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    Plasma Protein Therapeutic Market

    ID: MRFR/HC/41568-HCR
    200 Pages
    Garvit Vyas
    October 2025

    Plasma Protein Therapeutic Market Research Report By Application (Immunology, Hematology, Neurology, Oncology), By Product Type (Intravenous Immunoglobulin, Coagulation Factor Concentrates, Albumin, Alpha-1 Antitrypsin), By End Use (Hospitals, Homecare Settings, Ambulatory Surgical Centers), By Patient Type (Pediatric, Adult, Geriatric) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa)- Forecast to 2035

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    Plasma Protein Therapeutic Market Infographic
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    Plasma Protein Therapeutic Market Summary

    As per MRFR analysis, the Plasma Protein Therapeutic Market Size was estimated at 28.7 USD Billion in 2024. The Plasma Protein Therapeutic industry is projected to grow from 29.9 USD Billion in 2025 to 44.98 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 4.17 during the forecast period 2025 - 2035.

    Key Market Trends & Highlights

    The Plasma Protein Therapeutic Market is experiencing robust growth driven by increasing demand and technological advancements.

    • Rising demand for immunoglobulin therapies is shaping the market landscape, particularly in North America.
    • Advancements in biotechnology are facilitating the development of innovative plasma-derived therapies across various segments.
    • Increased awareness of plasma donation is contributing to a more stable supply chain, especially in the Asia-Pacific region.
    • The rising incidence of hemophilia and regulatory support for plasma-derived therapies are key drivers propelling market expansion.

    Market Size & Forecast

    2024 Market Size 28.7 (USD Billion)
    2035 Market Size 44.98 (USD Billion)
    CAGR (2025 - 2035) 4.17%

    Major Players

    Grifols (ES), CSL Behring (AU), Takeda Pharmaceutical Company Limited (JP), Octapharma (CH), Baxter International Inc. (US), Kedrion S.p.A. (IT), LFB S.A. (FR), Biotest AG (DE), Emergent BioSolutions Inc. (US)

    Plasma Protein Therapeutic Market Trends

    The Plasma Protein Therapeutic Market is currently experiencing notable growth, driven by an increasing prevalence of chronic diseases and a rising demand for immunoglobulin therapies. This market encompasses a range of products derived from human plasma, including clotting factors, albumin, and immunoglobulins, which are essential for treating various medical conditions. The ongoing advancements in biotechnology and the development of novel therapies appear to enhance the efficacy and safety of plasma-derived products, thereby attracting a broader patient population. Furthermore, regulatory support and favorable reimbursement policies may contribute to the expansion of this market, as healthcare providers seek effective treatment options for patients with rare and complex disorders. In addition, the Plasma Protein Therapeutic Market is likely to benefit from the increasing awareness of plasma donation and its critical role in therapy production. Educational initiatives aimed at encouraging plasma donation could potentially lead to a more robust supply chain, ensuring that manufacturers can meet the growing demand for these life-saving therapies. As the market evolves, collaboration between stakeholders, including manufacturers, healthcare providers, and regulatory bodies, may play a pivotal role in addressing challenges related to supply, quality, and accessibility of plasma-derived therapies. Overall, the future of the Plasma Protein Therapeutic Market appears promising, with numerous opportunities for innovation and growth.

    Rising Demand for Immunoglobulin Therapies

    The demand for immunoglobulin therapies is on the rise, driven by their effectiveness in treating autoimmune diseases and immunodeficiencies. This trend suggests a growing recognition of the importance of these therapies in managing complex health conditions.

    Advancements in Biotechnology

    Recent advancements in biotechnology are likely to enhance the development of plasma-derived products. Innovations in manufacturing processes and purification techniques may improve the safety and efficacy of these therapies, potentially expanding their applications.

    Increased Awareness of Plasma Donation

    There appears to be a growing awareness regarding the significance of plasma donation. Educational campaigns aimed at promoting plasma donation could lead to a more stable supply of raw materials, thereby supporting the ongoing growth of the Plasma Protein Therapeutic Market.

    The Global Plasma Protein Therapeutic Market appears to be experiencing robust growth, driven by increasing demand for immunoglobulin therapies and advancements in manufacturing technologies.

    U.S. Food and Drug Administration (FDA)

    Plasma Protein Therapeutic Market Drivers

    Growing Geriatric Population

    The aging population is a significant driver of the Plasma Protein Therapeutic Market. As individuals age, they become more susceptible to various health conditions, including immune deficiencies and chronic diseases that often require plasma-derived therapies. The World Health Organization projects that the number of people aged 60 years and older will reach 2 billion by 2050, highlighting a substantial market opportunity. This demographic shift is likely to increase the demand for immunoglobulin therapies and other plasma protein products, as older adults often require more frequent medical interventions. Consequently, pharmaceutical companies and healthcare providers must focus on developing targeted therapies that cater to the unique needs of this population within the Plasma Protein Therapeutic Market.

    Regulatory Support for Plasma-Derived Therapies

    Regulatory bodies are increasingly recognizing the importance of plasma-derived therapies, which is positively impacting the Plasma Protein Therapeutic Market. Initiatives aimed at streamlining the approval process for new therapies and enhancing safety standards are fostering innovation and encouraging investment in this sector. For example, the introduction of expedited review pathways for breakthrough therapies allows for faster access to life-saving treatments for patients. This regulatory support not only boosts confidence among manufacturers but also ensures that patients receive timely access to essential therapies. As a result, the Plasma Protein Therapeutic Market is likely to witness accelerated growth, driven by a favorable regulatory environment that promotes the development and commercialization of new plasma-derived products.

    Increasing Investment in Research and Development

    Investment in research and development (R&D) is a critical driver of the Plasma Protein Therapeutic Market. Pharmaceutical companies are allocating substantial resources to discover and develop novel therapies that leverage the therapeutic potential of plasma proteins. This focus on R&D is essential for addressing unmet medical needs and improving existing treatment options. Recent data indicates that R&D spending in the biopharmaceutical sector has reached unprecedented levels, with many companies prioritizing plasma-derived therapies. This trend is likely to result in the introduction of innovative products that enhance patient outcomes and expand the therapeutic applications of plasma proteins. As the industry continues to evolve, sustained investment in R&D will be pivotal in shaping the future landscape of the Plasma Protein Therapeutic Market.

    Technological Innovations in Plasma Fractionation

    Technological advancements in plasma fractionation are significantly influencing the Plasma Protein Therapeutic Market. Innovations such as improved separation techniques and enhanced purification processes are leading to higher yields and better quality of plasma-derived products. For instance, the introduction of chromatography and membrane filtration technologies has streamlined the production process, resulting in more efficient extraction of immunoglobulins and clotting factors. This not only increases the availability of essential therapies but also reduces production costs, making treatments more accessible. As the industry continues to evolve, these technological innovations are expected to play a crucial role in meeting the rising demand for plasma protein therapies, thereby shaping the future of the Plasma Protein Therapeutic Market.

    Rising Incidence of Hemophilia and Other Rare Disorders

    The Plasma Protein Therapeutic Market is experiencing a notable surge due to the increasing incidence of hemophilia and other rare disorders. Hemophilia A and B, which require regular infusions of clotting factor concentrates, are becoming more prevalent, thereby driving demand for plasma-derived therapies. According to recent estimates, the prevalence of hemophilia is approximately 1 in 5,000 male births, indicating a substantial patient population reliant on these therapies. This growing patient base necessitates the expansion of treatment options within the Plasma Protein Therapeutic Market, as healthcare providers seek to improve patient outcomes and quality of life. Furthermore, advancements in treatment protocols and the introduction of new therapies are likely to enhance the market landscape, making it imperative for stakeholders to adapt to these evolving needs.

    Market Segment Insights

    By Application: Immunology (Largest) vs. Oncology (Fastest-Growing)

    In the Plasma Protein Therapeutic Market, the application segment is primarily dominated by immunology, which holds a substantial market share. This segment encompasses various therapies that leverage plasma-derived proteins to treat immune disorders, thereby reinforcing its position as the largest application. Other significant segments include hematology and neurology, but they do not capture the same level of market interest and share as immunology, primarily due to the broader range and higher prevalence of immune-related disorders that require plasma protein therapies. The growth trends for the plasma protein therapeutic applications reflect a dynamic landscape, particularly with oncology emerging as the fastest-growing segment. This shift is driven by an increasing incidence of cancer globally, leading to surges in demand for innovative therapies that utilize plasma proteins. Additionally, advancements in technology and more extensive research into plasma-derived treatments fuel the development of targeted therapies in oncology, paving the way for growth and investment within this segment.

    Immunology (Dominant) vs. Oncology (Emerging)

    Immunology remains the dominant application in the Plasma Protein Therapeutic Market, characterized by its extensive array of treatments for a variety of autoimmune diseases and related conditions. This segment benefits from established protocols and significant healthcare provider familiarity, contributing to its leadership in the market. Conversely, oncology is quickly becoming an emerging focus area due to rising cancer incidences and growing awareness regarding the role of plasma protein therapies in adjunctive treatments. While immunology therapies tend to be broadly applicable with established patient bases, oncology applications are experiencing transformative developments as novel therapies relying on plasma proteins show considerable clinical promise, compelling stakeholders to increase investments in this evolving sector.

    By Product Type: Intravenous Immunoglobulin (Largest) vs. Coagulation Factor Concentrates (Fastest-Growing)

    The Plasma Protein Therapeutic Market is dynamically segmented, with Intravenous Immunoglobulin (IVIG) leading in market share due to its extensive use in treating various immunodeficiency disorders and autoimmune diseases. Coagulation Factor Concentrates, vital for hemophilia treatment, follow closely but are recognized as the fastest-growing segment driven by advancements in biotechnology and increasing awareness of hemophilia treatments. Additionally, Albumin and Alpha-1 Antitrypsin also play significant roles but have comparatively lower market shares than IVIG and Coagulation Factor Concentrates. Growth trends in the Plasma Protein Therapeutic Market suggest a robust future for both IVIG and Coagulation Factor Concentrates. The increasing prevalence of autoimmune diseases and hemophilia drives demand, while manufacturers focus on enhancing the efficacy and safety of these therapies through biotechnology innovations. Additionally, the rise in healthcare expenditure and supportive regulatory frameworks contribute to accelerating the growth trajectories of these segments, especially for Coagulation Factor Concentrates, which may see burgeoning interest from new entrants and investors.

    Intravenous Immunoglobulin (Dominant) vs. Albumin (Emerging)

    Intravenous Immunoglobulin (IVIG) remains the dominant player in the Plasma Protein Therapeutic Market. Its widespread applications, particularly in treating conditions such as primary immunodeficiency and certain autoimmune disorders, ensure consistent demand. Furthermore, its proven track record and established treatment protocols solidify its market leader status. On the other hand, Albumin emerges as a growing segment, increasingly recognized for its critical role in treating conditions like liver cirrhosis and burn injuries. Though historically overshadowed by IVIG, advancements in therapeutic formulations and increasing awareness of Albumin's therapeutic potential position it for growth. The competitive landscape for Albumin indicates significant opportunities, especially as research continues to unveil new applications and improve production efficiencies, reflecting an evolving market.

    By End Use: Hospitals (Largest) vs. Homecare Settings (Fastest-Growing)

    In the Plasma Protein Therapeutic Market, hospitals have established a dominant position. They account for a significant share of the market due to their capacity to handle complex plasma-derived therapies and the availability of comprehensive care facilities. Homecare settings, although smaller currently, are quickly gaining traction, fueled by patient preference for at-home treatment options and advancements in medical technology that enable effective monitoring and therapy administration outside traditional hospital settings.

    Hospitals (Dominant) vs. Homecare Settings (Emerging)

    Hospitals represent the dominant segment in the Plasma Protein Therapeutic Market, characterized by their extensive resources, advanced facilities, and capability to deploy sophisticated treatments requiring specialized oversight. Offering a wide range of therapies, they remain a reliable source for patients needing immediate or intensive interventions. Conversely, homecare settings are emerging as a fast-growing alternative, driven by convenience and the push for patient-centric care. These settings are becoming increasingly equipped to deliver plasma therapies, allowing for greater flexibility in treatment schedules. As technological innovations continue to enhance at-home therapeutic delivery, this segment is poised to expand significantly, targeting the growing patient population seeking effective outpatient solutions.

    By Patient Type: Adult (Largest) vs. Pediatric (Fastest-Growing)

    In the Plasma Protein Therapeutic Market, the patient type segmentation is crucial for understanding therapeutic needs. The adult patient group currently dominates the market, accounting for the largest share. This is largely due to the increasing prevalence of chronic diseases among adults, driving the demand for plasma-derived therapies. Meanwhile, the pediatric segment is emerging as the fastest-growing area, fueled by a heightened focus on treating rare pediatric conditions with targeted therapies and the overall growth in healthcare access across various regions.

    Patient Type: Adult (Dominant) vs. Pediatric (Emerging)

    The adult patient segment represents a significant portion of the Plasma Protein Therapeutic Market, driven by the rising incidences of autoimmune disorders and hemophilia, which require ongoing treatment with plasma-derived proteins. Adults benefit from established therapies and a robust healthcare infrastructure. In contrast, the pediatric segment is gaining traction as novel therapies tailored for children enter the market. This growth is supported by advancements in clinical research specifically aimed at pediatric applications, leading to the development of safer and effective treatments that cater to children's unique physiological needs. As a result, the pediatric segment is set to expand rapidly, showcasing the evolving landscape of plasma proteins in therapeutic applications.

    Get more detailed insights about Plasma Protein Therapeutic Market

    Regional Insights

    The Global Plasma Protein Therapeutic Market is projected to experience diverse growth across its regional segments. In 2024, North America is expected to hold a majority share, valued at 12.1 USD Billion, and will rise to 18.5 USD Billion by 2035, driven by advanced healthcare infrastructure and increased prevalence of plasma-related conditions. Europe follows with a valuation of 8.3 USD Billion in 2024, reaching 13.0 USD Billion in 2035, benefiting from robust regulatory support for plasma therapies.

    The APAC region, valued at 5.4 USD Billion in 2024 and anticipated to grow to 8.5 USD Billion by 2035, shows significant potential due to rising healthcare demands and increased awareness about therapeutics.

    South America and MEA, while currently smaller markets are expected to expand from 1.5 USD Billion to 2.3 USD Billion and from 1.4 USD Billion to 2.7 USD Billion, respectively, reflecting growing healthcare investments and improving access to treatments. Overall, the Global Plasma Protein Therapeutic Market data highlights a landscape where North America leads significantly, demonstrating the importance of this region in setting the trend and fostering innovation within the industry.

    Plasma Protein Therapeutic Market Region

    Source: Primary Research, Secondary Research, Market Research Future Database and Analyst Review

    Key Players and Competitive Insights

    The Global Plasma Protein Therapeutic Market has witnessed significant growth and diversity in recent years due to an increasing focus on advanced therapies and therapies derived from human plasma. This market comprises a range of products aimed at diseases such as hemophilia, immunodeficiencies, and neurological disorders, with plasma-derived therapies being pivotal for patient care. The competitive landscape is characterized by several key players who have established a robust foothold in the industry, leveraging their technological advances, extensive distribution networks, and strategic collaborations to meet the evolving needs of healthcare providers and patients alike.

    As the demand for these therapies escalates, companies are increasingly focusing on innovation, regulatory compliance, and operational excellence to enhance their market positioning and capitalize on emerging opportunities within this dynamic environment.

    Innovative Bioresearch has emerged as a notable contender within the Global Plasma Protein Therapeutic Market, recognized for its commitment to quality and patient-centered solutions. The company is distinguished by its advanced research capabilities and innovative manufacturing processes, which contribute to the development of high-quality plasma-derived therapeutics. These strengths are reflected in their ability to address unmet medical needs with a portfolio that emphasizes efficacy and safety. Additionally, Innovative Bioresearch is known for its strategic partnerships with healthcare providers and academic institutions to accelerate product development and improve access to treatments. 

    This collaborative approach enhances their market presence and solidifies their reputation as a leader in the domain of plasma protein therapeutics. Their focus on customization and responsiveness to market demands positions them favorably against competitors.ADMA Biologics stands out in the Global Plasma Protein Therapeutic Market, particularly for its specialized focus on immunoglobulin-based therapies. The company is recognized for its extensive product pipeline and dedication to addressing the needs of patients with immunodeficiency disorders.

    ADMA Biologics has invested significantly in its state-of-the-art manufacturing facilities, which adhere to the highest standards of quality control and regulatory compliance, ensuring that their products meet industry benchmarks. 

    Their ability to produce high-purity immunoglobulin products has fostered a high degree of trust among healthcare professionals and patients. Furthermore, ADMA Biologics is strategically pursuing opportunities for growth through product differentiation and acquisitions, allowing them to expand their market share effectively. Their unique positioning within the market, along with a customer-centric approach, further underlines their potential to thrive amidst competition in the Global Plasma Protein Therapeutic Market.

    Key Companies in the Plasma Protein Therapeutic Market market include

    Industry Developments

    • Q2 2024: Takeda Opens New Plasma-Derived Therapies Manufacturing Facility in Japan Takeda announced the opening of a new manufacturing facility in Osaka, Japan, dedicated to the production of plasma-derived therapies, aiming to increase supply capacity and meet growing demand for plasma protein therapeutics.
    • Q2 2024: Grifols Receives FDA Approval for New Plasma Fractionation Plant in North Carolina Grifols received approval from the U.S. FDA to begin operations at its new plasma fractionation facility in Clayton, North Carolina, expanding its production capabilities for plasma protein therapeutics.
    • Q2 2024: CSL Behring Announces Launch of New Immunoglobulin Therapy in Europe CSL Behring launched a new intravenous immunoglobulin (IVIG) therapy in several European countries, expanding its plasma protein therapeutics portfolio for the treatment of immune deficiencies.
    • Q3 2024: Kedrion and Kamada Announce Strategic Partnership to Develop Plasma-Derived Therapies Kedrion and Kamada entered into a strategic partnership to co-develop and commercialize new plasma-derived protein therapeutics, focusing on rare and orphan diseases.
    • Q3 2024: Octapharma Opens New Plasma Collection Center in the United States Octapharma announced the opening of a new plasma collection center in Texas, USA, to support the growing need for plasma used in the production of plasma protein therapeutics.
    • Q4 2024: Biotest Receives European Commission Approval for New Albumin Product Biotest AG received approval from the European Commission for its new albumin product, expanding its plasma protein therapeutics offerings in the European market.
    • Q4 2024: Grifols Completes Acquisition of Plasma Collection Centers in Canada Grifols completed the acquisition of several plasma collection centers in Canada, strengthening its plasma sourcing network for the production of plasma protein therapeutics.
    • Q1 2025: CSL Behring Announces $200 Million Investment in New Plasma Fractionation Facility in Australia CSL Behring announced a $200 million investment to build a new plasma fractionation facility in Melbourne, Australia, to increase production capacity for plasma protein therapeutics.
    • Q1 2025: Takeda Receives FDA Approval for Expanded Use of Plasma-Derived Therapy for CIDP Takeda received U.S. FDA approval for the expanded use of its plasma-derived therapy for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP).
    • Q2 2025: Kamada Announces FDA Approval of Plasma-Derived Alpha-1 Antitrypsin Therapy Kamada Ltd. received FDA approval for its plasma-derived alpha-1 antitrypsin therapy for the treatment of alpha-1 antitrypsin deficiency in the United States.
    • Q2 2025: Bio Products Laboratory Opens New Plasma Collection Center in Germany Bio Products Laboratory (BPL) opened a new plasma collection center in Germany to support the supply chain for plasma protein therapeutics.
    • Q2 2025: Octapharma Receives EMA Approval for New Intravenous Immunoglobulin Product Octapharma received approval from the European Medicines Agency (EMA) for its new intravenous immunoglobulin (IVIG) product, expanding its plasma protein therapeutics portfolio in Europe.

    Future Outlook

    Plasma Protein Therapeutic Market Future Outlook

    The Plasma Protein Therapeutic Market is projected to grow at a 4.17% CAGR from 2024 to 2035, driven by increasing demand for immunoglobulin therapies and advancements in manufacturing technologies.

    New opportunities lie in:

    • Expansion into emerging markets through strategic partnerships
    • Development of personalized plasma therapies for niche conditions
    • Investment in automated plasma collection technologies to enhance efficiency

    By 2035, the market is expected to solidify its position as a leader in biopharmaceutical innovations.

    Market Segmentation

    Plasma Protein Therapeutic Market End Use Outlook

    • Hospitals
    • Homecare Settings
    • Ambulatory Surgical Centers

    Plasma Protein Therapeutic Market Application Outlook

    • Immunology
    • Hematology
    • Neurology
    • Oncology

    Plasma Protein Therapeutic Market Patient Type Outlook

    • Pediatric
    • Adult
    • Geriatric

    Plasma Protein Therapeutic Market Product Type Outlook

    • Intravenous Immunoglobulin
    • Coagulation Factor Concentrates
    • Albumin
    • Alpha-1 Antitrypsin

    Report Scope

    MARKET SIZE 202428.7(USD Billion)
    MARKET SIZE 202529.9(USD Billion)
    MARKET SIZE 203544.98(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR)4.17% (2024 - 2035)
    REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR2024
    Market Forecast Period2025 - 2035
    Historical Data2019 - 2024
    Market Forecast UnitsUSD Billion
    Key Companies ProfiledMarket analysis in progress
    Segments CoveredMarket segmentation analysis in progress
    Key Market OpportunitiesAdvancements in gene therapy and personalized medicine enhance growth potential in the Plasma Protein Therapeutic Market.
    Key Market DynamicsRising demand for innovative therapies drives competition and regulatory scrutiny in the Plasma Protein Therapeutic Market.
    Countries CoveredNorth America, Europe, APAC, South America, MEA

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    FAQs

    What is the projected market size of the Global Plasma Protein Therapeutic Market in 2024?

    The Global Plasma Protein Therapeutic Market is expected to be valued at 28.7 billion USD in 2024.

    What is the anticipated market value of the Global Plasma Protein Therapeutic Market by 2035?

    By 2035, the market is projected to reach a value of 45.0 billion USD.

    What is the expected compound annual growth rate (CAGR) for the market from 2025 to 2035?

    The expected CAGR for the Global Plasma Protein Therapeutic Market from 2025 to 2035 is 4.17%.

    Which region is expected to dominate the Global Plasma Protein Therapeutic Market by 2035?

    North America is expected to dominate the market, projected to reach 18.5 billion USD by 2035.

    What will be the market value for Immunology applications in the Global Plasma Protein Therapeutic Market in 2035?

    The market value for Immunology applications is anticipated to reach 13.5 billion USD by 2035.

    Which are the major players in the Global Plasma Protein Therapeutic Market?

    Key players include Innovative Bioresearch, ADMA Biologics, Baxalta, Grifols, and CSL Behring.

    What is the projected market size for the Hematology segment by 2035?

    The Hematology segment is expected to reach a market value of 11.0 billion USD by 2035.

    How much is the APAC region expected to grow in the Global Plasma Protein Therapeutic Market by 2035?

    The APAC region is projected to grow to 8.5 billion USD by 2035.

    What is the estimated market value for Neurology applications in 2024?

    The estimated market value for Neurology applications in 2024 is 6.0 billion USD.

    What will be the Oncology market value in 2035 within the Global Plasma Protein Therapeutic Market?

    The Oncology market value is anticipated to reach 11.5 billion USD by 2035.

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