Cell Therapy Market Analysis

Global Cell Therapy Market Overview

Cell Therapy Market Size was valued at USD 14.8 Billion in 2023. The Cell Therapy market industry is projected to grow from USD 16.14 Billion in 2024 to USD 31.2 Billion by 2032, exhibiting a compound annual growth rate (CAGR) of 8.58% during the forecast period (2023 - 2032). The expansion of financing for cell therapy clinical research, the adoption of practical manufacturing methods, and the commercial success of innovative products, are the key market drivers enhancing the market growth. 

Source Secondary Research, Primary Research, MRFR Database and Analyst Review

In May 2024, ProPharma, a US company that offers regulatory, clinical, and compliance services for the life sciences industry, partnered with PBL, an Italian company that provides custom solutions to the pharmaceutical, chemical, and diagnostics sectors. Together, they introduced the Cell Factory Box (CF Box), a fully automated device for creating cells, enclosed within a container. This device facilitates the distributed production of various cell and gene therapies (CGTs) in areas categorized as Class D (ISO8) or restricted but not classified. The CF Box utilizes pre-approved artificial intelligence (AI) technology and is highly automated, resulting in a substantial reduction in manual labor. The device's nature also diminishes the necessity for high-grade clean rooms. The CF Box utilizes authorized AI technology to implement batch detection identification, which remains in a fixed state during validation and batch manufacturing processes. Users have the ability to choose modules according to their specific requirements and select the required sort of items or technology. Supplementary modules might be incorporated at subsequent stages as well.

In December 2023, Max Healthcare introduced chimeric antigen receptor (CAR)-T cell therapy at its hospital in Delhi-NCR. The acquisition of CAR-T cells for this therapy is carried out in partnership with ImmunoACT, a startup incubated by IIT Bombay. ImmunoACT recently obtained marketing authorization permission from the Central Drugs Standard Control Organisation (CDSCO) for its CAR-T cell therapy product. This license allows the company to commercialize the therapy in India for the treatment of relapsed/refractory B-cell lymphomas and leukemia. Max Healthcare's implementation of CAR-T cell therapy is a substantial advancement in their dedication to delivering state-of-the-art treatment for individuals with cancer. This unique method demonstrates our ongoing commitment to pushing the limits of cancer treatment, providing patients with the most cutting-edge therapeutic choices currently accessible. Referred to as a "living drug," this therapy offers long-lasting advantages and is suggested for individuals who are unable to receive a stem cell transplant or are experiencing a relapse after a transplant. When compared to traditional treatments, this method involves a short, one-time administration of medication, which improves the overall well-being of numerous patients. On average, patients only need to stay in the hospital for two weeks.

The FDA approved the IND for NKX01 9, Nkarta Incorporated’s lupus nephritis treatment candidate allogeneic and CD19 CAR-directed NK cell therapy in October 2023.

Lonza and Vertex Pharmaceuticals Incorporated announced a collaboration in June 2023 aimed at enabling the manufacture of Vertex's stem cell therapies that are currently under investigation. These programs mainly concentrate on individuals with Type1 Diabetes (T1D), including a special emphasis on the ongoing clinical trials of VX-880 and VX-264.

In May 2023, Cellular Biomedicine Group entered into a global collaboration & licensing agreement with Johnson & Johnson to create next-generation CAR-T therapies.

During March 2023, Adatimmune Therapeutics plc. entered into strategic partnerships with TCR2 Therapeutics in order to cure multiple cancers by establishing one of the world’s top solid tumor cell therapy organizations.

Cell Therapy Market Trends

• The rise in funding for cell therapy clinical studies is driving the market growth

The market for cell treatment is constantly seeing the introduction of new cell types, creating enormous opportunity for companies to strengthen their market positions. As a result, during the past several years, there has been a sharp rise in the number of companies developing cell treatments. The increase in funding for cell therapy clinical research, the adoption of useful standards for cell therapy production, and the success of innovative products are some of the major factors influencing the growth in the number of businesses in the market. A decrease in the price of stem cell treatments has also increased consumer interest. The creation of cell banking facilities and the subsequent expansion of cell production, storage, and characterization have improved the market's capacity to deal with significant volumes on a  basis. The market's improved income generation over the preceding few years has been directly attributed to this.

The existence of both public and private financing organisations, which routinely grant approvals to projects to assist across all stages of clinical trials, can be ascribed to a rise in the number of clinical studies. Most late-stage projects in Europe receive funding from grants from the EU. For instance, Achilles Therapeutics announced in July 2022 that it had received a USD 4.2 million grant dubbed "Horizon Europe." It is the main funding programme for research and innovation in the EU. The production of personalised therapies will advance thanks to this support. Due to its uses in treating autoimmune and metabolic illnesses, stem cell treatment is also gaining popularity. It is crucial for a person to build their immunity so they can fight off different metabolic problems. For instance, in May 2022, Sernova and Evotec agreed to work together to develop cell therapies based on induced pluripotent stem cells (iPSCs) for the treatment of insulin-dependent diabetes.

The major technologies anticipated to have a favourable impact on the market growth for adult and cord blood cells are automation in adult stem cell processing and storage as well as cord blood storage. Additionally, major players in the market are working together to convert newborn stem cells from tissue and umbilical cord blood into induced pluripotent stem cells (iPSCs). Over the course of the projected period, these advancements are anticipated to fuel market expansion.

The primary drivers driving growth of the cell therapy market are an increase in the use of human cells for research in cell therapeutics, technological developments in the field of cell therapy, and an increase in the prevalence of diseases like cancer and cardiac abnormalities. Furthermore, it is projected that the installation of strong government rules regulating the use of cell therapy will limit market expansion. On the other hand, the market for cell treatment is anticipated to benefit from an increase in the number of rules promoting stem cell therapy and an increase in research funding in emerging nations. Thus, driving the Cell Therapy market revenue.

Cell Therapy Market Segment Insights

Cell Therapy Cell Type Insights

The  Cell Therapy market segmentation, based on cell type, includes stem cell and non-stem cell. Stem cell segment dominated the  market in 2022. This is a result of the rising need for new, improved medications to treat cardiovascular, neurological, and immunological diseases. Cell regeneration treatment is another name for stem cell therapy. However, the category with the quickest rate of growth over the anticipated period is non-stem cells. Non-stem cell therapy can increase the production of collagen and the creation of new, healthy skin tissue.

Cell Therapy Therapy Type Insights

The  Cell Therapy market segmentation, based on therapy type, includes autologous and allogeneic. The autologous segment dominated the  market in 2022. Additionally, it is anticipated that during the forecast period, this segment will increase more quickly. Due to the widespread use of CAR-T treatments and their successful outcomes in the treatment of various malignancies and genetic abnormalities, the market is expected to rise.

Cell Therapy Therapeutic Area Insights

The Cell Therapy market segmentation, based on therapeutic area, includes malignancies, musculoskeletal disorders, autoimmune disorders, dermatology, and others. Malignancies segment dominated the  cell therapy market in 2022. Patients with acute lymphocytic leukaemia (ALL) have allegedly seen high percentages of full and long-lasting remissions thanks to CAR T-cells that target CD19. Additionally, the sector for cell therapies is anticipated to increase as the FDA continues to approve more new therapies.

Cell Therapy End User Insights

The  Cell Therapy market segmentation, based on end user, includes hospitals & clinics and academic & research institutes. The hospital & clinics segment dominated the  cell therapy market in 2022. This is as a result of the anticipated period's rising need for gene and cell therapy. However, the category with the fastest growth is academic and research institutions. The major purpose of the stem cells is for research, which has resulted in a sizeable revenue share for the research usage.

Figure 1  Cell Therapy Market, by End User, 2023 & 2032 (USD Billion)

Source Secondary Research, Primary Research, MRFR Database and Analyst Review

Cell Therapy Regional Insights

By region, the study provides the market insights into North America, Europe, Asia-Pacific and Rest of the World. The North America Cell Therapy Market dominated this market in 2022 (45.80%). This is a result of regional pharmaceutical industry titans and academic institutes collaborating on research projects. Through several partnerships, there are new developments in the area. Further, the U.S. Cell Therapy market held the largest market share, and the Canada Cell Therapy market was the fastest growing market in the North America region.

Further, the major countries studied in the market report are The US, Canada, German, France, the UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil.

Figure 2  CELL THERAPY MARKET SHARE BY REGION 2022 (USD Billion)

Source Secondary Research, Primary Research, MRFR Database and Analyst Review

Europe Cell Therapy market accounted for the healthy market share in 2022. The market in Europe is anticipated to grow as a result of increased market participants' spending in the development and use of cell-based therapies in the United States. Further, the German Cell Therapy market held the largest market share, and the U.K Cell Therapy market was the fastest growing market in the European region

The Asia Pacific Cell Therapy market is expected to register significant growth from 2024 to 2032. This is a result of the region's rising need for cell treatment. During the projection period, it is projected that a number of variables, including rising investments, rising investments in novel medicines, and anticipated favourable government regulations, will boost market expansion. Moreover, China’s Cell Therapy market held the largest market share and the Indian Cell Therapy market was the fastest growing market in the Asia-Pacific region.

Cell Therapy Key Market Players & Competitive Insights

Leading market players are investing heavily in research and development in order to expand their product lines, which will help the Cell Therapy market, grow even more. Market participants are also undertaking a variety of strategic activities to expand their  footprint, with important market developments including new product launches, contractual agreements, mergers and acquisitions, higher investments, and collaboration with other organizations. To expand and survive in a more competitive and rising market climate, Cell Therapy industry must offer cost-effective items.

Manufacturing locally to minimize operational costs is one of the key business tactics used by manufacturers in the  Cell Therapy industry to benefit clients and increase the market sector. In recent years, the Cell Therapy industry has offered some of the most significant advantages to medicine. Major players in the Cell Therapy market, including Kolon TissueGene Inc., AlloSource, Holostem Terapie Avanzate S.R.L., AlloSource, Holostem Terapie Avanzate S.R.L., Castle Creek Biosciences Inc., Anterogen Co. Ltd, Celgene Corporation, and Tameika Cell Technologies Inc., are attempting to increase market demand by investing in research and development Products.

A biotechnology business is Immunocore Holdings Plc (Immunocore). It focuses on the creation of immunotherapeutic medicines for the management of autoimmune, infectious, and cancerous disorders. The business uses its own T cell receptor (TCR) technology to create its medications. It is currently working on the IMC-C103C, IMC-F106C, IMC-I109V, IMC-M113V, and IMCgp100 products. To develop its therapeutic candidates for the treatment of metastatic cutaneous melanoma, cancer, and other indications, the company collaborates with a number of pharmaceutical firms. It is present in the US, Australia, New Zealand, Asia, and Europe in addition to the UK. The U.K. county of Oxfordshire serves as the home base for Immunocore. The Food and Drug Administration granted Immunocore approval for KIMMTRAK (tebentafusp-tebn) in January 2022 to treat unresectable or metastatic uveal melanoma.

The goal of Novadip Biosciences is to increase access to tissue regeneration treatments through the development of cell-based regeneration medicines. With the help of the company's therapies, clinicians and patients can achieve better clinical outcomes and long-term quality of life. These therapies help heal bone disorders and deformities as well as hard and soft tissue restoration using autologous adipose stem cells. For the treatment of a rare paediatric bone condition, Novadip Biosciences' regenerating bone medicine NVD-003 got FDA approval as an investigational new drug (IND) in March 2021.

Key Companies in the Cell Therapy market include

• Kolon TissueGene Inc.


• AlloSource


• AlloSource


• Holostem Terapie Avanzate S.R.L.


• Castle Creek Biosciences Inc.


• Anterogen Co. Ltd


• Holostem Terapie Avanzate S.R.L.


• Celgene Corporation


• Tameika Cell Technologies Inc.

Cell Therapy Industry Developments

April 2023: Bristol Myers Squibb collaborated with Novartis to strengthen cell therapy capabilities by introducing a U.S. manufacturing facility for viral vector production of CAR T cell therapies.

March 2023: Arsenal Biosciences, Inc. and Thermo Fisher Scientific collaborated on the manufacturing processes for new cancer treatments. ArsenalBio has developed a robust manufacturing process for their next-generation, programmable autologous T cells for cancer treatment as a result of this research and process development collaboration.

March 2023: Danaher has formed a strategic partnership with the University of Pennsylvania to address manufacturing challenges affecting cell therapy uptake.

March 2022: Novartis Kymriah® CAR-T cell therapy has been approved by the FDA for patients with relapsed or refractory follicular lymphoma. Kymriah is now FDA approved for three indications and is the only CAR-T cell therapy that is approved for both adults and children.

December 2022: Kite, a Gilead Company, has formed a strategic alliance with Arcellx, Inc. to develop and commercialise CART-ddBCMA for the treatment of relapsed multiple myeloma. IN December 2022, the parties agreed to collaborate on the development and marketing of a CART-ddBCMA candidate for relapsed or refractory multiple myeloma.

December 2022: Kite acquired Tmunity Therapeutics in order to develop next-generation CAR T-cell therapies for cancer treatment. As a result of the acquisition, Kite will gain access to pre-clinical and clinical projects, as well as a 'armoured' CAR T technology platform that can be applied to a variety of CAR Ts to improve anti-tumor efficacy and speed up production procedures.

Lifileucel, the first cell-based treatment for a solid tumor in the US, may receive its first regulatory approval from Iovance Biotherapeutics in a few months. As a one-time, customized treatment for people with advanced melanoma, the FDA has formally begun an immediate examination of the tumor-infiltrating lymphocyte (TIL) therapy with an effective date of 25th November. Additionally, the FDA has no plans to convene an advisory committee. The encouraging results of CAR-Ts in treating blood cancers could inspire Iovance, which is attempting to pave the way for cell therapies in solid tumors.

The first patient dosed in Phase 1 clinical trial of A2B530, according to A2 Biotherapeutics, Inc. (A2 Bio), a clinical-stage cell treatment business developing first-in-class logic-gated cell therapies for tumors that are solid. Patients with colorectal, pancreatic, and lung cancers that are not small cells will be enrolled in the multi-center Phase 1 dose escalation study known as EVEREST-1 (NCT05736731). The safety of A2B530 will be assessed, and the optimal dosage will be determined by EVEREST-1. The initial autologous cell therapy created using the exclusive Tmod platform of A2 Bio is called A2B530. Utilizing a dual-receptor architecture, the Tmod platform targets tumor cells with an activator and shields normal cells with a blocker. The ability to target and kill tumor cells specifically is the fundamental problem with solid tumor cancer treatments.

Two presentations showcasing clinical data from the company's autologous CD30 were announced today by Tessa Therapeutics Ltd. (Tessa), a clinical-stage cell therapy business developing next-generation cancer therapies for hematological malignancies and solid tumors. Off-the-shelf CD30 CAR EBVST treatment (TT11X) and CAR-T therapy (TT11). Tessa's autologous CD30 is TT11.In a Phase 1B (ACTION) study aimed at patients with R/R traditional Hodgkin Lymphoma (cHL), CAR-T therapy is currently being investigated with Nivolumab.

Cell Therapy Market Segmentation

Cell Therapy Cell Type Outlook

• Stem Cell


• Non-Stem Cell

Cell Therapy Therapy Type Outlook

• Autologous


• Allogeneic

Cell Therapy Therapeutic Area Outlook

• Malignancies


• Musculoskeletal Disorders


• Autoimmune Disorders


• Dermatology


• Others

Cell Therapy End User Outlook

• Hospitals & Clinics


• Academic & Research Institutes

Cell Therapy Regional Outlook

• North America
  
  
  
  • U.S.
  
  
  • Canada
  
  
  
  


• Europe
  
  
  
  • Germany
  
  
  • France
  
  
  • UK
  
  
  • Italy
  
  
  • Spain
  
  
  • Rest of Europe
  
  
  
  


• Asia-Pacific
  
  
  
  • China
  
  
  • Japan
  
  
  • India
  
  
  • Australia
  
  
  • South Korea
  
  
  • Australia
  
  
  • Rest of Asia-Pacific
  
  
  
  


• Rest of the World
  
  
  
  • Middle East
  
  
  • Africa
  
  
  • Latin America