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Unnatural Amino Acids Market Size

ID: MRFR//3479-CR | 216 Pages | Author: Rahul Gotadki| July 2020

Unnatural amino acids, distinct from the proteinogenic amino acids constituting natural proteins, can either occur naturally or be synthesized through chemical processes. The prominence of unnatural amino acids is notably increasing in diverse fields such as pharmaceuticals, food and feed additives, agrochemicals, and various industrial applications. The driving forces behind the growth of the unnatural amino acids market encompass their expanding applications in the pharmaceutical sector, the overall growth trajectory of the pharmaceutical industry, and the rising prevalence of chronic disorders. These amino acids play a crucial role in drug discovery and development, enhancing the activity and plasma stability of peptides. Despite the favorable factors propelling the market, there exists a counteracting influence due to the rising adoption of non-invasive drug delivery systems. This shift in drug delivery methods poses a challenge to the traditional use and demand for unnatural amino acids, impacting the overall growth of the market. Unnatural or unusual amino acids, whether occurring naturally through post-translational processes in plants and bacteria or being synthetically created, have become instrumental in optimizing the efficacy of peptides within drug discovery and development. As the demand for innovative pharmaceutical solutions continues to grow, the role of unnatural amino acids becomes increasingly pivotal, contributing to advancements in drug formulations and therapeutic interventions. Unnatural amino acids, a distinctive category outside the realm of naturally occurring proteinogenic amino acids, are gaining prominence for their diverse applications. Whether occurring naturally in plants and bacteria or synthetically created, these amino acids find utility in pharmaceuticals, food and feed additives, agrochemicals, and various industrial spheres. The continuous expansion of their applications within the pharmaceutical sector, coupled with the overall growth of the pharmaceutical industry, underscores the significant role these amino acids play in drug discovery and development. However, challenges arise from the increasing adoption of non-invasive drug delivery systems, impacting the conventional demand for unnatural amino acids in therapeutic formulations.

Covered Aspects:

Report Attribute/Metric Details
Market Size Value In 2023 USD 2.0938billion Billion
Growth Rate 10.20%(2023-2032)

Unnatural Amino Acids Market Overview


The Unnatural Amino Acids Market Size was valued at USD 2.09 billion in 2023. The Unnatural Amino Acids market industry is projected to grow from USD 2.3 Billion in 2024 to USD 4.55 billion by 2032, exhibiting a compound annual growth rate (CAGR) of 10.74% during the forecast period (2024 - 2032). Developing examination on food drug and feed expansion and agrochemicals and expanding interest in drug intermediatesare the key market drivers enhancing the market growth. 

Global Unnatural Amino Acids Market Overview


Source: Secondary Research, Primary Research, MRFR Database, and Analyst Review


Unnatural Amino Acids Market Trends



  • Growing applications in diagnostics and biosensors are driving the market growth.


The growing applications in diagnostics and biosensors are driving the trend in the unnatural amino acids market. Unnatural amino acids, or non-canonical amino acids, are synthetic or modified amino acids that do not naturally occur in living organisms. These amino acids have unique properties and functionalities that make them valuable in various fields, including diagnostics and biosensors.In diagnostics, unnatural amino acids are used to develop novel diagnostic tools and techniques for detecting and monitoring diseases. They can be incorporated into diagnostic probes and sensors to enhance their sensitivity and specificity. Unnatural amino acids can also be used to design specific peptide sequences that bind to disease markers, enabling the development of highly accurate diagnostic assays.Unnatural amino acids play a crucial role in biosensors in developing biosensing platforms. They can be used as sensing elements or as part of the recognition elements in biosensors. 


Their unique properties allow for the selective and sensitive detection of target analytes, such as biomarkers or environmental pollutants. Unnatural amino acids can be engineered to interact specifically with the target analyte, enabling the biosensor to provide rapid and accurate results.The growing applications in diagnostics and biosensors are driven by the increasing Demand for more efficient and reliable diagnostic tools and biosensing technologies. The need for early and accurate disease detection and the monitoring of various parameters in healthcare and environmental settings has fueled the Market CAGR of unnatural amino acids.


Additionally, demand for novel drug candidates: Unnatural amino acids provide researchers with a broad range of possibilities to design and develop novel drug candidates with improved potency, selectivity, and pharmacokinetic properties. The pharmaceutical industry's need for innovative therapies drives the Demand for unnatural amino acids in drug discovery.Furthermore, Expansion of protein-based therapeutics: Protein-based therapeutics, including monoclonal antibodies, enzymes, and peptide drugs, are gaining prominence in the pharmaceutical market. Unnatural amino acids enable the development of engineered proteins with enhanced stability, activity, and specificity, driving their adoption in this field.


Growing Demand for protein engineering: 


Protein engineering has emerged as a powerful tool in drug discovery, enzymology, and industrial biotechnology. Unnatural amino acids play a crucial role in expanding the genetic code and introducing new functionalities into proteins, enabling the creation of novel enzymes, therapeutics, and biomaterials. Advancements in chemical synthesis and genetic engineering The development of efficient synthetic methodologies and genetic engineering tools has facilitated the production and incorporation of unnatural amino acids into proteins. These advancements have expanded the possibilities for protein design, drug discovery, and biotechnological applications. 3. Increasing investment in biopharmaceutical research: The biopharmaceutical industry invests heavily in research and development to discover new drugs and therapeutic modalities. Unnatural amino acids offer the potential to develop highly specific and effective drugs, leading to increased interest and investments in this field. Thus, driving the Unnatural Amino Acids market revenue.


Unnatural Amino Acids MarketSegment Insights


Unnatural Amino Acids Type Insights


 The Unnatural Amino Acids market segmentation, based on type, includes D-Amino Acids & Derivatives, DL-Amino Acids & Derivatives, B-Amino Acids & Derivatives, Cyclic Amino Acids & Derivatives L-Amino Acid Derivatives, Gamma-Amino Butyric Acid {GABA}, Gamma-Amino-Beta-Hydroxybutyric Acid (GABOB), Synthetic-Amino Acids, Others. The d-amino acids & derivatives segment dominates the market;due to the unique properties and versatile applications of D-amino acids in pharmaceuticals, biotechnology, and chemical industries. The increasing Demand for peptide-based therapeutics, enzyme inhibitors, and specialty chemicals drives the market growth, supported by advancements in synthetic biology and chemical synthesis techniques.


Unnatural Amino Acids Application Insights


Based on Application, the Unnatural Amino Acids market segmentation includes Liver Diseases, Cancer, Inflammatory Diseases, and Genetic Diseases. The liver diseases segment dominates the market; due to the increasing prevalence of liver diseases globally and the rising Demand for effective diagnostic tools and therapies. Unnatural amino acids play a vital role in liver disease diagnosis, treatment, and tissue engineering, driving their significance within this application segment. Ongoing research and development efforts advance knowledge and innovation in liver diseases and unnatural amino acids.


Unnatural Amino Acids End-UserInsights


The Unnatural Amino Acids market segmentation, based on End-User, includes Pharmaceutical & Biotechnological, Companies and Research Laboratories. The pharmaceutical & biotechnological segment dominates the market; due to the extensive applications of these amino acids in drug development, biotechnological products, diagnostics, and biosensors. Their ability to enhance the efficacy and specificity of pharmaceutical treatments, modify protein properties, and enable precise detection methods make them essential in the pharmaceutical and biotechnological industries. Ongoing research and development efforts further drive the significance of unnatural amino acids in these fields.


Figure1: Unnatural Amino Acids Market, by End-User, 2022 & 2032 (USD billion) 


Unnatural Amino Acids Market by End-User


Source: Secondary Research, Primary Research, MRFR Database, and Analyst Review


Unnatural Amino Acids Regional Insights


By Region, the study providesmarket insights into North America, Europe, Asia-Pacific, and Rest of the World. The North American Unnatural Amino Acids market will dominate this market due to the rising need for unnatural amino acids from research laboratories, academic institutes, and pharmaceutical and biotechnological companies.


Further, the major countries studied in the market report are The U.S., Canada, German, France, the UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil.


Figure2: Unnatural Amino Acids Market Share By Region 2022 (%)


UNNATURAL AMINO ACIDS MARKET SHARE BY REGION


Source: Secondary Research, Primary Research, MRFR Database, and Analyst Review


Europe's Unnatural Amino Acids market accounts for the second-largest market share due to thedeveloping examination of food drug and feed expansion and agrochemicals and expanding interest in drug intermediates. Further, the German Unnatural Amino Acids market held the largest market share, and the UK Unnatural Amino Acids market was the fastest-growing market in the European Region.


The Asia-Pacific Unnatural Amino Acids Market is expected to grow fastest from 2024 to 2032. This is due totechnological advancements, research and development activities, and regulatory policies. Moreover, China’s Unnatural Amino Acids market held the largest market share, and the Indian Unnatural Amino Acids market was the fastest-growing market in the Asia-Pacific region.


Unnatural Amino Acids Key Market Players& Competitive Insights


Major Unnatural Amino Acids market companies are investing significantly in research and development activities to broaden their range of products. These strategic initiatives aim to fuel further growth in the market. Market participants are also undertaking various strategic activities to expand their footprint, with important market developments including new product launches, contractual agreements, mergers and acquisitions, higher investments, and collaboration with other organizations. To thrive in a highly competitive and growing market environment, the unnatural Amino Acids industry needs to provide cost-effective solutions. Companies in this industry must offer affordable products and provide value for money to their customers.


Manufacturing locally to minimize operational costs is one of the key business tactics manufacturers use in the Unnatural Amino Acids industry to benefit clients and increase the market sector. In recent years, the Unnatural Amino Acids industry has offered some of the most significant medical advantages. Major players in the Unnatural Amino Acids market, including Abbott, AbbVie, Ajinomoto Co., Inc., Aminologics Co., AnaSpec Inc., AstraZeneca, BASF SE, Bayer, CU ChemieUetikon, Enzo-Life-Sciences Inc., GlaxoSmithKline Plc., Miat S.P.A., Novartis AG, Pfizer, Sigma-Aldrich Corporation., and To stimulate market demand, several companies in the unnatural Amino Acids industry are strategically investing in research and development initiatives. By focusing on R&D operations, these companies aim to enhance their product offerings, improve product quality, and explore new applications and uses for unnatural Amino Acids.


Evotec SE is a publicly listed drug discovery and development company headquartered in Hamburg, Germany. The company operates globally through external alliances with pharmaceutical and biotechnology companies, academic institutions, patient advocacy groups, and venture capitalists. Evotec and Novo Nordisk partnered strategically to discover and develop small molecule therapies using Evotec's proprietary drug discovery platform. The collaboration aimed to leverage Evotec's expertise in medicinal chemistry and Novo Nordisk's knowledge in protein engineering to develop innovative therapies targeting metabolic diseases.


Kyowa Kirin Co., Ltd. is a Japanese pharmaceutical and biotechnology company under Kirin Holdings and is among the 40 largest in the world by revenue. The company is headquartered in Chiyoda-ku, Tokyo, and is a Nikkei 225 stock index member.Kyowa Kirin and Ultragenyx Pharmaceutical announced a collaboration to develop and commercialize a novel enzyme replacement therapy for treating LAL-D (lysosomal acid lipase deficiency). The partnership aimed to combine Kyowa Kirin's expertise in protein engineering and Ultragenyx's capabilities in rare disease drug development to bring a new treatment option to patients with LAL-D.


Key CompaniesIn The Unnatural Amino Acids Market Include



  • Abbott

  • AbbVie

  • Ajinomoto Co., Inc.

  • Aminologics Co.

  • AnaSpec Inc.

  • AstraZeneca

  • BASF SE

  • Bayer

  • CU ChemieUetikon,

  • Enzo-Life-Sciences Inc.

  • GlaxoSmithKline Plc.

  • Miat S.P.A.


Unnatural Amino Acids Industry Developments


June 2021: Evotec and Novo Nordisk entered a strategic collaboration to discover and develop small molecule therapies using Evotec's proprietary drug discovery platform. The collaboration aimed to leverage Evotec's expertise in medicinal chemistry and Novo Nordisk's knowledge in protein engineering to develop innovative therapies targeting metabolic diseases.
August 2021: Kyowa Kirin and Ultragenyx Pharmaceutical announced a collaboration to develop and commercialize a novel enzyme replacement therapy for treating LAL-D (lysosomal acid lipase deficiency). The partnership aimed to combine Kyowa Kirin's expertise in protein engineering and Ultragenyx's capabilities in rare disease drug development to bring a new treatment option to patients with LAL-D.

Unnatural Amino Acids Market Segmentation


Unnatural Amino Acids Type Outlook



  • D-Amino Acids & Derivatives

  • DL-Amino Acids & Derivatives

  • B-Amino Acids & Derivatives

  • Cyclic Amino Acids & Derivatives L-Amino Acid Derivatives

  • Gamma-Amino Butyric Acid {GABA}

  • Gamma-Amino-Beta-Hydroxybutyric

  • Acid (GABOB)

  • Synthetic-Amino Acids

  • Others


Unnatural Amino Acids Application Outlook



  • Liver Diseases

  • Cancer

  • Inflammatory Disease

  • Genetic Diseases


Unnatural Amino Acids End-User Outlook



  • Pharmaceutical & Biotechnological

  • Companies

  • Research Laboratories


Unnatural Amino Acids Regional Outlook




  • North America








    • US




    • Canada








  • Europe








    • Germany




    • France




    • UK




    • Italy




    • Spain




    • Rest of Europe








  • Asia-Pacific




    • China




    • Japan




    • India




    • Australia




    • South Korea




    • Australia




    • Rest of Asia-Pacific






  • Rest of the World




    • Middle East




    • Africa




    • Latin America






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