Isothermal Nucleic Acid Amplification Market Research Report Information By Product (Assays, Kits, & Reagents, and Systems), By Technology (Transcription Mediated Amplification (TMA), Loop-mediated Isothermal Amplification (LAMP), Strand Displacement Amplification (SDA), Helicase-dependent Amplification (HDA), Nucleic Acid Sequence-based Amplification (NASBA), Nicking Enzyme Amplification Reaction (NEAR), Single Primer Isothermal Amplification (SPIA), and Other Technologies), By Application (Disease Diagnosis, Blood Screening, and Other App

Global Isothermal Nucleic Acid Amplification Market Overview

Isothermal Nucleic Acid Amplification Market Size was valued at USD 4.6 Billion in 2022. The Isothermal Nucleic Acid Amplification Market industry is projected to grow from USD 5.0 Billion in 2023 to USD 10.4 Billion by 2032, exhibiting a compound annual growth rate (CAGR) of 9.50% during the forecast period (2024 - 2032). The increasing geriatric population globally and the rising prevalence of cancer and other chronic medical disorders, along with the escalating demand for efficient diagnosis and treatment alternatives, are expected to be significant market drivers for the Isothermal Nucleic Acid Amplification Market.

Source: Secondary Research, Primary Research, MRFR Database and Analyst Review

Isothermal Nucleic Acid Amplification Market Trends

• Increasing incidences of chronic diseases, an aging population, and a rise in demand for low-cost and effective diagnostics procedures are driving the market growth

Market CAGR for Isothermal Nucleic Acid Amplification is being driven by the increasing incidences of chronic diseases and an aging population, as well as a rise in demand for low-cost and effective diagnostics procedures. According to a World Health Organization report released in February 2022, cancer stands out as a major global cause of mortality. The report highlights that annually, approximately 400,000 children are diagnosed with cancer, with cervical cancer being the most prevalent in 23 countries. A report published by the International Agency for Research on Cancer (IARC) in December 2020 underscores the global cancer burden, which has surged to 19.3 million cases. Consequently, the escalating prevalence of cancer worldwide has spurred an increased demand for effective therapeutic interventions, driving market growth.

Nucleic acid amplification technology finds diverse applications across the healthcare industry, spanning from research to clinical settings. Historically, polymerase chain reaction (PCR) has been the predominant amplification technique worldwide. PCR necessitates a thermal cycler to maintain various temperatures at distinct stages of the amplification process. Furthermore, the removal of contaminants is imperative for successful amplification via this technology. The thermal cycler itself incurs a significant cost, and the process of sample preparation to eliminate contaminants adds to the overall expense and duration of the procedure.

As a result, it is anticipated that throughout the projection period, demand for the Isothermal Nucleic Acid Amplification Market will increase due to the Increasing incidences of chronic diseases and an aging population and a rise in demand for low-cost and effective diagnostics procedures. Thus, driving the Isothermal Nucleic Acid Amplification Market revenue.

Isothermal Nucleic Acid Amplification Market Segment Insights

• Isothermal Nucleic Acid Amplification Market Product Insights

The Isothermal Nucleic Acid Amplification Market segmentation, based on Product, includes Assays, Kits, & Reagents and Systems. The assays, kits, & reagents segment dominated the market, accounting for 58% of market revenue. The increasing need for molecular diagnostic methods stems from their precise, sensitive, and swift detection capabilities for infectious diseases, genetic disorders, and cancer biomarkers. Isothermal nucleic acid amplification techniques are preferred over conventional PCR methods due to their simplicity, rapidity, and cost-effectiveness. This surge in demand is driving the expansion of assays, kits, and reagents utilized in isothermal amplification methods.

Figure 1: Isothermal Nucleic Acid Amplification Market, by Product, 2023 & 2032 (USD Billion)

Source: Secondary Research, Primary Research, MRFR Database and Analyst Review

Isothermal Nucleic Acid Amplification Market Technology Insights

The Isothermal Nucleic Acid Amplification Market segmentation, based on Technology includes Transcription Mediated Amplification (TMA), Loop-mediated Isothermal Amplification (LAMP), Strand Displacement Amplification (SDA), Helicase-dependent Amplification (HDA), Nucleic Acid Sequence-based Amplification (NASBA), Nicking Enzyme Amplification Reaction (NEAR), Single Primer Isothermal Amplification (SPIA), and Other Technologies. The loop-mediated isothermal amplification (LAMP) segment dominated the market, accounting for 58% of market revenue. The LAMP technique presents two key competitive advantages over PCR technology. Firstly, it exhibits tolerance towards PCR inhibitors, enabling direct sample analysis. Secondly, it operates at a fixed temperature, eliminating the need for a thermocycler. These benefits position it favorably for point-of-care diagnostics, a segment witnessing notable growth. As per the World Ageing 2020 report, the global population aged 65 years and older is projected to reach 1.5 billion by 2050. Additionally, by 2050, one in six individuals worldwide will be over 65 years of age. These demographic trends suggest potential proportional growth in the studied LAMP market segment.

Isothermal Nucleic Acid Amplification Market Application Insights

The Isothermal Nucleic Acid Amplification Market segmentation, based on Application, includes Disease Diagnosis, Blood Screening, and Other Applications. The blood screening segment dominated the market, accounting for 60% of market revenue. Due to the increasing, continuously rising demand for blood screening and analysis resulting from the rates of blood donation and transfusions globally, this segment has emerged as a crucial application area for isothermal amplification techniques in recent times.

Isothermal Nucleic Acid Amplification Market End-User Insights

The Isothermal Nucleic Acid Amplification Market segmentation, based on Users, includes Hospitals, Reference Laboratories, Academic & Research Institutes, and Other End Users. The hospital segment dominated the market, accounting for 60% of market revenue. The hospital sector is poised to lead the market due to the growing utilization of INAAT kits in disease treatment. Moreover, the majority of diagnostic procedures are conducted under supervision, minimizing the likelihood of errors and ensuring accurate results, thus positively influencing revenue growth throughout the forecast period. Additionally, the escalating demand for nucleic acid amplification technology within hospitals, compared to other end-use industries, is propelling growth in this segment.

Isothermal Nucleic Acid Amplification Market Regional Insights

By region, the study provides market insights into North America, Europe, Asia-Pacific, and Rest of the World. North America has secured the largest market share, primarily due to its well-established research infrastructure and the rising demand for nucleic acid amplification-based diagnostics aimed at preventing infectious diseases in the region. Moreover, the region's high per capita healthcare expenditure and increasing emphasis on point-of-care diagnostic techniques are projected to propel market growth. The per capita healthcare expenditure in North America is also expected to bolster market expansion. According to data released by the United States Department of Commerce in 2021, healthcare spending in Canada is forecasted to reach USD 308 billion, accounting for approximately 12.7% of the country's GDP.

Further, the major countries studied in the market report are the US, Canada, Germany, France, the UK, Italy, Spain, China, Japan, India, Australia, and South Korea.

Figure 2: Isothermal Nucleic Acid Amplification Market Share By Region 2023 (USD Billion)

Source: Secondary Research, Primary Research, MRFR Database and Analyst Review

Europe's Isothermal Nucleic Acid Amplification Market accounts for the second-largest market share as Europe is projected to maintain a prominent role in the worldwide isothermal nucleic acid amplification technology market, primarily due to the rising incidence of chronic diseases across the region. In 2022, chronic ischaemic heart disease was responsible for the majority of male deaths in Germany, totaling 42.9 thousand fatalities. Notably, among the top 10 causes of death, four were associated with cardiovascular complications, resulting in a cumulative total of 102.3 thousand deaths. Further, the German Isothermal Nucleic Acid Amplification Market held the largest market share, and the UK Isothermal Nucleic Acid Amplification Market was the fastest-growing market in the European region.

The Asia-Pacific Isothermal Nucleic Acid Amplification Market is expected to grow at the fastest CAGR from 2024 to 2032, driven by factors such as the increasing prevalence of chronic diseases, heightened participation of market players in the region, and rising investments in research and development. Before the onset of the pandemic, ischaemic heart disease ranked as the primary cause of death in India, followed by chronic obstructive pulmonary disorder and stroke, as reported by the WHO. Collectively, these three non-communicable diseases (NCDs) accounted for approximately 226 deaths per 100,000 population in India in 2019. Conversely, diarrhoeal diseases, tuberculosis, and neonatal conditions were responsible for 112 deaths per 100,000 population. Moreover, China’s Isothermal Nucleic Acid Amplification Market held the largest market share, and the Indian Isothermal Nucleic Acid Amplification Market was the fastest-growing market in the Asia-Pacific region.

Isothermal Nucleic Acid Amplification Market Key Market Players & Competitive Insights

Leading market players are investing heavily in research and development to expand their product lines, which will help the Isothermal Nucleic Acid Amplification market grow even more. Market participants are also undertaking a variety of strategic activities to expand their global footprint, with important market developments including new product launches, contractual agreements, mergers and acquisitions, higher investments, and collaboration with other organizations. To expand and survive in a more competitive and rising market climate, the Isothermal Nucleic Acid Amplification industry must offer cost-effective items.

Manufacturing locally to minimize operational costs is one of the key business tactics used by manufacturers in the global Isothermal Nucleic Acid Amplification industry to benefit clients and increase the market sector. In recent years, the Isothermal Nucleic Acid Amplification industry has offered some of the most significant advantages to the entertainment and music production sectors. Major players in the Isothermal Nucleic Acid Amplification Market, including Grifols, S.A. (Spain), Hologic, Inc. (US), Abbott Laboratories (US), Becton, Dickinson and Company (US), Meridian Bioscience (US), Eiken Chemical Co., Ltd. (Japan), bioMérieux SA (France), Tecan Trading AG (Switzerland), New England Biolabs (US), QIAGEN N.V. (Germany) are attempting to increase market demand by investing in research and development operations.

Abbott Laboratories engages in the discovery, development, manufacturing, and distribution of a diverse portfolio of healthcare products, spanning branded generic pharmaceuticals, diagnostic systems, pediatric and adult nutritional products, medical devices, minerals and nutrition products, and dietary supplements. Its medical device offerings include heart failure, electrophysiology, rhythm management, vascular and structural heart devices, and neuromodulation devices. The company operates research and development facilities across the United States, Colombia, India, Singapore, Spain, and the United Kingdom, with manufacturing facilities worldwide. Abbott markets its products across North America, Latin America, the Middle East, Europe, Asia-Pacific, and Africa. Headquartered in Abbott Park, Illinois, United States, Abbott gained approval from Health Canada for its ID NOW rapid COVID-19 testing device for Canadian use in September 2020.

Becton Dickinson and Company is a leading medical technology company specializing in the manufacture and distribution of medical devices, reagents, and instruments. Its extensive product line includes syringes, intravenous catheters, infusion pumps, automated medication dispensing systems, pre-fillable drug delivery systems, respiratory ventilation equipment, diagnostic equipment, and consumables for diagnostic specimen collection. BD also offers instruments and reagent systems for detecting various infectious diseases and cancers, as well as clinical research tools. Serving life science researchers, healthcare institutions, clinical laboratories, the pharmaceutical industry, and the general public, BD markets its products across the Americas, Europe, the Middle East, Africa, and the Asia-Pacific region. Headquartered in New Jersey, United States, BD remains a key player in the medical technology sector.

Key companies in the Isothermal Nucleic Acid Amplification Market include

• Grifols, S.A. (Spain)


• Hologic, Inc. (US)


• Abbott Laboratories (US)


• Becton, Dickinson and Company (US)


• Meridian Bioscience (US)


• Eiken Chemical Co., Ltd. (Japan)


• BioMérieux SA (France)


• Tecan Trading AG (Switzerland)


• New England Biolabs (US)


• QIAGEN N.V. (Germany)

Isothermal Nucleic Acid Amplification Industry Developments

August 2022: LGC Clinical Diagnostics announced the expansion of their exclusive partnership with Stanford Medicine's Department of Obstetrics and Gynecology and Metabolic Health Center to bolster global genetic and metabolic diagnostic testing.

May 2022: Meridian Bioscience, Inc. launched the latest Lyo-Ready Direct RNA/DNA LAMP and Lyo-Ready Direct DNA LAMP Saliva Mix master mixes designed for isothermal amplification applications.

Isothermal Nucleic Acid Amplification Market Segmentation

Isothermal Nucleic Acid Amplification Market Product Outlook

• Assays, Kits, & Reagents


• Systems

Isothermal Nucleic Acid Amplification Market Technology Outlook

• Transcription Mediated Amplification (TMA)


• Loop-mediated Isothermal Amplification (LAMP)


• Strand Displacement Amplification (SDA)


• Helicase-dependent Amplification (HDA)


• Nucleic Acid Sequence-based Amplification (NASBA)


• Nicking Enzyme Amplification Reaction (NEAR)


• Single Primer Isothermal Amplification (SPIA)


• Other Technologies

Isothermal Nucleic Acid Amplification Market Application Outlook

• Disease Diagnosis


• Blood Screening


• Other Applications

Isothermal Nucleic Acid Amplification Market End-User Outlook

• Hospitals


• Reference Laboratories


• Academic & Research Institutes


• Other End Users

Isothermal Nucleic Acid Amplification Market Regional Outlook

• North America
  
  
  
  • US
  
  
  • Canada
  
  
  
  


• Europe
  
  
  
  • Germany
  
  
  • France
  
  
  • UK
  
  
  • Italy
  
  
  • Spain
  
  
  • Rest of Europe
  
  
  
  


• Asia-Pacific
  
  
  
  • China
  
  
  • Japan
  
  
  • India
  
  
  • South Korea
  
  
  • Australia
  
  
  • Rest of Asia-Pacific
  
  
  
  


• Rest of the World
  
  
  
  • Middle East
  
  
  • Africa
  
  
  • Latin America