G Protein Coupled Receptors Market Analysis

ID: MRFR/HC/6884-HCR

111 Pages

Rahul Gotadki

February 2026

G Protein-Coupled Receptors Market Research Report By Type (Class A, Class B, Class C, Frizzled, Tachykinin), By Therapeutic Application (Neurological Disorders, Metabolic Disorders, Cardiovascular Diseases, Cancer, Respiratory Diseases), By End Use (Pharmaceuticals, Biotechnology, Academic Research, Contract Research Organizations), By Research Type (Basic Research, Applied Research, Clinical Research) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Growth & Industry Forecast 2025 To 2035

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Market Analysis

In-depth Analysis of G Protein Coupled Receptors Market Industry Landscape

G-protein coupled Receptors (GPCRs) form a crucial elegance of cell membrane proteins that play a pivotal role in signal transduction. They are involved in mediating the cellular responses to a wide range of stimuli, making them attractive goals for drug development. GPCRs are essential to drug discovery efforts, with a giant variety of prescribed drugs concentrated on those receptors. This has caused the improvement of medicine for diverse scientific conditions, which include cardiovascular illnesses, neurological issues, and cancer. The therapeutic capacity of GPCRs keeps forcing innovation within the pharmaceutical industry. Technological advancements, including cryo-electron microscopy and X-ray crystallography, have revolutionized the structural elucidation of GPCRs. These techniques have supplied special insights into the 3-dimensional systems of GPCRs, facilitating shape-based drug design and improving our know-how of receptor activation mechanisms. The emergence of biologics and biopharmaceuticals has stimulated the market dynamics of GPCRs. Monoclonal antibodies and other biologics targeting GPCRs have won traction, supplying new avenues for healing interventions. This shift towards biologics displays the enterprise's non-stop model of novel technologies. While numerous well-known GPCRs have been appreciably studied, there's a growing recognition of orphan GPCRs—those with unknown endogenous ligands or features. Targeting orphan GPCRs provides untapped opportunities for drug discovery, and the enterprise is actively exploring those receptors for their therapeutic potential. Despite the enormous capacity, GPCR drug development faces demanding situations, including ligand bias, receptor desensitization, and constrained achievement in targeting positive GPCRs. Overcoming these challenges calls for revolutionary processes and ongoing study objectives to address those issues to release the overall healing capacity of GPCRs. The GPCR market is witnessing international developments, with growing investments in research and improvement. The Asia-Pacific location, especially, is emerging as a giant player in GPCR research and drug development, providing new possibilities for marketplace increase and collaboration. The destiny of the GPCR marketplace is poised for exciting developments, including the combination of customized medicinal drugs. As our understanding of GPCR polymorphisms and character variations grows, there's the ability to tailor GPCR-focused treatment plans to individual patient profiles, ushering in a new technology of precision medicinal drugs.

Market Highlights

Author

Rahul Gotadki

Assistant Manager

He holds an experience of about 7+ years in Market Research and Business Consulting, working under the spectrum of Life Sciences and Healthcare domains. Rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. His expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. In addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives

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FAQs

What is the projected market valuation for the G Protein-Coupled Receptors Market in 2035?

The projected market valuation for the G Protein-Coupled Receptors Market in 2035 is 65.52 USD Billion.

What was the overall market valuation of the G Protein-Coupled Receptors Market in 2024?

The overall market valuation of the G Protein-Coupled Receptors Market in 2024 was 40.12 USD Billion.

What is the expected CAGR for the G Protein-Coupled Receptors Market during the forecast period 2025 - 2035?

The expected CAGR for the G Protein-Coupled Receptors Market during the forecast period 2025 - 2035 is 4.56%.

Which therapeutic applications are expected to drive growth in the G Protein-Coupled Receptors Market?

Therapeutic applications such as Cancer, Cardiovascular Diseases, and Neurological Disorders are expected to drive growth, with valuations reaching 16.0, 15.0, and 13.0 USD Billion respectively by 2035.

What are the key segments of the G Protein-Coupled Receptors Market?

Key segments of the G Protein-Coupled Receptors Market include Type, Therapeutic Application, End Use, and Research Type.

Which companies are considered key players in the G Protein-Coupled Receptors Market?

Key players in the G Protein-Coupled Receptors Market include Pfizer, Novartis, Roche, Johnson & Johnson, and Merck & Co.

What is the expected market size for the Pharmaceuticals segment by 2035?

The expected market size for the Pharmaceuticals segment in the G Protein-Coupled Receptors Market is projected to reach 25.0 USD Billion by 2035.

How does the market for Clinical Research compare to other research types in 2035?

By 2035, the market for Clinical Research is expected to reach 24.52 USD Billion, indicating strong growth compared to Basic and Applied Research.

What is the anticipated market size for the Biotechnology segment by 2035?

The anticipated market size for the Biotechnology segment in the G Protein-Coupled Receptors Market is projected to be 15.0 USD Billion by 2035.

What are the expected valuations for Class A and Class B types in the G Protein-Coupled Receptors Market by 2035?

By 2035, Class A is expected to reach 17.0 USD Billion, while Class B is projected to attain 12.0 USD Billion in the G Protein-Coupled Receptors Market.

1. Market Overview

2. Market Trends

3. Market Segment Insights

4. Key Players and Competitive Insights

5. Industry Developments

6. Market Segmentation

7. Report Scope

8. Market Highlights

9. FAQs

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Market Summary

As per Market Research Future analysis, the G Protein-Coupled Receptors Market Size was estimated at 40.12 USD Billion in 2024. The G Protein-Coupled Receptors industry is projected to grow from 41.95 USD Billion in 2025 to 65.52 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 4.56% during the forecast period 2025 - 2035

Key Market Trends & Highlights

The G Protein-Coupled Receptors Market is poised for substantial growth driven by technological advancements and increasing demand for targeted therapies.

The market is witnessing an increased focus on targeted therapies, particularly in the North American region, which remains the largest market. Technological advancements in drug discovery are enhancing the development of Class A GPCRs, which dominate the market. Collaboration between pharmaceutical and biotechnology sectors is growing, especially in the Asia-Pacific region, recognized as the fastest-growing market. Rising prevalence of chronic diseases and increased investment in pharmaceutical R&D are key drivers propelling market expansion.

G Protein Coupled Receptors Market

CAGR

4.56%

Market Size & Forecast

2024 Market Size	40.12 (USD Billion)
2035 Market Size	65.52 (USD Billion)
CAGR (2025 - 2035)	4.56%
Largest Regional Market Share in 2024	North America

Major Players

Pfizer (US), Novartis (CH), Roche (CH), Johnson & Johnson (US), Merck & Co. (US), AstraZeneca (GB), Bristol-Myers Squibb (US), Gilead Sciences (US), Sanofi (FR)

Market Trends

The G Protein-Coupled Receptors Market is currently experiencing a dynamic evolution, driven by advancements in biotechnology and pharmacology. This sector is characterized by a growing interest in the therapeutic potential of GPCRs, which play a crucial role in various physiological processes. As research progresses, the understanding of GPCR signaling pathways is becoming more sophisticated, leading to the development of novel drugs targeting these receptors. The increasing prevalence of chronic diseases and the demand for more effective treatments are further propelling innovation in this field. Moreover, collaborations between pharmaceutical companies and research institutions are fostering a conducive environment for breakthroughs in GPCR-targeted therapies. In addition to therapeutic applications, the G Protein-Coupled Receptors Market is witnessing a surge in interest from the biotechnology sector. The integration of advanced technologies, such as artificial intelligence and high-throughput screening, is enhancing drug discovery processes. This trend suggests a shift towards more personalized medicine, where treatments can be tailored to individual patient profiles based on GPCR activity. Furthermore, the regulatory landscape is evolving, with agencies increasingly recognizing the importance of GPCRs in drug development. This recognition may lead to streamlined approval processes for new therapies, thereby accelerating market growth and expanding the range of available treatment options for patients.

Increased Focus on Targeted Therapies

The G Protein-Coupled Receptors Market is witnessing a heightened emphasis on targeted therapies. This trend reflects a broader shift towards precision medicine, where treatments are designed to interact specifically with GPCRs associated with particular diseases. Such an approach not only enhances efficacy but also minimizes side effects, making it a preferred strategy among researchers and clinicians.

Technological Advancements in Drug Discovery

Recent technological innovations are transforming the landscape of drug discovery within the G Protein-Coupled Receptors Market. The application of artificial intelligence and machine learning is streamlining the identification of potential drug candidates, thereby expediting the development process. This trend indicates a future where drug discovery becomes more efficient and cost-effective.

Growing Collaboration Between Sectors

The G Protein-Coupled Receptors Market is experiencing an increase in collaborations between pharmaceutical companies and academic institutions. These partnerships are fostering a rich environment for research and development, enabling the sharing of knowledge and resources. Such collaborations are likely to accelerate the pace of innovation and lead to the emergence of novel GPCR-targeted therapies.

G Protein Coupled Receptors Market Market Drivers

Advancements in Biotechnology

Technological innovations in biotechnology are significantly influencing the G Protein-Coupled Receptors Market. The advent of high-throughput screening and advanced molecular modeling techniques has streamlined the drug discovery process, allowing for the rapid identification of GPCR-targeting compounds. This has led to a surge in the number of clinical trials focused on GPCRs, with a notable increase in successful drug candidates entering the market. Data indicates that the biotechnology sector is projected to grow at a compound annual growth rate of over 7% in the coming years, further bolstering the G Protein-Coupled Receptors Market. As these technologies continue to evolve, they are likely to enhance the efficiency and effectiveness of GPCR-targeted therapies.

Rising Prevalence of Chronic Diseases

The increasing incidence of chronic diseases such as diabetes, cardiovascular disorders, and cancer is driving the G Protein-Coupled Receptors Market. These conditions often require targeted therapies that leverage the unique mechanisms of GPCRs. According to recent data, chronic diseases account for a substantial portion of healthcare expenditures, prompting pharmaceutical companies to invest in GPCR-targeted drug development. This trend is likely to continue, as the demand for effective treatments grows. The G Protein-Coupled Receptors Market is thus positioned to expand, as more therapies are developed to address these pressing health issues. Furthermore, the aging population is expected to exacerbate this trend, leading to a higher demand for innovative GPCR-based therapies.

Growing Demand for Personalized Medicine

The shift towards personalized medicine is a key driver of the G Protein-Coupled Receptors Market. As healthcare moves away from one-size-fits-all approaches, there is an increasing emphasis on tailoring treatments to individual patient profiles. GPCRs play a crucial role in this paradigm shift, as they are involved in numerous signaling pathways that can be targeted based on genetic and phenotypic variations. The market for personalized medicine is projected to reach over $2 trillion by 2030, indicating a robust growth trajectory. This trend is likely to enhance the relevance of GPCRs in drug development, as more therapies are designed to cater to specific patient needs within the G Protein-Coupled Receptors Market.

Increased Investment in Pharmaceutical R&D

The G Protein-Coupled Receptors Market is experiencing a boost due to heightened investment in pharmaceutical research and development. Companies are recognizing the therapeutic potential of GPCRs, leading to increased funding for research initiatives aimed at discovering new GPCR-targeting drugs. Recent statistics reveal that global pharmaceutical R&D spending has surpassed $200 billion annually, with a significant portion allocated to GPCR-related projects. This influx of capital is expected to accelerate the pace of innovation within the G Protein-Coupled Receptors Market, resulting in a broader array of treatment options for various diseases. As the pharmaceutical landscape evolves, the focus on GPCRs is likely to remain a priority for many organizations.

Regulatory Support for Innovative Therapies

Regulatory bodies are increasingly supporting the development of innovative therapies, which is positively impacting the G Protein-Coupled Receptors Market. Initiatives aimed at expediting the approval process for breakthrough therapies are encouraging pharmaceutical companies to invest in GPCR-targeted drug development. Recent regulatory changes have introduced pathways that facilitate faster access to market for novel GPCR-based treatments, thereby stimulating research and development efforts. This supportive regulatory environment is expected to foster innovation within the G Protein-Coupled Receptors Market, as companies are more inclined to pursue ambitious projects that target GPCRs. As a result, the market is likely to witness a surge in new therapeutic options in the near future.

Market Segment Insights

By Type: Class A (Largest) vs. Class B (Fastest-Growing)

In the G Protein-Coupled Receptors (GPCR) market, Class A receptors dominate the landscape, accounting for a significant share due to their widespread presence and involvement in various physiological processes. Class B receptors, while having a smaller current share, are rapidly gaining attention thanks to their potential therapeutic applications, particularly in pain management and metabolic disorders.

Receptor Class: Class A (Dominant) vs. Class C (Emerging)

Class A G Protein-Coupled Receptors are the most prevalent, playing a crucial role in neurotransmission and hormone regulation, which underpins their dominant market position. In contrast, Class C receptors, although emerging, are attracting interest for their unique mechanisms and implications in psychiatric and neurological disorders. Their distinct signaling pathways suggest potential as novel drug targets, which could drive significant growth as research continues to uncover their roles in health and disease. The distinction in their pharmacology positions Class A as a staple in drug development, while Class C may soon become a key focus for innovative therapeutic strategies.

By Therapeutic Application: Cancer (Largest) vs. Neurological Disorders (Fastest-Growing)

The G Protein-Coupled Receptors (GPCR) market is seeing a diverse distribution of therapeutic applications, with cancer treatments representing the largest segment. This area benefits from significant research investments and advanced pharmaceutical developments that target various cancer pathways. Meanwhile, neurological disorders are emerging as the fastest-growing segment, driven by increased awareness, an aging population, and a pressing need for effective treatments. These applications reflect evolving clinical priorities, highlighting the dynamic nature of GPCR therapeutic development. Growth in the GPCR market is significantly influenced by shifts in patient demographics and healthcare approaches. The rising incidence of cancer propels research and drug discovery, while neurological disorders gain attention due to their complex pathology and unmet medical needs. Advances in genomics and biotechnology are catalyzing innovation in these applications, ensuring that GPCRs remain central to the next generation of therapeutics. As a result, investments in both areas are intensifying, aiming to tackle these pressing health challenges effectively.

Cancer (Dominant) vs. Neurological Disorders (Emerging)

Cancer is established as a dominant application in the G Protein-Coupled Receptors market, characterized by extensive clinical research and a wide array of targeted therapies. This segment is heavily focused on leveraging GPCRs to develop innovative treatments that can disrupt tumor growth and metastasis. In contrast, neurological disorders are recognized as an emerging area, showcasing significant growth potential. The complexity of GPCR signaling in the central nervous system presents unique therapeutic opportunities, particularly for conditions like Alzheimer's and Parkinson's disease. As research progresses, both segments demonstrate the importance of GPCRs in driving advancements, with cancer maintaining a leading role while neurological applications rapidly gain ground.

By End Use: Pharmaceuticals (Largest) vs. Biotechnology (Fastest-Growing)

In the G Protein-Coupled Receptors (GPCR) market, the end-use segment exhibits a diverse distribution of applications, with Pharmaceuticals holding the largest share. Pharmaceuticals extensively utilize GPCRs for drug development, given their critical role in various physiological processes. Conversely, the Biotechnology sector is on the rise, harnessing innovative biotechnological approaches to develop GPCR-targeted therapies, which positions it as the fastest-growing segment within this market.

Pharmaceuticals (Dominant) vs. Biotechnology (Emerging)

The Pharmaceuticals segment remains dominant in the GPCR market due to its extensive reliance on GPCRs in drug discovery and therapeutic interventions. This segment benefits from established frameworks for research and development, facilitating the introduction of novel GPCR-targeted medications. On the other hand, the Biotechnology segment is emerging rapidly, primarily owing to advancements in gene editing technology and personalized medicine. This growth is supported by a surge in <a href="https://www.marketresearchfuture.com/reports/biotechnology-reagents-market-43534">biotechnology </a>firms focusing on innovative GPCR-targeted therapies, indicating a shift towards more tailored and effective treatment options for patients.

By Research Type: Clinical Research (Largest) vs. Basic Research (Fastest-Growing)

In the G Protein-Coupled Receptors Market, the research type segment is primarily dominated by Clinical Research, which holds the largest share due to its crucial role in drug discovery and development. This research type not only attracts substantial funding but also serves as a pivotal phase for translating findings from Basic Research into therapeutic applications. The applied research component, while significant, is relatively smaller and focuses on translating the findings of basic research into practical outcomes for drug development and disease management. Looking ahead, Basic Research emerges as the fastest-growing area within the G Protein-Coupled Receptors market, driven by increasing investments in fundamental biological studies and the expanding knowledge base of receptor functionality. This growth is supported by technological advancements that enhance research capabilities, paving the way for novel drug targets and therapeutic strategies. As healthcare systems prioritize innovative treatments, the emphasis on Basic and Clinical Research is expected to intensify, shaping the future landscape of receptor-focused therapies.

Clinical Research (Dominant) vs. Basic Research (Emerging)

The G Protein-Coupled Receptors Market encapsulates a dynamic landscape defined by Clinical Research, recognized as the dominant segment. Clinical Research is instrumental in evaluating the safety and efficacy of new drugs, making it a cornerstone of pharmaceutical development. Its prominence is underscored by the increasing number of regulatory approvals and clinical trials aimed at understanding the therapeutic potentials of GPCRs. In contrast, Basic Research represents the emerging segment, providing essential insights into fundamental biological processes that underpin receptor function. As advances in molecular biology and genetic engineering continue to unfold, Basic Research is positioned to unveil new therapeutic targets, thereby enhancing its significance in the drug development pipeline. This symbiotic relationship between both segments fosters a robust ecosystem for innovation within the G Protein-Coupled Receptors Market.

Get more detailed insights about G-Protein Coupled Receptors Market Research Report - Forecast till 2035

Regional Insights

In the Global G Protein-Coupled Receptors Market, the Regional segment plays a crucial role in overall market dynamics, characterized by varying growth trajectories across different areas. In 2024, North America leads with a market revenue of 15.0 USD Billion, anticipated to grow significantly to 25.0 USD Billion by 2035, thus holding a majority share driven by advanced healthcare infrastructure and robust Research and Development initiatives.

Europe follows with a valuation of 10.0 USD Billion in 2024, increasing to 18.0 USD Billion in 2035, supported by strong pharmaceutical investments aimed at innovative therapeutic solutions.The Asia-Pacific region, with a value of 9.0 USD Billion in 2024 and expected to reach 15.5 USD Billion by 2035, showcases rapid growth potential due to rising healthcare expenditures and increasing prevalence of chronic diseases.

Meanwhile, South America and the Middle East and Africa (MEA) present smaller market sizes at 4.0 USD Billion and 2.12 USD Billion, respectively, in 2024, with gradual growth forecasts by 2035. South America is gaining traction primarily due to expanding access to healthcare, while the MEA region is more stable, reflecting challenges in healthcare access and infrastructure.Overall, the Global G Protein-Coupled Receptors Market segmentation highlights the diverse growth landscape driven by regional healthcare advancements, investments, and varying disease burdens across these areas.

Key Players and Competitive Insights

The Global G Protein-Coupled Receptors Market is a dynamic arena characterized by rapid advancements in biopharmaceuticals and an increasing demand for drug discovery solutions targeting these crucial receptors. G protein-coupled receptors (GPCRs) are pertinent in various physiological processes and the pharmacology of numerous therapeutic agents, making them a focal point for many companies engaged in drug development. The market landscape is characterized by a mix of established players and innovative startups, all striving to harness the therapeutic potential of GPCRs to address unmet medical needs.Competitive insights reveal a landscape where technological advancements, strategic partnerships, and an emphasis on research and development play pivotal roles in driving growth and innovation within the sector. This competitive environment is underscored by collaborations among pharmaceutical companies, academic institutions, and research organizations, which together propel the market toward enhanced therapeutic options for patients worldwide.Vertex Pharmaceuticals has made significant strides in the Global G Protein-Coupled Receptors Market through its robust pipeline focusing on innovative therapeutic solutions. The company has built a strong market presence around its commitment to precision medicine and understanding the underlying mechanisms of diseases that involve GPCRs.The strengths of Vertex Pharmaceuticals lie in its research capabilities, ability to create targeted therapies, and focus on specific disease areas such as cystic fibrosis and other genetic disorders. This targeted approach has allowed them to capitalize on niche segments within the GPCR market, making strides in drug development with a notable commitment to understanding receptor biology. Vertex's strategic initiatives in collaboration and partnerships further enhance its competitive edge by fostering an environment of shared knowledge and innovation.Pfizer, a leading player in the Global G Protein-Coupled Receptors Market, exhibits a broad portfolio of products aimed at addressing various therapeutic areas, including cardiovascular, metabolic, and neurological disorders. The company’s market presence is supported by a combination of blockbuster drugs and emerging therapies that target GPCRs effectively. Pfizer's strengths are amplified by its extensive research and development capabilities, which are complemented by strategic mergers and acquisitions that enhance its ability to access cutting-edge technologies and new therapeutic avenues. The company’s commitment to advancing its pipeline includes leveraging its experience in drug formulation and market strategies, allowing it to remain competitive amid evolving consumer healthcare demands. This emphasis on innovation, along with a strong legacy in the pharmaceutical sector, positions Pfizer favorably in the Global G Protein-Coupled Receptors Market, giving it the potential to lead in various therapeutic domains while effectively addressing unmet patient needs.

Key Companies in the G Protein Coupled Receptors Market include

Industry Developments

Q2 2024: Domain Therapeutics and GPCR Therapeutics Announce Strategic Partnership to Advance GPCR-Targeted Cancer Therapies Domain Therapeutics and GPCR Therapeutics entered a strategic partnership to co-develop novel immuno-oncology drugs targeting G-protein coupled receptors, aiming to accelerate clinical development and expand their oncology pipelines.
Q2 2024: Sosei Heptares Announces FDA Clearance of IND Application for HTL0039732, a Novel GPCR-Targeted Drug for Alzheimer’s Disease Sosei Heptares received FDA clearance for its Investigational New Drug (IND) application for HTL0039732, a new G-protein coupled receptor modulator intended for the treatment of Alzheimer’s disease, enabling the start of Phase 1 clinical trials.
Q2 2024: Tectonic Therapeutic Raises $80 Million Series B to Advance GPCR Drug Discovery Platform Tectonic Therapeutic secured $80 million in Series B funding to expand its proprietary platform for discovering and developing novel therapeutics targeting G-protein coupled receptors, with a focus on rare and underserved diseases.
Q3 2024: Confo Therapeutics Announces Opening of New R&D Facility to Accelerate GPCR Drug Development Confo Therapeutics inaugurated a new research and development facility in Belgium dedicated to advancing its pipeline of GPCR-targeted therapies, aiming to increase capacity for high-throughput screening and preclinical research.
Q3 2024: Pfizer Signs Licensing Agreement with Sosei Heptares for Novel GPCR Drug Candidates Pfizer entered into a licensing agreement with Sosei Heptares to access a portfolio of novel GPCR-targeted drug candidates, strengthening Pfizer’s position in neurological and metabolic disease therapeutics.
Q4 2024: Novartis Appoints Dr. Maria Sanchez as Head of GPCR Research Division Novartis announced the appointment of Dr. Maria Sanchez as the new head of its GPCR research division, signaling a strategic focus on expanding its pipeline of GPCR-targeted drugs for oncology and rare diseases.
Q4 2024: Ardemis Pharma Receives EMA Orphan Drug Designation for GPCR Modulator in Rare Pulmonary Disease Ardemis Pharma was granted orphan drug designation by the European Medicines Agency (EMA) for its GPCR modulator targeting a rare pulmonary disease, providing regulatory incentives and market exclusivity in the EU.
Q1 2025: Sosei Heptares and AbbVie Expand Collaboration to Develop Next-Generation GPCR Therapies Sosei Heptares and AbbVie expanded their existing collaboration to co-develop next-generation GPCR-targeted therapies, focusing on advancing candidates for neurological and immunological disorders.
Q1 2025: Tectonic Therapeutic Files for IPO to Fund GPCR Drug Discovery Programs Tectonic Therapeutic filed for an initial public offering (IPO) with the SEC, aiming to raise capital to accelerate its GPCR drug discovery and development programs targeting multiple disease areas.
Q2 2025: GPCR Therapeutics Wins $50 Million Contract from NIH to Develop Novel GPCR-Targeted Therapies GPCR Therapeutics was awarded a $50 million contract by the National Institutes of Health (NIH) to develop innovative therapies targeting G-protein coupled receptors for cancer and metabolic diseases.
Q2 2025: Confo Therapeutics Announces Positive Phase 2 Results for CFTX-1554, a GPCR Modulator for Neuropathic Pain Confo Therapeutics reported positive Phase 2 clinical trial results for CFTX-1554, a novel GPCR modulator for the treatment of neuropathic pain, demonstrating significant efficacy and safety.
Q3 2025: Domain Therapeutics Acquires GPCR Biotech Startup for $120 Million to Expand Oncology Pipeline Domain Therapeutics acquired a GPCR-focused biotech startup for $120 million, aiming to strengthen its oncology pipeline and accelerate the development of next-generation GPCR-targeted cancer therapies.

Future Outlook

G Protein Coupled Receptors Market Future Outlook

The G Protein-Coupled Receptors Market is projected to grow at a 4.56% CAGR from 2025 to 2035, driven by advancements in drug discovery and increasing prevalence of chronic diseases.

New opportunities lie in:

Development of targeted therapeutics for rare diseases</p><p>Integration of AI in GPCR drug discovery processes</p><p>Expansion of personalized medicine approaches in treatment protocols

By 2035, the market is expected to achieve substantial growth, reflecting evolving therapeutic landscapes.

Market Segmentation

G Protein Coupled Receptors Market Type Outlook

Class A
Class B
Class C
Frizzled
Tachykinin

G Protein Coupled Receptors Market End Use Outlook

Pharmaceuticals
Biotechnology
Academic Research
Contract Research Organizations

G Protein Coupled Receptors Market Research Type Outlook

Basic Research
Applied Research
Clinical Research

G Protein Coupled Receptors Market Therapeutic Application Outlook

Neurological Disorders
Metabolic Disorders
Cardiovascular Diseases
Cancer
Respiratory Diseases

Report Scope

MARKET SIZE 2024	40.12(USD Billion)
MARKET SIZE 2025	41.95(USD Billion)
MARKET SIZE 2035	65.52(USD Billion)
COMPOUND ANNUAL GROWTH RATE (CAGR)	4.56% (2025 - 2035)
REPORT COVERAGE	Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR	2024
Market Forecast Period	2025 - 2035
Historical Data	2019 - 2024
Market Forecast Units	USD Billion
Key Companies Profiled	Pfizer (US), Novartis (CH), Roche (CH), Johnson & Johnson (US), Merck & Co. (US), AstraZeneca (GB), Bristol-Myers Squibb (US), Gilead Sciences (US), Sanofi (FR)
Segments Covered	Type, Therapeutic Application, End Use, Research Type, Regional
Key Market Opportunities	Advancements in targeted therapies enhance potential in the G Protein-Coupled Receptors Market.
Key Market Dynamics	Rising demand for targeted therapies drives innovation and competition in the G Protein-Coupled Receptors market.
Countries Covered	North America, Europe, APAC, South America, MEA