Nutraceuticals, which are fortified food products, play a crucial role in modifying and maintaining the normal physiological functions of the human body. These products encompass a variety of items such as dietary supplements, prebiotics, probiotics, antioxidants, and others. Their significance lies in their ability to combat and prevent major medical concerns, including obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, and cholesterol issues. A 2014 study published in the International Journal of Preventive Medicine highlighted that nutraceuticals, specifically in the form of vitamins, antioxidants, dietary fibers, minerals, and nโ3 PUFAs, when combined with physical exercises, have been reported to effectively prevent and treat cardiovascular diseases (CVD).
The escalating prevalence of obesity, CVD, and other diseases has led to an increased demand for nutraceutical products. According to the World Health Organization's 2017 report, approximately 17.7 million people succumbed to CVDs in 2015, constituting 31% of the total global deaths. This alarming trend in health concerns is driving the growth of the nutraceutical industry, consequently influencing a parallel expansion of the nutraceutical excipients market. Nutraceutical excipients play a pivotal role by being extensively employed to facilitate stabilization and protect nutraceuticals from undesirable chemical reactions.
The term "nutraceutical excipients" refers to substances that are used to support the formulation and manufacturing of nutraceutical products. These excipients are crucial in enhancing the stability, bioavailability, and overall effectiveness of the nutraceuticals. They act as carriers, binders, disintegrants, lubricants, and antioxidants, contributing to the overall quality and performance of nutraceutical formulations.
The increasing demand for nutraceuticals has led to a corresponding surge in the utilization of nutraceutical excipients. One of the primary functions of these excipients is to stabilize the nutraceutical products, ensuring that they maintain their potency and effectiveness throughout their shelf life. Additionally, nutraceutical excipients aid in protecting the active ingredients from degradation caused by environmental factors such as light, moisture, and temperature fluctuations.
Nutraceutical excipients are also employed to enhance the bioavailability of active ingredients in the human body. Bioavailability refers to the proportion of the active ingredient that enters the bloodstream when introduced into the body and is available for therapeutic effects. The inclusion of appropriate excipients in nutraceutical formulations can improve the absorption and utilization of these active ingredients, maximizing their beneficial effects.
Moreover, nutraceutical excipients play a crucial role in the manufacturing processes of nutraceutical products. They assist in creating consistent and uniform formulations, ensuring that each product meets the desired quality standards. These excipients contribute to the physical and chemical stability of the nutraceuticals, preventing issues such as ingredient separation, degradation, or undesired reactions during the manufacturing process.
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