticipated to be 7.5 billion USD in 2035.

    What challenges does the US Geographic Atrophy GA Market face going forward?

    The market faces challenges such as regulatory hurdles and competition in treatment innovations.

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